Method for reducing visible foreign matters in myocardial protection cardioplegic liquid

Abstract

The invention discloses a method for reducing visible foreign matters in myocardial protection arrest liquid, and belongs to the technical field of medicine production. The problems that in high-speed production, due to the fact that a glass bottle and a needle deviate, a bottle opening is damaged, and glass chips fall into liquid medicine to generate visible foreign matter are solved. The method comprises the following steps: firstly, cleaning and drying a glass bottle, and then placing the glass bottle on a filling production line comprising a conveying part, an injection part and a protection part; the conveying part stably conveys the liquid medicine and automatically supplements the liquid medicine to a plurality of material boxes; the injection part drives the spray pipe to be inserted into a glass bottle under the action of the electromagnet ring, and a conical rubber ring of the protection part protects a bottle opening, adjusts the position and prevents collision. The conical rubber ring is integrated with a pressure relief structure, so that exhaust is facilitated; the method can reduce visible foreign matters, improve product quality and production efficiency, and reduce quality risk and economic loss.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical manufacturing technology, and in particular to a method for reducing visible foreign matter in cardioprotective stop fluid. Background Technology

[0002] During the production of myocardial protection cardioplegic solution, the product qualification rate has never been ideal. The rate of defective products rejected at the light inspection station alone is about 5%. After sorting and classifying the products by QA personnel, it was found that most of the defective products were visible foreign objects such as small glass, white spots, color spots, and small fibers. The high rate of defective products has put considerable pressure on the light inspection station and also poses a risk to the production quality of the product.

[0003] In the actual operation of filling cardioplegic solution on the filling production line, a large-diameter needle with a fixed trajectory is usually used for filling. However, in a high-speed production environment, the conveyor chain inevitably experiences slight vibrations, and the glass bottles themselves also have dimensional tolerance issues. These factors cause the center of the bottle mouth and the center of the needle to easily deviate slightly. When the large needle descends to fill, it will directly hit the inner wall of the bottle mouth, causing minor damage to the bottle mouth. The glass shards generated by the breakage will fall directly into the liquid, leading to product scrap, seriously affecting production efficiency and product quality, and causing significant economic losses to the company.

[0004] To address the aforementioned problems, this technical solution proposes a method for reducing visible foreign bodies in myocardial protection cardioplegic solution. Summary of the Invention

[0005] The purpose of this invention is to solve the problem of visible foreign matter in myocardial protection cardioplegic solution caused by misalignment between the glass bottle and the needle during high-speed production, which leads to bottle mouth breakage and glass fragments falling into the drug solution.

[0006] To achieve the above objectives, the present invention adopts the following technical solution:

[0007] A method for reducing visible foreign bodies in cardioprotective cardioplegic solution includes the following steps:

[0008] S1. Place the glass bottles to be cleaned on the conveyor line, and transport them to the cleaning tank via the conveyor line.

[0009] S2. Before the glass bottles are transported to the cleaning tank, the glass bottles are pre-filled with water using a pre-installed injection machine.

[0010] S3. After the glass bottle filled with water is transported into the cleaning tank, the ultrasonic generator in the cleaning tank can be turned on to rinse the glass bottle in the form of ultrasonic waves.

[0011] S4. After cleaning the glass bottles, the glass bottles can be taken out of the cleaning box and placed in the drying box for drying.

[0012] S5. Place the dried glass bottles on the filling production line and inject myocardial protection and cardioplegic solution into the glass bottles.

[0013] In one possible design, the filling production line includes a support base disposed on one side of the filling production line, and a conveying component is disposed on the support base. The filling production line also includes:

[0014] A mounting plate is fixedly installed on one side of the support base. Multiple injection components are installed through the mounting plate at equal intervals. The injection components are used to inject the myocardial protection and cardioplegic solution into the corresponding glass bottle.

[0015] A protective component is attached to the injection component. The protective component is used to protect the mouth of the glass bottle when the injection component is inserted into the corresponding glass bottle, so as to prevent the mouth of the glass bottle from being bumped or knocked.

