Synergistic anticorrosive composition containing diethylene glycol monobutyl ether and phenoxyethanol

Abstract

The invention provides a synergistic anti-corrosion composition containing diethylene glycol butyl ether and phenoxyethanol. The synergistic anti-corrosion composition comprises the following components in percentage by weight: 2-10% of diethylene glycol butyl ether; 0.2 to 1 wt% of phenoxyethanol; and a carrier acceptable in the field of home-cleaning products. The invention also relates to an application of the synergistic preservative composition containing diethylene glycol monobutyl ether and phenoxyethanol in preparation of a home cleaning product with a bacteriostatic effect.

Description

TECHNICAL FIELD

[0001] The present application relates to a composition containing diethylene glycol butyl ether and phenoxy ethanol. The composition is compounded by diethylene glycol butyl ether and phenoxy ethanol in a system with water as the main solvent, which can improve the antiseptic effect of the system on yeast and mold. The composition avoids the cost of adding and compounding preservatives with phenoxy ethanol in the formula to enhance the antiseptic ability of mold and yeast, realizes the purpose of cost saving and synergistic effect, and the composition can be used in household cleaning products. BACKGROUND

[0002] People in life will use various household cleaning products to meet the daily cleaning needs. These household cleaning products (such as laundry detergent, dishwashing detergent, softener, and hard surface cleaner, etc.) generally contain surfactants, dispersants, and functional additives, etc., which provide basic nutrient sources for the growth and reproduction of microorganisms. Therefore, a certain amount of preservative is added in these formulas to inhibit the growth and reproduction of microorganisms, thereby delaying the spoilage caused by the growth of microorganisms in the product, so as to effectively prolong the use time of the product.

[0003] Phenoxy ethanol is a high-boiling, low-volatility solvent, and also a low-sensitization, high-efficiency, broad-spectrum preservative and bactericide. Since the early 1950s, phenoxy ethanol has been widely used as a preservative in cosmetics. In recent years, due to its low sensitization, the use trend has been continuously expanding. The bactericidal mechanism of phenoxy ethanol is to act on the cell membrane, increase the permeability of the cell membrane to potassium ions, and inhibit the activity of enzymes required for cell growth, thereby achieving the effect of antibiosis.

[0004] Phenoxy ethanol has better bactericidal effect on bacteria, especially on gram-negative bacteria, but its bactericidal effect on fungi is generally poor, and it is often combined with other preservatives to improve the preservative effect.

[0005] Some organic solvents are often added to household cleaning products to improve the cleaning power of the products. Diethylene glycol butyl ether is an organic compound that can be mixed with water in any proportion, which can effectively dissolve and remove stubborn oil stains, and improve the cleaning power of the product.

[0006] Chinese patent application CN 104583293 A discloses a preservative mixture and a polymer solution stabilized with the same, discloses a polymer aqueous solution stabilized with a preservative mixture, the preservative mixture comprises 0.01-0.2 wt% of hexyl glycerol, 0.001-0.01 wt% of 2-methylisothiazolinone and 0.05-0.5 wt% of phenoxy ethanol. The stabilized polymer solution is suitable for use in cosmetic formulations such as skin and hair care products, cosmetic modifiers and cosmetic cleaners Chinese patent application CN 113301802 A discloses a synergistic preservative composition, a method of making and using the same, describes a synergistic preservative composition for providing broad spectrum antibacterial activity, comprising: (i) about 0.1 wt.% to about 99.9 wt.% of propylene carbonate; (ii) about 0.1 wt.% to about 99.9 wt.% of one or more organic compounds selected from the group consisting of: propylene glycol, caprylyl oxy fatty acid and isopropyl methyl phenol; and (iii) about 0.1 wt.% to 99.0 wt.% of phenoxyethanol, i.e. a preservative compound, and wherein the composition provides a synergistic effect with a Synergistic Index (SI) value of the total composition of about 0.05 to about 1.0. A method of making the synergistic preservative composition and a method of using the same are also described.

[0007] The present application unexpectedly found a composition containing diethylene glycol butyl ether and phenoxyethanol. The composition is compounded by diethylene glycol butyl ether and phenoxyethanol in a system with water as the main solvent, which can enhance the preservative effect of the system on yeast and mold. The composition avoids the cost of adding and compounding preservatives with phenoxyethanol in the formula to enhance the preservative ability of mold and yeast, achieves the purpose of cost saving and synergistic effect, and the composition can be used in household cleaning products. SUMMARY

[0008] The present application provides a composition of diethylene glycol butyl ether and phenoxyethanol, which can enhance the preservative effect of the system on yeast and mold. The composition avoids the cost of adding and compounding preservatives with phenoxyethanol in the formula to enhance the preservative ability of mold and yeast, achieves the purpose of cost saving and synergistic effect, and the composition can be used in household cleaning products.

