Drug intermediate separation device and method thereof

Abstract

The invention discloses a drug intermediate separation device and method, belongs to the technical field of drug intermediate separation, and provides the following scheme that the drug intermediate separation device comprises a catalyst infusion mechanism, a drug separation mechanism is arranged on the catalyst infusion mechanism, the drug separation mechanism comprises a separation tank, a first stirring assembly is arranged in the separation tank, and a second stirring assembly is arranged in the separation tank. The opening cylinder of the first stirring assembly is fixedly connected with a material turning net; according to the method, reaction products are separated in time in the reaction process, and the reaction is carried out in the direction of generating the products, so that the reaction is promoted to be carried out more thoroughly, the conversion rate of the drug intermediates is increased, meanwhile, the retention time of the reaction products is prevented, the probability of side reactions is reduced, and the drug intermediates are continuously separated in the reaction process; the content of impurities in a reaction system is relatively low, only a small amount of residual impurities need to be separated and purified subsequently, the whole separation process is simplified, and the separation efficiency and the product quality are improved.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical intermediate separation technology, and more particularly to a pharmaceutical intermediate separation apparatus and method. Background Technology

[0002] Drug intermediate separation is a crucial step in pharmaceutical manufacturing, typically following a "catalysis first, separation later" technical approach. In drug synthesis, the target intermediate is first generated through catalytic reactions (such as oxidation, reduction, and condensation), followed by separation of the reaction mixture and subsequent efficient purification.

[0003] Currently, traditional catalytic processes mainly rely on reaction vessels, which have significant limitations in their operation. During the catalytic reaction start-up phase, the entire catalyst must be added at once. Due to the lack of precise dosage control mechanisms, it is difficult to achieve small-scale, continuous, and controllable catalyst delivery. This extensive addition method causes the catalyst concentration in the reaction system to reach its peak instantaneously, easily leading to the risk of initial reaction rate runaway. When the reactant concentration gradient increases sharply, the active sites on the catalyst surface may become deactivated due to overloading, not only weakening catalytic efficiency but also increasing the probability of side reactions.

[0004] More importantly, the design limitations of existing reactors lead to inherent flaws in product removal strategies. All reactants must undergo a complete catalytic cycle before being discharged uniformly, meaning that early-formed intermediates are subjected to unnecessary prolonged mechanical agitation within the reaction system. This continuous exposure to the reaction environment not only increases the risk of over-reaction of intermediates, leading to decomposition or isomerization of the target product, but also significantly reduces overall conversion efficiency. Simultaneously, the homogeneous nature of the reaction system allows unreacted reactants to coexist with products, further increasing the probability of intermolecular collisions and triggering a series of side reactions, ultimately resulting in decreased purity and yield loss of the target product. This non-instantaneous separation process characteristic has become a key bottleneck restricting the production efficiency and quality stability of pharmaceutical intermediates.

[0005] To address the above-mentioned problems, this invention proposes a pharmaceutical intermediate separation device and method. Summary of the Invention

[0006] The purpose of this invention is to address the shortcomings of existing technologies that generally use reaction vessels to achieve catalysis, but the reaction rate is difficult to control because the catalyst cannot be added in small, gradual, and uniform amounts. Furthermore, the reactants generated during the catalysis process can only be removed after the entire catalysis process is completed, resulting in the earlier-generated reactants being continuously stirred inside the reaction vessel. This may not only produce a series of side reactions but also affect the conversion rate of drug intermediates. Therefore, this invention proposes a drug intermediate separation device and method.

[0007] To achieve the above objectives, the present invention adopts the following technical solution:

[0008] A drug intermediate separation device includes a catalyst infusion mechanism, wherein a drug separation mechanism is provided on the catalyst infusion mechanism;

[0009] The drug separation mechanism includes a separation tank, in which a first stirring assembly is provided. A turning net is fixedly connected to the notch of the first stirring assembly. A brush is provided on the turning net. A load-bearing plate is fixedly connected to one side of the brush. Two magnets are fixedly installed on both the load-bearing plate and the turning net. The two magnets are magnetically connected. Two elastic components are provided on the load-bearing plate. The two elastic components pass through the turning net and are respectively squeezed and cooperated with two arc-shaped blocks to push the load-bearing plate to move, so that the brush discharges the reaction product from the turning net.

[0010] The two arc-shaped blocks are fixedly connected to the top wall of the separation tank. The separation tank is equipped with a material conveying assembly. An inclined cylinder is connected below the material conveying assembly. Semi-annular bevel teeth are installed on the inclined cylinder. The inclined cylinder is located in the notched cylinder. Multiple second stirring assemblies are installed on the notched cylinder.

[0011] The catalyst delivery mechanism includes a base plate, the separation tank is mounted on the base plate, a conveying assembly is provided above the base plate, the conveying assembly passes through the separation tank and extends into the notched cylinder to connect with the nozzle assembly, a first bevel tooth is connected above the nozzle assembly, the first bevel tooth meshes with a semi-circular bevel tooth, and the nozzle assembly is also driven by multiple second stirring assemblies through a chain drive structure.

