System for improving stability of vitamin C or derivative thereof as well as preparation method and application of system

Abstract

The invention discloses a system for improving the stability of vitamin C or derivatives thereof, which is characterized by comprising the following components: ethyoxyl diglycol, phytantriol, butanediol, tocopheryl acetate, tocopherol and bisabolol. In addition, the system also comprises polysiloxane (11) and polydimethylsiloxane (PDMS). Researches show that the vitamin C or the derivative thereof has better stability in the system disclosed by the invention; the important application value is realized.

Description

Technical Field

[0001] This invention relates to the field of biomedical technology, specifically to a system for improving the stability of vitamin C or its derivatives, its preparation method, and its application. Background Technology

[0002] Vitamin C (ascorbic acid) and its derivatives, such as tetraisopalmitate ascorbate, are widely used in the cosmetics and health supplement industries due to their significant antioxidant, skin-whitening, and collagen-synthesizing effects. However, vitamin C is susceptible to degradation by environmental factors (such as light, temperature, and oxygen), affecting its efficacy. Therefore, developing a formulation system that effectively protects the stability of vitamin C is particularly important. Summary of the Invention

[0003] In order to overcome at least one technical problem existing in the prior art, the present invention provides a system for improving the stability of vitamin C or its derivatives, a method for preparing the system, and its application.

[0004] The technical solution of the present invention to solve the above-mentioned technical problems is as follows: This invention first provides a system for improving the stability of vitamin C or its derivatives. It contains the following components: ethoxydiethylene glycol, phytanetriol, butanediol, tocopherol acetate, tocopherol, and bisabolol.

[0005] The inventors have provided a novel system for improving the stability of vitamin C or its derivatives. Studies have shown that vitamin C or its derivatives exhibit good stability in the system described in this invention.

[0006] Preferably, the system for improving the stability of vitamin C or its derivatives comprises the following components: Ethoxydiethylene glycol 3-8 parts; phytanetriol 1-3 parts; butanediol 10-15 parts; tocopheryl acetate 0.5-1 part; tocopherol 0-0.5 parts; bisabolol 0-0.3 parts.

[0007] More preferably, the system for improving the stability of vitamin C or its derivatives comprises the following components: Ethoxydiethylene glycol 4-6 parts; phytanetriol 1-2 parts; butanediol 10-12 parts; tocopheryl acetate 0.5-1 part; tocopherol 0.2-0.5 parts; bisabolol 0.1-0.3 parts.

[0008] Most preferably, the system for improving the stability of vitamin C or its derivatives comprises the following components: Ethoxydiethylene glycol 5 parts; phytanetriol 2 parts; butanediol 12 parts; tocopheryl acetate 0.7 parts; tocopherol 0.2 parts; bisabolol 0.1 parts.

[0009] Preferably, the system further comprises polysiloxane-11 and polydimethylsiloxane.

[0010] Further research by the inventors revealed that adding polysiloxane-11 and polydimethylsiloxane to a system containing ethoxydiethylene glycol, phytanetriol, butanediol, tocopherol acetate, tocopherol, and bisabolol can significantly improve the stability of vitamin C or its derivatives.

[0011] Furthermore, the inventors discovered in their research that in systems containing ethoxydiethylene glycol, phytanetriol, butylene glycol, tocopherol acetate, tocopherol, and bisabolol, the simultaneous addition of polysiloxane-11 and polydimethylsiloxane is necessary to significantly improve the stability of vitamin C or its derivatives; however, simply adding polysiloxane-11 or polydimethylsiloxane alone does not significantly improve the stability of vitamin C or its derivatives. In systems containing ethoxydiethylene glycol, phytanetriol, butylene glycol, tocopherol acetate, tocopherol, and bisabolol, the simultaneous addition of polysiloxane-11 and polydimethylsiloxane synergistically improves the stability of vitamin C or its derivatives.

[0012] More preferably, the weight parts of polysiloxane-11 and polydimethylsiloxane in the system are: 10-46 parts of polysiloxane-11 and 0-18 parts of polydimethylsiloxane.

