Antibacterial nano coating on surface of oropharyngeal airway and processing technology of antibacterial nano coating

Abstract

The invention discloses an oropharynx airway surface antibacterial nano coating and a processing technology thereof, and relates to the technical field of oropharynx airways. The chitosan antibacterial microcapsule is added into the antibacterial nano coating, so that the antibacterial performance of the oropharyngeal airway is enhanced. The chitosan antibacterial microcapsule contains tea tree essential oil and polylysine, and the tea tree essential oil and the polylysine are compounded for use, so that the antibacterial property of the antibacterial nano-coating is enhanced. A silver nitrate solution is also added to modify the chitosan antibacterial microcapsule, and nano-silver can play a good antibacterial role. The oropharyngeal airway is also prepared from polylactic acid, calcium carbonate, ethylene bis stearamide and sulfhydrylated oyster shell powder as raw materials. And the sulfhydrylated oyster shell powder is used as the raw material, so that the oropharyngeal airway is greener and more environment-friendly.

Description

Technical Field

[0001] This invention relates to the field of oropharyngeal airway technology, specifically to an antibacterial nano-coating for the surface of an oropharyngeal airway and its processing technology. Background Technology

[0002] Oropharyngeal airways are commonly used medical devices in clinical emergency care and anesthesia. Traditional oropharyngeal airways are prone to bacterial growth during use, increasing the risk of infection for patients. To reduce infection rates and improve medical safety, developing antibacterial surface coatings for oropharyngeal airways is crucial. In terms of processing technology, existing methods include chemical plating and thermal spraying, which can uniformly deposit nano-antibacterial materials onto the substrate surface, forming a stable antibacterial coating that inhibits bacterial growth and reproduction. However, existing antibacterial coating technologies still have some shortcomings. For example, the adhesion and durability of the coating need improvement; it may peel off or fail after prolonged use. Therefore, the coating preparation process needs further optimization to reduce costs and improve production efficiency.

[0003] To address the aforementioned issues and improve antibacterial properties and coating adhesion, this invention provides an antibacterial nano-coating for the surface of the oropharyngeal airway and its processing technology. Summary of the Invention

[0004] The purpose of this invention is to provide an antibacterial nano-coating for the surface of the oropharyngeal airway and its processing technology, so as to solve the problems raised in the prior art.

[0005] To achieve the above objectives, the present invention provides the following technical solution: A processing technology for an antibacterial nano-coating on the surface of an oropharyngeal airway, wherein the antibacterial nano-coating is obtained by curing an antibacterial nano-coating applied to the surface of the oropharyngeal airway; the preparation method of the antibacterial nano-coating is as follows: vinyl chitosan and deionized water are mixed evenly, anhydrous sodium carbonate and sodium trimetaphosphate are added, and the mixture is stirred and reacted for 1-1.5 hours; chitosan antibacterial microcapsules, agar, and 2-hydroxy-2-methyl-1-phenyl-1-propanone are added, and the mixture is stirred evenly to obtain the antibacterial nano-coating.

[0006] More preferably, the antibacterial nano-coating comprises the following components by weight: 45-50 parts vinyl chitosan, 500-550 parts deionized water, 10-12 parts anhydrous sodium carbonate, 8-11 parts sodium trimetaphosphate, 13-16 parts chitosan antibacterial microcapsules, 13-15 parts agar, and 2-3 parts 2-hydroxy-2-methyl-1-phenyl-1-propanone.

[0007] In a more optimized manner, the preparation method of the chitosan antibacterial microcapsules is as follows: take sodium dodecylbenzenesulfonate, deionized water, tea tree oil, and polylysine, shear for 2-3 minutes, add chitosan mixed solution dropwise, add sodium hyaluronate, add glutaraldehyde, react at 60-65℃ for 2-3 hours, add silver nitrate solution, and obtain chitosan antibacterial microcapsules.