[0012] Preferably, the conveying assembly includes a catalytic chamber, which is mounted on a base plate. The catalytic chamber is connected to a separation tank via a pipe. Two valves are installed on the pipe. The pipe is connected to a conveying pump, which is connected to a connecting pipe. The connecting pipe is connected to the conveying pipe, and the conveying pipe is rotatably mounted on the connecting pipe via a bearing.

[0013] Preferably, the nozzle assembly includes a nozzle tube, the first bevel tooth is fixedly installed above the nozzle tube, two nozzle groups are provided on the nozzle tube, the delivery pipe passes through the notch cylinder and the separation tank and is connected to the nozzle tube, and the nozzle tube is rotatably installed on one end of the notch cylinder and the delivery pipe respectively through two bearings.

[0014] Preferably, the conveying assembly includes a conveying cylinder, the bottom of which is installed at one end of an inclined cylinder, and the inclined cylinder is installed horizontally across the separator. Liquid inlets and material inlets are respectively provided on both sides of the conveying cylinder.

[0015] Preferably, the liquid outlet is installed above the separation tank, and a filter screen is also installed in the liquid outlet.

[0016] Preferably, the feed cylinder is provided with a spiral extrusion shaft inside, the spiral blade pitch of the spiral extrusion shaft decreases upwards, the spiral extrusion shaft is rotatably mounted on the feed cylinder through bearings, and the top end of the spiral extrusion shaft is fixedly connected to the output shaft of the second motor, the second motor is fixedly mounted on the top of the feed cylinder.

[0017] Preferably, the first stirring assembly includes a first motor, which is fixedly mounted on the separation tank. The output shaft of the first motor is fixedly connected to a first gear, and a second gear meshes above the first gear. The second gear is fixedly connected to a notched cylinder, which is rotatably mounted on the separation tank via bearings, and a plurality of first stirring blades are fixedly connected to the notched cylinder.

[0018] Preferably, the second stirring assembly includes a stirring shaft, which is rotatably mounted on the notched cylinder via bearings. Multiple second stirring blades are fixedly connected to the stirring shaft, and the multiple stirring shafts and the nozzle pipe are connected by a chain drive structure.

[0019] Preferably, the elastic component includes a sliding sleeve, which is fixedly installed on the turning net. A sliding rod slides in the sliding sleeve, one end of which overlaps with the load-bearing plate, and a roller is fixedly installed at the other end of the sliding rod. A spring is fixedly connected between the roller and the sliding sleeve.

[0020] The material turning net is installed in the separation tank. Two guide bars are fixedly connected to the material turning net. The two ends of the load-bearing plate slide on the guide bars, and a stop is provided at the end of the guide bar away from the load-bearing plate.

[0021] A method of using a pharmaceutical intermediate separation device includes the following steps:

[0022] S1. During the separation reaction of drug intermediates, the first gear is driven to rotate by the first motor. The first gear and the second gear are driven to rotate, and the second gear drives the notched cylinder to rotate. The notched cylinder drives the first stirring blade to stir the drug intermediates. The notched cylinder also drives the second stirring assembly and the nozzle assembly to rotate.

[0023] S2. When the first bevel tooth rotates to mesh with the semi-ring bevel tooth, the first bevel tooth drives the nozzle tube to rotate, the nozzle tube drives the nozzle assembly to rotate, and the nozzle tube drives the stirring shaft to rotate through the chain transmission structure. The stirring shaft drives the second stirring blade to rotate, so that the second stirring blade and the first stirring blade can perform multi-directional stirring.

[0024] S3. During the stirring process, by opening one of the valves, the pipeline is connected to the catalyst box. At this time, the delivery pump draws the catalyst from inside the catalyst box, and the catalyst enters the nozzle pipe through the connecting pipe and the delivery pipe, and is sprayed out through the nozzle assembly. With the rotation of the nozzle assembly, the catalyst is evenly dispersed in the drug intermediate. Then, the first stirring component and the second stirring component are used for stirring reaction.

[0025] S4. Next, after the catalyst is metered and delivered, close the valve connected to the catalyst and open another valve to allow the reaction mixture to be sprayed out through the nozzle assembly to assist in the stirring reaction.

[0026] S5. During the reaction process, the notched cylinder drives the turning screen to rotate. Each time the turning screen enters the reaction mixture, it retrieves the reaction products and filters out the drug intermediates. When the turning screen flips upward, it drives the elastic component to contact the arc block, causing the arc block to squeeze the roller and slide bar to move. This causes the slide bar to push the load plate, separating the magnets. The load plate then drives the brush downward, allowing the brush to clean the reaction products into the inclined cylinder. When the turning screen flips downward, the load plate returns to its original position and is positioned by the magnet. This process of retrieving reaction products is repeated.

[0027] S6. When the reaction product enters the inclined cylinder and enters the bottom of the conveying cylinder, the second motor drives the screw extrusion shaft to rotate. The screw extrusion shaft conveys the reaction product upward. As the screw blades of the screw extrusion shaft decrease upward, the screw extrusion shaft compresses and conveys the reaction product. The reaction product is squeezed and the residual drug intermediates are returned to the separation tank through the filter layer and liquid port, while the reaction product is discharged through the material port.