[0013] Most preferably, the weight parts of polysiloxane-11 and polydimethylsiloxane in the system are: 30-40 parts of polysiloxane-11 and 10-15 parts of polydimethylsiloxane.

[0014] Most preferably, the weight parts of polysiloxane-11 and polydimethylsiloxane in the system are: 35 parts of polysiloxane-11 and 15 parts of polydimethylsiloxane.

[0015] Preferably, the system further comprises octyl polydimethylsiloxane and PEG-12 dimethylsiloxane / PPG-20 crosslinked polymer.

[0016] Further research by the inventors revealed that adding octyl polydimethylsiloxane and PEG-12 dimethylsiloxane / PPG-20 crosspolymer to a system containing ethoxydiethylene glycol, phytanetriol, butanediol, tocopheryl acetate, tocopherol, bisabolol, polysiloxane-11, and polydimethylsiloxane can significantly improve the stability of vitamin C or its derivatives.

[0017] More preferably, the weight parts of octyl polydimethylsiloxane, PEG-12 dimethylsiloxane / PPG-20 crosslinked polymer system are 15 to 40 parts.

[0018] Most preferably, the weight parts of the octyl polydimethylsiloxane, PEG-12 dimethylsiloxane / PPG-20 crosslinked polymer system are 30 parts.

[0019] Preferably, in the system, the amount of vitamin C or its derivative added accounts for 1 to 10% of the weight of the system.

[0020] The present invention also provides a method for preparing the above-mentioned system for improving the stability of vitamin C or its derivatives, comprising the following steps: Ethoxydiethylene glycol, phytanetriol, ascorbate tetraisopalmitate, butylene glycol, tocopheryl acetate, tocopherol, and bisabolol are mixed evenly to obtain the system described above for improving the stability of vitamin C or its derivatives. Alternatively, ethoxydiethylene glycol, phytanetriol, ascorbate tetraisopalmitate, butanediol, tocopheryl acetate, tocopherol, bisabolol, polysiloxane-11, and polydimethylsiloxane can be mixed evenly to obtain the system described above for improving the stability of vitamin C or its derivatives.

[0021] Beneficial effects: This invention provides a novel system for improving the stability of vitamin C or its derivatives. Studies have shown that vitamin C or its derivatives have good stability in the system described in this invention; it has significant application value. Detailed Implementation

[0022] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to specific examples. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0023] Example 1: Preparation of a system for improving the stability of vitamin C or its derivatives Raw material composition by weight: 5 parts ethoxydiethylene glycol; 2 parts phytanetriol; 12 parts butanediol; 0.7 parts tocopheryl acetate; 0.2 parts tocopherol; 0.1 parts bisabolol.

[0024] Preparation method: Take the above-mentioned parts by weight of raw materials, mix them evenly to obtain the system for improving the stability of vitamin C or its derivatives.

[0025] Example 2: Preparation of a system for improving the stability of vitamin C or its derivatives Raw material composition by weight: 3 parts ethoxydiethylene glycol; 1 part phytanetriol; 15 parts butanediol; 0.5 parts tocopheryl acetate; 0.1 parts tocopherol; 0.1 parts bisabolol.

[0026] Preparation method: Take the above-mentioned parts by weight of raw materials, mix them evenly to obtain the system for improving the stability of vitamin C or its derivatives.

[0027] Example 3: Preparation of a system for improving the stability of vitamin C or its derivatives Raw material composition by weight: 8 parts ethoxydiethylene glycol; 3 parts phytanetriol; 10 parts butanediol; 1 part tocopherol acetate; 0.5 parts tocopherol; 0.3 parts bisabolol.

[0028] Preparation method: Take the above-mentioned parts by weight of raw materials, mix them evenly to obtain the system for improving the stability of vitamin C or its derivatives.

[0029] Example 4: Preparation of a system for improving the stability of vitamin C or its derivatives Raw material composition by weight: 5 parts ethoxydiethylene glycol; 2 parts phytanetriol; 12 parts butanediol; 0.7 parts tocopheryl acetate; 0.2 parts tocopherol; 0.1 parts bisabolol; 35 parts polysiloxane-11; 15 parts polydimethylsiloxane.

