Strong shading gel eye protection patch and preparation method thereof

Abstract

The invention discloses a strong shading gel eye protection patch and a preparation method thereof, and relates to the field of biomedical materials.The eye protection patch comprises a polyvinyl alcohol gel substrate and superfine graphite powder evenly dispersed in the polyvinyl alcohol gel substrate, the gel substrate further comprises glycerol serving as a plasticizer, and the thickness of the gel eye protection patch is 3 mm; the preparation method comprises the following steps: dissolving polyvinyl alcohol in preheated deionized water, adding graphite powder, stirring and dispersing, adding glycerol, stirring to form a uniform suspension, injecting the suspension into a mold, carrying out freezing and thawing cycle treatment of-80 DEG C freezing and room temperature thawing for 1-3 times, and demolding to obtain the eye protection patch. The product is low in light transmittance, can be tightly attached to the periphery of eyes, and effectively obstructs strong light in laser treatment; meanwhile, the eyeshade is soft and hydrophilic in texture, comfortable and breathable to wear, free of oppression and stuffiness of a traditional rope type eyeshade, mild in preparation process, good in biocompatibility and suitable for clinical application and popularization.

Description

Technical Field

[0001] This invention relates to the field of biomedical materials, and in particular to a strong light-blocking gel eye patch and its preparation method. Background Technology

[0002] In laser treatment of facial skin diseases, it is often necessary to continuously irradiate the affected area with a specific wavelength of laser. For example, in treating facial melasma, a 694nm ruby ​​laser is typically used to irradiate the face with high energy density for about 20 minutes, and multiple treatments are often required. During laser treatment, patients usually lie flat, allowing their face to be completely exposed to the laser radiation. At this time, the eye area is also exposed to strong light. Due to the high intensity of the laser, prolonged direct or indirect irradiation may cause irreversible damage to the retina and other eye tissues, seriously affecting the patient's visual health and treatment experience. Therefore, strict light protection measures must be taken for the eyes throughout the treatment process.

[0003] To protect the eyes from light stimulation, patients need to wear opaque, rope-type protective goggles during laser treatment. However, most opaque goggles currently used are made of thick, rigid black plastic. While they offer some light-blocking effect, they present several problems in actual use: First, the goggle material is quite rigid, requiring the straps to be tightened to achieve complete light blocking, resulting in a strong feeling of pressure and poor comfort. Second, the rigid structure makes it difficult to conform to the curvature of the eye area, easily creating gaps. During treatment, light leakage can occur due to changes in body position or equipment adjustments, potentially damaging the eyes and posing a safety hazard. Third, the goggles are thick and not breathable, and prolonged wear can cause the skin around the eyes to become damp and hot, even leading to local discomfort or skin irritation. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to provide a strong light-blocking gel eye patch and its preparation method, which can effectively ensure the light-blocking protection performance of the eyes during strong light therapy, while significantly improving wearing comfort and fit, and having good breathability and soothing properties.

[0005] To achieve the above objectives, the technical solution adopted by the present invention is as follows: In a first aspect, the present invention provides a strong light-blocking gel eye patch, comprising a polyvinyl alcohol gel base and ultrafine graphite powder uniformly dispersed therein, wherein the gel base further comprises glycerol as a plasticizer, and the thickness of the gel eye patch is 2-4 mm.

[0006] As a preferred embodiment, the thickness of the gel eye patch is 3mm.

[0007] As a preferred embodiment, the ultrafine graphite powder has a particle size of 600 mesh and its surface is modified with stearic acid.

[0008] Secondly, the present invention provides a method for preparing the above-mentioned strong light-blocking gel eye patch, comprising the following steps: S1. Add polyvinyl alcohol to deionized water preheated to 90°C and stir until completely dissolved to form a colorless and transparent solution. S2, add ultrafine graphite powder to the solution obtained in step S1, and continue stirring at 90°C to make the graphite powder evenly dispersed. S3, add glycerol to the mixture obtained in step S2, stir until homogeneous, and form a uniform suspension; S4. Inject the suspension obtained in step S3 into the mold and let it stand and spread out. S5, the mold is subjected to freeze-thaw cycle treatment, which includes freezing at -80℃ for 12 hours and then thawing at room temperature for 2 hours. The cycle is repeated 1 to 3 times. After demolding, the gel eye patch is obtained.

