Hose pump filling system with CIP and SIP functions and control method thereof

By designing a tubular pump filling system with CIP and SIP functions, online cleaning and sterilization of the tubular pump were achieved, solving the problems of cumbersome operation and poor cleaning effect in the existing technology, meeting the GMP specifications for aseptic filling of formulations, and improving cleaning efficiency and safety.

CN121734760APending Publication Date: 2026-03-27CHANGSHA ZENITHSUN INTELLIGENCE QUANTITATIVE TECH CO LTD
View PDF 0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-26
Publication Date
2026-03-27

AI Technical Summary

Technical Problem

Existing hose pumps have poor online cleaning and sterilization effects in pharmaceutical production, are cumbersome to operate, time-consuming and labor-intensive, do not comply with GMP standards, and pose a risk of contamination.

Method used

Design a hose pump filling system with CIP and SIP functions, including a buffer tank, a distributor, a roller clamping assembly, a bypass clamp, a filling clamp, a filling pump tube, a filling outlet hose, a bypass cleaning hose, a bypass cleaning collection tube, and a filling syringe box. Online cleaning and sterilization are achieved through pneumatic control valves and diaphragm valves. Parallel filling outlet hoses and bypass cleaning hoses are connected to the filling syringe box to achieve overall cleaning and sterilization of the buffer tank, distributor, filling pump tube, and tailpipe.

Benefits of technology

It improves the cleaning efficiency of the tubing pump, meets the GMP requirements for aseptic filling of formulations, reduces operation time and labor costs, and lowers the risk of contamination.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN121734760A_ABST
    Figure CN121734760A_ABST
Patent Text Reader

Abstract

The invention discloses a hose pump filling system with CIP and SIP functions and a control method thereof.In the filling system, a buffer tank is connected to a liquid separator through a first connecting pipe, a plurality of filling pump pipes are arranged at the liquid outlet end of the liquid separator, and roller pipe pressing assemblies are arranged on the outer sides of the filling pump pipes; a filling liquid outlet hose and a bypass cleaning hose which are arranged side by side are arranged at the liquid outlet end of the filling pump pipe, the filling liquid outlet hose is connected to the needle filling box, and the bypass cleaning hose is connected to the needle filling box through a bypass cleaning collecting pipe; an upper discharge port is formed in the top end of the needle filling box, a lower discharge port is formed in the bottom end of the needle filling box, the upper discharge port is connected to the tail discharge pipe through a second connecting pipe, the lower discharge port is connected to the tail discharge pipe through a third connecting pipe, and the second connecting pipe and the third connecting pipe are arranged in parallel. The cleaning device has the characteristics of simple principle, convenience in operation, high cleaning efficiency, low pollution degree and the like, and the working efficiency of the hose pump filling system is improved.
Need to check novelty before this filing date? Find Prior Art

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of soft tube fluid transmission, in particular to a soft tube pump filling system with CIP and SIP functions and a control method thereof. BACKGROUND

[0002] At present, the soft tube transmission pump using soft tube as a carrier is widely used in the medical field, and the soft tube of the soft tube transmission pump needs to be cleaned and sterilized in the medical production environment with high production requirements. Since the soft tube pump mainly transmits fluid by extruding the soft tube, if the extrusion of the soft tube is not good in the online cleaning and sterilization, the extrusion of the soft tube usually needs to be disassembled from the pump body for cleaning, sterilization and other operations, and after sterilization, it is installed back into the pump body, which has defects such as troublesome operation, time-consuming and laborious, increasing the cost of enterprise labor, reducing work efficiency and the like.

[0003] The existing joint connecting the soft tube pump and the extrusion soft tube at both ends adopts a straight-through joint to ensure that the fluid is transmitted without resistance. When online cleaning and sterilization is performed, if the inner diameter of the extrusion soft tube is much larger than the inner diameter of the transmission soft tube at the needle filling end and the distributor end, the flow rate difference of the cleaning liquid exists in each section of the soft tube, the inner wall of the transmission soft tube at the needle filling end and the distributor end can be cleaned, but the cleaning degree of the inner wall of the extrusion soft tube is difficult to achieve the expected effect, and offline cleaning and sterilization are often used. In sterile preparation, it does not meet the requirements of relevant GMP specifications, and there is a risk of contamination. SUMMARY

[0004] The technical problem to be solved by the present application is to overcome the poor online cleaning and sterilization effect of the extrusion soft tube in the existing soft tube pump, and to provide a soft tube pump filling system with CIP and SIP functions and a control method thereof, which has simple principle, convenient operation, high cleaning efficiency and small pollution.

