Pharmaceutical composition for preventing birth defects and improving memory

Abstract

The invention discloses a pharmaceutical composition for preventing birth defects and improving memory, and belongs to the technical field of biological medicine and health food. The composition comprises vitamin A, beta-carotene, vitamin complex B, vitamin C, vitamin D, vitamin E, vitamin k, macroelements including calcium, phosphorus, potassium and magnesium and microelements including zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine and manganese, traditional Chinese medicines including glossy privet fruit, astragalus membranaceus, fructus lycii, semen cuscutae and nucleic acid, and bioactive components including lutein, lutein fat, zeaxanthin, grape seed extract, chlorophyll and taurine. The device is mainly used for pre-pregnancy preparation of pregnant women, dosages thereof, pregnant women and wet nurses. The composition eliminates various factors causing birth defects from multiple systems, multiple links and multiple targets, can significantly reduce the total occurrence rate of birth defects, has the effect of improving memory, is beneficial to the health of parents and children, has no incompatibility, and does not generate any toxic or side effect after being taken for a long time.

Description

[0001] Technical Field: This invention relates to the fields of biomedicine and health food technology; in particular, to pharmaceutical compositions for preventing birth defects and improving memory.

[0002] Background: Birth defects refer to developmental disorders of the embryo and its offspring caused by various factors during embryonic development in the mother's womb and after birth. These include four types: morphological and structural abnormalities, physiological and metabolic dysfunction, congenital intellectual disability, and intrauterine growth retardation. The overall incidence of birth defects in my country is approximately 5.6%. The overall incidence of perinatal birth defects is on the rise. Birth defects have a significant impact on population quality, placing a heavy burden on families and society, and have become a major public health issue of global concern.

[0003] The causes of birth defects are complex, including genetic factors, environmental factors, and many other uncertain factors. Genetic factors are passed on to offspring through the reproductive cells of parents; therefore, improving the quality of reproductive cells is a key factor in preventing birth defects. Environmental factors include biological, physical, and chemical factors. Damage to reproductive cells, embryos, and young bodies from harmful environmental factors and other uncertain factors increases the incidence of birth defects, while eliminating these harmful factors reduces the incidence of birth defects.

[0004] The pharmaceutical composition of this invention follows the principles of eugenics and aims to improve the reproductive health of women preparing for pregnancy and their partners, thereby enhancing the quality of reproductive cells. For pregnant women and lactating mothers, it eliminates factors that cause birth defects in the embryo and offspring, preventing birth defects and reducing their incidence, thus benefiting the health of both parents and children. This composition also improves memory. The composition includes vitamin A, β-carotene, B complex vitamins, vitamin C, vitamin D, vitamin E, vitamin K, and macroelements such as calcium, phosphorus, potassium, and magnesium, as well as trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese; traditional Chinese medicines such as privet fruit, astragalus, wolfberry, and dodder seed; essential nutrients such as nucleic acids; and bioactive components such as lutein, lutein lipids, zeaxanthin, grape seed extract, chlorophyll and / or chlorophyll acid, and taurine.

[0005] Vitamin A, also known as retinol, improves vision and prevents night blindness and cataracts. A deficiency can cause corneal epithelial shedding, thickening, and keratinization, making the cornea opaque and leading to decreased and blurred vision. Sufficient vitamin A increases corneal smoothness and improves vision. Vitamin A enhances immune function by regulating cellular and humoral immunity, hence it is also known as the "anti-infection" vitamin. Vitamin A also has antioxidant properties, inhibits tumor growth, enhances the resistance of pregnant women, promotes mucopolysaccharide synthesis, and affects bone tissue renewal and development, causing long bones to grow towards both ends. Vitamin A deficiency reduces reproductive capacity, hindering sperm and egg development. Parental vitamin A deficiency can lead to congenital cataracts, eye deformities, anophthalmia, poor intellectual development, miscarriage, fetal aberrations, microcephaly, various heart malformations, intrauterine growth retardation, low birth weight, and other birth defects in offspring. Beta-carotene can be converted into vitamin A in the body through enzymes, thus fulfilling its functions.

[0006] B vitamins participate in the metabolism of proteins, fats, and carbohydrates in the body, working synergistically to exert physiological functions. Deficiency can lead to decreased reproductive quality and a wide range of birth defects in offspring. B vitamins include vitamin B1, vitamin B2, niacinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1. 12 Vitamin B1, also known as the anti-beriberi factor and anti-neuritis factor, is essential for the development of beriberi. Its deficiency is clinically classified into adult beriberi and infantile beriberi based on age. Congenital beriberi in infants is usually caused by maternal vitamin B1 deficiency during pregnancy. Infantile beriberi commonly occurs in infants aged 2-5 months, often due to maternal vitamin B1 deficiency. It has a sudden onset and rapid progression, with late-stage symptoms including cyanosis, edema, cardiomegaly, heart failure, and tonic-clonic seizures. Sudden death often occurs 1-2 days after symptom onset, and symptoms rapidly improve after administration of vitamin B1. 1缺乏可导致记忆力下降，影响脑的正常功能。如果维生素B1充足，可提高记忆力。集中力及学习能力。Vitamin B2, also known as riboflavin, is a component of many important coenzymes in the body. It participates in the redox reactions of metabolism and plays an important role in maintaining life activities and promoting the growth and development of the fetus and infant. Vitamin B2 deficiency or insufficiency in pregnant women can cause or trigger vomiting in early pregnancy, angular cheilitis, glossitis, cheilitis in mid-pregnancy, and fetal skeletal malformations. Fetal skeletal malformations include: "shortened bones, intercostal, finger or toe growth malformations, shortened fingers and reduced finger joints", cleft lip, cataracts and other birth defects, and can also lead to an increased incidence of premature infants. Vitamin B2 deficiency is often accompanied by deficiencies in other nutrients, such as affecting the metabolism of niacin and vitamin B6, interfering with the absorption, storage and mobilization of iron in the body, resulting in a decrease in stored iron, and in severe cases, iron deficiency anemia. Nicotinamide, also known as anti-pellagra factor, has the physiological functions of participating in the metabolism of substances and energy in the body, maintaining normal nervous system function, ensuring the synthesis of sex hormones, etc., being related to nucleic acid synthesis, lowering blood cholesterol levels, and being a component of glucose tolerance factor. Deficiency can lead to pellagra, the typical symptoms of which are dermatitis, diarrhea, and dementia. This disease often coexists with beriberi, riboflavin deficiency, and other nutrient deficiencies. Pantothenic acid, also known as pantothenic acid, primarily functions as a component of coenzyme A and acyl carrier proteins, playing a role in metabolism. It is widely present in every organism and participates in a wide range of metabolic activities. More than 70 enzymes are known to require pantothenic acid to catalyze various biochemical reactions in the body; otherwise, metabolic disorders will occur. Pantothenic acid deficiency is often accompanied by insufficient intake of the three macronutrients and other vitamins, leading to impaired metabolism. When experiencing unexpected psychological stress, a series of changes occur in the body and mind: increased heart rate, elevated blood pressure, rapid breathing, muscle tension, and elevated blood sugar—all stress responses. These stress responses involve significant energy expenditure, and pantothenic acid can reduce energy consumption during stress responses; therefore, it is also called an anti-stress vitamin. Pantothenic acid is used to prevent low birth weight in newborns due to pantothenic acid deficiency caused by maternal psychological stress. Biotin, also known as vitamin B7, works in coordination with other B vitamins to participate in the metabolism of substances and energy in the human body. Biotin is a coenzyme for many carboxylases in the body, playing an important role in the metabolism of carbohydrates, lipids, proteins, and nucleic acids. It participates in the metabolism of vitamin B12, folic acid, and pantothenic acid; promotes protein synthesis, urea synthesis and excretion; and participates in the synthesis of pancreatic amylase and other digestive enzymes, thus biotin is closely related to the digestive process of food. It is closely related to the synthesis of nucleic acids and sex hormones; deficiency leads to reproductive dysfunction. Maternal biotin deficiency can cause fetal developmental abnormalities. Infants in breastfeeding periods may develop typical infantile exfoliative erythroderma and seborrheic dermatitis due to maternal biotin deficiency, and may also experience loss of appetite, muscle pain, anemia, etc. Biotin supplementation shows significant therapeutic effects.Choline, also a B vitamin, acts as a precursor to acetylcholine in the body, improving cognitive decline; it helps the liver process fat, preventing fatty liver, promoting lipoprotein synthesis, and regulating cholesterol levels; it maintains cell membrane integrity and supports key physiological processes such as DNA methylation. Choline deficiency in pregnant women can affect the neural development of the embryo. Vitamin B6 is crucial for central nervous system development; deficiency can lead to delayed development and intellectual impairment. In the first few months after birth, maternal vitamin B6 deficiency during brain development can cause permanent damage to brain structure development and the transmission of nerve impulses. (Vitamin B...) 12 Folic acid participates in the synthesis of nucleic acids, choline, and amino acids, as well as the metabolism of fats and sugars. It plays a role in the integrity of bone marrow hematopoiesis, digestive tract epithelial cell function, liver function, and the myelin sheath function of the nervous system. It is an essential vitamin for normal intelligence; deficiency can cause intellectual impairment and nutritional anemia, affecting blood supply to the brain. Folic acid participates in the synthesis of amino acids and nucleic acids and works with vitamin B1. 12 These substances work together to promote cell generation and maturation. A deficiency can prevent normal cells from undergoing mitosis, leading to neurological symptoms such as memory loss, depression, and dementia. Folic acid, vitamin B6, and vitamin B12 are also essential. 12 It can synergistically clear homocysteine ​​from the human body. Homocysteine ​​is a neurotoxin that can cause brain self-destruction. Studies have shown that homocysteine ​​is an independent potential teratogenic factor for development, which can induce differential gene expression. Elevated maternal homocysteine ​​levels can lead to serious and fatal birth defects in offspring, such as congenital heart disease and neural tube defects. In addition, elevated homocysteine ​​levels can also cause clinical consequences such as miscarriage, premature birth, and preeclampsia.