[0028] Compared with the prior art, the present invention provides a pharmaceutical intermediate separation device and method, which has the following beneficial effects:

[0029] 1. The drug intermediate separation device and method, wherein the drug intermediate is initially stirred longitudinally by a first stirring component, which simultaneously drives a second stirring component to revolve. Through the transmission of the first bevel gear and the semi-circular bevel gear, and under the action of a chain drive structure, the second stirring component is rotated laterally, thus enabling multi-directional rotation to accelerate the reaction rate. Next, the notched cylinder drives the turning screen to rotate, causing the turning screen to circulate downwards into the drug intermediate and scoop out the reaction products. When the elastic component is squeezed by the arc-shaped block, it pushes the load plate away from the magnet. At this time, the brush downwards discharges the reaction products into the inclined cylinder, and then through the conveyor... The material assembly extrudes and conveys the reaction products, quickly expelling residual drug intermediates and avoiding waste. It can also directly discharge the reaction products. This method allows for timely separation of reaction products during the reaction process, directing the reaction towards product formation and promoting a more thorough reaction, thus increasing the conversion rate of drug intermediates. At the same time, it prevents the residence time of reaction products, reducing the probability of side reactions. Furthermore, the continuous separation of drug intermediates during the reaction process results in a relatively low impurity content in the reaction system. Subsequent separation and purification of only a small amount of remaining impurities are required, simplifying the overall separation process and improving separation efficiency and product quality.

[0030] 2. The drug intermediate separation device and method, by opening a valve, connects the catalytic tank to the delivery pump. The delivery pump draws the catalyst and sends it through the connecting pipe and delivery pipe into the nozzle pipe. Finally, the catalyst is sprayed out through the nozzle assembly. Simultaneously, the first stirring component drives the nozzle pipe to rotate synchronously, causing the nozzle pipe to revolve downwards. This drives the first bevel gear and the semi-circular bevel gear, which in turn causes the nozzle pipe to drive the nozzle assembly to rotate. This allows for omnidirectional discharge of the catalyst, maintaining a uniform distribution of the catalyst. Moreover, this method uses uniform feeding, which allows the reactants to react smoothly under the action of the catalyst. This facilitates the observation and control of the reaction process, ensuring the reaction proceeds at the expected rate, reducing the formation of by-products, and maintaining the reactant concentration within a suitable range to allow the catalyst to perform optimally, avoiding excessive concentration that could affect its activity and selectivity.

[0031] 3. The drug intermediate separation device and method utilizes a first stirring assembly to drive a first umbrella and a semi-annular bevel gear in a cyclic transmission. Under the action of a chain transmission structure, the nozzle assembly and the second stirring assembly rotate synchronously. The second stirring assembly and the first stirring assembly help accelerate the reaction rate, while the rotating nozzle assembly evenly discharges the catalyst and reactants. During the reaction process, a turning net collects the reaction products, and an elastic component, compressed by an arc-shaped block, pushes the load plate away from the magnet, allowing a brush to clean the reaction products into an inclined cylinder. Residual drug intermediates are then squeezed out by a conveying assembly, and excess reaction products are directly discharged, reducing cleaning steps. Furthermore, direct separation after product generation continuously removes reaction products from the reaction system, promoting the reaction in the forward direction, increasing the conversion rate of raw materials, and ensuring a continuous and stable supply of reaction products. This further improves reaction efficiency and maintains reaction stability, facilitating precise control of reaction conditions and resulting in more stable product quality. This combined approach accelerates the reaction process, reduces reaction time and production cycle, increases equipment utilization, and thus lowers production costs. Attached Figure Description

[0032] Figure 1 This is a perspective view of a pharmaceutical intermediate separation device proposed in this invention;

[0033] Figure 2 This is a perspective view of the catalyst delivery mechanism of a pharmaceutical intermediate separation device proposed in this invention;

[0034] Figure 3 This is a cross-sectional perspective view of a pharmaceutical intermediate separation device proposed in this invention;

[0035] Figure 4 This is a three-dimensional cross-sectional view of the drug separation mechanism of a drug intermediate separation device proposed in this invention;

[0036] Figure 5 This is a three-dimensional cross-sectional view of the separation tank of a drug intermediate separation device proposed in this invention;

[0037] Figure 6 This is a perspective view of the connection between the conveying component and the first stirring component of a pharmaceutical intermediate separation device proposed in this invention;

[0038] Figure 7 This is a three-dimensional cross-sectional view of the first stirring assembly of a pharmaceutical intermediate separation device proposed in this invention.

[0039] Figure 8 In this invention Figure 7 Enlarged view of point A;

[0040] Figure 9This is a perspective view of the connection between the notched cylinder and the turning mesh of a pharmaceutical intermediate separation device proposed in this invention;

[0041] Figure 10 This is a three-dimensional cross-sectional view of the turning screen of a pharmaceutical intermediate separation device proposed in this invention;

[0042] Figure 11 In this invention Figure 10 Enlarged view at point B.