[0016] In one possible design, the conveying component includes electric push rods fixedly mounted at equal intervals on a support base, and multiple material bins fixedly mounted at equal intervals on the support base. The output shaft of the electric push rod extends into the corresponding material bin and is fixedly mounted with a piston plate. The piston plate is tightly slidably connected to the inner wall of the material bin. A connecting pipe is fixedly mounted on one side inner wall of the material bin. One end of the connecting pipe extends to the outside of the material bin and is fixedly mounted with a transfer box. A conveying pipe is fixedly mounted on one side inner wall of the transfer box. The bottom end of the conveying pipe extends to one side of the support base and is connected to the corresponding injection component.

[0017] In one possible design, a delivery pump is fixedly installed on the other side of the support base. The suction end of the delivery pump is connected to a pipe for delivering myocardial protection and cardioplegic solution. A diversion pipe is fixedly installed on the output end of the delivery pump. The top of the diversion pipe extends above multiple hoppers. Multiple flow pipes are fixedly installed at equal intervals on the bottom inner wall of the diversion pipe. The bottom end of the flow pipe extends into the corresponding hopper and is fixedly connected to the top inner wall of the hopper.

[0018] In one possible design, the injection component includes an injection box that penetrates and is fixedly connected to the mounting plate. The bottom end of a delivery tube extends into the injection box and is fixedly connected to the top inner wall of the injection box. A connecting tube is fixedly installed inside the delivery tube. A pushing assembly is installed inside the injection box. A nozzle is connected to the pushing assembly. A second compression spring is sleeved on the nozzle. The top and bottom ends of the second compression spring are fixedly connected to the pushing assembly and the bottom inner wall of the injection box, respectively. The bottom end of the nozzle extends below the injection box. The bottom end of the connecting tube extends into the nozzle. The connecting tube is slidably connected to the inner wall of the nozzle. A protective component is installed on the corresponding nozzle and is located below the injection box.

[0019] In one possible design, the pushing assembly includes a pushing plate slidably connected inside the injection chamber, a second compression spring having its top end fixedly connected to the bottom of the pushing plate, a nozzle passing through the pushing plate and fixedly connected thereto, two limiting tubes symmetrically fixedly installed on the top inner wall of the injection chamber, limiting rods slidably connected inside the limiting tubes, the bottom ends of the limiting rods extending into the injection chamber and fixedly connected to the top of the pushing plate, a first electromagnet ring fixedly installed at the bottom end of the limiting tubes, and a second electromagnet ring fixedly installed on the limiting rods below the first electromagnet ring, with N or S poles provided on the sides of the first and second electromagnet rings that are close to each other.

[0020] In one possible design, the protective component includes a conical rubber ring slidably connected to the nozzle, and a support spring sleeved on the nozzle, with the top and bottom ends of the support spring fixedly connected to the nozzle and the top of the conical rubber ring, respectively.

[0021] In one possible design, the conical rubber ring has multiple connecting holes spaced at equal intervals. A baffle tube is slidably connected to each connecting hole. The top of the baffle tube extends above the conical rubber ring and is fixedly fitted with a sealing plate. The sealing plate contacts the top of the conical rubber ring. Air holes are provided on both sides of the inner wall of the baffle tube. A support frame is fixedly installed inside the baffle tube. A support rod is slidably connected through the support frame. An installation ring is fixedly fitted on the conical rubber ring. The bottom end of the support rod is fixedly connected to the top of the installation ring. A first compression spring is fitted on the support rod inside the baffle tube. The top and bottom ends of the first compression spring are fixedly connected to the top of the support rod and the top of the support frame, respectively.