[0009] The present application provides a synergistic preservative composition containing diethylene glycol butyl ether and phenoxyethanol, which comprises: 2-10% by weight of diethylene glycol butyl ether; 0.2-1% by weight of phenoxyethanol; and a carrier acceptable in the field of household cleaning products.

[0010] In a preferred embodiment, the composition comprises 2.5-6% by weight of diethylene glycol butyl ether.

[0011] In a preferred embodiment, the composition comprises 0.2-0.5% by weight of phenoxyethanol.

[0012] In a preferred embodiment, the weight ratio of diethylene glycol butyl ether to phenoxyethanol is 5-20: 1.

[0013] In a preferred embodiment, the composition further comprises a pH adjusting agent, and the pH adjusting agent is sodium citrate.

[0014] In a preferred embodiment, the pH value of the composition is 6-7.

[0015] In a preferred embodiment, the composition is capable of inhibiting microorganisms selected from the following: Candida chromatosa ATCC10231, Aspergillus niger ATCC16404, and Paecilomyces ATCC18502.

[0016] On the other hand, the present invention also provides a synergistic preservative composition containing diethylene glycol butyl ether and phenoxyethanol, for use in the preparation of household cleaning products with antibacterial properties.

[0017] In a preferred embodiment, the household cleaning product is selected from: disinfectant products and detergents.

[0018] In a preferred embodiment, the household cleaning product comprises 0.1-10% by weight of the composition. Detailed Implementation

[0019] The inventors of this invention have unexpectedly discovered a composition containing diethylene glycol butyl ether and phenoxyethanol. This composition, formulated by compounding diethylene glycol butyl ether and phenoxyethanol in a water-based system, enhances the system's preservative effect against yeast and mold. This composition avoids the cost of adding preservatives compounded with phenoxyethanol to enhance the preservative effect against mold and yeast in the formulation, achieving cost savings and synergistic effects. This composition can be used in household cleaning products.

[0020] pH adjusting agent The pH adjuster described in this invention is sodium citrate prepared as a 20% by weight aqueous solution. As a pH adjuster, it helps to adjust the pH value (stock solution) of the composition containing dipropylene glycol butyl ether and phenoxyethanol to about 6.5.

[0021] To provide a more concise description, some of the quantitative expressions given herein are not modified by the term "approximately". It should be understood that, whether or not the term "approximately" is explicitly used, each quantity given herein is intended to refer to an actual given value, and also to an approximation of such given values ​​that can be reasonably inferred by one of ordinary skill in the art, including approximations of such given values ​​caused by experimental and / or measurement conditions.

[0022] To provide a more concise description, some quantities in this document are described as a range from approximately X to approximately Y. It should be understood that when describing a range, the range is not limited to the upper and lower limits stated, but should include the entire range from approximately X to approximately Y, or any quantities in between.

[0023] The following describes the technical solution of the present invention in detail through preferred embodiments. However, the scope of the present invention is not limited to these embodiments, which are intended to illustrate the technical solution of the present invention and not to limit the scope of the present invention. Test methods in the following embodiments that do not specify specific conditions are generally performed under conventional conditions or as recommended by the manufacturer. Unless otherwise stated, all percentages and parts are by weight.

[0024] The experimental materials used in the embodiments, comparative examples, and application examples of this invention are as follows: Diethylene glycol butyl ether, trade name Butyl CARBITOL™ Solvent, purchased from Dow Chemical (Shanghai) Co., Ltd. Phenoxyethanol, trade name NEOLONE™ PH 100 preservative, purchased from Micromcg Biotechnology (Shanghai) Co., Ltd. Sodium citrate, trade name trisodium citrate dihydrate, purchased from Sinopharm Chemical Reagent Co., Ltd. Sodium fatty alcohol polyoxyethylene ether sulfate, trade name Texapon® N 70, purchased from BASF (China) Co., Ltd. Polyoxyethylene (9) fatty alcohol ether, trade name Lutensol A 9 N, purchased from Yangzi Petrochemical-BASF Co., Ltd. Citric acid, trade name: citric acid monohydrate, purchased from Shandong Yingxuan Industrial Co., Ltd. Sodium bicarbonate, trade name sodium bicarbonate, purchased from Tongbai Haijing Alkali Industry Co., Ltd. Dipropylene glycol, trade name Dipropylene Glycol LO+, purchased from Dow Chemical. Example 1: A composition that can enhance the antifungal effect of phenoxyethanol Weigh 2 parts by weight of diethylene glycol butyl ether and add it to a beaker containing 90 parts by weight of deionized water. Mix and stir at 200 rpm until completely dissolved. Then add 0.5 parts by weight of phenoxyethanol, stir and mix thoroughly, and adjust the pH of the solution to about 6.5 with sodium citrate solution. Make up the remaining amount with deionized water to 100 parts by weight.