[0043] In the diagram: 100, Catalyst delivery mechanism; 101, Base plate; 102, Conveying assembly; 1021, Catalytic chamber; 1022, Pipeline; 1023, Valve; 1024, Delivery pump; 1025, Connecting pipe; 1026, Delivery pipe; 103, Nozzle assembly; 1031, Nozzle group; 1032, Nozzle pipe; 104, First bevel gear; 200, Drug separation mechanism; 201, Separation tank; 202, First stirring assembly; 2021, First motor; 2022, First gear; 2023, Second gear; 2024, Notched cylinder; 2025, First stirring blade; 203, Second... 2031. Stirring assembly; 2032. Second stirring blade; 2033. Stirring shaft; 204. Semi-annular bevel gear; 205. Chain drive structure; 206. Material conveying assembly; 2061. Material conveying cylinder; 2062. Spiral extrusion shaft; 2063. Liquid inlet; 2064. Material inlet; 2065. Second motor; 2066. Filter screen; 207. Inclined cylinder; 208. Elastic component; 2081. Roller; 2082. Spring; 2083. Slide rod; 2084. Sliding sleeve; 209. Arc block; 210. Tilting net; 211. Loading plate; 212. Magnet; 213. Guide bar; 214. Brush. Detailed Implementation

[0044] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments.

[0045] In the description of this invention, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0046] Example 1: Refer to Figures 1-7 and Figures 9-11A drug intermediate separation device includes a catalyst infusion mechanism 100, on which a drug separation mechanism 200 is provided;

[0047] The drug separation mechanism 200 includes a separation tank 201, in which a first stirring assembly 202 is installed. The first stirring assembly 202 includes a first motor 2021, which is fixedly mounted on the separation tank 201. A first gear 2022 is fixedly connected to the output shaft of the first motor 2021. A second gear 2023 meshes above the first gear 2022. Through the transmission between the first gear 2022 and the second gear 2023, power can be transmitted, causing the second gear 2023 to drive the notched cylinder 2024 and the first stirring blade 2025 to rotate, thereby performing the stirring and mixing of drugs and catalysts. The second gear 2023 is fixedly connected to the notched cylinder 2024, which is connected to the first stirring blade 2025 via a shaft. The first stirring assembly 202 is mounted on the separator 201, and multiple first stirring blades 2025 are fixedly connected to the notched cylinder 2024. A turning screen 210 is fixedly connected to the notched cylinder 2024 of the first stirring assembly 202. The turning screen 210 can scoop up the reaction products and filter the drug intermediates through the mesh. A brush 214 is provided on the turning screen 210, and a load-bearing plate 211 is fixedly connected to one side of the brush 214. The center of gravity of the load-bearing plate 211 is downward, which can drive the brush 214 to smoothly clean the reaction products into the inclined cylinder 207, which is convenient for cleaning the reaction products on the turning screen 210. Two magnets 212 are fixedly installed on both the load-bearing plate 211 and the turning screen 210. The two magnets 212 are magnetically connected, and the two magnets 212 are connected by magnetic attraction. The magnetic attraction between 12 maintains the stability of the load-bearing plate 211 and prevents it from moving. Two elastic components 208 are provided on the load-bearing plate 211. Each elastic component 208 includes a sliding sleeve 2084, which is fixedly mounted on the turning mesh 210. A sliding rod 2083 slides within the sliding sleeve 2084. One end of the sliding rod 2083 overlaps with the load-bearing plate 211, and a roller 2081 is fixedly mounted on the other end. A spring 2082 is fixedly connected between the roller 2081 and the sliding sleeve 2084. The spring 2082 can drive the sliding rod 2083 to reset, thus preventing the sliding rod 2083 from obstructing the reset of the load-bearing plate 211. Furthermore, when the roller 2081 is pressed against the arc-shaped block 209, the roller 2081... 081 can push the load plate 211 away from the magnet 212 via the slide rod 2083. At this time, the load plate 211 drives the brush 214 to move down and clean the reaction products on the turning screen 210. The turning screen 210 is set in the separation tank 201. Two guide strips 213 are fixedly connected to the turning screen 210. The two ends of the load plate 211 slide on the guide strips 213. The guide strips 213 can guide the load plate 211 and keep it sliding smoothly up and down. A stop is set at one end of the guide strip 213 to limit the load plate 211 and prevent it from sliding directly out of the guide strip 213. A stop is also set at the end of the guide strip 213 away from the load plate 211. Two elastic components 208 pass through the turning screen 210.And, in conjunction with the two curved blocks 209, respectively, push the load-bearing plate 211 to move, so that the brush 214 discharges the reaction products from the turning net 210;