[0022] In this application, the glass bottles to be cleaned are first placed on a conveyor line, which then transports them to a cleaning tank. Before the bottles are transported to the cleaning tank, they are pre-filled with water using an injection machine. Once the water-filled bottles enter the cleaning tank, an ultrasonic generator is activated to rinse the bottles using ultrasonic waves. After cleaning, the bottles are removed from the cleaning tank and placed in a drying oven for drying. The dried bottles are then placed on the filling production line. At this point, a delivery pump is started, and its suction end is connected to a pipe for delivering cardiopulmonary bypass fluid, which delivers the fluid to a distribution pipe. The fluid is then dispersed through multiple flow pipes to multiple hoppers, achieving automatic replenishment of the cardiopulmonary bypass fluid. An electric push rod is activated, and its output shaft moves a piston plate towards the side of the connecting pipe, injecting the cardiopulmonary bypass fluid through the connecting pipe, transfer box, and delivery pipe into the injection chamber of the injection unit. Next, the two first electromagnet rings and two second... When the two electromagnets are energized, their repulsive force causes the second electromagnet to move downwards, which in turn moves the limiting rod downwards. The limiting rod, through the push plate, moves the nozzle downwards, causing the conical rubber ring on the nozzle to move downwards as well. The conical rubber ring engages with the bottle opening, protecting the opening and adjusting the bottle's position. Simultaneously, the support spring provides elastic support to the conical rubber ring, preventing the bottle opening from being bumped. Once the nozzle is inserted into the bottle, the cardiopulmonary bypass fluid is injected into the bottle through the connecting pipe and the nozzle. During injection, the air pressure inside the bottle increases, causing multiple sealing plates to move upwards along with their corresponding baffles. The two vents also move upwards, facilitating the release of gas from the bottle. After filling, the first and second electromagnets are de-energized, eliminating their repulsive force. The second compression spring, now under pressure, moves the push plate upwards to reset, allowing the nozzle to be pulled out of the bottle opening, completing the injection of the cardiopulmonary bypass fluid into the bottle.

[0023] The present invention has the following beneficial effects:

[0024] 1. Reduce visible foreign matter: By connecting a protective component to the injection unit, the protective component can protect the mouth of the glass bottle when the injection unit is inserted into the glass bottle, effectively preventing the mouth of the glass bottle from being bumped, thereby avoiding glass shards falling into the glass bottle, greatly reducing the generation of visible foreign matter in the myocardial protection cardioplegic solution, and improving the quality and safety of the product.

[0025] 2. Automatic cleaning and drying: This method includes cleaning and drying steps. First, the glass bottle is filled with water, then the glass bottle is rinsed using an ultrasonic generator, and finally the glass bottle is dried. This can thoroughly remove impurities and foreign objects from the glass bottle, further ensuring the cleanliness of the glass bottle and providing a guarantee for high-quality filling in the future.

[0026] 3. Stable drug delivery: The electric push rod drives the piston plate to move, injecting the cardioplegic solution into the injection unit through the connecting tube, transfer box and delivery tube. This allows for convenient and stable delivery of the cardioplegic solution, ensuring the stability and accuracy of the filling process.

[0027] 4. Automatic drug replenishment: The cardioplegic solution is delivered to the diversion pipe by the delivery pump, and then distributed to multiple material tanks through multiple flow pipes. During the filling of cardioplegic solution, the cardioplegic solution can be automatically replenished to multiple material tanks, which improves production efficiency and reduces the tediousness and error of manual operation.

[0028] 5. Precise control of filling: The repulsive force between the first and second electromagnet rings drives the limit rod and the push plate to move downward, thereby driving the nozzle to move downward and insert it into the glass bottle for filling. After filling, the second compression spring drives the push plate to return to its original position by cutting off the power, and the nozzle is pulled out from the mouth of the glass bottle. This achieves precise control of the filling process and improves the accuracy and reliability of filling.

[0029] 6. Adjusting the bottle mouth position: The conical rubber ring in the protective component can fit tightly with the bottle mouth when the nozzle moves downward. This not only protects the bottle mouth but also adjusts the position of the glass bottle, ensuring that the nozzle is accurately inserted into the glass bottle, further improving the filling accuracy.

[0030] This invention utilizes an electromagnet ring to adjust the position of the nozzle, allowing the conical rubber ring to protect the bottle mouth, adjust the position, and prevent impacts. This avoids the coarse needle striking the bottle mouth and causing glass shards to fall into the liquid, reducing visible foreign matter, lowering the defect rate at the light inspection station, relieving production pressure, reducing quality risks, improving production efficiency and product quality, and reducing economic losses. Attached Figure Description

[0031] Figure 1 This is a structural block diagram of a method for reducing visible foreign matter in cardioprotective amputation fluid proposed in this invention;

[0032] Figure 2 This is a three-dimensional schematic diagram of the overall structure of a filling production line for a method to reduce visible foreign matter in cardioprotective amputation fluid proposed in this invention.