[0008] A more optimized method for preparing polylysine is as follows: take L-lysine hydrochloride, o-vanillin, and potassium hydroxide, mix them evenly, heat to 145-150℃, add zirconium butoxide solution, react for 10-14 hours, cool to 25-30℃, add methanol, stir evenly, filter, wash, and dry to obtain polylysine.

[0009] A more optimized method for preparing the chitosan mixed solution is as follows: take vinyl chitosan, chitosan, and deionized water, stir evenly, and obtain a chitosan mixed solution.

[0010] A more optimized method for preparing the vinyl chitosan is as follows: take chitosan and an aqueous acetic acid solution, stir evenly, add glycidyl methacrylate dropwise, stir for 22-26 hours, add excess acetone, precipitate, filter, wash, and dry to obtain vinyl chitosan.

[0011] A more optimized method for preparing the oropharyngeal airway with an antibacterial nano-coating on its surface includes the following steps: S1: Take polylactic acid, calcium carbonate, ethylene bis-stearamide, and mercaptoized oyster shell powder, dry them, and injection mold them at 150-160℃ to obtain an oropharyngeal airway; S2: Apply antibacterial nano-coating to the surface of the oropharyngeal airway, dry for 2 hours, and then cure under ultraviolet light for 2.5-3 hours to obtain an oropharyngeal airway with an antibacterial nano-coating on the surface.

[0012] A more optimized method for preparing the thiolized oyster shell powder is as follows: take oyster shell powder, sodium periodate, and deionized water, stir for 3-4 hours, add ethylene glycol, centrifuge, wash, add cysteine, and under nitrogen protection, heat to 35-40°C and stir for 5-6 hours to obtain thiolized oyster shell powder.

[0013] Compared with the prior art, the beneficial effects of the present invention are: 1. This invention involves coating and curing an antibacterial nano-coating onto the surface of an oropharyngeal airway to obtain an oropharyngeal airway with an antibacterial nano-coating. The invention incorporates chitosan antibacterial microcapsules into the antibacterial nano-coating, enhancing the antibacterial properties of the oropharyngeal airway. The chitosan antibacterial microcapsules contain tea tree oil and polylysine; the combined use of tea tree oil and polylysine further enhances the antibacterial properties of the antibacterial nano-coating. Furthermore, this invention modifies the chitosan antibacterial microcapsules with silver nitrate solution; the nano-silver provides excellent antibacterial activity.

[0014] 2. This invention also prepares an oropharyngeal airway using polylactic acid, calcium carbonate, ethylene bis-stearamide, and thiolized oyster shell powder as raw materials. Using thiolized oyster shell powder as a raw material makes the oropharyngeal airway more green and environmentally friendly. Simultaneously, cysteine ​​is used to thiolize the oyster shell powder, allowing the thiol groups in the oropharyngeal airway to react with the vinyl groups in the antibacterial nano-coating under the action of a photoinitiator, thereby enhancing the bonding ability between the oropharyngeal airway and the antibacterial nano-coating. Detailed Implementation

[0015] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0016] The sources and types of raw materials designed in this invention are not particularly limited. Examples include: oyster shell powder: 10-20nm; calcium carbonate: 5-20nm; tea tree oil: S49792, which can be purchased from Shanghai Yuanye Biotechnology Co., Ltd.; sodium hyaluronate: type: S12034, which can be purchased from Shanghai Yuanye Biotechnology Co., Ltd.

