Stomach tumor model manufacturing method and mold
By assembling molds and selecting materials, a gastric tumor model with adjustable shape and hardness was prepared, solving the problem that existing models could not preset the location of lesions. This enabled high-precision and highly flexible repetitive surgical simulation, significantly improving the yield and production efficiency.
Patent Information
- Application Number
- CN202511777037.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-11-28
- Publication Date
- 2026-02-13
AI Technical Summary
Existing gastric tumor models cannot adjust shape and hardness, cannot preset lesion location, and are difficult to simulate repeated surgeries, lacking flexibility and accuracy.
The process involves steps such as mold assembly, partial gastric cavity shaping, gastric tumor simulation, fabrication of a second core, and overall gastric cavity shaping. Using liquid flexible materials and easily soluble materials, the shape and hardness are adjusted through molds, and the lesion location is preset to form a reusable gastric tumor model.
The model allows for adjustable shape and rigidity of gastric tumor models, enables pre-setting of lesion locations, improves the accuracy and flexibility of repeated surgical simulations, increases the yield rate to over 95%, and reduces manufacturing complexity and production cycle.
Smart Images
Figure CN121528094A_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the field of tumor models, in particular to a gastric tumor model manufacturing method and a mold. BACKGROUND
[0002] The gastric tumor model can restore the mechanical properties of the extracellular matrix and accurately simulate the biological behaviors such as proliferation and invasion of gastric cancer. In patient individualized treatment, the gastric tumor model can assist in formulating surgical plans and reducing intraoperative risks.
[0003] However, the existing common gastric tumor models are hard body and ex vivo tissue models. The shape and hardness of the hard body are fixed and cannot be adjusted, such as the hardness change of the "diseased stomach wall" cannot be simulated. The structure and properties of the ex vivo tissue model are determined by the animal itself, and the disease location or hardness cannot be artificially customized, and the flexibility is very poor. Therefore, it is difficult to achieve repeated surgical simulation, and only anatomical display or one-time operation effect can be achieved. SUMMARY
[0004] In order to overcome the deficiencies of the prior art, one of the purposes of the present application is to provide a gastric tumor model manufacturing method which can adjust the shape and hardness and preset the "disease location".
[0005] In order to overcome the deficiencies of the prior art, the second purpose of the present application is to provide a gastric tumor model manufacturing mold which can adjust the shape and hardness and preset the "disease location".
[0006] One of the purposes of the present application is achieved by the following technical solutions: A gastric tumor model manufacturing method, comprising the following steps: Mold assembly: fixedly connecting the bottom plate and the first upper shell, forming a cavity between the bottom plate and the first upper shell, placing a first core in the cavity, and forming a first gap between the first core and the bottom plate and the first upper shell; Partial gastric cavity forming: injecting a liquid flexible material into the first gap, and solidifying the liquid flexible material to form a partial gastric cavity; Gastric tumor simulation: using a metal powder mixed with a liquid flexible material to manufacture a simulated tumor, and fixing the simulated tumor at a corresponding position of the partial gastric cavity; Manufacturing a second core: using a readily soluble material to manufacture a second core, placing the second core and the partial gastric cavity in the assembled mold, at this time the partial gastric cavity is located in the cavity, the end of the second core extends into the partial gastric cavity, and the second upper shell is installed on the bottom plate, at this time the second core forms a second gap with the second upper shell and the bottom plate; forming a whole stomach cavity by injecting liquid flexible material into the second gap, the liquid flexible material being solidified in the local stomach cavity to form the whole stomach cavity, at this time the second core being located in the whole stomach cavity; removing the second core by placing the whole stomach cavity with the second core in a dissolving solution, the second core being dissolved in the dissolving solution to form the stomach tumor model.
[0007] Further, in the mold assembling step, the bottom plate is provided with a positioning block, the first core comprises a main body and a positioning plate fixed to the main body, and the positioning plate cooperates with the positioning block to position the first core in the cavity.
[0008] Further, in the local stomach cavity forming step, the liquid flexible material is silica gel.
[0009] Further, in the stomach tumor modeling step, the metal powder is tungsten powder.
[0010] Further, in the mold assembling step, the fixed bottom plate and the first upper shell side are covered with clay to prevent overflow of the liquid flexible material.
[0011] Further, in the second core making step, the easily soluble material is water-soluble material.
[0012] Further, the water-soluble material is polyvinyl alcohol.