[0005] In order to solve the above technical problems, the technical scheme adopted by the present application is: A soft tube pump filling system with CIP and SIP functions, comprising: a buffer tank, a distributor, a roller tube pressing assembly, a bypass pinch tube, a filling pinch tube, a filling pump tube, a filling outflow soft tube, a bypass cleaning soft tube, a bypass cleaning collection tube and a needle filling box; The buffer tank is connected to the distributor through a first connecting pipe, the outflow end of the distributor is provided with a plurality of filling pump tubes, the outer side of the filling pump tube is provided with a roller tube pressing assembly, the outflow end of the filling pump tube is provided with a filling outflow soft tube and a bypass cleaning soft tube arranged side by side, the filling outflow soft tube is connected to the needle filling box, and the bypass cleaning soft tube is connected to the needle filling box through the bypass cleaning collection tube; The top end of the needle filling box is provided with an upper discharge port, the bottom end of the needle filling box is provided with a lower discharge port, the upper discharge port is connected to the tail discharge pipe through a second connecting pipe, the lower discharge port is connected to the tail discharge pipe through a third connecting pipe, and the second connecting pipe and the third connecting pipe are arranged in parallel. As a further improvement of the present application, the buffer tank is provided with a lye inlet with a first pneumatic control valve, a water inlet with a second pneumatic control valve, a steam inlet with a third pneumatic control valve, a chemical liquid inlet with a fourth pneumatic control valve and a compressed air inlet with a fifth pneumatic control valve; the lye inlet, the water inlet and the compressed air inlet are arranged in parallel on the same feed pipe, and a cleaning ball is arranged at the outlet of the feed pipe. As a further improvement of the present application, the first connecting pipe is provided with a first pneumatic diaphragm valve, a temperature sensor and a pressure sensor; the first connecting pipe passes through the distributor and is in communication with the liquid inlet of the liquid inlet connecting pipe in the distributor, and the liquid outlet of the liquid inlet connecting pipe is in communication with the filling pump pipe; the outlet of the first connecting pipe outside the distributor is provided with a first connecting branch pipe and a second connecting branch pipe in parallel, both of which are in communication with the tail discharge pipe, the first connecting branch pipe is provided with a second pneumatic diaphragm valve, and the second connecting branch pipe is provided with a third pneumatic diaphragm valve. As a further improvement of the present application, the bypass cleaning collection pipe is provided with a first temperature transmitter; the side of the needle filling box is provided with a second temperature transmitter; the second connecting pipe is provided with a fifth pneumatic diaphragm valve, and the third connecting pipe is provided with a fourth pneumatic diaphragm valve. As a further improvement of the present application, the tail discharge pipe is provided with a first tail discharge branch pipe and a second tail discharge branch pipe in parallel, the front ends of the first tail discharge branch pipe and the second tail discharge branch pipe are provided with a pressure transmitter and a third temperature transmitter, and the rear ends of the first tail discharge branch pipe and the second tail discharge branch pipe are provided with a sampling valve and an electric conductivity detector; the outlet of the tail discharge pipe is connected to a floor drain. As a general technical concept, the present application also provides a control method of the hose pump filling system with CIP and SIP functions, the control method comprising cleaning control, when the cleaning control is performed, comprising the following steps: Step S1, pressure holding leak detection: the pressure holding pressure value is set to 2.0±0.2bar, the pressure holding time is set to 180±10s, the first pneumatic control valve is closed, the second pneumatic control valve is closed, the third pneumatic control valve is closed, the fourth pneumatic control valve is closed, the fifth pneumatic control valve is opened, the first pneumatic diaphragm valve is opened, the rollers of the roller pressure pipe assembly are opened, the bypass pinch valve is opened, the filling pinch valve is opened, the second pneumatic diaphragm valve is closed, the fourth pneumatic diaphragm valve is opened, the fifth pneumatic diaphragm valve is opened, the sixth pneumatic diaphragm valve is closed, the flow regulating valve is closed, and the third pneumatic diaphragm valve is closed; after the pressure holding is completed, the flow regulating valve is opened, the pressure reduction time is set to 30±2s, and when the pressure detection is 0, the flow regulating valve is closed; Step S2, the buffer tank and the distributor are cleaned with water or alkali solution; Step S3, the pump pipeline and the needle filling box are cleaned with water or alkali solution online; Step S4, residual gas charging and purging: gas charging and purging are performed, the purging pressure in the buffer tank is set to the lower limit 2.5±0.2bar and the upper limit 3.0±0.2bar, automatic air supply is performed, the time is set to 1200±10s, the first pneumatic control valve is closed, the second pneumatic control valve is closed, the third pneumatic control valve is closed, the fourth pneumatic control valve is closed, the fifth pneumatic control valve is opened, the first pneumatic diaphragm valve is opened, the rollers of the roller pressure pipe assembly are opened, the bypass pinch valve is opened, the filling pinch valve is opened, the second pneumatic diaphragm valve and the third pneumatic diaphragm valve are opened and closed in cycles for 10s, the fourth pneumatic diaphragm valve and the fifth pneumatic diaphragm valve are alternately opened and closed at intervals of 10s, the sixth pneumatic diaphragm valve is closed, and the flow regulating valve is opened.