[0017] Example 1: A processing method for an oropharyngeal airway with an antibacterial nano-coating on its surface, comprising the following steps: Step 1: Preparation of thiolized oyster shell powder: Take 5g of oyster shell powder, 2.5g of sodium periodate, and 100mL of deionized water, stir for 3.5h, add 12mL of ethylene glycol, centrifuge and wash, add 5g of cysteine, heat to 38℃ under nitrogen protection, stir for 5.5h to obtain thiolized oyster shell powder; Step 2: Preparation of vinyl chitosan: Take 3g of chitosan and 150mL of 0.5% acetic acid aqueous solution, stir well, add 5g of glycidyl methacrylate dropwise, stir for 24h, add excess acetone, precipitate, filter, wash and dry to obtain vinyl chitosan. Step 3: Preparation of chitosan mixed solution: Take 0.6g of vinyl chitosan, 0.4g of chitosan, and 100mL of deionized water, stir well to obtain a chitosan mixed solution; Step 4: Preparation of polylysine: Take 20g of L-lysine hydrochloride, 1.8g of o-vanillin and 6g of potassium hydroxide, mix them evenly, heat to 148℃, add 2.7g of zirconium butoxide solution, react for 12h, cool to 28℃, add 200mL of methanol, stir evenly, filter, wash and dry to obtain polylysine. Step 5: Preparation of chitosan antibacterial microcapsules: Take 0.2g of sodium dodecylbenzenesulfonate (1% by mass), 200mL of deionized water, 3.5g of tea tree oil, and 0.3g of polylysine. Shear for 2.5min, add 50mL of chitosan mixed solution, add 50mL of sodium hyaluronate (1% by mass), add 2mL of glutaraldehyde, react at 62℃ for 2.5h, add 10mL of silver nitrate solution to obtain chitosan antibacterial microcapsules; Step Six: Preparation of Antibacterial Nanocoatings: At 50°C, vinyl chitosan and deionized water were mixed evenly, and then anhydrous sodium carbonate and sodium trimetaphosphate were added. The mixture was stirred and reacted for 1 hour. Chitosan antibacterial microcapsules, agar, and 2-hydroxy-2-methyl-1-phenyl-1-propanone were added and stirred evenly to obtain an antibacterial nano-coating. The antibacterial nano-coating comprises the following components by weight: 48 parts vinyl chitosan, 520 parts deionized water, 11 parts anhydrous sodium carbonate, 10 parts sodium trimetaphosphate, 15 parts chitosan antibacterial microcapsules, 14 parts agar, and 2.5 parts 2-hydroxy-2-methyl-1-phenyl-1-propanone. Step 7: Preparation of the oropharyngeal airway with an antibacterial nano-coating on its surface: Take 110g of polylactic acid, 7g of calcium carbonate, 2g of ethylene bis-stearamide, and 5g of thiolized oyster shell powder, dry them, and injection mold them at 155℃ to obtain an oropharyngeal airway; coat the surface of the oropharyngeal airway with an antibacterial nano-coating, dry it for 2 hours, and then place it under a UV lamp for 2.8 hours to obtain an oropharyngeal airway with an antibacterial nano-coating on the surface.

