Solid dispersion preparation drying device
By switching the states of the heat-conducting stirring component and the rotating plate, combined with the isolation design, the problem of uneven drying of solid dispersion formulations is solved, achieving efficient and uniform drying and a stable production process.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-30
- Publication Date
- 2026-03-13
AI Technical Summary
The existing technology for drying solid dispersion formulations uses a single method, resulting in low drying efficiency and uneven product quality. Existing stirring components cannot achieve uniform mixing of materials at different levels, and hot air cannot penetrate evenly, affecting the quality and efficiency of the finished product.
The stirring component with thermal conductivity is used for horizontal tumbling and stirring. The state switching between the first rotating plate and the second rotating plate enables flexible switching between the drying space, the sealing space and the feeding space. Combined with the design of the isolation column and the isolation plate, it ensures uniform distribution of materials and uniform heat penetration.
This technology enables uniform drying of solid dispersion formulations, improves drying efficiency and the uniformity of finished product quality, and ensures the stability and continuity of the production process.
Smart Images
Figure CN121655237A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of pharmaceutical drying technology, and more specifically to a drying apparatus for solid dispersion formulations. Background Technology
[0002] In the drying process of solid dispersion formulations, the drying process commonly used in the industry is relatively simple. Specifically, the solid dispersion formulation to be dried is directly poured into a special drying container, and the material is stirred and agitated by a stirring component in the container. At the same time, hot air is continuously introduced into the container, and the moisture is removed by heat exchange between the hot air and the material, thereby completing the drying process.
[0003] This type of drying process has significant technical drawbacks: the existing stirring components have limited operating range and function, only able to stir and disrupt solid dispersions within the same layer of the container, making it difficult to drive materials at different layers to form a continuous flow. In this situation, the introduced hot air cannot penetrate evenly within the material layer, resulting in differences in the degree of drying of solid dispersions at different levels and in different areas, ultimately affecting the uniformity of the finished product quality. Based on the aforementioned drying methods, existing technologies struggle to achieve uniform drying, thus impacting the final product quality and drying efficiency. Summary of the Invention
[0004] To address the aforementioned technical shortcomings, the purpose of this invention is to provide a drying device for solid dispersion formulations, thereby solving the problem of poor drying efficiency and effectiveness caused by the reliance on a single drying method in the prior art.
[0005] To solve the above-mentioned technical problems, the present invention adopts the following technical solution: The present invention provides a solid dispersion preparation drying device, comprising: a first shell; a second shell, the second shell being fixed to the first shell and communicating with the first shell; a first rotating plate and a second rotating plate, the first rotating plate and the second rotating plate being respectively disposed inside the first shell; a stirring part, the stirring part being rotatably connected inside the first shell; wherein, hot air is circulated in the stirring part, and the first rotating plate and the second rotating plate slide within the first shell, forming at least the following states: first state: the first rotating plate and the second rotating plate and the first shell together form a drying space; second state: the first rotating plate and the second rotating plate and the first shell together form a sealed space; third state: the first rotating plate and the second rotating plate and the first shell together form a feeding space.
[0006] Optionally, a groove is provided on the first housing, and a slider is fixed on both the first rotating plate and the second rotating plate, the slider being slidably connected in the groove.
[0007] Optionally, a cylinder is rotatably connected to the second housing, and the output end of the cylinder is rotatably connected to the slider.
[0008] Optionally, the first rotating plate has a first filtering part, a first sealing part, and a first through part. The first filtering part has a plurality of evenly distributed ventilation holes, and the first through part has a through opening. The second rotating plate has a second filtering part, a second sealing part, and a second through part. The second filtering part also has a plurality of evenly distributed ventilation holes, and the second through part also has a through opening.
[0009] Optionally, the first state is formed when the first filter portion and the second filter portion overlap; the second state is formed when the first sealing portion and the second sealing portion overlap; and the third state is formed when the first through portion and the second through portion overlap.
[0010] Optionally, the stirring part is made of a material with thermal conductivity. The stirring part is hollow inside, with both sides open, and is connected to the first air duct through a bearing. The first air duct is supplied with drying hot air by an air source. The air source is also provided with a second air duct, which is connected to the second housing.
[0011] Optionally, the second housing has a feeding section, and an isolation section is inserted inside the feeding section.
[0012] Optionally, a plurality of isolation columns are fixed inside the second housing, and a plurality of isolation plates are provided inside the second housing corresponding to the isolation columns, with two adjacent isolation plates forming a feeding channel.