[0007] Vitamin C, also known as ascorbic acid, is a highly bioactive substance with multiple physiological functions in the body: It is an important free radical scavenger, playing an anti-aging role; it is closely related to collagen, not only softening blood vessels but also purifying the blood and preventing arteriosclerosis; it promotes the absorption of iron and calcium from food; it can reduce folic acid to bioactive tetrahydrofolate, preventing megaloblastic anemia; it participates in the synthesis of neurotransmitters, and a deficiency hinders neurotransmitter formation; it promotes antibody formation, increasing the body's resistance; and large doses of vitamin C can alleviate the toxicity of toxic substances such as mercury, lead, arsenic, benzene, and certain drugs and bacterial toxins; during pregnancy, vitamin C deficiency or insufficiency can cause subcutaneous bleeding, swollen, bleeding, and ulcerated gums; long-term vitamin C deficiency increases susceptibility to viral colds, increases the risk of fetal malformations, and severe deficiency can lead to miscarriage.

[0008] Vitamin D derivatives refer to a large class of substances containing a cyclopentanenylphenanthrene ring structure and possessing calciferol biological activity, with vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol) being the most common. Vitamin D participates in maintaining intracellular and extracellular calcium concentrations and regulating calcium and phosphorus metabolism. Maternal deficiency of vitamin D and calcium can cause bone and teeth development disorders and rickets in offspring. In adults, especially pregnant women, lactating mothers, and the elderly, vitamin D deficiency can lead to demineralization of mature bones, resulting in osteoporosis and osteomalacia.

[0009] Vitamin E is a collective term for all chromone derivatives with α-tocopherol biological activity. Among them, α-tocopherol has the highest activity and can eliminate free radicals, delay aging, and prevent macrocytic hemolytic anemia. In medicine, vitamin E is often used to treat male and female infertility and prevent threatened abortion and habitual abortion. Vitamin E deficiency or insufficiency can damage the reproductive system of pregnant women, causing irreversible changes in the reproductive epithelium and resulting in low birth weight premature infants. In men, vitamin E deficiency can lead to testicular atrophy and epithelial cell degeneration, resulting in abnormal pregnancy.

[0010] Vitamin K is a fat-soluble vitamin that is mainly stored in the liver. Its main physiological functions are: 1. Regulating the synthesis of clotting proteins to ensure the synthesis of prothrombin and other clotting factors in the liver and ensure the operation of the clotting mechanism; 2. Ensuring the health of bone tissue, as the synthesis of three proteins in osteoblasts depends on the participation of vitamin K; if the mother is deficient in vitamin K during pregnancy, the newborn often suffers from intracranial hemorrhage at birth.

[0011] Calcium is an important macro-element in the human body, playing two main roles: first, it forms hard tissues such as bones and teeth; second, it combines with proteins or exists as calcium ions to form substances with specific functions, forming a so-called miscible calcium pool that maintains a dynamic balance with calcium in bones and teeth. All cells in the body need calcium to perform their normal functions. Calcium deficiency in pregnant and lactating women can affect their physical condition and the development of the fetus or infant, leading to various birth defects such as congenital rickets and osteomalacia. Calcium deficiency can also cause endocrine disorders and malregulation of cell growth. Due to their physiological characteristics, pregnant and lactating women generally have insufficient calcium intake.

[0012] Phosphorus is one of the most abundant mineral elements in the human body. An adult's body contains about 600-900g of phosphorus, which accounts for about 1% of body weight. Phosphorus is an important element in the body. It is a component of cell membranes and nucleic acids, as well as an essential building block of bones and teeth. Premature infants are prone to phosphorus deficiency, which can lead to rickets-like skeletal abnormalities.

[0013] Potassium participates in cellular metabolism and provides suitable conditions for the normal activity of certain enzymes. Its prominent role is to maintain the normal excitability, automaticity, and conductivity of myocardial cells. It also plays an important role in regulating acid-base balance, maintaining osmotic pressure, and maintaining fluid balance. Both hypokalemia and hyperkalemia can cause serious damage to the human body. Mild cases may lead to fatigue and irritability, while severe cases may cause arrhythmia or even death.

[0014] The most important function of magnesium in the human body is to inhibit the production of free radicals, which are major factors in promoting aging and causing birth defects. Another function of magnesium is to work with calcium and vitamin D to protect bones. Magnesium deficiency can easily lead to osteoporosis and fractures. In addition, magnesium also has the functions of protecting the heart and preventing diabetes. In clinical practice, magnesium is used to prevent premature birth and preeclampsia caused by maternal magnesium deficiency. Offspring of mothers with magnesium deficiency are more likely to have low birth weight and other birth defects.

[0015] The trace element zinc is incorporated into biological macromolecular ligands—proteins, nucleic acids, and membranes (mainly membrane proteins)—to form stable metal-containing biological macromolecular complexes—metallothioneins, metallonucleic acid complexes, etc. These substances are known to participate in the synthesis and degradation of carbohydrates, lipids, proteins, and nucleic acids. Zinc-containing enzymes are present in all six major classes of enzymes. Zinc is also a key element for enhancing immune activity. Zinc can promote the conversion of proinsulin to insulin by activating carboxypeptidase B. Zinc deficiency inhibits the activity of insulin in peripheral tissues, leading to abnormal glucose tolerance curves. Recent studies have shown that zinc deficiency can cause obstacles in nucleic acid and protein synthesis, induce chromosomal aberrations, fetal developmental arrest, and growth disorders. Zinc deficiency in men can lead to gonadal dysfunction, reduced sperm count, and infertility; low zinc levels in semen can cause oligospermia and necrospermia. Maternal zinc deficiency can lead to anencephaly, neural tube defects, poor brain development, intellectual disability, intrauterine growth retardation, premature birth, miscarriage, and abnormal immune function in offspring and subsequent generations. Zinc can also enhance the sensitivity of the optic nerve. Zinc is a component of retinol reductase in retinal cells. Deficiency directly affects the synthesis and metabolism of retinin by vitamin A, impairs the function of retinaldehyde, and thus weakens the ability to adapt to low light. Zinc deficiency can also affect the color perception of cone cells in the retina.