[0018] Example 2: A processing method for an oropharyngeal airway with an antibacterial nano-coating on its surface, comprising the following steps: Step 1: Preparation of thiolized oyster shell powder: Take 5g of oyster shell powder, 2.5g of sodium periodate, and 100mL of deionized water, stir for 3 hours, add 12mL of ethylene glycol, centrifuge and wash, add 5g of cysteine, heat to 35℃ under nitrogen protection, stir for 5 hours to obtain thiolized oyster shell powder. Step 2: Preparation of vinyl chitosan: Take 3g of chitosan and 150mL of 0.5% acetic acid aqueous solution, stir well, add 5g of glycidyl methacrylate dropwise, stir for 22h, add excess acetone, precipitate, filter, wash and dry to obtain vinyl chitosan. Step 3: Preparation of chitosan mixed solution: Take 0.6g of vinyl chitosan, 0.4g of chitosan, and 100mL of deionized water, stir well to obtain a chitosan mixed solution; Step 4: Preparation of polylysine: Take 20g of L-lysine hydrochloride, 1.8g of o-vanillin and 6g of potassium hydroxide, mix them evenly, heat to 145℃, add 2.7g of zirconium butoxide solution, react for 10h, cool to 25℃, add 200mL of methanol, stir evenly, filter, wash and dry to obtain polylysine. Step 5: Preparation of chitosan antibacterial microcapsules: Take 0.2g of sodium dodecylbenzenesulfonate (1% by mass), 200mL of deionized water, 3.5g of tea tree oil, and 0.3g of polylysine. Shear for 2 minutes, add 50mL of chitosan mixed solution, add 50mL of sodium hyaluronate (1% by mass), add 2mL of glutaraldehyde, react at 60℃ for 2 hours, and add 10mL of silver nitrate solution to obtain chitosan antibacterial microcapsules. Step Six: Preparation of Antibacterial Nanocoatings: At 50°C, vinyl chitosan and deionized water were mixed evenly, and then anhydrous sodium carbonate and sodium trimetaphosphate were added. The mixture was stirred and reacted for 1 hour. Chitosan antibacterial microcapsules, agar, and 2-hydroxy-2-methyl-1-phenyl-1-propanone were added and stirred evenly to obtain an antibacterial nano-coating. The antibacterial nano-coating comprises the following components by weight: 45 parts vinyl chitosan, 500 parts deionized water, 10 parts anhydrous sodium carbonate, 8 parts sodium trimetaphosphate, 13 parts chitosan antibacterial microcapsules, 13 parts agar, and 2 parts 2-hydroxy-2-methyl-1-phenyl-1-propanone. Step 7: Preparation of the oropharyngeal airway with an antibacterial nano-coating on its surface: Take 110g of polylactic acid, 7g of calcium carbonate, 2g of ethylene bis-stearamide, and 5g of mercapto-modified oyster shell powder, dry them, and injection mold them at 150℃ to obtain an oropharyngeal airway; coat the surface of the oropharyngeal airway with an antibacterial nano-coating, dry it for 2 hours, and then place it under a UV lamp for 2.5 hours to cure it, thus obtaining an oropharyngeal airway with an antibacterial nano-coating on the surface.

[0019] Example 3: A processing method for an oropharyngeal airway with an antibacterial nano-coating on its surface, comprising the following steps: Step 1: Preparation of thiolized oyster shell powder: Take 5g of oyster shell powder, 2.5g of sodium periodate, and 100mL of deionized water, stir for 4 hours, add 12mL of ethylene glycol, centrifuge and wash, add 5g of cysteine, heat to 40℃ under nitrogen protection, stir for 6 hours to obtain thiolized oyster shell powder. Step 2: Preparation of vinyl chitosan: Take 3g of chitosan and 150mL of 0.5% acetic acid aqueous solution, stir well, add 5g of glycidyl methacrylate dropwise, stir for 26h, add excess acetone, precipitate, filter, wash and dry to obtain vinyl chitosan. Step 3: Preparation of chitosan mixed solution: Take 0.6g of vinyl chitosan, 0.4g of chitosan, and 100mL of deionized water, stir well to obtain a chitosan mixed solution; Step 4: Preparation of polylysine: Take 20g of L-lysine hydrochloride, 1.8g of o-vanillin and 6g of potassium hydroxide, mix them evenly, heat to 150℃, add 2.7g of zirconium butoxide solution, react for 14h, cool to 30℃, add 200mL of methanol, stir evenly, filter, wash and dry to obtain polylysine. Step 5: Preparation of chitosan antibacterial microcapsules: Take 0.2g of sodium dodecylbenzenesulfonate (1% by mass), 200mL of deionized water, 3.5g of tea tree oil, and 0.3g of polylysine. Shear for 3 minutes, add 50mL of chitosan mixed solution, add 50mL of sodium hyaluronate (1% by mass), add 2mL of glutaraldehyde, react at 65℃ for 3 hours, and add 10mL of silver nitrate solution to obtain chitosan antibacterial microcapsules. Step Six: Preparation of Antibacterial Nanocoatings: At 50°C, vinyl chitosan and deionized water were mixed evenly, and then anhydrous sodium carbonate and sodium trimetaphosphate were added. The mixture was stirred and reacted for 1 hour. Chitosan antibacterial microcapsules, agar, and 2-hydroxy-2-methyl-1-phenyl-1-propanone were added and stirred evenly to obtain an antibacterial nano-coating. The antibacterial nano-coating comprises the following components by weight: 50 parts vinyl chitosan, 550 parts deionized water, 12 parts anhydrous sodium carbonate, 11 parts sodium trimetaphosphate, 16 parts chitosan antibacterial microcapsules, 15 parts agar, and 3 parts 2-hydroxy-2-methyl-1-phenyl-1-propanone. Step 7: Preparation of the oropharyngeal airway with an antibacterial nano-coating on its surface: Take 110g of polylactic acid, 7g of calcium carbonate, 2g of ethylene bis-stearamide, and 5g of mercapto-modified oyster shell powder, dry them, and injection mold them at 160℃ to obtain an oropharyngeal airway; coat the surface of the oropharyngeal airway with an antibacterial nano-coating, dry it for 2 hours, and then place it under a UV lamp for 3 hours to obtain an oropharyngeal airway with an antibacterial nano-coating on the surface.