[0025] Example 2: A composition that can enhance the antifungal effect of phenoxyethanol: Weigh 2.5 parts by weight of diethylene glycol butyl ether and add it to a beaker containing 90 parts by weight of deionized water. Mix and stir at 200 rpm until completely dissolved. Then add 0.5 parts by weight of phenoxyethanol, stir and mix thoroughly, and adjust the pH of the solution to about 6.5 with sodium citrate solution. Make up the remaining amount with deionized water to 100 parts by weight.

[0026] Example 3: A composition that can enhance the antifungal effect of phenoxyethanol: Weigh 4 parts by mass of diethylene glycol butyl ether and add it to a beaker containing 90 parts by mass of deionized water. Mix and stir at 200 rpm until completely dissolved. Then add 0.5 parts by mass of phenoxyethanol, stir and mix thoroughly, and adjust the pH of the solution to about 6.5 with sodium citrate solution. Make up the remaining amount with deionized water to 100 parts by mass.

[0027] Example 4: A composition that can enhance the antifungal effect of phenoxyethanol: Weigh 6 parts by mass of diethylene glycol butyl ether and add it to a beaker containing 90 parts by mass of deionized water. Mix and stir at 200 rpm until completely dissolved. Then add 0.5 parts by mass of phenoxyethanol, stir and mix thoroughly, and adjust the pH of the solution to about 6.5 with sodium citrate solution. Make up the remaining amount with deionized water to 100.

[0028] Example 5: A composition that can enhance the antifungal effect of phenoxyethanol: Weigh 4 parts by mass of diethylene glycol butyl ether and add it to a beaker containing 90 parts by mass of deionized water. Mix and stir at 200 rpm until completely dissolved. Then add 0.2 parts by mass of phenoxyethanol, stir and mix thoroughly, and adjust the pH of the solution to about 6.5 with sodium citrate solution. Make up the remaining amount with deionized water to 100.

[0029] Example 6: A composition that can enhance the antifungal effect of phenoxyethanol: Weigh 4 parts by mass of diethylene glycol butyl ether and add it to a beaker containing 90 parts by mass of deionized water. Mix and stir at 200 rpm until completely dissolved. Then add 0.3 parts by mass of phenoxyethanol, stir and mix thoroughly, and adjust the pH of the solution to about 6.5 with sodium citrate solution. Make up the remaining amount with deionized water to 100 parts by mass.

[0030] Comparative Example 1 Weigh 0.5 parts by weight of phenoxyethanol and add it to a beaker containing 90 parts by weight of deionized water. Mix and stir at 200 rpm until completely dissolved. Then adjust the pH of the solution to about 6.5 with sodium citrate solution, and make up the remaining amount with deionized water to 100 parts by weight.

[0031] Comparative Example 2 Weigh 4 parts by mass of dipropylene glycol and add it to a beaker containing 90 parts by mass of deionized water. Mix and stir at 200 rpm until completely dissolved. Then add 0.5 parts by mass of phenoxyethanol, stir thoroughly and mix evenly. Adjust the pH of the solution to about 6.5 with sodium citrate solution, and add the remaining amount with deionized water to make up to 100 parts by mass.

[0032] Test Example 1 To avoid the influence of the system's pH value on the fungal preservation results, sodium citrate solution was used to adjust the pH of the system to about 6.5, and the pH of Examples 1 to 6, and Comparative Examples 1 to 2 was measured using a pH meter (Mettler Toledo) (25°C, direct measurement of the original solution).

[0033] Table 1: pH values ​​of Examples 1-6 and Comparative Examples 1-2 Test Example 2 The solutions of the above-prepared examples and comparative examples were subjected to microbial challenge tests according to ISO 11930-2019 Test Method for Evaluation of Antimicrobial Protective Effects in Cosmetics. The microbial strains used for testing were as follows: Candida albicans ATCC10231, Aspergillus niger ATCC16404, and Penicillium tumefaciens ATCC18502. The inoculation method was mixed inoculation.

