Biocompatible membrane, preparation method thereof and analyte sensor

By using a biocompatible membrane made of amphiphilic polyurethane as the outer membrane of the analyte sensor, the complex process of requiring two outer membrane layers in the prior art is solved, enabling accurate monitoring of glucose and β-hydroxybutyric acid, simplifying the preparation process and improving the detection range and stability.

CN121555060APending Publication Date: 2026-02-24SINOCARE
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Patent Information

Application Number
CN202610077130.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-01-21
Publication Date
2026-02-24

AI Technical Summary

Technical Problem

Existing dual-analyte monitoring systems require two outer membrane layers, which complicates the preparation process and affects detection accuracy, making it difficult to simultaneously control the permeation rate and concentration of the two analytes within the linear range.

Method used

A biocompatible membrane, made of amphiphilic polyurethane through chemical bonding or addition polymerization, is used as the outer membrane of the analyte sensor. Only one layer is needed to simultaneously control the permeation ratio of two analytes, thus meeting the detection requirements.

Benefits of technology

The sensor manufacturing process has been simplified, and the accuracy and stability of detection have been improved. It can accurately monitor glucose and β-hydroxybutyric acid over a wide concentration range, meeting the needs of implantable monitoring systems.

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Abstract

The invention provides a biocompatible membrane which is prepared from a membrane layer working solution through a membrane forming process, the membrane layer working solution comprises amphiphilic polyurethane, and the amphiphilic polyurethane is prepared by any one of the following methods: hydrophilic molecules and hydrophobic molecules form an amphiphilic polymer through chemical bonding, the amphiphilic polymer and an isocyanate substance are subjected to an addition polymerization reaction to prepare the polyurethane resin. Or one of hydrophilic molecules or hydrophobic molecules and isocyanate substances are subjected to an addition polymerization reaction to prepare polyurethane, and then the polyurethane and the other molecule are subjected to chemical bonding to form the amphiphilic polyurethane. The invention also provides a preparation method of the biocompatible membrane and an analyte sensor using the biocompatible membrane. The biocompatible membrane provided by the invention can simultaneously control the permeation ratio of two analytes, when the biocompatible membrane is used as an outer membrane of an analyte sensor, only one layer of biocompatible membrane is needed to meet the monitoring requirement, and the detection accuracy can be ensured.
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