[0020] Comparative Example 1: No thiolation treatment was performed on the oyster shell powder; all other aspects were the same as in Example 1. Step 1: Preparation of vinyl chitosan: Take 3g of chitosan and 150mL of 0.5% acetic acid aqueous solution, stir well, add 5g of glycidyl methacrylate dropwise, stir for 24h, add excess acetone, precipitate, filter, wash and dry to obtain vinyl chitosan. Step 2: Preparation of chitosan mixed solution: Take 0.6g of vinyl chitosan, 0.4g of chitosan, and 100mL of deionized water, stir well to obtain a chitosan mixed solution; Step 3: Preparation of polylysine: Take 20g of L-lysine hydrochloride, 1.8g of o-vanillin and 6g of potassium hydroxide, mix them evenly, heat to 148℃, add 2.7g of zirconium butoxide solution, react for 12h, cool to 28℃, add 200mL of methanol, stir evenly, filter, wash and dry to obtain polylysine. Step 4: Preparation of chitosan antibacterial microcapsules: Take 0.2g of sodium dodecylbenzenesulfonate (1% by mass), 200mL of deionized water, 3.5g of tea tree oil, and 0.3g of polylysine. Shear for 2.5min, add 50mL of chitosan mixed solution, add 50mL of sodium hyaluronate (1% by mass), add 2mL of glutaraldehyde, react at 62℃ for 2.5h, add 10mL of silver nitrate solution to obtain chitosan antibacterial microcapsules; Step 5: Preparation of antibacterial nano-coating: At 50°C, vinyl chitosan and deionized water were mixed evenly, and then anhydrous sodium carbonate and sodium trimetaphosphate were added. The mixture was stirred and reacted for 1 hour. Chitosan antibacterial microcapsules, agar, and 2-hydroxy-2-methyl-1-phenyl-1-propanone were added and stirred evenly to obtain an antibacterial nano-coating. The antibacterial nano-coating comprises the following components by weight: 48 parts vinyl chitosan, 520 parts deionized water, 11 parts anhydrous sodium carbonate, 10 parts sodium trimetaphosphate, 15 parts chitosan antibacterial microcapsules, 14 parts agar, and 2.5 parts 2-hydroxy-2-methyl-1-phenyl-1-propanone. Step Six: Preparation of an oropharyngeal airway with an antibacterial nano-coating on its surface: Take 110g of polylactic acid, 7g of calcium carbonate, 2g of ethylene bis-stearamide, and 5g of oyster shell powder, dry them, and injection mold them at 155℃ to obtain an oropharyngeal airway; coat the surface of the oropharyngeal airway with an antibacterial nano-coating, dry it for 2 hours, and then place it under a UV lamp for 2.8 hours to obtain an oropharyngeal airway with an antibacterial nano-coating on the surface.