[0006] As a further improvement of the present application, the control method further comprises sterilization control, when the sterilization control is performed, comprising the following steps: Step Y1, initial condensate discharge: the third pneumatic control valve of the steam inlet is opened, the initial condensate is discharged, the buffer tank, the filling pump and the distributor are emptied, and the sterilization pipeline is preheated at the same time, the time is set to 120±10s, the first pneumatic control valve is closed, the second pneumatic control valve is closed, the third pneumatic control valve is opened, the fourth pneumatic control valve is closed, the fifth pneumatic control valve is closed, the first pneumatic diaphragm valve is opened, the rollers of the roller pressure pipe assembly are opened, the bypass pinch valve is opened, the filling pinch valve is opened, the second pneumatic diaphragm valve and the third pneumatic diaphragm valve are opened and closed at intervals of 10s, the fourth pneumatic diaphragm valve and the fifth pneumatic diaphragm valve are alternately opened and closed at intervals of 10s, the sixth pneumatic diaphragm valve is closed, and the flow regulating valve is opened; Step Y2, sterilization: sterilization pressure set 2.0±0.1bar, sterilization temperature set 120±5℃; temperature rise to filling system temperature greater than the preset value, into the sterilization time starting point definition phase, sterilization time set for 1800±10s; the first pneumatic control valve closed, the second pneumatic control valve closed, the third pneumatic control valve open, the fourth pneumatic control valve closed, the fifth pneumatic control valve closed, the first pneumatic diaphragm valve open, the roller of the roller pressure pipe assembly open, the bypass pinch valve open, the filling pinch valve open, the second pneumatic diaphragm valve closed, the third pneumatic diaphragm valve open, the fourth pneumatic diaphragm valve and the fifth pneumatic diaphragm valve open alternately at intervals of 10s, the sixth pneumatic diaphragm valve open, the flow regulating valve closed; Step Y3, pressure relief: after sterilization, close the third pneumatic control valve of the steam inlet, open the flow regulating valve, and perform pressure relief. When the pressure detection is 0.1bar, close the sixth pneumatic diaphragm valve and the flow regulating valve; Step Y4, use air purge to reduce temperature, purge pressure in the buffer tank is set to lower limit 2.5±0.2bar, upper limit 3.0±0.2bar, automatically supplement air, set temperature to 30±2℃; the first pneumatic control valve closed, the second pneumatic control valve closed, the third pneumatic control valve closed, the fourth pneumatic control valve closed, the fifth pneumatic control valve open, the first pneumatic diaphragm valve open, the roller of the roller pressure pipe assembly open, the bypass pinch valve open, the filling pinch valve open, the second pneumatic diaphragm valve and the third pneumatic diaphragm valve cycle open 10s, close 50s, the fourth pneumatic diaphragm valve and the fifth pneumatic diaphragm valve open alternately at intervals of 10s, the sixth pneumatic diaphragm valve closed, the flow regulating valve open; when the temperature decreases to 30℃, close the fifth pneumatic control valve, when the pressure detection is 0.1bar, close the second pneumatic diaphragm valve, the third pneumatic diaphragm valve, the sixth pneumatic diaphragm valve and the flow regulating valve. As a further improvement of the present application, in step S2, when performing clean water cleaning, the cleaning ball in the buffer tank sprays cleaning, the first pneumatic control valve closed, the second pneumatic control valve open, the third pneumatic control valve closed, the fourth pneumatic control valve closed, the fifth pneumatic control valve closed, the first pneumatic diaphragm valve open, the roller of the roller pressure pipe assembly closed, the bypass pinch valve closed, the filling pinch valve closed, the second pneumatic diaphragm valve open, the fourth pneumatic diaphragm valve closed, the fifth pneumatic diaphragm valve closed, the sixth pneumatic diaphragm valve closed, the flow regulating valve closed, the third pneumatic diaphragm valve open; flush time set for 300±10s, conductivity set 2.0±0.1us / cm, if conductivity fails to judge, re-clean until the conductivity reaches the set requirement; When the alkaline cleaning is carried out, the cleaning ball in the buffer tank sprays the alkaline cleaning, the first pneumatic control valve is opened, the second pneumatic control valve is closed, the third pneumatic control valve is closed, the fourth pneumatic control valve is closed, the fifth pneumatic control valve is closed, and the first pneumatic diaphragm valve is closed; the cleaning liquid level is set to 80% of the volume of the buffer tank, the alkaline liquid is not discharged, and after reaching the preset liquid level, the spraying of the alkaline liquid is stopped; When the alkaline cleaning is carried out, the cleaning ball in the buffer tank sprays the alkaline cleaning, the first pneumatic control valve is opened, the second pneumatic control valve is closed, the third pneumatic control valve is closed, the fourth pneumatic control valve is closed, the fifth pneumatic control valve is closed, and the first pneumatic diaphragm valve is closed; the cleaning liquid level is set to 80% of the volume of the buffer tank, the alkaline liquid is not discharged, and after reaching the preset liquid level, the spraying of the alkaline liquid is stopped; As a further improvement of the present application, when the water cleaning is carried out in step S3, the cleaning liquid level of the buffer tank is set to 30% of the volume of the buffer tank, the purge pressure in the buffer tank is set to the lower limit of 2.5±0.2bar and the upper limit of 3.0±0.2bar, the water and gas are automatically supplemented, the cleaning time is set to 300±10s, the first pneumatic control valve is closed, the second pneumatic control valve is opened, the third pneumatic control valve is closed, the fourth pneumatic control valve is closed, the fifth pneumatic control valve is opened, the first pneumatic diaphragm valve is opened, the rollers of the roller tube assembly are opened, the bypass pinch valve is opened, the filling pinch valve is opened, the second pneumatic diaphragm valve is closed, the third pneumatic diaphragm valve is closed, the fourth pneumatic diaphragm valve and the fifth pneumatic diaphragm valve are alternately opened and closed at intervals of 10s, the sixth pneumatic diaphragm valve is closed, and the flow regulating valve is opened; the conductivity is set to 2.0±0.1us / cm, and if the conductivity fails to meet the requirements, the cleaning is restarted until the conductivity meets the set requirements; When the alkaline cleaning is carried out, the cleaning ball in the buffer tank sprays the alkaline cleaning, the first pneumatic control valve is opened, the second pneumatic control valve is closed, the third pneumatic control valve is closed, the fourth pneumatic control valve is closed, the fifth pneumatic control valve is closed, and the first pneumatic diaphragm valve is closed; the cleaning liquid level is set to 80% of the volume of the buffer tank, the alkaline liquid is not discharged, and after reaching the preset liquid level, the spraying of the alkaline liquid is stopped; Lye soaking, first pneumatic control valve closed, second pneumatic control valve closed, third pneumatic control valve closed, fourth pneumatic control valve closed, fifth pneumatic control valve closed, first pneumatic diaphragm valve opened, rollers of the roller press pipe assembly spread, bypass pinch valve opened, filling pinch valve opened, second pneumatic diaphragm valve closed, third pneumatic diaphragm valve closed, fourth pneumatic diaphragm valve opened, fifth pneumatic diaphragm valve opened, sixth pneumatic diaphragm valve closed, flow regulating valve closed, and the lye soaking time is set as 600±10s. As a further improvement of the present application, in step Y2, if the temperature of the filling system is kept greater than the preset temperature for 180s, the sterilization starts timing, and the equipment enters the sterilization stage; if the temperature of the filling system fails to keep for the set time, the timing is restarted until the temperature of the filling system is kept for more than 210s, and the sterilization stage is entered. Compared with the prior art, the present application has the following advantages: The hose pump filling system with CIP and SIP functions and the control method thereof have the following advantages: the buffer tank, the distributor, the filling pump pipe, the filling needle box and the tail discharge pipe are connected into an integral whole, clean water or lye can be conveyed to the distributor, the filling pump pipe and the filling needle box through the buffer tank for online cleaning, high-temperature steam can be conveyed to the distributor, the filling pump pipe and the filling needle box through the buffer tank for online sterilization, and pressurized gas can be conveyed to the distributor, the filling pump pipe and the filling needle box through the buffer tank for purging and drying, the effectiveness of cleaning and sterilization of the direct contact channel with the liquid is improved, and the requirements of the relevant GMP specifications in aseptic filling of preparations are met. BRIEF DESCRIPTION OF DRAWINGS