[0030] Preparation method: Take the above-mentioned parts by weight of raw materials, mix them evenly to obtain the system for improving the stability of vitamin C or its derivatives.

[0031] Example 5: Preparation of a system for improving the stability of vitamin C or its derivatives Raw material composition by weight: 5 parts ethoxydiethylene glycol; 2 parts phytanetriol; 12 parts butanediol; 0.7 parts tocopheryl acetate; 0.2 parts tocopherol; 0.1 parts bisabolol; 35 parts polysiloxane-11; 15 parts polydimethylsiloxane; 30 parts by weight of octyl polydimethylsiloxane, PEG-12 dimethylsiloxane / PPG-20 crosslinked polymer system.

[0032] Preparation method: Take the above-mentioned parts by weight of raw materials, mix them evenly to obtain the system for improving the stability of vitamin C or its derivatives.

[0033] Comparative Example 1: Preparation of a system for improving the stability of vitamin C or its derivatives Raw material composition by weight: 5 parts ethoxydiethylene glycol; 2 parts phytanetriol; 12 parts butanediol; 0.7 parts tocopheryl acetate; 0.2 parts tocopherol; 0.1 parts bisabolol; 35 parts polysiloxane-11.

[0034] Preparation method: Take the above-mentioned parts by weight of raw materials, mix them evenly to obtain the system for improving the stability of vitamin C or its derivatives.

[0035] Comparative Example 2: Preparation of a system for improving the stability of vitamin C or its derivatives Raw material composition by weight: 5 parts ethoxydiethylene glycol; 2 parts phytanetriol; 12 parts butanediol; 0.7 parts tocopheryl acetate; 0.2 parts tocopherol; 0.1 parts bisabolol; 15 parts polydimethylsiloxane.

[0036] Preparation method: Take the above-mentioned parts by weight of raw materials, mix them evenly to obtain the system for improving the stability of vitamin C or its derivatives.

[0037] Experimental Example: Vitamin C Stability Experiment Referring to the test method in Appendix XIX C of Part II of the 2010 edition of the Chinese Pharmacopoeia, vitamin C was added at a weight percentage of 5% to the systems prepared for improving the stability of vitamin C or its derivatives, namely, Examples 1, 4, 5, and Comparative Examples 1 and 2. The systems were then stored for 6 months under accelerated stability testing conditions at 40℃ ± 2℃ and 75% ± 5% relative humidity. The vitamin C content in each system was determined by ultraviolet spectrophotometry at 1 month, 2 months, 3 months, and 6 months. The test results are shown in Table 1.

[0038] Table 1. Vitamin C content at different time points in accelerated testing

[0039] As can be seen from the experimental results in Table 1, the system prepared in Example 1 still maintained a high vitamin C content after 2 months of acceleration. This indicates that the system of the present invention, comprising ethoxydiethylene glycol, phytanetriol, butylene glycol, tocopheryl acetate, tocopherol, and bisabolol, has a good effect on improving the stability of vitamin C. However, the vitamin C content decreased significantly after 6 months of acceleration, indicating room for improvement.

[0040] As can be seen from the experimental results in Table 1, the vitamin C content of the system prepared in Example 4 is significantly higher than that of the system prepared in Example 1 after 6 months of accelerated processing. This indicates that the addition of polysiloxane-11 and polydimethylsiloxane to the system containing ethoxydiethylene glycol, phytanetriol, butanediol, tocopherol acetate, tocopherol, and bisabolol can significantly improve the stability of vitamin C or its derivatives.

[0041] As can be seen from the experimental results in Table 1, although the vitamin C content of the systems prepared in Comparative Examples 1 and 2 was increased after 6 months of accelerated processing compared to the system prepared in Example 1, the increase was much smaller than that of the system prepared in Example 4. This indicates that in systems containing ethoxydiethylene glycol, phytanetriol, butylene glycol, tocopherol acetate, tocopherol, and bisabolol, it is necessary to simultaneously add polysiloxane-11 and polydimethylsiloxane to significantly improve the stability of vitamin C or its derivatives. However, simply adding polysiloxane-11 or polydimethylsiloxane alone cannot significantly improve the stability of vitamin C or its derivatives. In systems containing ethoxydiethylene glycol, phytanetriol, butylene glycol, tocopherol acetate, tocopherol, and bisabolol, simultaneously adding polysiloxane-11 and polydimethylsiloxane can synergistically improve the stability of vitamin C or its derivatives.