[0021] Comparative Example 2: No vinyl treatment was applied to chitosan; all other aspects were the same as in Example 1. Step 1: Preparation of thiolized oyster shell powder: Take 5g of oyster shell powder, 2.5g of sodium periodate, and 100mL of deionized water, stir for 3.5h, add 12mL of ethylene glycol, centrifuge and wash, add 5g of cysteine, heat to 38℃ under nitrogen protection, stir for 5.5h to obtain thiolized oyster shell powder; Step 2: Preparation of chitosan solution: Take 1g of chitosan and 100mL of deionized water, stir well to obtain a chitosan solution; Step 3: Preparation of polylysine: Take 20g of L-lysine hydrochloride, 1.8g of o-vanillin and 6g of potassium hydroxide, mix them evenly, heat to 148℃, add 2.7g of zirconium butoxide solution, react for 12h, cool to 28℃, add 200mL of methanol, stir evenly, filter, wash and dry to obtain polylysine. Step 4: Preparation of chitosan antibacterial microcapsules: Take 0.2g of 1% sodium dodecylbenzenesulfonate, 200mL of deionized water, 3.5g of tea tree oil, and 0.3g of polylysine. Shear for 2.5min, add 50mL of chitosan solution, 50mL of 1% sodium hyaluronate, and 2mL of glutaraldehyde. React at 62℃ for 2.5h, and add 10mL of silver nitrate solution to obtain chitosan antibacterial microcapsules. Step 5: Preparation of antibacterial nano-coating: Chitosan and deionized water were mixed evenly at 50℃, and then anhydrous sodium carbonate and sodium trimetaphosphate were added. The mixture was stirred and reacted for 1 hour. Chitosan antibacterial microcapsules, agar, and 2-hydroxy-2-methyl-1-phenyl-1-propanone were added and stirred evenly to obtain an antibacterial nano-coating. The antibacterial nano-coating comprises the following components by weight: 48 parts chitosan, 520 parts deionized water, 11 parts anhydrous sodium carbonate, 10 parts sodium trimetaphosphate, 15 parts chitosan antibacterial microcapsules, 14 parts agar, and 2.5 parts 2-hydroxy-2-methyl-1-phenyl-1-propanone. Step Six: Preparation of an oropharyngeal airway with an antibacterial nano-coating on its surface: Take 110g of polylactic acid, 7g of calcium carbonate, 2g of ethylene bis-stearamide, and 5g of thiolized oyster shell powder, dry them, and injection mold them at 155℃ to obtain an oropharyngeal airway; coat the surface of the oropharyngeal airway with an antibacterial nano-coating, dry it for 2 hours, and then place it under a UV lamp for 2.8 hours to obtain an oropharyngeal airway with an antibacterial nano-coating on the surface.