[0016] Selenium, a trace element, is essential for human embryonic development. It possesses strong antioxidant properties, protecting the embryo from superoxide damage. Selenium can alleviate or reduce the toxicity caused by mercury, cadmium, lead, arsenic, thallium, nickel, sulfur, etc., and promote the excretion of toxic metals from the body. Environmental pollution has led to a year-on-year increase in exposure to these toxic elements, which are also major causes of birth defects. Selenium deficiency increases the toxicity of these elements to pregnant women and fetuses, causing weakened immune function, birth defects, stillbirth, miscarriage, etc. Selenium deficiency in men can lead to decreased sperm density and count, infertility, or low pregnancy rates. Selenium deficiency in women of childbearing age can cause infertility, miscarriage, and retained placenta. Keshan disease is common in women of childbearing age, and pregnant women with low selenium levels are more susceptible to Keshan disease. Selenium deficiency can also lead to reduced insulin secretion, decreased glucose tolerance, and decreased antioxidant capacity, thus accelerating aging and cognitive decline. Selenium is an important trace element for maintaining vision; selenium deficiency can lead to amblyopia.

[0017] The main physiological function of the trace element iron is to participate in the transport of oxygen and tissue respiration in the body as a component of hemoglobin, myoglobin, and cytochromes; it plays a core role in the transport of oxygen and electrons; the structure of catalase contains iron, and hydrogen peroxide is degraded by catalase, which is one of the most dangerous free radicals in the human body; iron deficiency is common in infants, pregnant women, and lactating mothers, leading to iron deficiency anemia, the main symptoms of which are physical weakness, impaired memory, and decreased work capacity; maternal iron deficiency can lead to fetal growth and development disorders, anemia, low birth weight, premature birth, and congenital intellectual disability in children.

[0018] Chromium is an essential trace element. Only trivalent chromium can be used as a chromium supplement. It can enhance and promote the physiological function of insulin, prevent arteriosclerosis, enhance immune function, and promote growth and development. Chromium deficiency can lead to growth retardation and accelerated aging. Chromium deficiency in the mother can lead to chromium deficiency anemia in the offspring. Timely chromium supplementation can gradually improve the condition.

[0019] Copper primarily functions in the human body in the form of copper-containing metalloenzymes, participating in a series of metabolic functions such as iron utilization, hematopoiesis, phospholipid synthesis, and collagen connective tissue formation. Copper deficiency in pregnant women affects the normal differentiation and development of the embryo and fetus, leading to congenital malformations, manifested as fetal brain atrophy, cerebellar hypoplasia, thinning of the cerebral cortex, cardiovascular abnormalities, tortuous and dilated cerebral blood vessels, and thinning of the blood vessel walls and elastic layer. Children often experience neurological and mental abnormalities, poor responsiveness to the surrounding environment, slow motor development, and dull visual reflexes. It can also lead to severe copper deficiency anemia (megacellular anemia), a common cause of anemia in infants.

[0020] Molybdenum is one of the essential trace elements for the human body. It is a constituent element of many enzymes, participates in iron utilization, promotes the development and maturation of red blood cells, can prevent anemia, and helps in the metabolism of carbohydrates and fats. It participates in detoxifying the body from toxic aldehydes, eliminating free radicals, and has anti-cancer, anti-aging, immune-enhancing, and anti-caries functions. It can be used to prevent birth defects caused by maternal molybdenum deficiency aggravated by selenium deficiency. Molybdenum has a resistant effect to mercury toxicity, can prevent lead poisoning, and has a synergistic effect with selenium. Maternal molybdenum deficiency can aggravate birth defects caused by selenium deficiency and exposure to mercury and lead, such as low immune function, birth defects, stillbirth, miscarriage, congenital heart disease, neural tube defects, Down syndrome, intrauterine growth retardation, and intellectual disability. Molybdenum deficiency can also induce cardiovascular disease, cancer, and tooth decay.

[0021] Iodine plays a major role in the synthesis of thyroid hormones in the human body. The physiological functions of thyroid hormones include regulating the body's metabolic level, affecting the body's heat production, blood sugar and ketone body levels, muscle and nerve tension, weight, intelligence and sexual function, among other things. Iodine deficiency during pregnancy can affect fetal neural development, causing congenital intellectual disability, muteness, deafness, microcephaly, low ear position, spastic paralysis, etc. Severe iodine deficiency can cause fetal growth retardation, intellectual disability, and congenital cretinism (cretinism), and can also lead to congenital goiter.

[0022] Fluorine is also an essential trace element for the human body. A normal human body contains approximately 2.6g of fluorine, mainly found in bones and teeth. Appropriate amounts of fluorine are beneficial for the utilization of calcium and phosphorus, promoting bone formation and strengthening bone, and accelerating bone growth. Fluorine can react with hydroxyapatite in tooth enamel to form a hard, acid-resistant protective layer of fluorapatite crystals on the tooth surface, inhibiting glycolysis and reducing the formation of acidic substances, thus preventing tooth decay. However, excessive fluorine intake can cause poisoning.

[0023] Manganese participates in the formation of some enzymes in the human body. It not only participates in the metabolism of sugars and lipids, but also plays a role in the synthesis of proteins, DNA, and RVA. Manganese is an essential trace element for maintaining human sexual function. When men are deficient in manganese, their reproductive function is impaired, leading to testicular degeneration, reduced sperm count, degenerative changes in seminiferous tubules, and even loss of sexual ability. It can also cause decreased libido, menstrual cycle disorders, and infertility. When mothers are deficient in manganese, mucopolysaccharide synthesis is impaired, and the formation of bone organic matter is reduced, leading to poor fetal bone development, widespread skeletal deformities, and irreversible congenital ataxia in infants.

[0024] Privet fruit is a natural Chinese medicinal herb used in health foods to nourish yin. It has the effects of tonifying the liver and kidneys, clearing heat and improving eyesight, and is mainly used to treat liver and kidney yin deficiency, and yin deficiency-related vision loss. Modern pharmacological research has confirmed that privet fruit enhances immune function; increases white blood cell count and promotes erythroid hematopoiesis; has anti-mutagenic and anti-allergic effects; lowers blood sugar and blood lipids; increases coronary blood flow; privet fruit contains both estradiol and testosterone, thus having a bidirectional regulatory effect on the endocrine system; protects the liver; has anti-aging effects; protects against chromosome damage; and has antioxidant, anti-inflammatory, and antibacterial effects. Astragalus is a natural Chinese medicinal herb that is both a food and a medicine, used to replenish qi. It has the effects of tonifying qi and raising yang, strengthening the defensive qi and consolidating the exterior, promoting tissue regeneration, and promoting diuresis and reducing edema. Clinically, it is used to treat spleen qi deficiency, qi failing to control blood, qi sinking, spleen and lung qi deficiency, qi and blood deficiency, qi deficiency fever, weakness and excessive sweating, qi deficiency edema, blood stasis and numbness, sequelae of stroke, and diabetes. Ancient Chinese medicine listed it as a superior herb. In the "Pregnancy-Preserving Pill" in the Pharmacopoeia, it is listed as the principal herb alongside Atractylodes macrocephala, having the effect of nourishing the fetus and stabilizing pregnancy. Modern pharmacological research... Astragalus has been shown to have the following effects: 1. Enhancing the body's immunity and bidirectionally regulating the body's immune function; 2. Anti-aging function; 3. Enhancing intelligence and improving learning and memory; 4. Anti-fatigue effect; 5. Anti-hypoxia effect; 6. Anti-radiation effect; 7. Anti-cold effect; 9. Anti-mutagenic effect; 10. Tumor-inhibiting effect; 11. Antibacterial, antiviral, and anti-inflammatory effects; 12. Liver-protecting, kidney-protecting, diuretic, and stomach-protecting effects; 13. Promoting bone growth; 14. Estrogen-like effects; 15. Cardiotonic, vasodilatory, and hypotensive effects; 16. Promoting DNA, RNA, and protein synthesis; 17. Regulating blood sugar; 18. Prolonging the lifespan of animal cells, etc.

