A magnetic response composite hydrogel for integrated repair of bone defects and a preparation method thereof

By utilizing the magnetothermal sensitization-calcium-iron synergistic composite hydrogel, and taking advantage of the magnetothermal effect and calcium ion release activated by the alternating magnetic field, a highly efficient integrated treatment for tumor-related bone defects has been achieved. This solves the problem of mutual constraints between anti-tumor and bone repair processes, simplifies the treatment process, and improves the repair effect.

CN121648358BActive Publication Date: 2026-05-19SICHUAN UNIV
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Patent Information

Application Number
CN202610182056.6
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2026-02-09
Publication Date
2026-05-19
Estimated Expiration
2046-02-09

AI Technical Summary

Technical Problem

In existing treatments for tumor-related bone defects, the anti-tumor and bone repair processes are mutually restrictive, making it difficult to achieve temporal synergistic regulation in a single material system. This results in prolonged treatment cycles, multiple surgical traumas, and a high risk of repair failure.

Method used

The magnetic thermosensitive-calcium-iron synergistic composite hydrogel is activated by an alternating magnetic field to achieve efficient killing of tumor cells and bone tissue regeneration. It utilizes the magnetothermal effect generated by ferric oxide magnetic nanoparticles and the release of calcium ions by calcium peroxide nanoparticles. Combined with mild thermal stimulation and ion action, it achieves an integrated anti-tumor and osteogenic process.

Benefits of technology

It achieves efficient killing of tumor cells and orderly regeneration of bone tissue, simplifies treatment procedures, reduces the risk of tumor recurrence, improves repair quality, and has the ability to fill irregular defects with minimally invasive techniques.

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Abstract

The application provides a magnetic response composite hydrogel for integrated repair of bone defects and a preparation method thereof, and belongs to the technical field of medical materials. The composite hydrogel can efficiently inhibit tumor cell activity under the time sequence regulation of an external alternating magnetic field, and then provide a suitable microenvironment and key components for bone tissue regeneration, so that signal conversion and function connection from tumor killing to bone repair are realized. The material has good injectability and self-healing ability, can minimally invasively fill irregular defects, and has significant advantages in simplifying the clinical treatment procedure, shortening the treatment course, reducing the risk of tumor recurrence and improving the repair quality, and provides a new and integrated treatment strategy for tumor-related bone defects.
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