[0022] Comparative Example 3: No polylysine added, otherwise the same as Example 1: Step 1: Preparation of thiolized oyster shell powder: Take 5g of oyster shell powder, 2.5g of sodium periodate, and 100mL of deionized water, stir for 3.5h, add 12mL of ethylene glycol, centrifuge and wash, add 5g of cysteine, heat to 38℃ under nitrogen protection, stir for 5.5h to obtain thiolized oyster shell powder; Step 2: Preparation of vinyl chitosan: Take 3g of chitosan and 150mL of 0.5% acetic acid aqueous solution, stir well, add 5g of glycidyl methacrylate dropwise, stir for 24h, add excess acetone, precipitate, filter, wash and dry to obtain vinyl chitosan. Step 3: Preparation of chitosan mixed solution: Take 0.6g of vinyl chitosan, 0.4g of chitosan, and 100mL of deionized water, stir well to obtain a chitosan mixed solution; Step 4: Preparation of chitosan antibacterial microcapsules: Take 0.2g of sodium dodecylbenzenesulfonate (1% by mass), 200mL of deionized water, and 3.5g of tea tree oil. Shear for 2.5min, add 50mL of chitosan mixed solution, add 50mL of sodium hyaluronate (1% by mass), add 2mL of glutaraldehyde, react at 62℃ for 2.5h, add 10mL of silver nitrate solution, and obtain chitosan antibacterial microcapsules. Step 5: Preparation of antibacterial nano-coating: At 50°C, vinyl chitosan and deionized water were mixed evenly, and then anhydrous sodium carbonate and sodium trimetaphosphate were added. The mixture was stirred and reacted for 1 hour. Chitosan antibacterial microcapsules, agar, and 2-hydroxy-2-methyl-1-phenyl-1-propanone were added and stirred evenly to obtain an antibacterial nano-coating. The antibacterial nano-coating comprises the following components by weight: 48 parts vinyl chitosan, 520 parts deionized water, 11 parts anhydrous sodium carbonate, 10 parts sodium trimetaphosphate, 15 parts chitosan antibacterial microcapsules, 14 parts agar, and 2.5 parts 2-hydroxy-2-methyl-1-phenyl-1-propanone. Step Six: Preparation of an oropharyngeal airway with an antibacterial nano-coating on its surface: Take 110g of polylactic acid, 7g of calcium carbonate, 2g of ethylene bis-stearamide, and 5g of thiolized oyster shell powder, dry them, and injection mold them at 155℃ to obtain an oropharyngeal airway; coat the surface of the oropharyngeal airway with an antibacterial nano-coating, dry it for 2 hours, and then place it under a UV lamp for 2.8 hours to obtain an oropharyngeal airway with an antibacterial nano-coating on the surface.

[0023] experiment: The oropharyngeal airways with antibacterial nano-coatings prepared in Examples 1 to 3 and Comparative Examples 1 to 3 were subjected to performance testing. The antibacterial rate of Escherichia coli on the oropharyngeal airways with antibacterial nano-coatings was tested. Then, the airways were washed 20 times with deionized water at 30°C for 10 minutes each, with a 60-minute interval between washes, using a wash fastness tester. The Escherichia coli suspension was diluted to 10... 6 The concentration of CFU / mL was used to incubate the washed oropharyngeal airway with the antibacterial nano-coating at 37°C for 24 hours in 1 mL of bacterial suspension. The antibacterial rate of Escherichia coli in the washed oropharyngeal airway with the antibacterial nano-coating was then tested. The data are shown in Table 1 below. Table 1 Conclusion: The data comparison in the table shows that Comparative Example 1, without thiolization treatment of oyster shell powder, exhibits poor binding ability between the oropharyngeal airway and the antibacterial nano-coating, resulting in a decrease in the antibacterial rate of the oropharyngeal airway after washing. Comparative Example 2, without vinyl treatment of chitosan, also shows poor binding ability between the oropharyngeal airway and the antibacterial nano-coating, leading to a decrease in the antibacterial rate of the oropharyngeal airway after washing. Comparative Example 3, without the addition of polylysine, shows a decrease in the antibacterial rate of the oropharyngeal airway. Examples 1 to 3 of this invention added chitosan antibacterial microcapsules to the antibacterial nano-coating, enhancing the antibacterial properties of the oropharyngeal airway. The chitosan antibacterial microcapsules contain tea tree oil and polylysine; the combined use of tea tree oil and polylysine enhances the antibacterial properties of the antibacterial nano-coating. Examples 1 to 3 of this invention also added silver nitrate solution to modify the chitosan antibacterial microcapsules; nano-silver can exert a good antibacterial effect. Examples 1 to 3 of this invention also prepared oropharyngeal airways using polylactic acid, calcium carbonate, ethylene bis-stearamide, and thiolated oyster shell powder as raw materials. The thiol groups in the oropharyngeal airway can react with the vinyl groups in the antibacterial nano-coating under the action of a photoinitiator, thereby enhancing the bonding ability between the oropharyngeal airway and the antibacterial nano-coating.

[0024] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within the present invention.