[0025] Goji berries are a natural Chinese medicinal herb that is both a food and a medicine, nourishing yin and replenishing blood. They have the effects of tonifying the liver and kidneys, nourishing yin and blood, benefiting essence and improving eyesight, and moistening the lungs and relieving cough. Clinically, they are significantly effective in treating male infertility. They are considered a mild tonic. Ancient Chinese medicine listed goji berries as a superior herb, with the *Compendium of Materia Medica* praising them highly, stating that they combine the advantages of more than ten other Chinese herbs, describing them as: "enriching qi, replenishing blood, generating yang, nourishing yin, reducing fire, and dispelling wind and dampness." They are mainly used for symptoms such as lower back and knee weakness, dizziness, premature graying of hair, decreased vision, and decreased sexual function caused by deficiency of both liver and kidneys and insufficient essence and blood. Modern pharmacological research has confirmed that goji berries have: 1. Enhance... 1. Immunoregulation and immune regulation; 2. Anti-cancer and tumor-suppressing effects; 3. Scavenging harmful free radicals in the body, lowering lipids and protecting the liver; 4. Lowering blood sugar; 5. Anti-fatigue and anti-heat effects; 6. Enhancing the activity of catalase and lactate dehydrogenase in animal heart and brain tissues, increasing the activity of superoxide dismutase in the blood of the elderly, reducing lipid peroxidation content, enhancing hematopoietic stem cells, and having anti-aging and growth-stimulating effects on animals; 7. Improving intelligence and memory; 8. Protecting the reproductive system; 9. Anti-mutation effects, etc.; Goji berries are mild in nature and have many beneficial values ​​for enhancing human physiological metabolism.

[0026] Cuscuta chinensis is a natural Chinese medicinal herb used in health foods to tonify Yang; it has functions such as tonifying Yang and Yin, strengthening essence and reducing urination, improving eyesight, and stopping diarrhea. Modern pharmacological studies have proven that: 1. Effects on the reproductive system: Cuscuta chinensis ketones have multifaceted effects on the endocrine function of the hypothalamus-pituitary-gonadal axis; Cuscuta chinensis promotes sperm motility and membrane function, and has a significant protective effect against oxidative damage to sperm membrane, acrosome structure, and sperm mitochondrial function caused by reactive oxygen species (ROS), thus having an anti-infertility effect; 2. Immunomodulatory effects; 3. Antioxidant and anti-aging effects; 5. Antimutagenic effects; 6. It also has effects such as improving eyesight, strengthening the body, protecting the liver, anti-cancer, and antibacterial properties.

[0027] Nucleic acids are one of the basic components of human cells. They play a dominant role in major life phenomena such as growth, development, reproduction, heredity, and variation. Their importance in biological science can be summarized by the statement, "Without nucleic acids, there is no life." When the amount of nucleic acid synthesized in the body cannot meet the needs of normal physiological functions, or when the endogenous nucleic acid synthesis capacity declines, nucleic acids become essential nutrients, hence they are currently called "conditionally essential nutrients." After entering the human body through the digestive tract, nucleic acids (products) are digested and degraded by nucleic acid hydrolysants into various nucleotide monomers, nucleosides, and bases, collectively known as nucleic acid substances, which can then be absorbed and utilized by the human body. Physiological functions: 1. Enhancing immunity and resistance to disease, increasing the number of white blood cells, cytotoxic cells, and neutrophils. 2. Delaying aging. After each cell division, the telomeres at both ends of chromosomes are damaged. When telomeres are depleted, cell division stops, and the cell enters the aging phase. Nucleic acids can stimulate the gonads to secrete telomere gene enzymes, which synthesize single nucleotide chains to replenish telomeres. This extends the number of cell divisions, thus delaying the aging process of cells. 3. It can regulate endocrine disorders, balancing the metabolism of the hypothalamus, pituitary gland, and gonads, thus alleviating various symptoms of aging and decline such as the degeneration of sexual characteristics and atrophy of sexual organs, and relieving or delaying menopausal syndrome. 4. It promotes metabolism and energy supply, eliminates free radicals, mobilizes overall function, and alleviates changes in various organs and systems. 5. It has anti-radiation effects. 6. It plays a regulatory role in the absorption and utilization of the three major nutrients. For lipid metabolism, it can increase the content of high-density lipoprotein (HDL) and polyunsaturated fatty acids in the blood, and reduce cholesterol levels. In the case of a low-protein diet, nucleic acid supplementation can promote protein absorption and utilization, eliminating various adverse effects caused by a low-protein diet. 7. The decomposition product of RNA, nucleosides, has the effect of dilating peripheral blood vessels. Adenosine triphosphate (AMP) is the energy source for brain metabolism; therefore, many experiments have proven its significant effect on improving vascular dementia. 8. Clinically, nucleic acid preparations such as c-AMP and ATP have long been used to treat visual and hearing impairments. 9. Improves the body's tolerance to environmental changes, significantly combats fatigue, enhances the body's resistance to cold and heat, and promotes the utilization of ingested oxygen. 10. Promotes the development of the reproductive system, etc.

[0028] Lutein is a carotenoid bioactive component with eight isomers, predominantly all-trans, accounting for over 80%. It belongs to the same lutein class as zeaxanthin. From a physiological perspective, both cis and trans lutein have the same physiological effects, while free lutein and lutein esters also provide nutritional supplementation. After absorption, the human body can convert and metabolize lutein esters into lutein, with the ester form exhibiting better stability than the free form. Physiological functions: 1. Lutein is a major component of the macula in the eye and has a preventive effect against age-related macular degeneration. Lutein can be deposited in the lens of the eye. Lutein and zeaxanthin inhibit free radical generation by quenching singlet oxygen, thus protecting and preventing the oxidative denaturation of polyunsaturated fatty acids in retinal cells, thereby inhibiting the development of cataracts. 2. Lutein has an inhibitory effect on various cancers, such as breast cancer, prostate cancer, rectal cancer, colon cancer, and skin cancer. 3. It slows the progression of early arteriosclerosis.

[0029] Zeaxanthin, a carotenoid bioactive component, is mainly found in the endosperm of yellow-grained maize seeds, a member of the Poaceae family. Its physiological functions include: 1. As an antioxidant vitamin, anti-oxidation is its primary physiological function. 2. Protecting eyesight: Zeaxanthin, along with lutein, constitutes a major component of the macula in the eye. The macula, located in the center of the retina and lacking other carotenoids, is the most sensitive and crucial part of the visual system. Damage to the macula can severely impair vision, leading to central vision loss and ultimately blindness. Zeaxanthin, together with lutein, helps prevent age-related macular degeneration (AMD). 3. One cause of cataracts is the oxidation of proteins in the lens of the eye. Zeaxanthin can prevent damage to the eyes from singlet oxygen produced by ultraviolet radiation, preventing the oxidation of proteins and lipids in the lens and reducing the risk of age-related cataracts. 4. Reducing blood lipid oxidation, thereby slowing down arteriosclerosis. 5. Lowering the risk of cancer.