[0034] The criteria for determining whether a microbial challenge against fungi is satisfied are as follows: In the first week, the logarithmic decrease in microbial count relative to the count at 0 must be greater than or equal to 1; in the second week, the logarithmic decrease must be greater than or equal to 2; and in the fourth week, the logarithmic decrease must be greater than or equal to 3. All of these conditions must be met to be considered to have met the microbial challenge requirements. The microbial challenge results for the above examples and comparative examples are as follows: Table 2: Results of fungal microbial challenge in Examples 1-6 and Comparative Examples 1-2 Conclusion: The results show that Comparative Example 1, with phenoxyethanol alone, failed to pass the first week's microbial challenge requirements for molds and yeasts, indicating that phenoxyethanol has limited antiseptic ability against fungi. Comparative Example 2, using a combination of phenoxyethanol and dipropylene glycol, also failed to pass the first week's microbial challenge requirements for molds and yeasts. However, when dipropylene glycol was replaced with an equal amount of diethylene glycol butyl ether, Example 3 met the microbial challenge requirements for molds and yeasts, indicating that diethylene glycol butyl ether can enhance the system's antiseptic ability against molds and yeasts when combined with phenoxyethanol, achieving synergistic effects. Further analysis of the phenoxyethanol addition amount revealed that when the phenoxyethanol addition amount was less than 0.5% to 0.2%, the system still met the microbial challenge requirements for molds and yeasts. When the phenoxyethanol addition amount remained constant, reducing the diethylene glycol butyl ether addition amount to 2.5% still met the microbial challenge requirements for molds and yeasts.

[0035] Application Example 1 Weigh 4 parts by weight of sodium fatty alcohol polyoxyethylene ether sulfate and add it to a beaker containing 4 parts by weight of diethylene glycol butyl ether. Add 80 parts by weight of deionized water and stir until homogeneous. Then add 2 parts by weight of polyoxyethylene (9) fatty alcohol ether, 0.5 parts by weight of phenoxyethanol, and 0.1 parts by weight of sodium bicarbonate in sequence, and stir until homogeneous. Adjust the pH of the formula to about 8 using citric acid.

[0036] Table 3: Application Example 1 Test Example 3 Furthermore, the combination of 0.5% phenoxyethanol and 4% diethylene glycol butyl ether was applied to the following household cleaning formula (Application Example 1), and the formula pH was adjusted to approximately 8. Microbial challenge testing was conducted according to the test methods for evaluating the antimicrobial protective effect of cosmetics in ISO 11930-2019. The test microbial strains used were: Candida albicans ATCC10231, Aspergillus niger ATCC16404, and Penicillium tumefaciens ATCC18502, using a mixed inoculation method. The judgment criteria were: in the first week, the logarithmic decrease in microbial count relative to the logarithmic count at 0°C was greater than or equal to 1; in the second week, the logarithmic decrease in microbial count relative to the logarithmic count at 0°C was greater than or equal to 2; and in the fourth week, the logarithmic decrease in microbial count relative to the logarithmic count at 0°C was greater than or equal to 3. All of the above conditions must be met to be considered as meeting the microbial challenge requirements against fungi.

[0037] Table 4: Results of the fungal microbial challenge in Application Example 1 Conclusion: The results of the application examples show that the application examples meet the requirements for the preservation of mold and yeast, proving that the composition can be applied to household cleaning formulations to enhance the system's ability to preserve mold and yeast.

Claims

1. A synergistic preservative composition comprising diethylene glycol butyl ether and phenoxyethanol, comprising: 2-10% by weight of diethylene glycol butyl ether; 0.2-1% by weight of phenoxyethanol; and a carrier acceptable in the field of household cleaning products.

2. The composition according to claim 1, characterized in that, The composition contains 2.5-6% by weight of diethylene glycol butyl ether.

3. The composition according to claim 1, characterized in that, The composition contains 0.2-0.5% by weight of phenoxyethanol.

4. The composition according to claim 1, characterized in that, The weight ratio of diethylene glycol butyl ether to phenoxyethanol is 5-20:

1.

5. The composition according to claim 1, characterized in that, The composition also includes a pH adjuster, wherein the pH adjuster is sodium citrate.

6. The composition according to claim 1, characterized in that, The pH value of the composition is 6-7.

7. The composition according to claim 1, characterized in that, The composition can inhibit microorganisms selected from the following: Candida chromatosa ATCC10231, Aspergillus niger ATCC16404, and Paecilomyces ATCC18502.

8. The use of the composition according to any one of claims 1-7 in the preparation of a household cleaning product with antibacterial properties.

9. The application as described in claim 8, characterized in that, The household cleaning products mentioned are selected from: disinfection products and detergents.

10. The application as described in claim 8, characterized in that, The household cleaning product contains 0.1-10% by weight of the composition.

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