Claims

1. A processing technology for an antibacterial nano-coating on the surface of an oropharyngeal airway, characterized in that: The antibacterial nano-coating is obtained by curing an antibacterial nano-coating applied to the surface of the oropharyngeal airway. The preparation method of the antibacterial nano-coating is as follows: vinyl chitosan and deionized water are mixed evenly, anhydrous sodium carbonate and sodium trimetaphosphate are added, and the mixture is stirred for 1-1.5 hours. Chitosan antibacterial microcapsules, agar, and 2-hydroxy-2-methyl-1-phenyl-1-propanone are added and stirred evenly to obtain the antibacterial nano-coating.

2. The processing technology of the antibacterial nano-coating for the surface of the oropharyngeal airway according to claim 1, characterized in that: The antibacterial nano-coating comprises the following components by weight: 45-50 parts vinyl chitosan, 500-550 parts deionized water, 10-12 parts anhydrous sodium carbonate, 8-11 parts sodium trimetaphosphate, 13-16 parts chitosan antibacterial microcapsules, 13-15 parts agar, and 2-3 parts 2-hydroxy-2-methyl-1-phenyl-1-propanone.

3. The processing technology of the antibacterial nano-coating for the surface of the oropharyngeal airway according to claim 1, characterized in that: The preparation method of the chitosan antibacterial microcapsules is as follows: take sodium dodecylbenzenesulfonate, deionized water, tea tree oil, and polylysine, shear for 2-3 minutes, add chitosan mixed solution, add sodium hyaluronate, add glutaraldehyde, react at 60-65℃ for 2-3 hours, add silver nitrate solution to obtain chitosan antibacterial microcapsules.

4. The processing technology of the antibacterial nano-coating for the surface of the oropharyngeal airway according to claim 3, characterized in that: The preparation method of polylysine is as follows: take L-lysine hydrochloride, o-vanillin and potassium hydroxide, mix them evenly, heat to 145-150℃, add zirconium butoxide solution, react for 10-14h, cool to 25-30℃, add methanol, stir evenly, filter, wash and dry to obtain polylysine.

5. The processing technology of the antibacterial nano-coating for the surface of the oropharyngeal airway according to claim 3, characterized in that: The chitosan mixed solution is prepared by taking vinyl chitosan, chitosan, and deionized water, stirring them evenly to obtain the chitosan mixed solution.

6. The processing technology of the antibacterial nano-coating for the surface of the oropharyngeal airway according to claim 5, characterized in that: The method for preparing the vinyl chitosan is as follows: take chitosan and an aqueous acetic acid solution, stir evenly, add glycidyl methacrylate dropwise, stir for 22-26 hours, add excess acetone, precipitate, filter, wash, and dry to obtain vinyl chitosan.

7. The processing technology of the antibacterial nano-coating for the surface of the oropharyngeal airway according to claim 1, characterized in that: The method for preparing the oropharyngeal airway with an antibacterial nano-coating on its surface includes the following steps: S1: Take polylactic acid, calcium carbonate, ethylene bis-stearamide, and mercaptoized oyster shell powder, dry them, and injection mold them at 150-160℃ to obtain an oropharyngeal airway; S2: Apply antibacterial nano-coating to the surface of the oropharyngeal airway, dry for 2 hours, and then cure under ultraviolet light for 2.5-3 hours to obtain an oropharyngeal airway with an antibacterial nano-coating on the surface.

8. The processing technology of the antibacterial nano-coating for the surface of the oropharyngeal airway according to claim 7, characterized in that: The preparation method of the thiolized oyster shell powder is as follows: take oyster shell powder, sodium periodate, and deionized water, stir for 3-4 hours, add ethylene glycol, centrifuge and wash, add cysteine, and under nitrogen protection, heat to 35-40℃ and stir for 5-6 hours to obtain thiolized oyster shell powder.

9. An oropharyngeal airway with an antibacterial nano-coating on its surface, obtained by a processing method for an antibacterial nano-coating on the surface of an oropharyngeal airway according to any one of claims 1-8.

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