Preparation method of 3-ethoxy isoamyl propionate

The two-step synthetic route for the preparation of isoamyl 3-ethoxypropionate solves the problems of difficult raw material acquisition and purification in existing technologies, and realizes the preparation of high-purity and low-cost isoamyl 3-ethoxypropionate, which is suitable for high-end coatings and inks.

CN121698744APending Publication Date: 2026-03-20EASOURCE NEW MATERIAL CO LTD
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Patent Information

Application Number
CN202511899529.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-16
Publication Date
2026-03-20

AI Technical Summary

Technical Problem

In the existing technology, the synthesis method of isoamyl 3-ethoxypropionate has problems such as the difficulty in obtaining raw materials, many side reactions, difficulty in product separation, low yield and great difficulty in purification, which limits its application in high-end fields.

Method used

A two-step synthetic route was adopted. First, ethyl 3-ethoxypropionate intermediate was prepared by the addition reaction of ethanol and ethyl acrylate. A polymerization inhibitor was added to control the reaction temperature, and the product was purified by vacuum distillation after neutralization. Then, isoamyl 3-ethoxypropionate was prepared by transesterification. The conversion rate and purity were improved by using an ethanol recovery system and vacuum distillation technology.

Benefits of technology

A high-purity, low-cost preparation of isoamyl 3-ethoxypropionate has been achieved, exhibiting good solubility and color development, making it suitable for high-end coatings and inks and meeting the needs of industrial production.

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Abstract

The invention relates to a preparation method of 3-ethoxy isoamyl propionate, and belongs to the technical field of organic solvent synthesis. The preparation method of the 3-ethoxy isoamyl propionate comprises the following steps: S1, adding ethanol, a polymerization inhibitor and a catalyst A into a reaction kettle, heating to 40-55 DEG C, then dropwise adding ethyl acrylate, preserving heat, and carrying out addition reaction for 1-3 hours to obtain a reaction mixture; s2, adding an acidic material for neutralization, and carrying out vacuum rectification to obtain ethyl 3-ethoxypropionate; s3, adding ethyl 3-ethoxypropionate and a catalyst B into a reaction kettle, heating to 100-120 DEG C, introducing isoamyl alcohol, controlling the reaction temperature to 100-115 DEG C, and carrying out transesterification for 2.5-4 hours to obtain a crude product; and S4, cooling to stop the reaction, separating to remove the catalyst B, and carrying out reduced pressure rectification on the obtained crude product to obtain the 3-ethoxypropionic acid isoamyl ester. The method has the effects of mild process, high conversion rate and high product yield.
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