[0033] Figure 3 This is a three-dimensional schematic diagram of the support base and the connection structure of multiple injection boxes in a filling production line for a method of reducing visible foreign matter in myocardial protection cardioplegic solution proposed in this invention.

[0034] Figure 4 This is a three-dimensional cross-sectional schematic diagram of the injection box in the filling production line of a method for reducing visible foreign matter in myocardial protection cardioplegic solution proposed in this invention.

[0035] Figure 5 This is a cross-sectional view of the injection box in the filling production line of a method for reducing visible foreign matter in cardioprotective amputation fluid proposed in this invention.

[0036] Figure 6 This is a three-dimensional schematic diagram of the connection structure of the push plate, nozzle, and conical rubber ring in the filling production line of a method for reducing visible foreign matter in myocardial protection cardioplegic solution proposed in this invention.

[0037] Figure 7 This is a three-dimensional schematic diagram of the mounting ring, multiple support rods, and multiple baffle tube connection structure in the filling production line of a method for reducing visible foreign matter in myocardial protection cardioplegic solution proposed in this invention.

[0038] Figure 8 This is a cross-sectional schematic diagram of the material bin and transfer box in the filling production line of a method for reducing visible foreign matter in cardioprotective amputation fluid proposed in this invention.

[0039] In the diagram: 1. Filling production line; 2. Support base; 3. Electric push rod; 4. Material box; 5. Piston plate; 6. Conveyor pump; 7. Diverter pipe; 8. Flow pipe; 9. Connecting pipe; 10. Transfer box; 11. Conveying pipe; 12. Mounting plate; 13. Injection box; 14. Push plate; 15. Spray nozzle; 16. Conical rubber ring; 17. Support spring; 18. Connecting hole; 19. Baffle pipe; 20. Air hole; 21. Sealing plate; 22. Support frame; 23. Support rod; 24. First compression spring; 25. Mounting ring; 26. Connecting pipe; 27. Limiting pipe; 28. Limiting rod; 29. ​​First electromagnet ring; 30. Second electromagnet ring; 31. Second compression spring. Detailed Implementation

[0040] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments.

[0041] In one embodiment: Refer to Figure 1-8 A method for reducing visible foreign matter in cardioprotective amputation fluid is described below. This method aims to effectively reduce visible foreign matter, such as glass particles, introduced during the filling process or due to incomplete cleaning of the glass bottle, through a specific cleaning and filling process combined with dedicated filling equipment.

[0042] In step S1, place the glass bottles to be cleaned one by one onto the conveyor line. The conveyor line uses a conveyor belt device to smoothly transport the glass bottles forward in sequence. The glass bottles are continuously transported until they enter a dedicated cleaning tank.

[0043] S2. Before entering the cleaning tank, the glass bottles pass through a pre-set injection machine station. The injection machine is equipped with water injection nozzles. As the glass bottles pass by on the conveyor line, the nozzles automatically extend into the bottle mouths and fill each glass bottle with deionized water or qualified water for injection, ensuring that the liquid completely fills the internal space of the bottle.

[0044] S3. After the water-filled glass bottles are placed into the cleaning tank and positioned, the operator or the automatic control system activates the ultrasonic generator inside the cleaning tank. The ultrasonic generator operates, generating high-frequency vibrations in the cleaning solution. Utilizing the cavitation effect and mechanical action of ultrasound, it thoroughly rinses the inner and outer walls of the glass bottles, especially the inner walls, to loosen and remove various particles and impurities adhering to the bottle walls.

[0045] S4. The glass bottles are removed from the cleaning chamber by a robotic arm or conveyor and transferred to an adjacent drying chamber. The drying chamber is equipped with a hot air circulation system to heat and blow air onto the damp glass bottles, ensuring that their inner and outer walls are completely dry and preventing residual water stains.