[0030] Grape seed extract belongs to the polyphenolic bioactive components and is also a substance that can be used as a raw material for health foods. Its physiological functions include: 1. Antioxidant and anti-aging effects: Grape seed extract has a strong antioxidant capacity, approximately 50 times that of vitamin E and 20 times that of vitamin C in the body. It can cross the blood-brain barrier to provide antioxidant protection to brain cells, preventing Alzheimer's disease and stabilizing the blood-brain barrier to protect the brain from harmful substances. 2. Lowering blood lipids. 3. Lowering blood pressure and protecting the cardiovascular system. 4. Inhibiting tumors. 5. Anti-radiation effects. 6. Improving memory. 7. Improving vision. 8. Anti-mutagenic effects. 9. Regulating immunity. 10. Anti-inflammatory, anti-allergic, and skin-beautifying effects.

[0031] Chlorophyll is widely found in the chloroplasts of higher plants. Chlorophyll is hydrolyzed in a warm alkaline ethanol aqueous solution. After neutralization with dilute hydrochloric acid, it can be extracted with aqueous ethanol to obtain chlorophyll containing three carboxylic acid groups. Both chlorophyll and chlorophyll are bioactive components that can be used as raw materials for health food. Physiological functions: 1. Anti-mutation effect. Chlorophyll and chlorophyll have strong mutagenic effects, deactivating the activity of mutagenic substances. Chlorophyll has a strong affinity for mutagens, forming complexes that inactivate them. Chlorophyll and chlorophyll can form complexes with the carcinogen Trp-p-2, deactivating its activity, and can also inhibit the metabolic activity of mutagenic substances, promote detoxification metabolism, and control the formation of mutagenic substances. In the human body, chlorophyll can absorb the carcinogen dioxin and excrete it with feces. Dioxin has reproductive toxicity, causing reduced sperm count, decreased sexual function, decreased androgen levels, and feminized behavior in men; in women, it can cause menstrual irregularities, decreased fertility, and miscarriage. Dioxin is teratogenic to many animals. Chlorophyll also has the effect of inhibiting carcinogenic and mutagenic substances such as aflatoxin B1 and benzo[a]pyrene. 2. Protects the gastric mucosa; 3. Has anti-stress effects; 4. Promotes wound healing, etc.

[0032] Taurine is a non-essential amino acid and a bioactive component that can be used as a raw material in health foods. Its physiological functions include: 1. Relieving fatigue in those who are overworked, exercise excessively, or are physically exhausted; 2. Maintaining normal brain function and promoting brain development in infants and young children. Insufficient intake can slow down or affect normal brain nerve development, thus impacting intellectual development in infants and young children; 3. Maintaining normal visual function; 4. Antioxidant and anti-aging effects; 5. Enhancing immunity; 6. Lowering blood sugar, participating in insulin secretion, and protecting insulin-producing cells; 7. Participating in endocrine activities and having a series of unique effects on the cardiovascular system, strengthening left ventricular function, increasing myocardial contractility, resisting arrhythmia, preventing congestive heart failure, and lowering blood pressure; 8. Enhancing the permeability of nutrients to cells, neutralizing cytotoxins, reducing the toxicity of secondary acids, and protecting liver cell membranes, thus possessing good choleretic, hepatoprotective, and detoxifying effects; 9. Protective effect against carbon tetrachloride poisoning.

[0033] The human body is a unified whole, and it carries out reproduction and physiological metabolism under the regulation of neurohumoral factors. The human body's reproduction and physiological metabolism cannot be separated from essential nutrients, and various essential nutrients need to coordinate with each other to realize the reproductive and physiological functions of the human body as a unified whole.

[0034] The product contains vitamin A, beta-carotene, vitamin B1, vitamin B2, nicotinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1. 12Combinations containing folic acid, vitamin C, vitamin D, vitamin E, vitamin K, and macroelements such as calcium, phosphorus, potassium, and magnesium, as well as trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese; traditional Chinese medicines such as privet fruit, astragalus, dodder seed, and wolfberry; conditionally essential nutrients such as nucleic acids; and bioactive components such as lutein, lutein lipids, zeaxanthin, grape seed extract, chlorophyll and / or chlorophyll acid, and taurine as active ingredients are known. However, compositions containing vitamin A, β-carotene, vitamin B1, vitamin B2, nicotinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1 as active ingredients are also known. 12 A drug composition for preventing birth defects and improving memory, including folic acid, vitamin C, vitamin D, vitamin E, vitamin K, macroelements such as calcium, phosphorus, potassium, and magnesium, and microelements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese, traditional Chinese medicines such as privet fruit, astragalus, wolfberry, and dodder seed, conditionally essential nutrients such as nucleic acids, and bioactive components such as lutein, lutein lipids, zeaxanthin, grape seed extract, chlorophyll and / or chlorophyll acid, and taurine, has not been reported.

[0035] Birth defects are numerous and have complex causes. Preventing and controlling birth defects is a comprehensive system implemented through three levels of prevention and control measures. Level 1 prevention proactively prevents birth defects by eliminating their causes. Level 2 prevention involves stopping the birth of a diagnosed, severely defective embryo (i.e., abortion), a passive measure taken only as a last resort. Level 2 prevention can cause unforgettable physical and psychological harm to the mother, and it accounts for a large proportion of prevention efforts in my country. Level 3 prevention refers to timely and effective diagnosis, treatment, and rehabilitation after the birth of a child with birth defects to improve the child's quality of life, prevent disability, and promote health. Mothers who have undergone Level 2 or 3 prevention still carry the defective genes from their children. The probability of developing the same birth defect in subsequent pregnancies is several times to 30 times higher than in mothers who have never had a child with that specific birth defect, depending on the heritability of the defect. Children with disabilities after Level 3 prevention may pass on the defective genes to their offspring after marriage, and the disease can persist for generations. In my country, folic acid is the only drug available for primary prevention of birth defects. It is used to prevent neural tube defects in offspring caused by maternal folic acid deficiency. However, folic acid cannot prevent neural tube defects caused by maternal deficiency of vitamin B12, zinc deficiency, exposure to toxic heavy metals such as cadmium, or excessive levels of teratogenic and mutagenic organic compounds. Folic acid cannot prevent the numerous types of birth defects caused by factors other than maternal folic acid deficiency, nor can it reduce the overall incidence of birth defects. The target for preventing birth defects is lacking, and its efficacy is limited, requiring further improvement.