[0007] Figure 1 It is a structural principle schematic diagram of the hose pump filling system in the embodiment of the present application; Figure 2 It is a structural principle schematic diagram of the hose pump filling system in the embodiment of the present application when pressure maintaining and leakage detection are performed; Figure 3 It is a structural principle schematic diagram of the hose pump filling system in the embodiment of the present application when online cleaning of the buffer tank and the distributor is performed; Figure 4 It is a structural principle schematic diagram of the hose pump filling system in the embodiment of the present application when online cleaning of the pump pipe and the filling needle box is performed; Figure 5 It is a structural principle schematic diagram of the hose pump filling system in the embodiment of the present application when air charging and purging are performed; Figure 6 The structure principle schematic diagram for alkali liquor cleaning of the buffer tank in the hose pump filling system in the specific embodiment of the present application is shown in the figure; Figure 7 The structure principle schematic diagram for alkali liquor filling of the distributor and the discharge pipeline in the hose pump filling system in the specific embodiment of the present application is shown in the figure; Figure 8 The structure principle schematic diagram for alkali liquor filling of the pump pipeline and the filling needle box discharge pipeline in the hose pump filling system in the specific embodiment of the present application is shown in the figure; Figure 9 The structure principle schematic diagram for alkali liquor soaking in the hose pump filling system in the specific embodiment of the present application is shown in the figure; Figure 10 The structure principle schematic diagram for initial discharge of condensate in the hose pump filling system in the specific embodiment of the present application is shown in the figure; Figure 11 The structure principle schematic diagram for sterilization in the hose pump filling system in the specific embodiment of the present application is shown in the figure; Legend: 1, alkali liquor inlet; 2, first pneumatic control valve; 3, water inlet; 4, second pneumatic control valve; 5, steam inlet; 6, third pneumatic control valve; 7, liquid medicine inlet; 8, fourth pneumatic control valve; 9, cleaning ball; 10, buffer tank; 11, first pneumatic diaphragm valve; 12, temperature sensor; 13, pressure sensor; 14, distributor; 15, second pneumatic diaphragm valve; 16, third pneumatic diaphragm valve; 17, roller pipe pressing assembly; 18, bypass pinch valve; 19, filling pinch valve; 20, fourth pneumatic diaphragm valve; 21, fifth pneumatic diaphragm valve; 22, sixth pneumatic diaphragm valve; 23, flow regulating valve; 24, liquid inlet connecting pipe; 25, lower joint; 26, filling pump pipe; 27, upper joint; 28, filling liquid outlet hose; 29, bypass cleaning hose; 30, first temperature transmitter; 31, bypass cleaning collection pipe; 32, first water valve; 33, conductivity detector; 34, sampling valve; 35, safety valve; 36, weighing sensor; 37, filling needle; 38, filling needle box; 39, upper discharge port; 40, second temperature transmitter; 41, lower discharge port; 42, pressure transmitter; 43, third temperature transmitter; 44, second water valve; 45, floor drain; 46, main machine table; 47, compressed air inlet; 48, fifth pneumatic control valve; 100, first connecting pipe; 101, first connecting branch pipe; 102, second connecting branch pipe; 201, second connecting pipe; 202, third connecting pipe; 300, tail discharge pipe; 301, first tail discharge branch pipe; 302, second tail discharge branch pipe. DETAILED DESCRIPTION