[0046] S5, the dried glass bottles are transferred to a dedicated filling production line 1 for further processing. Filling production line 1 is the core component for achieving aseptic filling. This production line includes a support base 2 fixed to the ground, on which a conveying component is installed to carry and intermittently transport the arranged glass bottles. A vertical mounting plate 12 is fixedly installed on one side of the support base 2. Multiple injection components are evenly spaced along the glass bottle conveying direction on the mounting plate 12. Each injection component is responsible for injecting cardioplegic solution into a corresponding glass bottle. Each injection component is also connected to a protective component. The function of this protective component is to cushion and protect the fragile bottle neck edge when the injection component moves downwards and inserts into the glass bottle, preventing impacts or micro-cracks caused by hard contact.

[0047] like Figure 3As shown, the specific implementation of the delivery components is as follows: An electric push rod 3 is fixedly installed on the support base 2, corresponding to the position of each injection component. Simultaneously, multiple material boxes 4, corresponding to the number of electric push rods 3, are also fixedly installed on the support base 2. The output shaft of the electric push rod 3 is horizontally positioned and extends into the corresponding material box 4, with a piston plate 5 fixedly installed at its end. The outer edge of the piston plate 5 maintains a tight sliding connection with the inner wall of the material box 4, forming a seal. A connecting pipe 9 is fixedly connected to one side of the inner wall of the material box 4, and the other end of the connecting pipe 9 extends to the outside of the material box 4 and connects to a fixedly installed transfer box 10. A delivery pipe 11 is fixedly connected below the transfer box 10, and the bottom end of the delivery pipe 11 extends downwards and finally connects to the corresponding injection component. The workflow is as follows: the cardioplegic solution is pre-delivered into each material box 4. When filling is required, the electric push rod 3 is activated, and the electric push rod 3 pushes the piston plate 5 within the material box 4 towards the side wall where the connecting pipe 9 is located. The movement of the piston plate 5 compresses the myocardial protection and cardioplegic solution in the feed tank 4, forcing the liquid to pass sequentially through the connecting pipe 9, the transfer box 10, and the delivery pipe 11, and finally be injected into the injection unit. This process achieves stable and quantitative delivery of the liquid.

[0048] like Figure 8 As shown, a delivery pump 6 is fixedly installed on the other side of the support base 2 to continuously replenish the medication to the tank 4. The suction end of the delivery pump 6 is connected to an external myocardial protection and cardioplegic solution storage tank via a pipe. The output end of the delivery pump 6 is connected to a horizontally arranged diversion pipe 7, the extension of which is located above multiple tanks 4. On the bottom inner wall of the diversion pipe 7, multiple flow tubes 8 are vertically fixedly installed at equal intervals, the bottom end of each flow tube 8 extending into and fixedly connected to the top of a corresponding tank 4. When the delivery pump 6 is started, the myocardial protection and cardioplegic solution is pumped from the storage tank into the diversion pipe 7, and then evenly distributed to each tank 4 through the flow tubes 8, achieving automatic replenishment.

[0049] like Figure 4-6As shown, the specific structure of the injection component includes: an injection chamber 13 vertically penetrating and fixed to the mounting plate 12. A delivery pipe 11 from above extends into the top of the injection chamber 13 and is fixed therein. A slender connecting pipe 26 is fixedly installed inside the delivery pipe 11, with its lower end extending into the injection chamber 13. A push assembly is located inside the injection chamber 13, and a nozzle 15 is fixedly connected to the push assembly. A second compression spring 31 is fitted onto the nozzle 15; the top end of the second compression spring 31 is fixed to the push assembly, and the bottom end is fixed to the bottom inner wall of the injection chamber 13. The bottom end of the nozzle 15 passes downwards through the bottom of the injection chamber 13 and is exposed. The bottom end of the connecting pipe 26 is inserted into the upper part of the nozzle 15, and the outer wall of the connecting pipe 26 and the inner wall of the nozzle 15 are tightly slidably connected, allowing for relative sliding while ensuring a liquid seal. A protective component is installed on the exposed portion of the nozzle 15 and is located below the injection chamber 13. When filling is required, the pushing component is activated, which moves the nozzle 15 downwards and inserts it into the glass bottle delivered below. During this process, the protective component first contacts the bottle opening to provide protection.