[0036] Summary of the Invention: To overcome the shortcomings of existing drugs for preventing birth defects and / or improving memory, the present invention aims to provide a composition comprising one or more components selected from Ligustrum lucidum, Astragalus membranaceus, Lycium barbarum, Cuscuta chinensis, nucleic acids, lutein, lutein esters, zeaxanthin, grape seed extract, chlorophyll and / or chlorophyll acid, taurine, etc., combined with various vitamins and essential micronutrients such as minerals. The components Ligustrum lucidum, Astragalus membranaceus, Lycium barbarum, Cuscuta chinensis, nucleic acids, lutein, lutein esters, zeaxanthin, grape seed extract, chlorophyll and / or chlorophyll acid, taurine, etc., can effectively promote the absorption and utilization of vitamins and minerals, and increase the levels of vitamin A, β-carotene, vitamin B1, vitamin B2, nicotinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1. 12 It contains folic acid, vitamin C, vitamin D, vitamin E, vitamin K, and macroelements such as calcium, phosphorus, potassium, and magnesium, as well as trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese, which can improve reproductive health, prevent birth defects, and / or improve memory. Simultaneously, through the intake of macroelements such as calcium, phosphorus, potassium, and magnesium, and trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese, as well as vitamins A, beta-carotene, vitamin B1, vitamin B2, nicotinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1, it can improve reproductive health, prevent birth defects, and / or improve memory. 12 It contains folic acid, vitamin C, vitamin D, vitamin E, vitamin K, etc., and supplements and enhances one or more components from privet fruit, astragalus, wolfberry, dodder seed, nucleic acid, lutein, lutein lipids, zeaxanthin, grape seed extract, chlorophyll and / or chlorophyll acid, taurine, etc., to enhance and regulate immunity, anti-oxidation, anti-aging, anti-mutation, prevent mutation, eliminate mental and physical fatigue, improve intelligence, promote DNA, RNA and protein synthesis, improve reproductive health, prevent birth defects and improve memory. Even with long-term use, there are no side effects. Based on extensive research, the inventors have discovered that vitamin A, β-carotene, vitamin B1, vitamin B2, nicotinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1 are also included. 12A novel combination of folic acid, vitamin C, vitamin D, vitamin E, vitamin K, and macroelements such as calcium, phosphorus, potassium, magnesium, and trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese, along with privet fruit, astragalus, wolfberry, dodder seed, nucleic acids, lutein, lutein esters, zeaxanthin, grape seed extract, chlorophyll and / or chlorophyll acid, and taurine, has a synergistic effect in preventing birth defects and improving memory. Conversely, using only vitamin A, beta-carotene, B complex vitamins, vitamin C, vitamin D, vitamin E, vitamin K, and macroelements such as calcium, phosphorus, potassium, magnesium, and trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese, along with privet fruit, astragalus, wolfberry, dodder seed, nucleic acids, lutein, and lutein esters... Zeaxanthin, grape seed extract, chlorophyll and / or chlorophyll, taurine, etc., are all less effective than this composition; and the active ingredients of each component have a variety of health benefits for the human body. For example, the dosage of privet fruit used in this composition can nourish the liver and kidneys, clear heat and improve eyesight, enhance immune function, resist mutation, lower blood sugar, lower blood lipids, and protect against chromosomal damage; Astragalus membranaceus can nourish the fetus and stabilize pregnancy, resist aging, resist oxidation, resist mutation, enhance and regulate immunity, improve intelligence, and enhance physical strength; Lycium barbarum can nourish the liver and kidneys, nourish yin and blood, benefit essence and improve eyesight, treat male infertility, improve memory, and moisten the lungs and relieve cough; Cuscuta chinensis can nourish yang and yin, consolidate essence and reduce urination, regulate immunity, resist oxidation, resist aging, resist cancer, resist mutation, strengthen the body, and resist infertility; nucleic acids can enhance immunity. It has effects such as delaying aging, regulating endocrine disorders, scavenging free radicals, treating visual and hearing impairments, and resisting radiation; lutein, lutein lipids, and zeaxanthin all have the effect of scavenging free radicals and preventing macular degeneration and cataracts; grape seed extract has strong antioxidant effects, delays aging, lowers blood lipids and increases high-density lipoprotein cholesterol, lowers blood pressure and protects the cardiovascular system, inhibits tumors, has anti-mutagenic effects, regulates immunity, improves memory, and improves vision; chlorophyll and / or chlorophyll acid have strong anti-mutagenic effects, anti-stress effects, aids wound healing, and protects the gastric mucosa; taurine can eliminate fatigue in those who overuse their brains, exercise excessively, or work overtime, maintain the normal physiological function of the human brain, and promote the growth of infants and young children. The trace element zinc plays a vital role in the development of the brain, improving memory, maintaining normal visual function, and has antioxidant and anti-aging effects. Zinc is an essential component of zinc-containing enzymes, one of the six major enzyme classes in the human body, and is also a key element in enhancing immune activity. It has multi-target effects in preventing birth defects and improving memory. Selenium accelerates the metabolism of excess fat in the body, has strong antioxidant functions, prevents heart disease, Keshan disease and Kashin-Beck disease, has anti-cancer functions, and alleviates or reduces the toxicity caused by teratogenic and mutagenic substances such as mercury, arsenic, lead, thallium, nickel, and sulfur. Iron participates in oxygen transport and tissue respiration, and is a key element in preventing iron-deficiency anemia. Chromium enhances and promotes the physiological function of insulin, strengthens immunity, prevents arteriosclerosis, and has anti-aging effects.The trace element copper participates in iron utilization, hematopoiesis, and phospholipid synthesis. Insufficient copper intake in pregnant women can lead to premature rupture of membranes, miscarriage, low birth weight in newborns, and congenital malformations, manifested as fetal brain atrophy, cerebellar hypoplasia, thinning of the cerebral cortex, cardiovascular abnormalities, tortuous and dilated cerebral blood vessels, and thinning of the elastic layer of blood vessel walls. The trace element molybdenum has anti-cancer, anti-aging, immune-enhancing, and anti-caries functions. The trace element iodine can prevent and treat goiter caused by iodine deficiency and can prevent severe developmental disorders such as cretinism, deafness, muteness, low ear position, spastic paralysis, intrauterine growth retardation, and congenital intellectual disability caused by iodine deficiency in fetuses and newborns. The trace element fluorine maintains the stability of bone and teeth structure, promotes bone formation and increases bone density, and accelerates bone growth. Growth and development, prevention of tooth decay, etc.; trace element manganese participates in the synthesis of proteins, DNA, and RNA; vitamin A improves eyesight and prevents night blindness; vitamin B1 can prevent beriberi and maintain the normal physiological activities of the nervous, digestive, muscular, and circulatory systems; vitamin B2 is an essential vitamin for maintaining healthy skin and eyes; nicotinamide deficiency can cause pellagra; pantothenic acid deficiency can cause metabolic disorders; biotin can prevent gray hair and baldness; choline helps the liver process fat, prevents fatty liver, promotes lipoprotein synthesis, regulates cholesterol levels, maintains cell membrane structural integrity, and supports key physiological processes such as DNA methylation; vitamin B6 can eliminate precancerous cells, enhance immune function, and protect blood vessels; vitamin B... 12 This invention is used to prevent megaloblastic anemia and diseases of the nervous system; folic acid also has the effects of protecting the heart and fighting cancer; vitamin C softens blood vessels, purifies blood, and prevents arteriosclerosis; vitamin E has the effect of scavenging free radicals and delaying aging; potassium maintains the normal excitability, automaticity, and conductivity of myocardial cells; calcium, phosphorus, magnesium, vitamin D, and vitamin K work together to ensure the health of bone tissue; this composition has no incompatibilities, no toxic side effects, and is low in cost, thus constituting the present invention.

[0037] This invention provides a pharmaceutical composition for preventing birth defects and improving memory, comprising, as active ingredients, vitamin A, β-carotene, vitamin B1, vitamin B2, nicotinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1. 12 Folic acid, vitamin C, vitamin D, vitamin E, vitamin K and macroelements such as calcium, phosphorus, potassium, magnesium and trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, manganese and ingredients such as privet fruit, astragalus, wolfberry, dodder seed, nucleic acid, lutein, lutein lipids, zeaxanthin, grape seed extract, chlorophyll and / or chlorophyll acid, taurine, etc.