[0048] Two arc-shaped blocks 209 are fixedly connected to the top wall of the separator 201. A conveying assembly 206 is installed on the separator 201. The conveying assembly 206 includes a conveying cylinder 2061. The bottom of the conveying cylinder 2061 is installed at one end of an inclined cylinder 207. The inclined cylinder 207 and the notched cylinder 2024 have corresponding openings at the top, allowing the turning net 210 to flip upwards and smoothly feed the reaction product into the inclined cylinder 207. The bottommost end of the inclined cylinder 207 is connected to the conveying cylinder 2061, allowing the reaction product to smoothly enter the conveying cylinder 2061. The inclined cylinder 207 is horizontally installed on the separator 201. Two side panels of the conveying cylinder 2061 are respectively provided with… Liquid inlet 2063 and material inlet 2064 allow for the separation and discharge of pharmaceutical intermediates and reaction products, respectively. Liquid inlet 2063 is installed above the separator 201 and contains a filter screen 2066. The filter screen 2066 filters the pharmaceutical intermediates extruded from the reaction products, ensuring their smooth return to the separator 201. A spiral extrusion shaft 2062 is installed inside the feed cylinder 2061. The spiral blade pitch of the spiral extrusion shaft 2062 decreases upwards. This decreasing spiral blade pitch allows for extrusion during the upward transport of the reaction products. This allows for the extrusion of residual drug intermediates, facilitating solid-liquid separation, reducing cleaning steps, and improving the utilization rate of drug intermediates. The spiral extrusion shaft 2062 is rotatably mounted on the feeding cylinder 2061 via bearings, and its top end is fixedly connected to the output shaft of the second motor 2065. The second motor 2065 is fixedly mounted on the top of the feeding cylinder 2061. An inclined cylinder 207 is connected below the feeding assembly 206, and semi-annular bevel gears 204 are installed on the inclined cylinder 207. The inclined cylinder 207 is located within a notched cylinder 2024, on which multiple second stirring assemblies 203 are installed. Each second stirring assembly 203 includes a stirring shaft 203. 2. The stirring shaft 2032 is rotatably mounted on the notched cylinder 2024 via bearings. The stirring shaft 2032 drives the second stirring blade 2031 to rotate, which can stir the drug and thus accelerate the reaction rate of the catalyst and the drug. Multiple second stirring blades 2031 are fixedly connected to the stirring shaft 2032. The multiple stirring shafts 2032 and the nozzle pipe 1032 are connected by a chain drive structure 205. The chain drive structure 205 consists of multiple sprockets and chains. The sprockets are connected to the stirring shaft 2032 and the nozzle pipe 1032, so that the sprockets and chains mesh and drive each other, thereby realizing the synchronous rotation of the stirring shaft 2032 and the nozzle pipe 1032.

[0049] The catalyst delivery mechanism 100 includes a base plate 101, a separation tank 201 mounted on the base plate 101, a conveying assembly 102 disposed above the base plate 101, the conveying assembly 102 passing through the separation tank 201 and extending into the notched cylinder 2024 to connect with the nozzle assembly 103, a first bevel tooth 104 connected above the nozzle assembly 103, and the nozzle assembly 103 is also driven by a chain drive structure 205 to a plurality of second stirring assemblies 203.

[0050] In this embodiment: the first motor 2021 drives the first gear 2022 and the second gear 2023 for transmission. The second gear 2023 drives the notched cylinder 2024 to rotate. The notched cylinder 2024 drives the first stirring blade 2025 to rotate longitudinally to stir the drug intermediate. At the same time, the first stirring assembly 202 also drives the second stirring assembly 203 to revolve. Through the transmission of the first bevel gear 104 and the semi-circular bevel gear 204, under the action of the chain transmission structure 205, the stirring shaft 2032 drives the second stirring blade 2031 to rotate laterally, thereby enabling multi-directional rotation to accelerate the reaction rate. Next, the notched cylinder 2024 drives the turning net 210 to rotate, so that the turning net 210 circulates down into the drug intermediate and retrieves the reaction product. When the turning net 210 drives the elastic component 208 to contact the arc block 209, the roller 2081 is squeezed by the arc block 209 and pushes the slide rod 2. Move 083 to push the slide bar 2083 away from the magnet 212. At this time, the slide bar 211 drives the brush 214 downward to discharge the reaction product into the inclined cylinder 207. Then, the second motor 2065 drives the screw extrusion shaft 2062 to move and squeeze and transport the reaction product. This can quickly discharge residual drug intermediates, avoid waste, and directly discharge the reaction product. This method can separate the reaction product in time during the reaction process, which will make the reaction proceed in the direction of product generation, thereby promoting a more thorough reaction and improving the conversion rate of drug intermediates. At the same time, it can prevent the residence time of reaction products, reduce the probability of side reactions, and continuously separate drug intermediates during the reaction process, so that the impurity content in the reaction system is relatively small. Only a small amount of residual impurities need to be separated and purified in the later stage, simplifying the overall separation process and improving separation efficiency and product quality.

[0051] Example 2: Refer to Figure 3 , Figures 7-8A pharmaceutical intermediate separation device includes a conveying assembly 102, which includes a catalyst tank 1021 mounted on a base plate 101. The catalyst tank 1021 is connected to a separation tank 201 via a pipe 1022. Two valves 1023 are installed on the pipe 1022, which can switch the connection between the pipe 1022 and the catalyst tank 1021 and the separation tank 201, thereby allowing the catalyst to be added at a uniform speed. After the catalyst is added, the drug mixture in the separation tank 201 can also be extracted as needed and discharged through a nozzle assembly 1031, which facilitates the fusion reaction of the drug mixture. The pipe 1022 is connected to a delivery pump 1024, which is connected to a connecting pipe 1025. The connecting pipe 1025 is connected to a delivery pipe 1026, which is rotatably mounted on the connecting pipe 1025 via a bearing. The delivery pipe 1026 can transport the catalyst and can also rotate smoothly via the bearing.