[0050] like Figure 4-5 As shown, the push assembly is configured as follows: A horizontally placed push plate 14 is slidably connected inside the injection box 13, and the push plate 14 can slide vertically. The top of the aforementioned second compression spring 31 is fixed to the bottom of the push plate 14. The nozzle 15 vertically penetrates the push plate 14 and is fixed thereto. On the top inner wall of the injection box 13, two vertical limiting tubes 27 are symmetrically fixed. A limiting rod 28 is slidably fitted inside each limiting tube 27, and the bottom end of the limiting rod 28 extends into the injection box 13 and is fixed to the top of the push plate 14. A first electromagnet ring 29 is fixedly installed at the bottom end of the limiting tube 27. A second electromagnet ring 30 is fixedly installed on the limiting rod 28, located directly below the first electromagnet ring 29. When the first electromagnet ring 29 and the second electromagnet ring 30 are energized, the sides of the first electromagnet ring 29 and the second electromagnet ring 30 that are close to each other are set to the same magnetic pole, for example, both are N poles or both are S poles. When the first electromagnet ring 29 and the second electromagnet ring 30 are energized, due to the repulsion of like poles, the second electromagnet ring 30 experiences a downward repulsive force, causing the limiting rod 28 and the connected push plate 14 to move downwards together. The downward movement of the push plate 14 causes the nozzle 15 to insert downwards into the glass bottle, simultaneously compressing the second compression spring 31. After filling is complete, the power supply to the first electromagnet ring 29 and the second electromagnet ring 30 is cut off, the magnetic field disappears, and the repulsive force also disappears. At this time, the compressed second compression spring 31 releases its elastic force, pushing the push plate 14 upwards to reset, thereby lifting the nozzle 15 out of the glass bottle.

[0051] This application can be used in the field of pharmaceutical manufacturing technology, or in other fields applicable to this application.

[0052] In another embodiment: Reference Figure 4-8 Based on the above embodiments, an improvement is made: a method for reducing visible foreign matter in cardiopulmonary bypass fluid, which is applied to the field of pharmaceutical manufacturing technology. The structure of this embodiment is basically the same as the previous embodiments, except that the protective component is a conical rubber ring 16 that is slidably fitted onto the rod of the nozzle 15, with the inner hole of the conical rubber ring 16 slidingly engaging with the outer wall of the nozzle 15. A support spring 17 is fitted on the nozzle 15 above the conical rubber ring 16, with the top end of the support spring 17 fixed to a protrusion or retaining ring on the nozzle 15 and the bottom end fixed to the top of the conical rubber ring 16. When the nozzle 15 is driven downward by the pushing component, it will drive the conical rubber ring 16 downward as well. When the nozzle 15 is about to be inserted into the bottle mouth, the conical surface of the conical rubber ring 16 will first contact and guide into the bottle mouth, using the elasticity of its rubber to form a tight fit with the inner wall of the bottle mouth. This fit allows for fine-tuning and centering of the bottle opening. More importantly, the soft rubber ring effectively cushions and isolates the hard nozzle from direct contact with the glass bottle opening, providing protection. Once the conical rubber ring 16 is fully fitted to the bottle opening, if the nozzle 15 continues to move slightly downwards, the support spring 17 will be compressed, thus providing continuous elastic support for the conical rubber ring 16 and preventing excessive rigid pressure on the bottle opening.

