Suction type rosemary moxibustion traditional Chinese medicine composition and preparation method thereof
The inhaled aromatic moxibustion herbal composition, prepared through scientific formulation and ultra-micro pulverization enzymatic hydrolysis technology, solves the problems of single ingredients in traditional Chinese medicine products and the inconvenience of traditional moxibustion, achieving rapid and effective therapeutic effects and safe use.
Patent Information
- Application Number
- CN202511771286.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-11-28
- Publication Date
- 2026-02-27
AI Technical Summary
Existing Chinese medicine inhalers or aromatherapy products have single ingredients and lack targeted formulations, resulting in limited efficacy. Furthermore, traditional moxibustion suffers from problems such as excessive smoke from open flames and inconvenient operation.
A scientific combination of multiple medicinal herbs, including cassia seed, dendrobium, agarwood, and mugwort, was used to prepare an inhalation-type moxibustion herbal composition through ultra-micro pulverization and bio-enzymatic hydrolysis technology. Plant-derived proteases were used to promote the release of active ingredients, and the product was administered via inhalation.
The product is fast-acting, safe and convenient to use, produces no open flame or smoke, and significantly relieves symptoms such as dizziness, insomnia, and allergic rhinitis. It meets the standards for microbial and heavy metal indicators, has low skin irritation, and is non-toxic in acute oral toxicity.
Abstract
Description
Technical Field
[0001] This invention belongs to the field of traditional Chinese medicine technology, and in particular relates to an inhalation-type aromatic moxibustion traditional Chinese medicine composition and its preparation method. Background Technology
[0002] Traditional moxibustion therapy treats diseases through the heat stimulation and medicinal effects of burning moxa sticks, but it has drawbacks such as open flame, excessive smoke, inconvenience of operation, and the risk of burns. For conditions such as headaches, insomnia, neurasthenia, and allergic rhinitis, although there are some Chinese herbal inhalers or aromatherapy products available, most of them have single ingredients or only have aromatic effects, lacking targeted formulations and thus having limited efficacy.
[0003] Therefore, there is an urgent need in this field for an inhaled traditional Chinese medicine product that has a reasonable composition, fast onset of action, and is safe and convenient to use. Summary of the Invention
[0004] The purpose of this invention is to overcome the shortcomings of the prior art and provide an inhalation-type aromatic moxibustion traditional Chinese medicine composition and its preparation method that is rationally formulated, fast-acting, safe and convenient to use.
[0005] To solve the above-mentioned technical problems, the specific technical solution of the present invention is as follows: In some embodiments of this application, an inhalation-type aromatic moxibustion herbal composition and its preparation method are provided, which is made from the following raw materials in parts by weight: 10-20 parts of cassia seed, 8-15 parts of dendrobium, 5-12 parts of senecio scandens, 10-18 parts of perilla leaf, 5-15 parts of agarwood powder, 15-25 parts of mugwort leaf, 5-10 parts of fennel, 3-8 parts of asarum, 8-15 parts of chuanxiong rhizome, 10-20 parts of angelica dahurica, and 0.1-1 parts of plant-derived protease.
[0006] In some embodiments of this application, the plant-derived protease is papain or bromelain.
[0007] In some embodiments of this application, the weight ratio of the raw materials is as follows: 15 parts of cassia seed, 10 parts of dendrobium, 8 parts of senecio scandens, 15 parts of perilla leaf, 10 parts of agarwood powder, 20 parts of mugwort leaf, 8 parts of fennel, 5 parts of asarum, 10 parts of chuanxiong rhizome, 15 parts of angelica root, and 0.5 parts of papain.
[0008] In some embodiments of this application, a method for preparing the above-mentioned inhalation-type moxibustion-inducing traditional Chinese medicine composition is disclosed, comprising the following steps: a) Cassia seed, Dendrobium, Senecio scandens, Perilla leaf, Artemisia leaf, Fennel, Asarum, Ligusticum chuanxiong, and Angelica dahurica were each subjected to ultra-fine pulverization to obtain ultra-fine powder of traditional Chinese medicine; b) Mix the aforementioned ultrafine powder of traditional Chinese medicine, moisten with water, and add plant-derived protease to carry out enzymatic hydrolysis; c) Dry the enzymatically hydrolyzed material at low temperature; d) Add agarwood powder to the dried material and mix well; e) Sterilize the mixed powder.
[0009] In some embodiments of this application, in step a), the particle size of the ultrafine pulverizer is sieve size 150-200 mesh.
[0010] In some embodiments of this application, in step b), the enzymatic hydrolysis reaction is carried out at a temperature of 35-45°C for 2-4 hours.
[0011] In some embodiments of this application, sterilization is performed using cobalt-60 irradiation in step e).
[0012] In some embodiments of this application, an inhalation-type aromatherapy moxibustion is disclosed, comprising the aforementioned traditional Chinese medicine composition.
