Glycosaminoglycan hydrogel with physical and chemical double crosslinking mechanism as well as preparation method and application of glycosaminoglycan hydrogel

The glycosaminoglycan hydrogel, through a dual physicochemical cross-linking mechanism, solves the problem of insufficient mechanical strength and stability of glycosaminoglycan hydrogels, enabling its effective application in dynamic physiological environments and providing wound care and antibacterial properties.

CN121846346APending Publication Date: 2026-04-14WENDE XILIN (HANGZHOU) BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202511686133.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-11-17
Publication Date
2026-04-14

AI Technical Summary

Technical Problem

Existing glycosaminoglycan hydrogels have low mechanical strength, poor stability, complex preparation processes, lack of bioactive functions, low cross-linking efficiency, and are difficult to apply in dynamic physiological environments.

Method used

Employing a dual physicochemical crosslinking mechanism, a dual network of chemical and physical crosslinking is formed by combining sodium hyaluronate, chondroitin sulfate, and ε-polylysine hydrochloride in a specific ratio with a polydopamine-titanium dioxide complex and a stabilizer, thereby enhancing mechanical support and bioactivity.

Benefits of technology

It significantly improves the mechanical support and stability of hydrogels, and has wound care, adhesion, non-wetting and antibacterial properties, making it suitable for skin wound repair and wound healing.

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Abstract

The invention provides glycosaminoglycan hydrogel with a physical and chemical double crosslinking mechanism as well as a preparation method and application thereof, and relates to the technical field of biological materials. The glycosaminoglycan hydrogel is prepared from the following raw materials: oxidized sodium hyaluronate, chondroitin sulfate, epsilon-polylysine hydrochloride, a polydopamine-titanium dioxide compound and a stabilizer. The glycosaminoglycan hydrogel is prepared through a physical and chemical double-crosslinking mechanism under the specific raw materials and proportion, the problems of cytotoxicity and the like caused by use of a crosslinking agent or introduction of other solvents are avoided, a stable covalent network is constructed through chemical crosslinking, the gel is endowed with the self-repairing characteristic through physical crosslinking, and the self-repairing performance of the hydrogel is improved. And the viscosity of the product is remarkably improved, so that the hydrogel has stronger mechanical support performance, is suitable for wound repair, wound healing and the like, and has good antibacterial activity and stability.
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