[0013] Optionally, it also includes a drive source connected to the stirring unit via a transmission assembly.
[0014] Optionally, the bottom of the first housing is provided with a discharge port.
[0015] The beneficial effects of this invention are as follows: The stirring unit of this invention is horizontally arranged inside the first housing. Its tumbling action can fully mix the solid dispersion formulations in the upper and lower layers of the first housing, ensuring that all materials can be evenly contacted by the drying air and avoiding incomplete drying caused by local materials not being in contact with the airflow. At the same time, the stirring unit adopts a hollow design. After hot air is introduced into the interior, the hot air can quickly heat the stirring unit body with thermal conductivity. This allows the stirring unit to not only achieve the tumbling and dispersion of materials during rotation, but also to conduct heat through direct contact with the materials. Under the dual drying mechanism, heat can be evenly penetrated to every part of the material, ensuring the drying uniformity of the solid dispersion formulation and avoiding local over-drying or under-drying.
[0016] Secondly, this invention features a first rotating plate and a second rotating plate. By sliding and switching between these two plates within the first housing, the device can operate in three states: a first state, a second state, and a third state, corresponding to the three core functions of ventilation, sealing, and material feeding, respectively, achieving seamless adaptation of each stage of the drying process. In the first state, the device can coordinate with the hot air intake function and the stirring action of the mixing unit to accelerate the evaporation of moisture from the material surface, further improving drying efficiency. In the second state, the sealing structure effectively blocks heat exchange between the device's interior and the outside environment, reducing heat loss and maintaining the temperature stability of the internal drying environment. This improves energy efficiency and prevents temperature fluctuations from affecting the drying effect. In the third state, the material feeding operation can be smoothly completed. The flexible switching between these three states allows the device to precisely adjust its operating mode according to the different stages of drying solid dispersion formulations, ensuring the orderly and efficient progress of the drying process.
[0017] Furthermore, the second housing of this invention is equipped with several isolation columns and several arrayed isolation plates, forming an orderly feeding and guiding structure. After the material enters the second housing from the feed section, it forms a normally distributed flow pattern under the diversion effect of the isolation columns, and then gradually enters the first housing through the layered guidance of the isolation plates. This design not only achieves relatively uniform feeding and ensures that the material is evenly distributed in the first housing, creating a good premise for subsequent uniform drying, but also effectively avoids the accumulation and agglomeration of material at the feed inlet, preventing feeding blockage or poor flow, and ensuring the continuity and stability of the entire production process.
[0018] In summary, this invention, through systematic optimization of existing drying methods, comprehensively improves the drying effect from multiple dimensions such as material contact, heat transfer, process adaptation, and feed assurance. It effectively solves the problems of insufficient and uneven drying of solid dispersion formulations in existing technologies, significantly improves drying efficiency, and ensures the uniformity of finished product quality and the stability of process operation. Attached Figure Description
[0019] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.
[0020] Figure 1 This invention provides a three-dimensional structure of a solid dispersion preparation drying device. Figure 1 .
[0021] Figure 2 This invention provides a three-dimensional structure of a solid dispersion preparation drying device. Figure 2 .
[0022] Figure 3 This is a partial side-view cross-sectional view of a solid dispersion preparation drying apparatus according to the present invention.
[0023] Figure 4 This is a partial perspective view of a solid dispersion preparation drying apparatus according to the present invention.
[0024] Figure 5 This is a partial exploded view of a solid dispersion preparation drying apparatus according to the present invention.
[0025] Figure 6 This is a three-dimensional structural diagram of the first rotating plate and the second rotating plate of a solid dispersion preparation drying device according to the present invention.
[0026] Figure 7 This is a partial front-view cross-sectional view of a solid dispersion preparation drying apparatus according to the present invention.
[0027] Explanation of reference numerals in the attached figures: 1. First housing; 11. Slide groove; 12. Cylinder; 2. Second housing; 21. Feed section; 22. Isolation section; 23. Isolation column; 24. Isolation plate; 3. First rotating plate; 31. First filter section; 32. First sealing section; 33. First through section; 4. Second rotating plate; 41. Second filter section; 42. Second sealing section; 43. Second through section; 5. Slider; 6. Stirring section; 7. Air source; 71. First air duct; 72. Second air duct; 8. Drive source; 81. Transmission assembly. Detailed Implementation
[0028] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.