[0008] The present application is further described below in conjunction with the drawings and specific preferred embodiments, but the protection scope of the present application is not limited thereby.

[0009] In the description of the present application, it should be understood that the terms "side", "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, which are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application.

[0010] In addition, the terms "first" and "second" are only for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the technical features indicated, so that the features with "first" and "second" can include one or more of the features explicitly or implicitly, and in the description of the present application, the meaning of "multiple" is two or more, unless otherwise explicitly and specifically limited.

[0011] Embodiment As Figure 1 shown, the hose pump filling system with CIP and SIP functions of the present application comprises a buffer tank 10, a distributor 14, a roller tube pressing assembly 17, a bypass pinch tube 18, a filling pinch tube 19, a filling pump tube 26, a filling outlet hose 28, a bypass cleaning hose 29, a bypass cleaning collection tube 31 and a filling needle box 38. The distributor 14, the roller tube pressing assembly 17, the filling pump tube 26 and the filling needle box 38 are all arranged on the main machine table plate 46.

[0012] The buffer tank 10 is connected to the distributor 14 through a first connecting tube 100, the outlet end of the distributor 14 is provided with a plurality of filling pump tubes 26, the outer side of the filling pump tube 26 is provided with a roller tube pressing assembly 17, the filling pump tube 26 is pressed through the roller tube pressing assembly 17 to realize material filling. The outlet end of the filling pump tube 26 is provided with a filling outlet hose 28 and a bypass cleaning hose 29 arranged side by side, the filling outlet hose 28 is connected to the filling needle box 38 and connected with the filling needle 37 to carry out material filling, the bypass cleaning hose 29 is connected to the filling needle box 38 through the bypass cleaning collection tube 31 to facilitate the filling needle box 38 to carry out online cleaning and sterilization.

[0013] The syringe filling box 38 has an upper discharge port 39 at its top and a lower discharge port 41 at its bottom. The upper discharge port 39 is connected to the tail drain pipe 300 via a second connecting pipe 201, and the lower discharge port 41 is connected to the tail drain pipe 300 via a third connecting pipe 202. The second connecting pipe 201 and the third connecting pipe 202 are connected in parallel. During online cleaning and sterilization, the cleaning solution or high-temperature steam in the syringe filling box 38 can be discharged from either the upper discharge port 39 or the lower discharge port 41. Simultaneously, a second temperature transmitter 40 is installed on the side of the syringe filling box 38 to monitor temperature changes within the syringe filling box 38 in real time.

[0014] In this embodiment, the buffer tank 10 is connected to the distributor 14 via a first connecting pipe 100, and the first connecting pipe 100 is also connected to the filling pump pipe 26. A parallel filling outlet hose 28 and a bypass cleaning hose 29 are provided at the outlet end of the filling pump pipe 26. Both the filling outlet hose 28 and the bypass cleaning hose 29 are connected to the filling needle box 38. The filling needle box 38 has discharge ports at its top and bottom, which are connected to the tail drain pipe 300. Thus, the buffer tank 10, distributor 14, filling pump pipe 26, filling needle box 38, and tail drain pipe are connected. The 300 units are connected as a whole, which facilitates the delivery of clean water or alkaline solution to the dispenser 14, filling pump line 26 and filling syringe 38 through the buffer tank 10 for online cleaning. It can also deliver high-temperature steam to the dispenser 14, filling pump line 26 and filling syringe 38 through the buffer tank 10 for online sterilization. Furthermore, it can deliver pressurized gas to the dispenser 14, filling pump line 26 and filling syringe 38 through the buffer tank 10 for purging and drying. This improves the effectiveness of cleaning and sterilization of the channels that are in direct contact with the liquid, and meets the relevant GMP requirements for aseptic filling formulations.