[0038] The following vitamins are used in this invention: Vitamin B1, Vitamin B2, Nicotinamide, Pantothenic Acid, Biotin, Choline, Vitamin B6, and Vitamin B1. 12 (Vitamin B) 12Folic acid and vitamin C are water-soluble vitamins that do not accumulate in the body; vitamin A, vitamin D, vitamin E, and vitamin K are fat-soluble vitamins; beta-carotene is a precursor to vitamin A and can be converted into vitamin A in the body, and is beneficial and harmless according to the dosage used in this invention; zinc (Zn), selenium (Se), iron (Fe), chromium (Cr), copper (Cu), molybdenum (Mo), iodine (I), and fluorine (F) are essential trace elements for the human body; manganese (Mn) is a potentially essential trace element for the human body; and calcium (Ca), phosphorus (P), potassium (K), and magnesium (Mg) are essential macroelements for the human body. In this invention, the essential element calcium can be selected from calcium gluconate, calcium acetate, casein calcium, calcium chloride, calcium citrate, calcium malate, calcium citrate-malate, calcium hydrogen phosphate, calcium dihydrogen phosphate, calcium phosphate, calcium sulfate, calcium ascorbate, calcium glycerophosphate, calcium lactate, calcium carbonate, etc.; the essential element phosphorus can be selected from calcium phosphate, calcium hydrogen phosphate, tricalcium phosphate, etc.; and the essential element potassium can be selected from potassium carbonate, potassium chloride, potassium citrate, dipotassium hydrogen phosphate, potassium gluconate, potassium sulfate, potassium glycerophosphate, potassium lactate, etc. For the macroelement magnesium, options include magnesium chloride, magnesium gluconate, magnesium lactate, magnesium citrate, magnesium hydrogen phosphate, magnesium phosphate, magnesium glycerophosphate, and magnesium carbonate. For the trace element zinc, options include zinc citrate, zinc gluconate, zinc acetate, zinc carbonate, zinc oxide, zinc chloride, zinc lactate, zinc sulfate, and zinc monomethionine. For the trace element selenium, options include selenomethionine, selenium methoxybenzyl cyanate, sodium selenite, selenized carrageenan, selenocysteine, selenomethionine, sodium selenate, and selenium yeast. For the trace element iron, options include... Ferrous gluconate, ferrous lactate, ferric chloride, ferric citrate, ferrous carbonate, ferrous citrate, ferrous fumarate, heme iron, ferric pyrophosphate, ferric heme chloride, ferrous succinate, and ferrous sulfate can be used for trace elements such as chromium, chromium trichloride, chromium nicotinate, chromium pyridinecarboxylate, and chromium yeast; copper can be made from copper carbonate, copper citrate, copper gluconate, and copper sulfate; molybdenum can be found in ammonium molybdate and sodium molybdate; iodine can be potassium iodate; and fluorine... Sodium fluoride, potassium fluoride, etc. can be used. For trace element manganese, manganese sulfate, manganese gluconate, manganese glycerophosphate, manganese chloride, manganese citrate, etc. are available. There are professional manufacturers and suppliers for various macro-elements and trace elements, various fat-soluble vitamins and water-soluble vitamins, extracts of traditional Chinese medicine such as privet fruit, astragalus, wolfberry, and dodder seed, nucleic acid, conditionally essential nutrients, and bioactive components such as lutein, lutein esters, zeaxanthin, grape seed extract, chlorophyll and chlorophyll acid, taurine, etc.

[0039] The pharmaceutical composition of this invention is mainly suitable for women preparing for pregnancy in the pre-conception period and their partners, pregnant women, and lactating mothers. The dosage of each component refers to the "Chinese Dietary Reference Intakes (2013 Edition)," and the standards or regulations formulated by the National Health Commission, the State Food and Drug Administration, and the former Ministry of Health. However, as a drug for the prevention and treatment of diseases, it must comply with the drug registration management principle of "safety, effectiveness, and quality control." Due to factors such as geology, food chain, dietary habits, and duration of use, the safe, effective, and quality-controllable dosage of each component of this composition may vary among different population groups. For example: iodine is not required in high-iodine areas; selenium is not required in high-selenium areas; fluorine is not required in high-fluorine areas; molybdenum may be omitted or reduced in high-molybdenum areas or for those not receiving long-term parenteral nutrition; potassium or magnesium may be omitted or reduced in normal-dietary populations or those not receiving long-term parenteral nutrition; phosphorus may be omitted or reduced in normal-dietary populations, or for premature infants and their lactating mothers, or for those not using large amounts of antithrombotic drugs long-term or with renal tubular reabsorption disorders. Choline is omitted or reduced; women preparing for pregnancy in the early stages and their partners may omit vitamin K. Based on dietary and lifestyle habits and nutritional health practices, this composition aims to prevent birth defects and improve memory. The components include traditional Chinese medicines such as Ligustrum lucidum, Astragalus membranaceus, Lycium barbarum, and Cuscuta chinensis; conditionally essential nutrients such as nucleic acids; and bioactive components such as lutein, lutein esters, zeaxanthin, grape seed extract, chlorophyll and / or chlorophyll acid, and taurine. These components can be used as single or multiple components combined with vitamins, minerals, and other essential micronutrients. The pharmaceutical composition of this invention is designed for the vast majority of applicable populations, while also considering populations in special geological environments, with special dietary or lifestyle habits, at special physiological stages, and those in sub-health or pathological states. It is prepared according to needs, serving various applicable populations, aiming to improve the reproductive health of a wider range of populations, reduce the overall incidence of birth defects, improve the quality of the newborn population, enhance national health, and reduce the burden on society and families.According to this invention, the effective dosage of *Ligustrum lucidum* extract, calculated as whole natural medicinal material, is 330-9980 mg / day; the effective dosage of *Astragalus membranaceus* extract, calculated as whole natural medicinal material, is 330-9980 mg / day; the effective dosage of *Lycium barbarum* extract, calculated as whole natural medicinal material, is 330-11980 mg / day; the effective dosage of nucleic acid is 500-1500 mg / day; the effective dosage of lutein is 5-20 mg / day; the effective dosage of lutein lipids is 10-40 mg / day; the effective dosage of zeaxanthin is 10-40 mg / day; the effective dosage of grape seed extract is 30-300 mg / day; and the effective dosage of chlorophyll and / or chlorophyll acid is 10-200 mg / day. The effective dosage of taurine is 30-1200 mg / day, the effective dosage of vitamin B1 is 1-19 mg / day, the effective dosage of vitamin B2 is 1-19 mg / day, the effective dosage of nicotinamide is 6-49 mg / day, the effective dosage of pantothenic acid is 3-19 mg / day, the effective dosage of biotin is 0.012-0.099 mg / day, the effective dosage of choline is 160-1490 mg / day, the effective dosage of vitamin B6 is 1-9.9 mg / day, and vitamin B... 12 The effective dosage is 0.0012–0.0099 mg / day; the effective dosage of folic acid is 0.3–0.99 mg / day; the effective dosage of vitamin C is 85–490 mg / day; the effective dosage of vitamin A and / or β-carotene (in retinol equivalents) is 260–2600 μg RAE / day; the effective dosage of vitamin D is 0.008–0.02 mg / day; the effective dosage of vitamin E (in α-tocopherol equivalents) is 6–149 mg α-TE / day; and the effective dosage of vitamin K is 0.025–0. The effective dosage of macroelements, calcium (calculated as elemental calcium), is 260-1200 mg / day; phosphorus (calculated as elemental phosphorus), is 160-800 mg / day; potassium (calculated as elemental potassium), is 1210-2600 mg / day; magnesium (calculated as elemental magnesium), is 310-400 mg / day; zinc (calculated as elemental zinc), is 6-36 mg / day; selenium (calculated as elemental selenium), is 0.016-0.39 mg / day; and iron (calculated as elemental iron), is 16-36 mg / day. The effective dosage of chromium (calculated as elemental chromium) is 0.016–0.148 mg / day, the effective dosage of copper (calculated as elemental copper) is 0.55–7 mg / day, the effective dosage of molybdenum (calculated as elemental molybdenum) is 0.03–0.8 mg / day, the effective dosage of iodine (calculated as elemental iodine) is 0.06–0.6 mg / day, the effective dosage of fluorine (calculated as elemental fluorine) is 0.5–3 mg / day, and the effective dosage of manganese (calculated as elemental manganese) is 3.1–10 mg / day.