[0013] The second purpose of the present application is achieved by using the following technical scheme: A stomach tumor model making mold is used to implement any one of the stomach tumor model making methods described above, and the stomach tumor model making mold comprises a bottom plate, a first upper shell, a second upper shell, a first core and a second core, the first upper shell and the second upper shell are detachably installed on the bottom plate, the first core is located between the first upper shell and the bottom plate, the first core is used to form a local stomach cavity, the second core is made of easily soluble material, and the second core is installed in the local stomach cavity to continue forming a whole stomach cavity on the local stomach cavity.
[0014] Further, the bottom plate comprises a positioning block, the first core comprises a main body and a positioning plate fixed to the main body, and the positioning plate cooperates with the positioning block to position the first core in the cavity.
[0015] Further, the bottom plate further comprises a plate body, the plate body is provided with a liquid injection hole and a core cavity in communication with the liquid injection hole, and the first core and the second core are located in the core cavity.
[0016] Compared with the prior art, the stomach tumor model manufacturing method has the advantages that the shape and hardness of the manufactured stomach tumor model can be adjusted, and the "lesion position" can be preset. BRIEF DESCRIPTION OF DRAWINGS
[0017] Figure 1 The flow chart of the stomach tumor model manufacturing method of the present application is shown in the figure. Figure 2 The perspective view of the mold of the stomach tumor model manufacturing method of the present application is shown in the figure. Figure 3 The exploded view of the mold of the stomach tumor model manufacturing method of the present application is shown in the figure. Figure 2 Figure 4 The process diagram of the stomach tumor model manufacturing method of the present application is shown in the figure. Figure 1
[0018] In the figure: 10, shell; 11, bottom plate; 111, plate body; 1110, liquid injection hole; 1111, cavity; 112, positioning block; 1121, positioning groove; 12, first upper shell; 13, second upper shell; 21, first core; 210, main body; 211, positioning plate; 22, second core. DETAILED DESCRIPTION
[0019] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.
[0020] It should be noted that when a component is referred to as being "fixed" to another component, it can be directly on the other component or there can be another intermediate component fixed by the intermediate component. When a component is referred to as being "connected" to another component, it can be directly connected to the other component or there can be another intermediate component. When a component is referred to as being "disposed" on another component, it can be directly disposed on the other component or there can be another intermediate component. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only.
[0021] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used in the description herein is for describing particular embodiments only and is not intended to be limiting of the application. The use herein of the terms "and / or" includes a set of one or more associated listed items.
[0022] Referring to Figures 1 to 4 The application is a method for making a gastric tumor model, comprising the following steps: Mold assembly: the bottom plate 11 and the first upper shell 12 are fixedly connected, and a cavity is formed between the bottom plate 11 and the first upper shell 12. The first core 21 is placed in the cavity, and a first gap is formed between the first core 21, the bottom plate 11 and the first upper shell 12. Partial gastric cavity forming: liquid flexible material is injected into the first gap, and the liquid flexible material is solidified to form a partial gastric cavity. Gastric tumor simulation: simulated tumors are made by mixing metal powder with liquid flexible material, and the simulated tumors are fixed at corresponding positions of the partial gastric cavity. Making the second core 22: the second core 22 is made of easily soluble material. The second core 22 and the partial gastric cavity are placed in the assembled mold, at this time the partial gastric cavity is located in the cavity, and the end of the second core 22 extends into the partial gastric cavity. The second upper shell 13 is installed on the bottom plate 11, at this time a second gap is formed between the second core 22, the second upper shell 13 and the bottom plate 11. Overall gastric cavity forming: liquid flexible material is injected into the second gap, and the liquid flexible material is solidified in the partial gastric cavity to form an overall gastric cavity, at this time the second core 22 is located in the overall gastric cavity. Removing the second core 22: the overall gastric cavity with the second core 22 is placed in a dissolving solution, and the second core 22 is dissolved in the dissolving solution to form a gastric tumor model.
[0023] The mold assembly step is as follows: the bottom plate 11 is provided with a positioning block 112, the first core 21 includes a main body 210 and a positioning plate 211 fixed to the main body 210. The positioning plate 211 cooperates with the positioning block 112 to position the first core 21 in the cavity, so that the first gap is formed between the first core 21, the bottom plate 11 and the first upper shell 12. Liquid flexible material is injected into the first gap to form a partial gastric cavity. Clay is spread on the side edges of the fixed bottom plate 11 and the first upper shell 12 to prevent the liquid flexible material from overflowing.