[0029] As mentioned earlier, existing drying processes have significant technical shortcomings: the operating range and function of existing stirring components are limited, only able to agitate and disrupt solid dispersions within the same layer of the container, making it difficult to drive materials at different layers to form a continuous flow. In this situation, the introduced hot air cannot penetrate evenly within the material layer, resulting in differences in the degree of drying of solid dispersions at different levels and in different areas, ultimately affecting the uniformity of the finished product quality. Based on the aforementioned drying methods, existing technologies struggle to achieve uniform drying, thus impacting the final product quality and drying efficiency.
[0030] To address this issue, the present invention provides a drying apparatus applied to the drying process of solid dispersion formulations. Through systematic optimization of existing drying methods, this apparatus comprehensively improves the drying effect from multiple dimensions, including material contact, heat transfer, process adaptation, and feed assurance. It effectively solves the problems of insufficient and uneven drying of solid dispersion formulations in existing technologies, significantly improving drying efficiency and ensuring the uniformity of finished product quality and the stability of process operation. The present invention is achieved through the following means.
[0031] Example 1: Please refer to the accompanying drawings in the specification. This first embodiment provides a drying apparatus for solid dispersion formulations, which includes, as shown in the figures below. Figure 1 The first housing 1 shown is horizontally elongated with multiple pressure relief ports. The bottom of the first housing 1 is arc-shaped, and a discharge section is formed within this arc. The first housing 1 is supported on a support surface (e.g., the ground) by support feet, and a second housing 2 is fixed to its top end face, communicating with the first housing 1. A feeding section 21 is fixed to the top end face of the second housing 2, and an isolation section 22 is inserted within the feeding section 21. When the isolation section 22 is inserted into the feeding section 21, and the discharge section and pressure relief ports are closed, a sealed drying space is formed within the first housing 1 and the second housing 2.
[0032] like Figures 1 to 6 As shown, in this embodiment, a stirring part 6 is rotatably connected to the first housing 1 via bearings. The stirring part 6 is made of a material with certain rigidity and thermal conductivity (e.g., copper alloy, stainless steel). The interior of the stirring part 6 is hollow and has a main shaft and secondary shafts distributed in an S-shape around the main shaft. The main shaft connects to the secondary shafts and has a protrusion extending out of the first housing 1. The protrusion has a rotating part and a fixed part. The rotating part and the fixed part are connected by bearings. The rotating part is connected to a first air duct 71, which is connected to an air source 7 (e.g., a hot air dryer). The fixed part is connected to a drive source 8 (e.g., a motor and a reducer) via a transmission assembly 81. The transmission assembly 81 includes transmission wheels (e.g., pulleys, sprockets) fixed to the fixed part and the drive shaft of the drive source 8, respectively. These two transmission wheels are connected by a transmission belt (e.g., a belt, a chain).
[0033] Therefore, in the specific implementation of this embodiment, hot air is introduced into the stirring section 6 through the air source 7 via the first air duct 71, the rotating part, and the fixed part. The hot air passes through the main shaft and the secondary shaft, exits from the other end, enters the first air duct 71, and then returns to the air source 7, completing the cycle. In this cycle, the air source 7 heats the stirring section 6, and the surface of the heated stirring section 6 has heat. This heat is conducted to the solid dispersion preparation inside the first housing 1, thereby drying it.
[0034] At the same time, the drive shaft of the drive source 8 rotates, which drives the fixed part to rotate through the transmission group 81, thereby causing the stirring part 6 to rotate. During the rotation, the stirring part 6 stirs the solid dispersion preparation in the first shell 1, thereby making the drying process uniform.
[0035] Example 2: Based on the above embodiments, in order to further clarify and completely explain the technical solutions therein, the present invention also provides an embodiment two. For example... Figures 1 to 7 As shown in this second embodiment, a first rotating plate 3 and a second rotating plate 4 are provided inside the first housing 1. Slider 5s are fixed to both sides of the first rotating plate 3 and the second rotating plate 4. A groove 11 is provided on the first housing 1 corresponding to the position of the slider 5, and the slider 5 is slidably connected within the groove 11. Simultaneously, a shielding part is provided at the junction of the first rotating plate 3 and the second rotating plate 4 with the slider 5, and the shielding part abuts against the groove 11 to seal and prevent wind damage. A cylinder 12 is rotatably connected to the outside of the second housing 2, and the output shaft of the cylinder 12 is rotatably connected to the slider 5.