[0040] The compositions of the present invention can be administered or taken directly in the following pharmaceutical formulations, such as oral preparations (e.g., granules, capsules, pills, tablets, dry syrups, liquid preparations), or foods such as solid foods (e.g., biscuits), prepared by mixing with other known additives, such as: carriers, disintegrants, sustained-release agents, excipients, fillers, coating agents, binders, lubricants, antioxidants, coating agents, colorants, flavoring agents, sweeteners, sucrose substitutes, nutritional fortifiers, flavoring agents, surfactants, plasticizers, pH adjusters, fresheners, suspending agents, defoamers, preservatives, thickeners, solubilizers, etc., prepared by conventional methods or added to foods as functional components or additives.

[0041] According to the present invention, vitamin A, β-carotene, vitamin B1, vitamin B2, nicotinamide, pantothenic acid, biotin, choline, vitamin B6, and vitamin B1 are present. 12 The formula contains folic acid, vitamin C, vitamin D, vitamin E, vitamin K, and macroelements such as calcium, phosphorus, potassium, and magnesium, as well as trace elements such as zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine, and manganese. It also contains the conditionally essential nutrient nucleic acid, Chinese medicinal herbs such as privet fruit, astragalus, wolfberry, and dodder seed, and bioactive components such as lutein, lutein lipids, zeaxanthin, grape seed extract, chlorophyll and / or chlorophyll acid, and taurine. Each component can be formulated separately, and the formulations of each component can be mixed together or used separately.

[0042] The advantages of this invention are that the composition eliminates multiple factors that cause birth defects from multiple systems, multiple links, and multiple targets. The components have a synergistic effect, which has a significant effect on improving reproductive health, reducing the overall incidence of birth defects, and preventing a wide variety of birth defects. It also has health benefits and memory-improving effects on the user. The raw materials are readily available and the cost is low. The components in the composition have no toxic side effects and no incompatibilities.

[0043] Detailed implementation: The following will compare the effects of the reference embodiments and test embodiments. The present invention will now be described in detail.

[0044] Appendix 1 shows the comparison of the effects of vitamins and minerals in maze tests on young mice, including single or multiple components of each of the following ingredients: privet fruit, astragalus, wolfberry, dodder seed, nucleic acid, zeaxanthin, grape seed extract, chlorophyll, and taurine, plus vitamins and minerals.

[0045] Example 1:

[0046] The above components are further mixed evenly with appropriate amounts of additives such as mannitol, hydroxypropyl cellulose, magnesium aluminosilicate, and flavoring agents. The resulting mixture is then made into 3 packets of granules. Take one packet three times daily.

[0047] Example 2:

[0048] The above components are further mixed evenly with appropriate amounts of additives such as mannitol, hydroxypropyl cellulose, magnesium aluminosilicate, and flavoring agents. The resulting mixture is then made into 9 granular packets. Take 3 packets 3 times daily.

[0049] Example 3:

[0050] The above components are further mixed evenly with appropriate amounts of additives such as microcrystalline cellulose, lactose, crospovidone, stearic acid, silicon dioxide, magnesium stearate and flavoring agent to make 3 tablets, which are then coated with triethyl citrate, polysorbate 80 and film coating premix (gastric-soluble type). Take 1 tablet 3 times a day.

[0051] Example 4:

[0052] The above components are further mixed evenly with appropriate amounts of additives such as microcrystalline cellulose, lactose, crospovidone, stearic acid, silicon dioxide, magnesium stearate and flavoring agent to make 4 tablets. The tablets are then coated with triethyl citrate, polysorbate 80 and film coating premix (gastric-soluble type). The tablets are taken twice a day, 2 tablets each time.

[0053] Example 5:

[0054] The above components are further mixed evenly with appropriate amounts of additives such as microcrystalline cellulose, lactose, crospovidone, stearic acid, silicon dioxide, magnesium stearate and flavoring agent to make 4 tablets. The tablets are then coated with triethyl citrate, polysorbate 80 and film coating premix (gastric-soluble type). The tablets are taken twice a day, 2 tablets each time.

[0055] Example 6:

[0056] The above components are further mixed evenly with appropriate amounts of additives such as microcrystalline cellulose, lactose, crospovidone, stearic acid, silicon dioxide, magnesium stearate and flavoring agent to make 4 tablets. The tablets are then coated with triethyl citrate, polysorbate 80 and film coating premix (gastric-soluble type). The tablets are taken twice a day, 2 tablets each time.

[0057] Example 7:

[0058] The above components are further mixed evenly with appropriate amounts of additives such as microcrystalline cellulose, lactose, crospovidone, stearic acid, silicon dioxide, magnesium stearate and flavoring agent to make 4 tablets. The tablets are then coated with triethyl citrate, polysorbate 80 and film coating premix (gastric-soluble type). The tablets are taken twice a day, 2 tablets each time.

[0059] Animal studies have confirmed that this composition is non-toxic, and no toxic side effects have been observed in human consumption.

[0060] Appendix 1: Comparison of the effects of vitamins and minerals in maze tests on young mice, including single or multiple components of each of the following ingredients: privet fruit, astragalus, wolfberry, dodder seed, nucleic acid, zeaxanthin, grape seed extract, chlorophyll, and taurine; and vitamins and minerals in addition to these components.

[0061] Appendix 2 compares the effects of vitamins and minerals in maze tests on aged mice, including single or multiple components of each of the following ingredients: privet fruit, astragalus, wolfberry, dodder seed, nucleic acid, zeaxanthin, grape seed extract, chlorophyll, and taurine, plus vitamins and minerals.

[0062] Note: For each group in Appendix 1 and Appendix 2, the dosage in the table was fed for 60 days and the test was conducted. The dosage in the table is converted per kilogram of body weight. Zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine and manganese are calculated as trace elements, while calcium, phosphorus, potassium and magnesium are calculated as elements.

[0063] Ninety newlywed healthy women and ninety healthy spouses were selected, with an average age of 26 years. The women and their spouses simultaneously took this composition (preferably the composition of Example 6 of the present invention) continuously for six months before conception until pregnancy. The pregnant women continued to take this composition (preferably the composition of Example 7 of the present invention) until the six-month breastfeeding period after the birth of the infant. At the six-month follow-up after the birth of the infant, there were no cases of birth defects. Compared with the statistical reports of related materials, the birth defect rate of infants was approximately 5.6% of the total birth population, which is significantly different.

[0064] As can be clearly seen from Tables 1 and 2, through mouse maze tests and comparisons with the individual components of traditional Chinese medicine, bioactive ingredients, and vitamins and minerals in the compositions, the statistical results of the error percentage show that the memory-improving efficacy of each composition is superior to that of the individual components of traditional Chinese medicine, bioactive ingredients, and vitamins and minerals. Compared with the blank control group, the memory-improving efficacy is significantly different.

Claims

1. A pharmaceutical composition for preventing birth defects and improving memory, characterized in that, It is made from the following raw materials in the following weight ratio:

2. The pharmaceutical composition for preventing birth defects and improving memory according to claim 1, characterized in that, It is made from the following raw materials in the following weight ratio:

3. The pharmaceutical composition for preventing birth defects and improving memory according to claim 1, characterized in that, It is made from the following raw materials in the following weight ratio:

4. The pharmaceutical composition for preventing birth defects and improving memory according to claim 2, characterized in that, It is made from the following raw materials in the following weight ratio:

5. The pharmaceutical composition for preventing birth defects and improving memory according to claim 3, characterized in that, It is made from the following raw materials in the following weight ratio:

6. The pharmaceutical composition for preventing birth defects and improving memory according to claim 5, characterized in that, It is made from the following raw materials in the following weight ratio:

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