[0013] Compared with existing technologies, the beneficial effects of this invention lie in its innovative combination of traditional Chinese medicine formulations with modern pharmaceutical processes. It scientifically combines multiple medicinal materials such as cassia seed, dendrobium, agarwood, and mugwort, and utilizes ultra-micro pulverization and bio-enzymatic hydrolysis technologies to significantly promote the release and absorption of active ingredients. The resulting incense moxibustion product is administered via inhalation, allowing for rapid absorption through the respiratory mucosa and direct action on the nervous system and nasal cavity. Compared to traditional moxibustion, it offers advantages such as rapid onset of action, safe and convenient use, and the absence of open flames and smoke. Testing has confirmed that this product significantly alleviates symptoms such as dizziness, insomnia, and allergic rhinitis. Furthermore, it meets the standards for microbial and heavy metal indicators, exhibits low skin irritation, and is classified as non-toxic in acute oral toxicity, ensuring its safety and effectiveness in clinical use. Detailed Implementation
[0014] The specific embodiments of the present invention will be described in further detail below with reference to the examples. These examples are for illustrative purposes only and are not intended to limit the scope of the invention.
[0015] To better understand the purpose, structure, and function of this invention, the invention will be further described in detail below with reference to embodiments.
[0016] Example 1 (1) Formula Weigh the raw materials according to the following weight ratio: Cassia seeds: 150 g Dendrobium: 100 g Senecio scandens: 80 g Perilla leaves: 150 g Mugwort: 200 g Fennel: 60 g Asarum: 40 g Chuanxiong: 100 g Angelica dahurica: 150 g Agarwood powder: 100 g (for later use) Papain (plant-derived protease): 8 g (2) Preparation method Raw material pretreatment and ultrafine grinding: Cassia seed, Dendrobium, Senecio scandens, Perilla leaf, Artemisia argyi, Fennel, Asarum, Ligusticum chuanxiong, and Angelica dahurica were washed with purified water and then dried in a 60℃ forced-air drying oven until the moisture content was below 8%. Subsequently, they were each ground using an ultrafine grinder and passed through a 180-mesh sieve to obtain ultrafine powder of traditional Chinese medicine, which was then mixed evenly.
[0017] Enzymatic hydrolysis: Place the uniformly mixed ultrafine powder of traditional Chinese medicine in a mixing tank, and add 1.5% of its total weight of purified water to moisten it. Then add 8g of papain, stir thoroughly, and incubate at 40℃ for 3 hours for enzymatic hydrolysis.
[0018] Low-temperature drying: Transfer the enzymatically hydrolyzed material to a tray and place it in a vacuum drying oven at 60°C until the moisture content of the material is below 7%.
[0019] Mixing: Add the dried material and 100g of agarwood powder into a three-dimensional motion mixer and mix for 45 minutes until a uniform light brown powder is obtained.
[0020] Sterilization and Packaging: The mixed powder is sterilized by irradiation with a cobalt-60 irradiation source at a dose of 8 kGy. After sterilization, the powder is packaged into breathable inhalation moxibustion tubes made of non-woven fabric using an automatic powder packaging machine in a Class 100,000 cleanroom. Each tube contains 0.8g of the powder and is then sealed to obtain the finished inhalation-type inhalation moxibustion product.
[0021] Example 2 This embodiment is used to illustrate that other proportions can also be implemented within the weight range described in this invention.
[0022] Weigh the following ingredients in the indicated weight ratio: 120g Cassia Seed, 120g Dendrobium, 60g Senecio scandens, 180g Perilla Leaf, 180g Artemisia argyi, 80g Fennel, 30g Asarum, 120g Ligusticum chuanxiong, 120g Angelica dahurica, 80g Agarwood Powder, and 5g Bromelain (plant-derived protease).
[0023] The preparation method is the same as in Example 1.
[0024] Example 3 This example illustrates that process parameters can be adjusted within a certain range.
[0025] Based on Example 1, the particle size of the ultrafine pulverization was adjusted to pass through a 150-mesh sieve; the enzymatic hydrolysis temperature was adjusted to 45°C and the time was shortened to 2 hours; and an irradiation dose of 10 kGy was used for sterilization.
[0026] Ultimately, it is also possible to produce an inhaled aromatherapy moxibustion product that meets the requirements.
[0027] Experimental Example: Product Safety and Efficacy Verification To demonstrate the safety and effectiveness of the product of this invention, the product prepared in Example 1 was subjected to the following tests: 1. Safety testing (commissioned to Guizhou Provincial Center for Disease Control and Prevention for testing, in accordance with the "Cosmetic Hygiene Standards" (2007 edition)). Microbiological tests: Total bacterial count 75 CFU / g (limit ≤1000); molds and yeasts 15 CFU / g (limit ≤100); fecal coliforms, Staphylococcus aureus, and Pseudomonas aeruginosa were not detected (not permitted).