[0036] like Figures 5 to 6 As shown, in this second embodiment, the first rotating plate 3 has a first filter part 31, a first sealing part 32 and a first through part 33. The first filter part 31 has a plurality of evenly distributed ventilation holes, and the first through part 33 has a through opening. The second rotating plate 4 has a second filter part 41, a second sealing part 42 and a second through part 43. The second filter part 41 also has a plurality of evenly distributed ventilation holes, and the second through part 43 also has a through opening.
[0037] Meanwhile, a second air duct 72 is connected to the air source 7, and the second air duct 72 connects to the second housing 2. The first rotating plate 3 and the second rotating plate 4 are driven by the cylinder 12 and slide within the first housing 1 respectively, forming at least the following states: First state: The first filter section 31 and the second filter section 41 overlap. In this first state, the first rotating plate 3, the second rotating plate 4, and the first housing 1 together form a drying space. In this drying space, in addition to drying the solid dispersion preparation via the stirring section 6 as in Example 1, the air source 7 also introduces hot air into the second housing 2 through the second air duct 72 (at this time, the isolation section 22 is inserted into the feed section 21). The hot air enters the first housing 1 through the second housing 2, passes through the first filter section 31 and the second filter section 41, and enters the drying space, directly acting on the solid dispersion preparation inside, thereby performing double drying and improving drying efficiency.
[0038] Second state: The first sealing part 32 and the second sealing part 42 overlap. In this second state, the first rotating plate 3, the second rotating plate 4, and the first housing 1 together form a sealed space, that is, the first sealing part 32 and the second sealing part 42 are in contact, the shielding part abuts against the slide groove 11, and the pressure relief port is closed. At this time, the air source 7 does not send air into the first housing 1 through the second air duct 72, but only through the heat conduction of the stirring part 6 for drying.
[0039] Third state: The first through section 33 and the second through section 43 overlap. In this third state, the first rotating plate 3, the second rotating plate 4, and the first shell 1 together form a feeding space. At this time, the operator can add solid dispersion formulations into the feed section 21, allowing them to enter the first shell 1.
[0040] Example 3: Based on the above embodiments, in order to further clarify and completely explain the technical solutions therein, the present invention also provides Embodiment Three. For example... Figure 7 As shown, in this third embodiment, a number of isolation columns 23 are fixed inside the second housing 2, and a number of isolation plates 24 are provided inside the second housing 2 corresponding to the isolation columns 23. The two adjacent isolation plates 24 enclose each other to form a feeding channel.
[0041] Therefore, in the specific implementation of this embodiment three, the material enters the second housing 2 from the feed section 21, strikes the isolation column 23 to change its orientation, and then enters different feed channels, with its overall arrangement following a normal distribution. This makes the material fed relatively uniform, avoiding blockages and material jams.
[0042] Therefore, in summary, the present invention and its embodiments have advantages over the prior art, including but not limited to the following: The stirring unit 6 of this invention is horizontally arranged inside the first housing 1. Its tumbling action can fully mix the solid dispersion formulations in the upper and lower layers of the first housing 1, ensuring that all materials can be evenly contacted by the drying air and avoiding incomplete drying caused by local materials not being in contact with the airflow. At the same time, the stirring unit 6 adopts a hollow design. After hot air is introduced into the interior, the hot air can quickly heat the stirring unit 6 body, which has thermal conductivity. During the rotation of the stirring unit 6, not only can the materials be tumbled and dispersed, but heat can also be conducted through direct contact with the materials. Under the dual drying mechanism, heat can be evenly penetrated to each part of the material, ensuring the drying uniformity of the solid dispersion formulation and avoiding local over-drying or under-drying.
[0043] Secondly, this invention features a first rotating plate 3 and a second rotating plate 4. By sliding and switching between these two plates within the first housing 1, the device can operate in three states: a first state, a second state, and a third state, corresponding to the three core functions of ventilation, sealing, and material feeding, respectively, achieving seamless adaptation of each stage of the drying process. In the first state, the device can coordinate with the stirring action of the mixing unit 6 through the hot air inlet function, accelerating the evaporation of moisture from the material surface and further improving drying efficiency. In the second state, the sealing structure effectively blocks heat exchange between the device's interior and the outside environment, reducing heat loss and maintaining the temperature stability of the internal drying environment. This improves energy utilization efficiency and prevents temperature fluctuations from affecting the drying effect. In the third state, material feeding can be smoothly completed. The flexible switching between these three states allows the device to precisely adjust its operating mode according to the different stages of drying solid dispersion formulations, ensuring the orderly and efficient progress of the drying process.