[0042] As can be seen from the experimental results in Table 1, the system prepared in Example 5 still has a high vitamin C content after 6 months of accelerated processing, and the vitamin C content is significantly higher than that of the system prepared in Example 4. This indicates that the addition of octyl polydimethylsiloxane and PEG-12 dimethylsiloxane / PPG-20 crosspolymer to the system containing ethoxydiethylene glycol, phytanetriol, butanediol, tocopheryl acetate, tocopherol, bisabolol, polysiloxane-11, and polydimethylsiloxane can significantly improve the stability of vitamin C or its derivatives, resulting in a system with excellent stability for vitamin C or its derivatives.

[0043] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within the present invention.

[0044] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A system for improving the stability of vitamin C or its derivatives, characterized in that, It contains the following components: ethoxydiethylene glycol, phytanetriol, butanediol, tocopherol acetate, tocopherol, and bisabolol.

2. The system for improving the stability of vitamin C or its derivatives according to claim 1, characterized in that, It contains the following components: Ethoxydiethylene glycol 3-8 parts; phytanetriol 1-3 parts; butanediol 10-15 parts; tocopheryl acetate 0.5-1 part; tocopherol 0-0.5 parts; 0-0.3 parts of bisabolol.

3. The system for improving the stability of vitamin C or its derivatives according to claim 1, characterized in that, It contains the following components: Ethoxydiethylene glycol 4-6 parts; phytanetriol 1-2 parts; butanediol 10-12 parts; tocopheryl acetate 0.5-1 part; tocopherol 0.2-0.5 parts; Bisabolol 0.1~0.3 parts.

4. The system for improving the stability of vitamin C or its derivatives according to claim 1, characterized in that, It contains the following components: Ethoxydiethylene glycol 5 parts; phytanetriol 2 parts; butanediol 12 parts; tocopheryl acetate 0.7 parts; tocopherol 0.2 parts; bisabolol 0.1 parts.

5. The system for improving the stability of vitamin C or its derivatives according to claim 1, characterized in that, The system also includes polysiloxane-11 and polydimethylsiloxane.

6. The system for improving the stability of vitamin C or its derivatives according to claim 5, characterized in that, The weight parts of polysiloxane-11 and polydimethylsiloxane in the system are: 10-46 parts of polysiloxane-11; 0-18 parts of polydimethylsiloxane.

7. The system for improving the stability of vitamin C or its derivatives according to claim 6, characterized in that, The weight parts of polysiloxane-11 and polydimethylsiloxane in the system are: 30-40 parts of polysiloxane-11 and 10-15 parts of polydimethylsiloxane.

8. The system for improving the stability of vitamin C or its derivatives according to claim 7, characterized in that, The weight parts of polysiloxane-11 and polydimethylsiloxane in the system are: 35 parts of polysiloxane-11 and 15 parts of polydimethylsiloxane.

9. The system for improving the stability of vitamin C or its derivatives according to claim 7, characterized in that, In the system described, the amount of vitamin C or its derivatives added accounts for 1 to 10% of the weight of the system.

10. A method for preparing the system for improving the stability of vitamin C or its derivatives according to any one of claims 1 to 8, characterized in that, It includes the following steps: Ethoxydiethylene glycol, phytanetriol, ascorbate tetraisopalmitate, butylene glycol, tocopheryl acetate, tocopherol, and bisabolol are mixed evenly to obtain the system described above for improving the stability of vitamin C or its derivatives. Alternatively, ethoxydiethylene glycol, phytanetriol, ascorbate tetraisopalmitate, butanediol, tocopheryl acetate, tocopherol, bisabolol, polysiloxane-11, and polydimethylsiloxane can be mixed evenly to obtain the system described above for improving the stability of vitamin C or its derivatives.

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