[0015] like Figure 1 As shown, the buffer tank 10 is equipped with an alkali inlet 1 with a first pneumatic control valve 2, a water inlet 3 with a second pneumatic control valve 4, a steam inlet 5 with a third pneumatic control valve 6, a pharmaceutical inlet 7 with a fourth pneumatic control valve 8, and a compressed air inlet 47 with a fifth pneumatic control valve 48. The alkali inlet 1, water inlet 3, and compressed air inlet 47 are connected in parallel on the same feed pipe, and a cleaning ball 9 is provided at the outlet of the feed pipe. The material enters the buffer tank 10 after being sprayed by the cleaning ball 9.

[0016] In this embodiment, a safety valve 35 is also provided at the top of the buffer tank 10 to release the pressure inside the buffer tank 10 and improve the safety of the buffer tank 10. A weighing sensor 36 is also provided at the bottom of the buffer tank 10 to monitor the weight change of the buffer tank 10 in real time, so as to keep track of the dosage of the agent. like Figure 1As shown, the first connecting pipe 100 is provided with a first pneumatic diaphragm valve 11, a temperature sensor 12 and a pressure sensor 13. The first connecting pipe 100 crosses in the distributor 14 and communicates with the liquid inlet of the liquid inlet connecting pipe 24 in the distributor 14, the liquid outlet of the liquid inlet connecting pipe 24 communicates with the lower joint 25 of the filling pump pipe 26, the upper joint 27 of the filling pump pipe 26 communicates with the filling liquid outlet hose 28 and the bypass cleaning hose 29, and the material in the buffer tank 10 can be delivered to the filling pump pipe 26 through the first connecting pipe 100 and the distributor 14. At the same time, the first connecting pipe 100 is provided with a parallel first connecting branch pipe 101 and a second connecting branch pipe 102 at the outlet outside the distributor 14, the first connecting branch pipe 101 and the second connecting branch pipe 102 both communicate with the tail pipe 300, and the first connecting branch pipe 101 is provided with a second pneumatic diaphragm valve 15, the second connecting branch pipe 102 is provided with a third pneumatic diaphragm valve 16 and a first water valve 32, and the first water valve 32 can be normally open.

[0017] As shown in Figure 1 The filling liquid outlet hose 28 is provided with a filling pinch valve 19, the bypass cleaning hose 29 is provided with a bypass pinch valve 18, the bypass cleaning collection pipe 31 is provided with a first temperature transmitter 30, the second connecting pipe 201 is provided with a fifth pneumatic diaphragm valve 21, and the third connecting pipe 202 is provided with a fourth pneumatic diaphragm valve 20.

[0018] As shown in Figure 1 The tail pipe 300 is provided with a parallel first tail branch pipe 301 and a second tail branch pipe 302. The first tail branch pipe 301 is provided with a sixth pneumatic diaphragm valve 22 and a second water valve 44, the second water valve 44 can be normally open, and the second tail branch pipe 302 is provided with a flow regulating valve 23. The front ends of the first tail branch pipe 301 and the second tail branch pipe 302 are provided with a pressure transmitter 42 and a third temperature transmitter 43, and the rear ends of the first tail branch pipe 301 and the second tail branch pipe 302 are provided with a sampling valve 34 and a conductivity detector 33; the outlet of the tail pipe 300 is connected to a floor drain 45.

[0019] The embodiment also provides a control method based on the above-mentioned soft pipe pump filling system with CIP and SIP functions, when the cleaning control is performed, comprising the following steps: Step S1, pressure holding leak detection: pressure holding pressure value is set to 2.0 bar, pressure holding time is set to 180 s, first pneumatic control valve 2 is closed, second pneumatic control valve 4 is closed, third pneumatic control valve 6 is closed, fourth pneumatic control valve 8 is closed, fifth pneumatic control valve 48 is opened, first pneumatic diaphragm valve 11 is opened, roller of roller tube assembly 17 is opened, bypass pinch valve 18 is opened, filling pinch valve 19 is opened, second pneumatic diaphragm valve 15 is closed, fourth pneumatic diaphragm valve 20 is opened, fifth pneumatic diaphragm valve 21 is opened, sixth pneumatic diaphragm valve 22 is closed, flow regulating valve 23 is closed, third pneumatic diaphragm valve 16 is closed. As shown in the figure, Figure 2 As shown in the middle red line, compressed air enters the buffer tank 10 through the compressed air inlet 47 and the fifth pneumatic control valve 48, and then is transported to the distributor 14, the filling pump tube 26, the filling liquid outlet hose 28, the bypass cleaning hose 29, the bypass cleaning collection tube 31 and the needle filling box 38 through the first connecting tube 100, and then flows into the tail exhaust tube 300 through the upper exhaust port 39 and the lower exhaust port 41 to detect the sealing state of the filling system. During the pressure holding process, if the pressure value decreases by 10% or less from the initial value, the pressure test is successful, otherwise the pressure test fails. If the pressure test fails, there is a leak, and the equipment is checked and then re-pressurized until the pressure holding is passed. After the pressure holding is finished, the flow regulating valve 23 is opened to release the pressure, and the pressure reduction time is set to 30 s. When the pressure is detected to be 0, the flow regulating valve 23 is closed.

