Bone mineralization particles based on bacterial fermentation platform as well as preparation method and application of bone mineralization particles

Bone mineralization particles were prepared by a bacterial fermentation platform, and calcium carbonate and magnesium carbonate precipitates were generated by fermentation with Pasteurella multocida. This solved the problem of matching mechanical strength and degradation rate in existing bone repair materials, and improved biocompatibility and osteogenic properties.

CN121714770APending Publication Date: 2026-03-24SUZHOU XIANJUE NEW MATERIALS TECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-02-25
Publication Date
2026-03-24

AI Technical Summary

Technical Problem

Existing bone repair materials face challenges in terms of mechanical strength, degradation rate matching, and immune microenvironment regulation, making it difficult to meet the needs of bone repair.

Method used

Bone mineralization particles were prepared using a bacterial fermentation platform. Calcium carbonate and magnesium carbonate precipitates were generated through fermentation with Pasteurella multocida, which then combined with magnesium chloride and calcium chloride to form bone mineralization materials.

Benefits of technology

The prepared bone mineralization particles have good biocompatibility and osteogenic properties. The synthesis process is economical and energy-saving, and has the potential to promote the development of bone repair materials towards biocompatibility and functional synergy.

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Abstract

The invention relates to a bone repair material and a preparation method thereof, and discloses bone mineralization particles based on a bacterial fermentation platform as well as a preparation method and application of the bone mineralization particles. The preparation method comprises: preparing a bacterial liquid and a mineralization culture medium; uniformly mixing the mineralization culture medium with magnesium chloride and calcium chloride, culturing the system in a shaking table at 37 DEG C, and finally freeze-drying to obtain the bone mineralization particles based on the bacterial fermentation platform. The bone mineralization particles based on the bacterial fermentation platform are successfully constructed, the bone mineralization material is synthesized through a mode of combining fermentation of sporosarcina pasteurii with magnesium chloride and calcium chloride, the bone mineralization material is good in biocompatibility and excellent in osteogenesis promoting performance, the synthesis process is economical, energy-saving and efficient, and the bone mineralization material is suitable for large-scale popularization and application. The bone repair material is expected to become the main force of promoting the bone repair material to evolve to a new generation of biological materials with biological adaptation and function cooperation.
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