[0044] Furthermore, the second housing 2 of this invention is provided with a plurality of isolation columns 23 and a plurality of arrayed isolation plates 24, forming an orderly feeding guidance structure. After the material enters the second housing 2 from the feed section 21, it forms a normally distributed flow pattern under the diversion effect of the isolation columns 23, and then gradually enters the first housing 1 through the layered guidance of the isolation plates 24. This design not only achieves relatively uniform feeding and ensures that the material is evenly distributed in the first housing 1, creating a good premise for subsequent uniform drying, but also effectively avoids the accumulation and agglomeration of material at the feed inlet, preventing feeding blockage or poor flow, and ensuring the continuity and stability of the entire production process.
[0045] In summary, this invention, through systematic optimization of existing drying methods, comprehensively improves the drying effect from multiple dimensions such as material contact, heat transfer, process adaptation, and feed assurance. It effectively solves the problems of insufficient and uneven drying of solid dispersion formulations in existing technologies, significantly improves drying efficiency, and ensures the uniformity of finished product quality and the stability of process operation.
[0046] Obviously, those skilled in the art can make various modifications and variations to this invention without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of this invention and its equivalents, this invention also intends to include these modifications and variations.
Claims
1. A drying apparatus for solid dispersion formulations, characterized in that, include: First shell (1); The second housing (2) is fixed to the first housing (1) and communicates with the first housing (1); The first rotating plate (3) and the second rotating plate (4) are respectively disposed inside the first housing (1); A stirring part (6) is rotatably connected inside the first housing (1); Hot air is supplied to the stirring section (6), and the first rotating plate (3) and the second rotating plate (4) slide within the first housing (1), forming at least the following states: First state: The first rotating plate (3), the second rotating plate (4), and the first shell (1) together form a drying space; Second state; the first rotating plate (3), the second rotating plate (4), and the first housing (1) together form a sealed space; Third state: The first rotating plate (3), the second rotating plate (4), and the first shell (1) together form a feeding space.
2. The solid dispersion preparation drying apparatus as described in claim 1, characterized in that, The first housing (1) is provided with a sliding groove (11), and the first rotating plate (3) and the second rotating plate (4) are both fixed with sliders (5), which are slidably connected in the sliding groove (11).
3. The solid dispersion preparation drying apparatus as described in claim 2, characterized in that, A cylinder (12) is rotatably connected to the second housing (2), and the output end of the cylinder (12) is rotatably connected to the slider (5).
4. The solid dispersion preparation drying apparatus as described in claim 1, characterized in that, The first rotating plate (3) has a first filter part (31), a first sealing part (32) and a first through part (33). The first filter part (31) has a plurality of evenly distributed ventilation holes, and the first through part (33) has a through opening. The second rotating plate (4) has a second filter section (41), a second sealing section (42) and a second through section (43). The second filter section (41) is also provided with a number of evenly distributed ventilation holes, and the second through section (43) is also provided with a through opening.
5. The solid dispersion preparation drying apparatus as described in claim 4, characterized in that, The first state is formed when the first filter section (31) and the second filter section (41) overlap; The second state is formed when the first sealing part (32) and the second sealing part (42) overlap; The third state is formed when the first through portion (33) and the second through portion (43) overlap.
6. The solid dispersion preparation drying apparatus as described in claim 1, characterized in that, The stirring part (6) is made of a material with thermal conductivity. The stirring part (6) is hollow inside and has two through sides. It is connected to the first air duct (71) through a bearing. The first air duct (71) is supplied with drying hot air by the air source (7). The air source (7) is also provided with a second air duct (72). The second air duct (72) is connected to the second housing (2).
7. The solid dispersion preparation drying apparatus as described in claim 1, characterized in that, The second housing (2) has a feeding section (21) and an isolation section (22) is inserted inside the feeding section (21).
8. The solid dispersion preparation drying apparatus as described in claim 1, characterized in that, The second housing (2) is also fixed with a number of isolation columns (23), and a number of isolation plates (24) are provided in the second housing (2) corresponding to the isolation columns (23). The two adjacent isolation plates (24) enclose each other to form a feeding channel.
9. The solid dispersion preparation drying apparatus as described in claim 1, characterized in that, It also includes a drive source (8), which is connected to the stirring part (6) via a transmission assembly (81).
10. A solid dispersion preparation drying apparatus as described in claim 1, characterized in that, The bottom of the first housing (1) is provided with a discharge port.