[0020] Step S2, when the buffer tank 10 and the distributor 14 are cleaned with clean water, the cleaning ball 9 in the buffer tank 10 sprays cleaning, the first pneumatic control valve 2 is closed, the second pneumatic control valve 4 is opened, the third pneumatic control valve 6 is closed, the fourth pneumatic control valve 8 is closed, the fifth pneumatic control valve 48 is closed, the first pneumatic diaphragm valve 11 is opened, the roller of the roller tube assembly 17 is closed, the bypass pinch valve 18 is closed, the filling pinch valve 19 is closed, the second pneumatic diaphragm valve 15 is opened, the fourth pneumatic diaphragm valve 20 is closed, the fifth pneumatic diaphragm valve 21 is closed, the sixth pneumatic diaphragm valve 22 is closed, the flow regulating valve 23 is closed, and the third pneumatic diaphragm valve 16 is opened. As shown in the figure, Figure 3 As shown in the middle red line, clean water enters the buffer tank 10 through the water inlet 3 and the second pneumatic control valve 4, and then is transported to the distributor 14 through the first connecting tube 100, and finally is discharged to the tail exhaust tube 300 through the first connecting branch tube 101 and the second connecting branch tube 102. The flushing time of the buffer tank 10 and the distributor 14 is set to 300 s, and the conductivity is set to 2.0 us / cm. If the conductivity fails, the cleaning is restarted until the conductivity reaches the set requirement.

[0021] After the flushing is completed, the air purge is required to be emptied, the time is set to 300s, the purge pressure in the buffer tank 10 is set to the lower limit 2.5bar, the upper limit 3.0bar, and the automatic air supplement; the first pneumatic control valve 2 is closed, the second pneumatic control valve 4 is closed, the third pneumatic control valve 6 is closed, the fourth pneumatic control valve 8 is closed, the fifth pneumatic control valve 48 is opened, the first pneumatic diaphragm valve 11 is opened, the rollers of the roller pressure pipe assembly 17 are closed, the bypass pinch valve 18 is closed, the filling pinch valve 19 is closed, the second pneumatic diaphragm valve 15 is opened, the fourth pneumatic diaphragm valve 20 is closed, the fifth pneumatic diaphragm valve 21 is closed, the sixth pneumatic diaphragm valve 22 is closed, the flow regulating valve 23 is closed, and the third pneumatic diaphragm valve 16 is opened. As shown in the figure, Figure 3 As shown by the middle red line, the compressed air enters the buffer tank 10 from the compressed air inlet 47 and the fifth pneumatic control valve 48, then is transported to the distributor 14 by the first connecting pipe 100, and finally is discharged to the tail discharge pipe 300 by the first connecting branch pipe 101 and the second connecting branch pipe 102. When the pump pipeline and the filling needle box 38 are online cleaned with water, the cleaning liquid level of the buffer tank 10 is set to 30% of the volume of the buffer tank 10, the purge pressure in the buffer tank is set to the lower limit 2.5bar and the upper limit 3.0bar, the automatic water and air supplement, the cleaning time is set to 300s, the first pneumatic control valve 2 is closed, the second pneumatic control valve 4 is opened, the third pneumatic control valve 6 is closed, the fourth pneumatic control valve 8 is closed, the fifth pneumatic control valve 48 is opened, the first pneumatic diaphragm valve 11 is opened, the rollers of the roller pressure pipe assembly 17 are opened, the bypass pinch valve 18 is opened, the filling pinch valve 19 is opened, the second pneumatic diaphragm valve 15 is closed, the third pneumatic diaphragm valve 16 is closed, the fourth pneumatic diaphragm valve 20 and the fifth pneumatic diaphragm valve 21 are alternately opened and closed with an interval of 10s, the sixth pneumatic diaphragm valve 22 is closed, and the flow regulating valve 23 is opened. As shown in the figure, Figure 4 As shown by the middle red line, the water enters the buffer tank 10 from the water inlet 3 and the second pneumatic control valve 4, then is transported to the distributor 14 by the first connecting pipe 100, the filling pump pipe 26, the filling liquid hose 28, the bypass cleaning hose 29, the bypass cleaning collection pipe 31 and the filling needle box 38, and flows into the second tail discharge branch pipe 302 by the upper discharge port 39 and the lower discharge port 41, and finally is discharged to the floor drain 45. The conductivity is set to 2.0us / cm, if the conductivity fails to be judged, the cleaning is restarted until the conductivity reaches the set requirement. Step S4, Purging Residue: After cleaning, purge and empty the system. The purging pressure in the buffer tank 10 is set to a lower limit of 2.5 bar and an upper limit of 3.0 bar. Automatic air replenishment is performed, and the purging time is set to 1200 seconds. The first pneumatic control valve 2 is closed, the second pneumatic control valve 4 is closed, the third pneumatic control valve 6 is closed, the fourth pneumatic control valve 8 is closed, the fifth pneumatic control valve 48 is open, the first pneumatic diaphragm valve 11 is open, the rollers of the roller clamping assembly 17 are opened, the bypass clamp valve 18 is open, and the filling clamp valve 19 is open. The second pneumatic diaphragm valve 15 and the third pneumatic diaphragm valve 16 cycle between opening for 10 seconds and closing for 50 seconds. The fourth pneumatic diaphragm valve 20 and the fifth pneumatic diaphragm valve 21 alternately open and close at 10-second intervals. The sixth pneumatic diaphragm valve 22 is closed, and the flow regulating valve 23 is open. Figure 5 As shown by the red line, compressed air enters the cleaning ball 9 of the buffer tank 10 through the compressed air inlet 47 and the fifth pneumatic control valve 48. Part of the compressed air is transported by the first connecting pipe 100 to the distributor 14, the filling pump pipe 26, the filling outlet hose 28, the bypass cleaning hose 29, the bypass cleaning collection pipe 31, and the filling needle box 38, and flows into the second tail drain branch pipe 302 through the upper discharge port 39 and the lower discharge port 41. The other part of the compressed air passes through the distributor 14 and is discharged into the tail drain pipe 300 through the first connecting branch pipe 101 and the second connecting branch pipe 102 to complete the purging of the entire filling system.