[0009] As a preferred embodiment, in step S1, the mass ratio of polyvinyl alcohol to deionized water is (5-9):100, and the stirring time is 1.5-2.5 hours.

[0010] As a preferred embodiment, the ultrafine graphite powder has a particle size of 600 mesh and its surface is modified with stearic acid.

[0011] As a preferred embodiment, in step S2, the stirring time is 15 to 35 minutes.

[0012] As a preferred embodiment, in step S3, the mass ratio of polyvinyl alcohol aqueous solution to glycerol is (105-109):(2-4), and the stirring time is 15 minutes.

[0013] As a preferred embodiment, in step S4, the mold is a silicone mold.

[0014] As a preferred option, in step S4, the time for allowing the surface to stand and flatten is 5 minutes.

[0015] According to the above technical solution, the beneficial effects of the present invention are: 1. The strong light-blocking gel eye patch provided by this invention adopts the form of a gel patch, eliminating the need for traditional straps or headbands for fixation. It can be directly applied to the eyes during use, making it simple to operate and providing a stable fit, avoiding the tight and oppressive feeling of traditional eye masks. The patch uses a flexible, smooth, and hydrophilic hydrogel as its base material, providing a soft and comfortable feel when worn, without any stuffiness. Its water-rich properties and cooling sensation not only relieve eye fatigue but also provide a continuous moisturizing environment for the skin around the eyes, achieving both soothing and moisturizing effects.

[0016] 2. In this invention, ultrafine graphite powder is uniformly dispersed inside the gel as a light-shielding filler. The material is dense and bubble-free with extremely low light transmittance, which can effectively block the strong light used in treatment. In addition, the gel is soft and can closely fit the contour of the eye, significantly reducing the risk of light leakage, thereby ensuring eye safety during treatment.

[0017] 3. The preparation process of this invention is mild, avoiding harmful substance residues and exhibiting superior biocompatibility. The method has clear raw material ratios and process parameters, is simple to operate, has high reproducibility, and is easy to scale up for stable production. Attached Figure Description

[0018] Figure 1 Light micrographs of L929 cells cultured in different extracts during cytotoxicity experiments; Figure 2 Statistical graph for cytotoxicity assay (CCK-8 assay); Figure 3 The transmittance curves of the gel eye patches prepared in Examples 1, 2, and 3 in the visible light range are shown. Figure 4 This diagram illustrates the light-blocking effect of materials under simulated clinical lighting conditions. Figure 5 This is a graph showing the tensile properties of the material. Figure 6 This is a schematic diagram illustrating the manual bending and stretching of materials. Figure 7 This is an image showing the actual wearing effect of the material applied around the human eye. Detailed Implementation

[0019] The present invention will now be described in further detail with reference to the accompanying drawings and specific embodiments.

[0020] A method for preparing a strong light-blocking gel eye patch includes the following steps: S1. Add polyvinyl alcohol (PVA) to deionized water preheated to 90°C, with a PVA:deionized water mass ratio of (5-9):100. Stir magnetically for 1.5-2.5 hours until the solution is colorless and transparent. S2, add spectrally pure 600-mesh ultrafine graphite powder to the solution obtained in step S1. The surface of the graphite powder is modified with stearic acid. The temperature is controlled at 90°C and the mixture is magnetically stirred for 15 to 35 minutes to make it uniformly dispersed. S3, add glycerol to the solution obtained in step S2, and control the mass ratio of the total mass of the polyvinyl alcohol aqueous solution to the mass of glycerol to be (105-109):(2-4), stir for 15 minutes, and prepare a uniform suspension. S4. Inject the suspension obtained in step S3 into the silicone mold and let it stand for 5 minutes to spread it evenly. S5. The mold is subjected to freeze-thaw cycle treatment, that is, first frozen at -80℃ for 12 hours, then thawed at room temperature for 2 hours, and the cycle is repeated 1 to 3 times. After demolding, a gel eye patch with a thickness of about 3mm is obtained.