[0052] The nozzle assembly 103 includes a nozzle tube 1032. A first bevel tooth 104 is fixedly installed above the nozzle tube 1032. The first bevel tooth 104 meshes with a semi-circular bevel tooth 204. Through the revolution of the first bevel tooth 104, the first bevel tooth 104 is driven to rotate downwards and mesh with the semi-circular bevel tooth 204, thereby driving the nozzle tube 1032 to rotate, which in turn causes the nozzle assembly 1031 to rotate and uniformly discharge the catalyst. Two nozzle assemblies 1031 are provided on the nozzle tube 1032. The conveying pipe 1026 passes through the notch cylinder 2024 and the separation tank 201 and is connected to the nozzle tube 1032. The nozzle tube 1032 can smoothly achieve rotation through the bearing. Moreover, the nozzle tube 1032 is connected to the conveying pipe 1026, which can smoothly convey the catalyst. The nozzle tube 1032 is rotatably installed on one end of the notch cylinder 2024 and the conveying pipe 1026 through two bearings respectively.

[0053] In this embodiment: by opening valve 1023, the catalyst tank 1021 is connected to the delivery pump 1024. The delivery pump 1024 draws the catalyst and enters the nozzle pipe 1032 through the connecting pipe 1025 and the delivery pipe 1026. Finally, the catalyst is sprayed out through the nozzle assembly 1031. At the same time, the first stirring assembly 202 drives the nozzle pipe 1032 to rotate synchronously. During the downward revolution of the nozzle pipe 1032, the first bevel tooth 104 and the semi-annular bevel tooth 204 are driven, which in turn causes the nozzle pipe 1032 to drive the nozzle assembly 1031 to rotate. This allows for omnidirectional discharge of the catalyst, maintaining a uniform distribution of the catalyst. Moreover, this method uses uniform feeding, which allows the reactants to react smoothly under the action of the catalyst. It is convenient to observe and control the reaction process, allowing the reaction to proceed at the expected rate, reducing the generation of by-products. At the same time, it maintains the reactant concentration within a suitable range, allowing the catalyst to perform at its best and avoiding excessive concentration from affecting its activity and selectivity.

[0054] Example 3: Reference Figures 3-6 and Figures 9-11 A drug intermediate separation device includes a drug separation mechanism 200, which includes a separation tank 201. A first stirring assembly 202 is provided in the separation tank 201. A turning net 210 is fixedly connected to the notch cylinder 2024 of the first stirring assembly 202. A brush 214 is provided on the turning net 210. A load plate 211 is fixedly connected to one side of the brush 214. Two magnets 212 are fixedly installed on both the load plate 211 and the turning net 210. The two magnets 212 are magnetically connected. Two elastic components 208 are provided on the load plate 211. The two elastic components 208 pass through the turning net 210 and are respectively squeezed and cooperated with two arc-shaped blocks 209 to push the load plate 211 to move, so that the brush 214 discharges the reaction product from the turning net 210.

[0055] Two arc-shaped blocks 209 are fixedly connected to the top wall of the separation tank 201. The separation tank 201 is provided with a material conveying assembly 206. An inclined cylinder 207 is connected below the material conveying assembly 206. A semi-annular bevel gear 204 is installed on the inclined cylinder 207. The inclined cylinder 207 is located in the notched cylinder 2024. Multiple second stirring assemblies 203 are installed on the notched cylinder 2024.

[0056] The catalyst delivery mechanism 100 includes a base plate 101, a separation tank 201 mounted on the base plate 101, a conveying assembly 102 disposed above the base plate 101, the conveying assembly 102 passing through the separation tank 201 and extending into the notched cylinder 2024 to connect with the nozzle assembly 103, a first bevel tooth 104 connected above the nozzle assembly 103, the first bevel tooth 104 meshing with the semi-annular bevel tooth 204, and the nozzle assembly 103 is also driven by a chain drive structure 205 to a plurality of second stirring assemblies 203.

[0057] In this embodiment: the rotation of the first stirring assembly 202 drives the first umbrella and the semi-annular bevel gear 204 to circulate, and under the action of the chain drive structure 205, the nozzle assembly 103 and the second stirring assembly 203 rotate synchronously. The second stirring assembly and the first stirring assembly 202 can help accelerate the reaction rate, while the rotation of the nozzle assembly 103 can evenly discharge the catalyst and reactants to fuse. During the reaction process, the reaction products are also collected by the turning net 210, and the elastic component 208 is squeezed by the arc block 209, so that the elastic component 208 can push the load plate 211 away from the magnet 212, and the brush 214 can clean the reaction products into the inclined cylinder 2. 07. The residual drug intermediate is extruded through the feeding component 206, and excess reaction products can be directly discharged, reducing cleaning steps. Moreover, the direct separation after the reaction products are generated can continuously remove the reaction products from the reaction system, promote the reaction in the forward direction, improve the conversion rate of raw materials, and ensure a continuous supply of reaction products, so that the reaction products can be continuously and stably carried out, further improving the reaction efficiency. At the same time, it maintains the stability of the reaction, which helps to accurately control the reaction conditions and make the quality of the product more stable. Secondly, this combination method can accelerate the reaction process, reduce the reaction time and production cycle, improve the utilization rate of equipment, and thus reduce production costs.