[0024] The local stomach cavity forming step is specifically: the liquid flexible material is silica gel. Specifically, the silica gel is formed by mixing two kinds of silica gel, the two kinds of silica gel are silica gel A and silica gel B, and the mixed liquid is formed after the silica gel A and the silica gel B are mixed in a ratio of 1:1 and stirred uniformly and then vacuumed to extract air bubbles. The silica gel formed after the silica gel liquid is solidified is a flexible material, which overcomes the disadvantage of the traditional hard stomach model, and changes the rigid model into a flexible model by the flexible silica gel material. Due to the wear resistance, corrosion resistance and other properties of the silica gel, the silica gel stomach model body made of the silica gel can be repeatedly used. Moreover, the silica gel formula (i.e. the ratio of the silica gel A to the silica gel B) can be adjusted to simulate the stomach wall in different states, and the silica gel stomach model body can be accurately made according to the average stomach size and the anatomical structure of the human body.
[0025] The stomach tumor simulation step is specifically: the local stomach cavity is taken out of the mold, the simulated tumor is bonded on the local stomach cavity, and the bonding position is a preset position. The size of the simulated tumor is changed according to the actual situation. In this embodiment, the simulated tumor is spherical, the diameter is 2 cm, and the metal powder is tungsten powder.
[0026] The step of making the second core 22 is specifically: The easily soluble material is a water-soluble material. In this embodiment, the water-soluble material is polyvinyl alcohol. The size of the second core 22 is smaller than the structure of the cavity, so as to form the second gap.
[0027] The overall stomach cavity forming step is specifically: The liquid flexible material is silica gel. Specifically, the silica gel is formed by mixing two kinds of silica gel, the two kinds of silica gel are silica gel A and silica gel B, and the mixed liquid is formed after the silica gel A and the silica gel B are mixed in a ratio of 1:1 and stirred uniformly and then vacuumed to extract air bubbles. The silica gel formed after the silica gel liquid is solidified is a flexible material, which overcomes the disadvantage of the traditional hard stomach model, and changes the rigid model into a flexible model by the flexible silica gel material. Due to the wear resistance, corrosion resistance and other properties of the silica gel, the silica gel stomach model body made of the silica gel can be repeatedly used. Moreover, the silica gel formula (i.e. the ratio of the silica gel A to the silica gel B) can be adjusted to simulate the stomach wall in different states, and the silica gel stomach model body can be accurately made according to the average stomach size and the anatomical structure of the human body.
[0028] Please continue to refer to Figures 2 to 4 The application also discloses a stomach tumor model making mold for implementing the stomach tumor model making method.
[0029] The stomach tumor model making mold comprises a shell 10 and a core, the shell 10 comprises a bottom plate 11, a first upper shell 12 and a second upper shell 13. The core comprises a first core 21 and a second core 22.
[0030] The bottom plate 11 comprises a plate body 111 and positioning blocks 112 extending from the plate body 111. The plate body 111 is provided with a liquid injection hole 1110 and a cavity 1111, and the liquid injection hole 1110 is in communication with the cavity 1111. Specifically, the liquid injection hole 1110 is arranged on the side wall of the plate body 111, and the cavity 1111 is arranged on the upper surface of the plate body 111.
[0031] The number of positioning blocks 112 is two, and the two positioning blocks 112 are respectively located on the two sides of the cavity 1111. Each positioning block 112 is provided with a positioning groove 1121. The positioning groove 1121 is used for positioning the first core 21, and the positioning groove 1121 determines the position of the first core 21 in the cavity 1111.
[0032] The first upper shell 12 is detachably fixed to the bottom plate 11, and a space for accommodating the first core 21 is formed between the first upper shell 12 and the bottom plate 11, which is used for making a partial stomach cavity.
[0033] The second upper shell 13 is detachably fixed to the bottom plate 11, and a space for accommodating the second core 22 is formed between the second upper shell 13 and the bottom plate 11, which is used for continuing to form the remaining stomach cavity on the partial stomach cavity.
[0034] The first core 21 comprises a main body 210 and a positioning plate 211 fixed to the main body 210, and the positioning plate 211 is inserted into the positioning groove 1121, so that the position of the first core 21 in the cavity 1111 is determined.
[0035] The second core 22 is made of a dissolving material, so that after the whole stomach cavity is formed, the second core 22 can be dissolved to make the inside of the whole stomach cavity hollow. In this embodiment, the second core 22 is made by 3D printing.