[0028] Hygiene and chemical testing: Lead 17.17 mg / kg (limit ≤40); Arsenic 0.98 mg / kg (limit ≤10); Mercury 0.021 mg / kg (limit ≤1).
[0029] Skin irritation test: Multiple skin irritation tests were conducted on New Zealand white rabbits. The average daily animal score was 0.70, which is considered mild irritation.
[0030] Acute oral toxicity test: LD50 was determined by oral gavage in Kunming mice. 50 A dose greater than 5000 mg / kg body weight is considered practically non-toxic.
[0031] 2. Efficacy Verification (Preliminary User Feedback) A one-week trial was conducted on 50 volunteers with symptoms of dizziness, insomnia, or allergic rhinitis. Results showed that over 85% of the volunteers reported significant relief from dizziness and headaches after use; 78% reported improved sleep quality; and 70% of the allergic rhinitis patients experienced relief from nasal congestion and runny nose.
[0032] Comparative Example 1 (excluding enzymatic hydrolysis step) The formulation and preparation method of Example 1 are followed, but the "enzymatic hydrolysis" step is omitted, that is, the raw materials are directly dried and mixed after ultra-fine pulverization.
[0033] Results: Compared with the product of Example 1, the product prepared in this comparative example showed a weaker release rate and intensity of volatile components (such as the aroma of agarwood and artemisia) within the same time period. This indicates that enzymatic hydrolysis helps promote the release of active ingredients.
[0034] Comparative Example 2 (Formulation beyond the scope of this invention) The formula was adjusted so that the amount of Senecio scandens was increased to 200g (far exceeding the range of 5-12 parts of this invention), and the rest was the same as in Example 1.
[0035] Results: The prepared product showed moderate irritation in the skin irritation test and had an unpleasant odor; some volunteers reported discomfort. This demonstrates that limiting the content range of each ingredient in this invention is crucial for ensuring product safety and user experience.
[0036] In the description of this application, it should be understood that the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the embodiments. They are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application.
[0037] The terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this application, unless otherwise stated, "a plurality of" means two or more.
[0038] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection between two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.
[0039] The various embodiments in this specification are described in a progressive manner, with each embodiment focusing on its differences from other embodiments. Similar or identical parts between embodiments can be referred to interchangeably. For the apparatus disclosed in the embodiments, since they correspond to the methods disclosed in the embodiments, the description is relatively simple; relevant parts can be referred to the method section.
[0040] The above description of the disclosed embodiments enables those skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims
1. A traditional Chinese medicine composition for inhalation-type moxibustion, characterized in that, It is made from the following raw materials in parts by weight: 10-20 parts of cassia seed, 8-15 parts of dendrobium, 5-12 parts of senecio scandens, 10-18 parts of perilla leaf, 5-15 parts of agarwood powder, 15-25 parts of mugwort leaf, 5-10 parts of fennel, 3-8 parts of asarum, 8-15 parts of chuanxiong rhizome, 10-20 parts of angelica dahurica, and 0.1-1 parts of plant-derived protease.
2. The herbal composition according to claim 1, characterized in that, The plant-derived protease is papain or bromelain.
3. The herbal composition according to claim 1 or 2, characterized in that, The weight ratio of the raw materials is as follows: 15 parts cassia seed, 10 parts dendrobium, 8 parts senecio scandens, 15 parts perilla leaf, 10 parts agarwood powder, 20 parts mugwort leaf, 8 parts fennel, 5 parts asarum, 10 parts chuanxiong rhizome, 15 parts angelica root, and 0.5 parts papain.
4. A method for preparing the herbal composition for inhalation-type moxibustion according to any one of claims 1-3, characterized in that, Includes the following steps: a) Cassia seed, Dendrobium, Senecio scandens, Perilla leaf, Artemisia leaf, Fennel, Asarum, Ligusticum chuanxiong, and Angelica dahurica were each subjected to ultra-fine pulverization to obtain ultra-fine powder of traditional Chinese medicine; b) Mix the aforementioned ultrafine powder of traditional Chinese medicine, moisten with water, and add plant-derived protease to carry out enzymatic hydrolysis; c) Dry the enzymatically hydrolyzed material at low temperature; d) Add agarwood powder to the dried material and mix well; e) Sterilize the mixed powder.
5. The method according to claim 4, characterized in that, In step a), the particle size of the ultrafine pulverizer is sieved through a 150-200 mesh sieve.
6. The method according to claim 4, characterized in that, In step b), the enzymatic hydrolysis reaction is carried out at a temperature of 35-45°C for 2-4 hours.
7. The method according to claim 4, characterized in that, In step e), sterilization is performed using cobalt-60 irradiation.
8. An inhalation-type aromatherapy moxibustion device, characterized in that, The traditional Chinese medicine composition comprising any one of claims 1-3.