[0021] Example 1 In this embodiment, a method for preparing a strong light-blocking gel eye patch includes the following steps: Step S1: Weigh 5g of polyvinyl alcohol (PVA) granules and 100g of deionized water. Preheat the deionized water to 90°C and add the PVA. Stir magnetically for 1.5 hours until the solution is colorless and transparent.

[0022] Step S2: Weigh 5g of ultrafine graphite powder (surface stearic acid modified, 600 mesh), add it to the solution obtained in step S1, and stir magnetically at 90℃ for 15 minutes.

[0023] Step S3: Add 2g of glycerol and continue stirring for 15 minutes to form a uniform suspension.

[0024] Step S4: Slowly inject the suspension into the silicone mold and let it stand for 5 minutes to spread it evenly.

[0025] Step S5: Freeze the mold at -80℃ for 12 hours, then thaw it at room temperature for 2 hours to complete one freeze-thaw cycle. After demolding, you will get a gel eye patch with a thickness of about 3mm.

[0026] Example 2 In this embodiment, a method for preparing a strong light-blocking gel eye patch includes the following steps: Step S1: Weigh 7g of polyvinyl alcohol (PVA) granules and 100g of deionized water. Preheat the deionized water to 90°C and add the PVA. Stir magnetically for 2 hours until the solution is colorless and transparent.

[0027] Step S2: Weigh 5g of ultrafine graphite powder (surface stearic acid modified, 600 mesh), add it to the solution obtained in step S1, and stir magnetically at 90℃ for 25 minutes.

[0028] Step S3: Add 3g of glycerol and continue stirring for 15 minutes to form a uniform suspension.

[0029] Step S4: Slowly inject the suspension into the silicone mold and let it stand for 5 minutes to spread it evenly.

[0030] Step S5: Freeze the mold at -80℃ for 12 hours, then thaw it at room temperature for 2 hours. Complete two freeze-thaw cycles. After demolding, you will get a gel eye patch with a thickness of about 3mm.

[0031] Example 3 In this embodiment, a method for preparing a strong light-blocking gel eye patch includes the following steps: Step S1: Weigh 9g of polyvinyl alcohol (PVA) granules and 100g of deionized water. Preheat the deionized water to 90°C and add the PVA. Stir magnetically for 2.5 hours until the solution is colorless and transparent.

[0032] Step S2: Weigh 5g of ultrafine graphite powder (surface stearic acid modified, 600 mesh), add it to the solution obtained in step S1, and stir magnetically at 90℃ for 35 minutes.

[0033] Step S3: Add 4g of glycerol and continue stirring for 15 minutes to form a uniform suspension.

[0034] Step S4: Slowly inject the suspension into the silicone mold and let it stand for 5 minutes to spread it evenly.

[0035] Step S5: Freeze the mold at -80℃ for 12 hours, then thaw it at room temperature for 2 hours. Complete 3 freeze-thaw cycles. After demolding, you will get a gel eye patch with a thickness of about 3mm.

[0036] Performance testing The following performance tests were performed on the gel eye patches prepared in Examples 1-3 above: (1) Cytotoxicity test: Following the requirements of GB / T 16886.12-2023, the sterilized materials and culture medium were prepared at a ratio of 1 g / 5 mL. The materials were completely immersed in the complete culture medium and soaked at 37°C for 24 hours. After filtration using a sterile syringe filter, the extract was aliquoted into centrifuge tubes and stored at 4°C. Cytotoxicity was assessed using L929 cells in a CCK-8 assay according to the requirements of GB / T 16886.5-2017. The experimental results are as follows: Figure 1 and 2 As shown, none of the materials are cytotoxic.