[0053] like Figure 7-8As shown, to address the issue of increased internal pressure during filling, a pressure relief structure is integrated into the conical rubber ring 16. Specifically, multiple connecting holes 18 are evenly spaced along the circumference of the conical rubber ring 16. A baffle tube 19 is slidably inserted into each connecting hole 18. The top of the baffle tube 19 extends upward beyond the connecting hole 18 and is fixed with a sealing plate 21 with a diameter larger than the connecting hole 18. The sealing plate 21 fits against the top of the conical rubber ring 16 in its natural state. Air holes 20 are provided at the upper and lower sections of the baffle tube 19. A support frame 22 is fixed inside the baffle tube 19. A support rod 23 passes through the support frame 22 and slides with it. The bottom end of the support rod 23 is fixed to the top of a mounting ring 25 fixedly fitted on the conical rubber ring 16. A first compression spring 24 is fitted on the support rod 23. The first compression spring 24 is located inside the baffle tube 19, with its top end fixed to the top of the support rod 23 and its bottom end fixed to the support frame 22. Initially, the elastic force of the first compression spring 24 causes the support rod 23 to tend upwards, but the connection between the mounting ring 25 and the conical rubber ring 16 keeps the sealing plate 21 in contact with the conical rubber ring 16. When the anti-skid liquid is poured into the glass bottle, the air inside the bottle is compressed, and the air pressure rises. The air pressure acts on the bottom of the sealing plate 21, generating an upward thrust. When the thrust overcomes the elastic force of the first compression spring 24 and the frictional force, the sealing plate 21 drives the baffle tube 19 to slide upwards within the connecting hole 18. After the baffle tube 19 moves upwards, the air holes 20 on its tube wall are gradually exposed, communicating with the space inside the bottle to form an exhaust channel, allowing the gas inside the bottle to be discharged, thereby balancing the pressure and ensuring smooth filling. After filling stops, the air pressure inside the bottle drops, the first compression spring 24 pushes the support rod 23 downwards, causing the baffle tube 19 to reset, and the sealing plate 21 re-closes the connecting hole 18.

[0054] However, as is well known to those skilled in the art, the working principles and wiring methods of the electric push rod 3, the delivery pump 6, the first electromagnet ring 29 and the second electromagnet ring 30 are conventional means or common knowledge, and will not be described in detail here. Those skilled in the art can make any selections according to their needs or convenience.

[0055] The accompanying drawings in this application are for illustrative purposes only. The dimensions and shapes of the components shown are not actual limitations but are merely schematic representations. In actual implementation, the components can be reasonably configured and adjusted according to specific needs and actual conditions.

[0056] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A method for reducing visible foreign matter in a cardioplegic solution, comprising, Comprise the following steps: S1, the glass bottle to be cleaned is placed on the conveying line, and the glass bottle is conveyed into the cleaning box through the conveying line; S2, before the glass bottle is conveyed into the cleaning box, the glass bottle is pre-filled with water by the injection machine; S3, after the glass bottle filled with water is conveyed into the cleaning box, the ultrasonic generator in the cleaning box can be turned on, and the glass bottle is washed in the form of ultrasonic wave; S4, after the glass bottle is cleaned, the glass bottle can be taken out from the cleaning box and placed in the drying box for drying treatment; S5, the dried glass bottle is placed on the filling production line (1), and the cardioplegic solution is injected into the glass bottle.

2. A method for reducing the visible foreign matter in a cardioplegic solution for myocardial protection according to claim 1, characterized in that, The filling production line (1) comprises a supporting seat (2) arranged on one side of the filling production line (1), and a conveying component is arranged on the supporting seat (2), and the filling production line further comprises: A mounting plate (12) fixedly installed on one side of the supporting seat (2), a plurality of injection components are installed on the mounting plate (12) at equal intervals, and the injection components are used for injecting the cardioplegic solution into the corresponding glass bottle; A protection component is connected to the injection component, and the protection component is used for protecting the bottle opening of the glass bottle when the injection component is inserted into the corresponding glass bottle, so as to prevent the bottle opening of the glass bottle from being bumped.

3. A method for reducing the visible foreign matter in a cardioplegic solution for myocardial protection according to claim 2, characterized in that, The conveying component comprises an electric push rod (3) fixedly installed on the supporting seat (2) at equal intervals, and a plurality of material boxes (4) fixedly installed on the supporting seat (2) at equal intervals, the output shaft of the electric push rod (3) extends into the corresponding material box (4) and is fixedly installed with a piston plate (5), the piston plate (5) is in close sliding connection with the inner wall of the material box (4), a connecting pipe (9) is fixedly installed on one side of the inner wall of the material box (4), one end of the connecting pipe (9) extends to the outside of the material box (4) and is fixedly installed with a transfer box (10), a conveying pipe (11) is fixedly installed on one side of the inner wall of the transfer box (10), and the bottom end of the conveying pipe (11) extends to one side of the supporting seat (2) and is connected with the corresponding injection component.