[0036] Compared with the prior art, the stomach tumor model manufacturing method of the present application comprises the steps of mold assembly, partial stomach cavity forming, stomach tumor simulation, second core 22 manufacturing, whole stomach cavity forming and second core 22 removing, so that the shape and hardness of the manufactured stomach tumor model can be adjusted, and the "lesion position" can be preset. By using water-soluble material PVA to print the second core 22, the effect of removing the core without damage is achieved, and the cavity is prevented from being damaged. The problem of low yield (the yield of traditional products is usually <70%, and the yield of the present application can be improved to more than 95%) caused by "rigid core scratching the inner cavity of silicone" in traditional molding is solved. Secondly, the production complexity is reduced, and the production cycle is shortened (without the need to design a complex split rigid mold). In addition, the compatibility of PVA core with medical silicone is good, which can quickly customize cavities of different specifications and functions, adapt to medical training, surgical robot testing, lesion simulation and other scenes, and meet medical safety standards, with high industrialization and application value. The problems of low forming precision of traditional silicone stomach cavity, difficulty in reproducing inner cavity details, and complicated core removal are solved.
[0037] The above embodiments only express several implementation manners of the present application, the description is more specific and detailed, but cannot be understood as the limitation of the scope of the patent. It should be pointed out that for ordinary skilled in the art, without departing from the concept of the present application, several modifications and improvements can be made, which are equivalent modifications and evolutions of the above embodiments according to the essential technology of the present application, and these all belong to the protection scope of the present application.
Claims
1. A method for creating a gastric tumor model, characterized in that, Includes the following steps: Mold assembly: The base plate and the first upper shell are fixedly connected, and a cavity is formed between the base plate and the first upper shell. The first core is placed in the cavity, and a first gap is formed between the first core and the base plate and the first upper shell. Local gastric cavity shaping: A liquid flexible material is injected into the first gap, and the liquid flexible material solidifies to form a local gastric cavity; Gastric tumor simulation: A simulated tumor is made using a flexible material made of metal powder mixed with liquid, and the simulated tumor is fixed at a corresponding position in the local gastric cavity; Fabrication of the second core: The second core is fabricated using an easily soluble material. The second core and the partial gastric cavity are placed in the assembled mold. At this time, the partial gastric cavity is located in the cavity. The end of the second core extends into the partial gastric cavity. The second upper shell is installed on the bottom plate. At this time, a second gap is formed between the second core, the second upper shell, and the bottom plate. Integral gastric cavity shaping: Liquid flexible material is injected into the second gap, and the liquid flexible material solidifies in the local gastric cavity to form an integral gastric cavity, at which time the second core is located in the integral gastric cavity; Removal of the second core: The entire gastric cavity with the second core is placed in a dissolving solution, and the second core dissolves in the dissolving solution to form a gastric tumor model.
2. The method for creating a gastric tumor model according to claim 1, characterized in that: In the mold assembly step, the base plate is provided with a positioning block, and the first core includes a main body and a positioning plate fixed to the main body. The positioning plate cooperates with the positioning block to position the first core in the cavity.
3. The method for creating a gastric tumor model according to claim 1, characterized in that: In the partial gastric cavity shaping step, the liquid flexible material is silicone.
4. The method for creating a gastric tumor model according to claim 1, characterized in that: In the gastric tumor simulation step, the metal powder is tungsten powder.
5. The method for creating a gastric tumor model according to claim 1, characterized in that: In the mold assembly step, clay is laid on the fixed base plate and the sides of the first upper shell to prevent liquid flexible material from overflowing.
6. The method for creating a gastric tumor model according to claim 1, characterized in that: In the step of making the second core, the easily soluble material is a water-soluble material.
7. The method for creating a gastric tumor model according to claim 6, characterized in that: The water-soluble material is polyvinyl alcohol.
8. A mold for fabricating a gastric tumor model, used to implement the gastric tumor model fabrication method according to any one of claims 1-7, the mold comprising a base plate, a first upper shell, a second upper shell, a first core, and a second core, the first upper shell and the second upper shell being detachably mounted on the base plate, the first core being located between the first upper shell and the base plate, the first core being used to form a partial gastric cavity, the second core being made of an easily soluble material, and the second core being mounted on the partial gastric cavity to continue forming an integral gastric cavity on the partial gastric cavity.
9. The mold for fabricating a gastric tumor model according to claim 8, characterized in that: The base plate includes a positioning block, and the first core includes a main body and a positioning plate fixed to the main body. The positioning plate cooperates with the positioning block to position the first core in the cavity.
10. The mold for fabricating a gastric tumor model according to claim 8, characterized in that: The base plate also includes a plate body, which has an injection hole and a cavity communicating with the injection hole, and the first core and the second core are located in the cavity.