[0037] (2) Light-blocking performance test: The transmittance of the prepared material (approximately 3 mm thick) was tested using a Hitachi UH4150 UV-Vis spectrophotometer to characterize its light-blocking performance. The results are as follows: Figure 3 As shown, all materials exhibited a 90% shading rate in the visible light range. To further simulate clinical lighting conditions, 3cm × 3cm holes were made in the foam baffle, a light source with an intensity equivalent to the treatment intensity was placed behind it, and the holes were covered with the prepared material. The shading effect was recorded using a digital camera. The experimental results are as follows. Figure 4 As shown, the material can completely block strong light from passing through, meeting the requirements for clinical light-shielding use.

[0038] (3) Tensile property test: Prepare standard tensile specimens (gauge length dimensions: 30mm long × 10mm wide × 3mm thick) and perform tensile property tests using a tensile testing machine. After fixing the specimen, set the tensile rate and tensile length, perform the tensile test, and record the tensile stress-tensile strain curve; the results are as follows: Figure 5 As shown, the elongation at break of each material exceeded 300%, demonstrating excellent flexibility and ductility. The materials were further cut into elliptical shapes to fit the eye socket (major axis approximately 4.6 cm, minor axis approximately 3.6 cm), and their practical performance was evaluated through manual bending and twisting operations; for example... Figure 6 As shown, the material has good operability and shape adaptability, and can meet the mechanical requirements for clinical wear.

[0039] (4) Actual application effect: The gel eye patches prepared in the above embodiments were directly applied to the periocular area of ​​the human eye to verify their actual fit. The results are as follows: Figure 7 As shown, the material surface is uniform and smooth, allowing it to closely conform to the contours of the eye socket. The patch can be cut or shaped into different forms according to clinical needs, all of which can effectively cover the eye and provide light protection. The patch exhibits excellent light-blocking performance and good practicality.

[0040] It should be noted that the above embodiments are only used to illustrate the present invention, but the present invention is not limited to the above embodiments. Any simple modifications, equivalent changes and alterations made to the above embodiments based on the technical essence of the present invention shall fall within the protection scope of the present invention.

Claims

1. A strong light-blocking gel eye patch, characterized in that: The gel eye patch comprises a polyvinyl alcohol gel base and ultrafine graphite powder uniformly dispersed therein, wherein the gel base also contains glycerol as a plasticizer, and the thickness of the gel eye patch is 2-4 mm.

2. The strong light-blocking gel eye patch according to claim 1, characterized in that: The thickness of the gel eye patch is 3mm.

3. The strong light-blocking gel eye patch according to claim 1, characterized in that: The ultrafine graphite powder has a particle size of 600 mesh and its surface is modified with stearic acid.

4. A method for preparing a strong light-blocking gel eye patch as described in any one of claims 1 to 2, characterized in that: Includes the following steps: S1. Add polyvinyl alcohol to deionized water preheated to 90°C and stir until completely dissolved to form a colorless and transparent solution. S2, add ultrafine graphite powder to the solution obtained in step S1, and continue stirring at 90°C to make the graphite powder evenly dispersed. S3, add glycerol to the mixture obtained in step S2, stir until homogeneous to form a uniform suspension; S4, Inject the suspension obtained in step S3 into the mold and let it stand and spread out. S5, the mold is subjected to freeze-thaw cycle treatment, which includes freezing at -80℃ for 12 hours and then thawing at room temperature for 2 hours. The cycle is repeated 1 to 3 times. After demolding, the gel eye patch is obtained.

5. The method according to claim 3, characterized in that: In step S1, the mass ratio of polyvinyl alcohol to deionized water is (5-9):100, and the stirring time is 1.5-2.5 hours.

6. The method according to claim 3, characterized in that: In step S2, the ultrafine graphite powder has a particle size of 600 mesh and its surface is modified with stearic acid.

7. The method according to claim 3, characterized in that: In step S2, the stirring time is 15 to 35 minutes.

8. The method according to claim 3, characterized in that: In step S3, the mass ratio of polyvinyl alcohol aqueous solution to glycerol is (105-109):(2-4), and the stirring time is 15 minutes.

9. The method according to claim 3, characterized in that: In step S4, the mold is a silicone mold.

10. The method according to claim 7, characterized in that: In step S4, the time for letting the surface to stand and flatten is 5 minutes.

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