4. A method for reducing the visible foreign matter in a cardioplegic solution for myocardial protection according to claim 3, characterized in that, The other side of the supporting seat (2) is fixedly installed with a conveying pump (6), the suction end of the conveying pump (6) is connected with a pipeline for conveying the cardioplegic solution, the output end of the conveying pump (6) is fixedly installed with a shunt pipe (7), the top of the shunt pipe (7) extends above the plurality of material boxes (4), and a plurality of flow pipes (8) are fixedly installed on the bottom inner wall of the shunt pipe (7) at equal intervals, the bottom end of the flow pipe (8) extends into the corresponding material box (4) and is fixedly connected with the top inner wall of the material box (4).

5. The method for reducing the visible foreign matter in the cardioplegic solution for myocardial protection according to claim 2, characterized in that, The injection component comprises an injection box (13) penetrating through the mounting plate (12) and fixedly connected with the mounting plate (12), the bottom end of the conveying pipe (11) extends into the injection box (13) and is fixedly connected with the inner wall of the top of the injection box (13), a butt joint pipe (26) is fixedly installed in the conveying pipe (11), a pushing assembly is installed in the injection box (13), the pushing assembly is connected with a spray pipe (15), the spray pipe (15) is sleeved with a second compression spring (31), the top end and the bottom end of the second compression spring (31) are fixedly connected with the pushing assembly and the bottom inner wall of the injection box (13) respectively, the bottom end of the spray pipe (15) extends below the injection box (13), the bottom end of the butt joint pipe (26) extends into the spray pipe (15), the butt joint pipe (26) is in close sliding connection with the inner wall of the spray pipe (15), a protection component is installed on the corresponding spray pipe (15), and the protection component is below the injection box (13).

6. A method for reducing the visible foreign matter in a cardioplegic solution for myocardial protection according to claim 5, characterized in that, The pushing assembly comprises a pushing plate (14) slidingly connected in the injection box (13), the top end of the second compression spring (31) is fixedly connected with the bottom of the pushing plate (14), the spray pipe (15) penetrates through the pushing plate (14) and is fixedly connected with the pushing plate (14), two limiting tubes (27) are symmetrically fixedly installed on the top inner wall of the injection box (13), a limiting rod (28) is in sliding connection in the limiting tube (27), the bottom end of the limiting rod (28) extends into the injection box (13) and is fixedly connected with the top of the pushing plate (14), a first electromagnet ring (29) is fixedly installed at the bottom end of the limiting tube (27), a second electromagnet ring (30) is fixedly installed on the limiting rod (28) below the first electromagnet ring (29), and the side, close to each other, of the first electromagnet ring (29) and the second electromagnet ring (30) is provided with an N pole or an S pole.

7. A method for reducing the visible foreign matter in a cardioplegic solution for myocardial protection according to claim 2, characterized in that, The protection component comprises a conical rubber ring (16) slidingly connected on the spray pipe (15), and further comprises a supporting spring (17) sleeved on the spray pipe (15), the top end and the bottom end of the supporting spring (17) are fixedly connected with the spray pipe (15) and the top of the conical rubber ring (16) respectively.

8. A method for reducing the visible foreign matter in a cardioplegic solution for myocardial protection according to claim 7, characterized in that, A plurality of connecting holes (18) are equally spaced on the conical rubber ring (16), a blocking pipe (19) is in close sliding connection in the connecting hole (18), the top end of the blocking pipe (19) extends above the conical rubber ring (16) and is fixedly installed with a sealing plate (21), the sealing plate (21) is in contact with the top of the conical rubber ring (16), air holes (20) are formed in the inner walls of the two sides of the blocking pipe (19), a supporting frame (22) is fixedly installed in the blocking pipe (19), a supporting rod (23) penetrates through and is in sliding connection on the supporting frame (22), an installation ring (25) is fixedly sleeved on the conical rubber ring (16), the bottom end of the supporting rod (23) is fixedly connected with the top of the installation ring (25), a first compression spring (24) is sleeved on the supporting rod (23) and located in the blocking pipe (19), and the top end and the bottom end of the first compression spring (24) are fixedly connected with the top end of the supporting rod (23) and the top of the supporting frame (22) respectively.

Images