[0058] A method of using a pharmaceutical intermediate separation device includes the following steps:

[0059] S1. During the separation reaction of the drug intermediate, the first motor 2021 drives the first gear 2022 to rotate. The first gear 2022 and the second gear 2023 are driven to rotate, so that the second gear 2023 drives the notched cylinder 2024 to rotate. The notched cylinder 2024 drives the first stirring blade 2025 to stir the drug intermediate. The notched cylinder 2024 also drives the second stirring assembly 203 and the nozzle assembly 103 to rotate.

[0060] S2. When the first bevel tooth 104 rotates to mesh with the semi-circular bevel tooth 204, the first bevel tooth 104 drives the nozzle tube 1032 to rotate, the nozzle tube 1032 drives the nozzle assembly 1031 to rotate, and the nozzle tube 1032 drives the stirring shaft 2032 to rotate through the chain transmission structure 205. The stirring shaft 2032 drives the second stirring blade 2031 to rotate, so that the second stirring blade 2031 and the first stirring blade 2025 perform multi-directional stirring.

[0061] S3. During the stirring process, by opening one of the valves 1023, the pipeline 1022 is connected to the catalyst tank 1021. At this time, the delivery pump 1024 draws the catalyst inside the catalyst tank 1021, and the catalyst enters the nozzle pipe 1032 through the connecting pipe 1025 and the delivery pipe 1026, and is sprayed out through the nozzle assembly 1031. With the rotation of the nozzle assembly 1031, the catalyst is evenly dispersed in the drug intermediate. Then, the first stirring assembly 202 and the second stirring assembly 203 are used to carry out the stirring reaction.

[0062] S4. Next, after the catalyst is metered and delivered, the valve 1023 connected to the catalyst is closed, and another valve 1023 is opened to allow the reaction mixture to be sprayed out through the nozzle assembly 1031 to assist in the stirring reaction.

[0063] S5. During the reaction process, the notched cylinder 2024 drives the turning net 210 to rotate. Each time the turning net 210 enters the reaction mixture, it retrieves the reaction products and filters out the drug intermediates. When the turning net 210 flips upward, it drives the elastic component 208 to contact the arc block 209, causing the arc block 209 to squeeze the roller 2081 and the slide rod 2083 to move. This causes the slide rod 2083 to push the load plate 211 and the magnet 212 to separate. The load plate 211 then drives the brush 214 to move downward, allowing the brush 214 to clean the reaction products into the inclined cylinder 207. When the turning net 210 flips downward, the load plate 211 returns to its original position and is attracted and positioned by the magnet 212. This process is repeated to retrieve the reaction products.

[0064] S6. When the reaction product enters the inclined cylinder 207 and enters the bottom of the conveying cylinder 2061, the second motor 2065 drives the screw extrusion shaft 2062 to rotate. The screw extrusion shaft 2062 conveys the reaction product upward. Since the spiral blades of the screw extrusion shaft 2062 decrease upward, the screw extrusion shaft 2062 compresses and conveys the reaction product. The reaction product is squeezed and the residual drug intermediate flows back to the separation tank 201 through the filter layer and liquid port 2063, while the reaction product is discharged through the material port 2064.

[0065] The above are merely preferred embodiments of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A pharmaceutical intermediate separation apparatus comprising a catalyst infusion mechanism, characterized by, The catalyst infusion mechanism is provided with a medicine separation mechanism; The medicine separation mechanism comprises a separation tank, a first stirring assembly is arranged in the separation tank, an opening barrel of the first stirring assembly is fixedly connected with a material turning net, a brush is arranged on the material turning net, one side of the brush is fixedly connected with a weight plate, two magnets are fixedly installed on the weight plate and the material turning net and are magnetically connected, two elastic assemblies are arranged on the weight plate and pass through the material turning net and are in extrusion fit with two arc blocks to push the weight plate to move, so that the brush discharges reaction products from the material turning net; The two arc blocks are fixedly connected to the top wall of the separation tank, a material conveying assembly is arranged on the separation tank, a slanting barrel is connected below the material conveying assembly, a half-ring bevel gear is installed on the slanting barrel, the slanting barrel is arranged in the opening barrel, and a plurality of second stirring assemblies are installed on the opening barrel. The catalyst infusion mechanism comprises a bottom plate, the separation tank is installed on the bottom plate, a conveying assembly is arranged above the bottom plate, the conveying assembly passes through the separation tank and extends into the opening barrel to be connected with a spray head assembly, a first bevel gear is connected above the spray head assembly, the first bevel gear is in mesh with the half-ring bevel gear, and the spray head assembly is further driven by a chain transmission structure and the plurality of second stirring assemblies.

2. A pharmaceutical intermediate separation apparatus according to claim 1, wherein, The conveying assembly comprises a catalyst box, the catalyst box is arranged on the bottom plate, the catalyst box is communicated with the separation tank through a pipeline, two valves are arranged on the pipeline, the pipeline is communicated with a conveying pump, the conveying pump is communicated with a connecting pipe, the connecting pipe is communicated with a conveying pipe, and the conveying pipe is rotatably installed on the connecting pipe through a bearing.

