Lung cancer organoid culture scaffold and organoid culture method

By designing a lung cancer organoid culture scaffold, and using a box-shaped scaffold and lifting mechanism to simulate the human lung's respiratory rhythm, the problem that existing devices cannot simulate the physiological environment has been solved, achieving a more realistic cell culture effect.

CN121592489APending Publication Date: 2026-03-03CHANGCHUN YIFU BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202511817505.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-04
Publication Date
2026-03-03

AI Technical Summary

Technical Problem

Existing lung cancer organoid culture devices cannot simulate the respiratory rhythm of human lungs, resulting in culture conditions that do not closely resemble the human physiological environment, thus affecting their core value as a clinical alternative model.

Method used

A lung cancer organoid culture scaffold was designed, comprising a box-shaped scaffold, a disk, an annular shell, a cylinder, a septum, an elastic membrane, and a lifting mechanism. Through the cooperation of a motor and a positioning mechanism, the respiratory rhythm of the human lung is simulated to create culture conditions for lung cancer organoid cells that closely resemble the physiological environment of the human body.

Benefits of technology

It significantly improves the biomimicry of cell culture, provides a more realistic cell model, expands the scope of application and research applicability, and can simulate normal and rapid breathing states.

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Abstract

The invention relates to the technical field of lung cancer organoid culture, in particular to a lung cancer organoid culture support which comprises a box-shaped support, a disc is fixedly connected to the position, close to the upper edge, of the inner wall of the box-shaped support, the outer wall of the box-shaped support communicates with an annular shell, and three cylinders are fixedly installed at the upper end of the disc in a penetrating mode; and the inner walls of the three cylinders are fixedly connected with spacer rings. The culture space in each culture dish simulates the normal breathing state, the lung breathing rhythm of the human body is mechanically simulated, culture conditions close to the physiological environment of the human body are constructed for lung cancer organ cells, the bionic degree of cell culture is remarkably improved, and a more real cell model is provided for related research. The culture spaces in the three culture dishes can simulate the state of tachypnea, and the tachypnea breathing amplitude and the normal breathing amplitude simulated by the culture spaces in the three culture dishes can be adjusted, so that the application range is expanded, and the research applicability is improved.
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