3. A pharmaceutical intermediate separation apparatus according to claim 2, wherein, The spray head assembly comprises a spray head pipe, the first bevel gear is fixedly installed above the spray head pipe, two spray head groups are arranged on the spray head pipe, the conveying pipe passes through the opening barrel and the separation tank and is communicated with the spray head pipe, and the spray head pipe is rotatably installed on the opening barrel and one end of the conveying pipe through two bearings respectively.

4. A pharmaceutical intermediate separation apparatus according to claim 3, wherein, The material conveying assembly comprises a material conveying barrel, the bottom of the material conveying barrel is installed at one end of the slanting barrel, the slanting barrel is transversely installed on the separation tank, and liquid ports and material ports are arranged on the two sides of the material conveying barrel respectively.

5. A pharmaceutical intermediate isolation apparatus according to claim 4, wherein, The liquid port is installed above the separation tank, and a filter screen is further installed in the liquid port.

6. A pharmaceutical intermediate separation apparatus according to claim 5, wherein, The inside of the material conveying barrel is provided with a spiral extrusion shaft, the spiral pitch of the spiral extrusion shaft decreases upwards, the spiral extrusion shaft is rotatably installed on the material conveying barrel through a bearing, and the top end of the spiral extrusion shaft is fixedly connected with an output shaft of a second motor, and the second motor is fixedly installed on the top of the material conveying barrel.

7. A pharmaceutical intermediate separation apparatus according to claim 6, wherein, The first stirring assembly comprises a first motor, the first motor is fixedly installed on the separation tank, a first gear is fixedly connected with an output shaft of the first motor, a second gear is meshed above the first gear, the second gear is fixedly connected to the opening barrel, the opening barrel is rotatably installed on the separation tank through a bearing, and a plurality of first stirring blades are fixedly connected to the opening barrel.

8. A pharmaceutical intermediate separation apparatus according to claim 7, wherein, The second stirring assembly comprises a stirring shaft, the stirring shaft is rotatably installed on the opening barrel through a bearing, a plurality of second stirring blades are fixedly connected to the stirring shaft, and the plurality of stirring shafts and the spray head pipe are drivingly connected through a chain transmission structure.

9. A pharmaceutical intermediate separation apparatus according to claim 8, wherein, The elastic assembly comprises a sliding sleeve, the sliding sleeve is fixedly installed on the material turning net, a sliding rod is slidably arranged in the sliding sleeve, one end of the sliding rod is lapped with the weight plate, the other end of the sliding rod is fixedly installed with a roller, and a spring is fixedly connected between the roller and the sliding sleeve. The material turning screen is installed in the separation tank. Two guide bars are fixedly connected to the material turning screen. The two ends of the load plate slide on the guide bars, and a stop is provided at the end of the guide bar away from the load plate.

10. A method of using a pharmaceutical intermediate separation apparatus according to claim 9, wherein, Includes the following steps: S1. During the separation reaction of drug intermediates, the first gear is driven to rotate by the first motor. The first gear and the second gear are driven to rotate, and the second gear drives the notched cylinder to rotate. The notched cylinder drives the first stirring blade to stir the drug intermediates. The notched cylinder also drives the second stirring assembly and the nozzle assembly to rotate. S2. When the first bevel tooth rotates to mesh with the semi-ring bevel tooth, the first bevel tooth drives the nozzle tube to rotate, the nozzle tube drives the nozzle assembly to rotate, and the nozzle tube drives the stirring shaft to rotate through the chain transmission structure. The stirring shaft drives the second stirring blade to rotate, so that the second stirring blade and the first stirring blade can perform multi-directional stirring. S3. During the stirring process, by opening one of the valves, the pipeline is connected to the catalyst box. At this time, the delivery pump draws the catalyst from inside the catalyst box, and the catalyst enters the nozzle pipe through the connecting pipe and the delivery pipe, and is sprayed out through the nozzle assembly. With the rotation of the nozzle assembly, the catalyst is evenly dispersed in the drug intermediate. Then, the first stirring component and the second stirring component are used for stirring reaction. S4. Next, after the catalyst is metered and delivered, close the valve connected to the catalyst and open another valve to allow the reaction mixture to be sprayed out through the nozzle assembly to assist in the stirring reaction. S5. During the reaction process, the notched cylinder drives the turning screen to rotate. Each time the turning screen enters the reaction mixture, it retrieves the reaction products and filters out the drug intermediates. When the turning screen flips upward, it drives the elastic component to contact the arc block, causing the arc block to squeeze the roller and slide bar to move. This causes the slide bar to push the load plate, separating the magnets. The load plate then drives the brush downward, allowing the brush to clean the reaction products into the inclined cylinder. When the turning screen flips downward, the load plate returns to its original position and is positioned by the magnet. This process of retrieving reaction products is repeated. S6. When the reaction product enters the inclined cylinder and enters the bottom of the conveying cylinder, the second motor drives the screw extrusion shaft to rotate. The screw extrusion shaft conveys the reaction product upward. As the screw blades of the screw extrusion shaft decrease upward, the screw extrusion shaft compresses and conveys the reaction product. The reaction product is squeezed and the residual drug intermediates are returned to the separation tank through the filter layer and liquid port, while the reaction product is discharged through the material port.

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