[0022] In step S2 of this embodiment, when the buffer tank 10 and the distributor 14 are performing alkaline cleaning, the cleaning ball 9 in the buffer tank 10 sprays alkaline cleaning solution. The first pneumatic control valve 2 is open, the second pneumatic control valve 4 is closed, the third pneumatic control valve 6 is closed, the fourth pneumatic control valve 8 is closed, the fifth pneumatic control valve 48 is closed, and the first pneumatic diaphragm valve 11 is closed. The cleaning liquid level is set to 80% of the volume of the buffer tank 10. No alkaline solution is discharged. Once the preset liquid level is reached, the spraying of alkaline solution stops. Figure 6 As shown by the red line, the alkaline solution enters the cleaning ball 9 inside the buffer tank 10 through the alkaline solution inlet 1 and the first pneumatic control valve 2, and is stored in the buffer tank 10 to soak and clean the buffer tank 10.

[0023] When the soaking of the buffer tank 10 is completed, the purge pressure in the buffer tank 10 is set to a lower limit of 2.5 bar and an upper limit of 3.0 bar, the automatic air supply is turned on, the first pneumatic control valve 2 is closed, the second pneumatic control valve 4 is closed, the third pneumatic control valve 6 is closed, the fourth pneumatic control valve 8 is closed, the fifth pneumatic control valve 48 is opened, the first pneumatic diaphragm valve 11 is opened, the rollers of the roller tube assembly 17 are closed, the bypass pinch valve 18 is closed, the filling pinch valve 19 is closed, the second pneumatic diaphragm valve 15 is opened, the third pneumatic diaphragm valve 16 is opened, the fourth pneumatic diaphragm valve 20 is closed, the fifth pneumatic diaphragm valve 21 is closed, the sixth pneumatic diaphragm valve 22 and the second water valve 44 are closed, and the flow regulating valve 23 is closed. The alkali washing filling time is set to 30 s. As shown in FIG. 6, the alkali solution in the buffer tank 10 enters the distributor 14 through the first connecting pipe 100, and then is discharged into the tail pipe 300 through the first connecting branch pipe 101 and the second connecting branch pipe 102. Figure 7 As shown by the middle red line, the alkali solution in the buffer tank 10 enters the distributor 14 through the first connecting pipe 100, and then is discharged into the tail pipe 300 through the first connecting branch pipe 101 and the second connecting branch pipe 102.

[0024] In step S3 of the embodiment, when the pump pipeline and the filling needle box 38 are subjected to alkali cleaning, the purge pressure in the buffer tank is set to a lower limit of 2.5 bar and an upper limit of 3.0 bar, the automatic air supply is turned on, the first pneumatic control valve 2 is closed, the second pneumatic control valve 4 is closed, the third pneumatic control valve 6 is closed, the fourth pneumatic control valve 8 is closed, the fifth pneumatic control valve 48 is opened, the first pneumatic diaphragm valve 11 is opened, the rollers of the roller tube assembly 17 are opened, the bypass pinch valve 18 is opened, the filling pinch valve 19 is opened, the second pneumatic diaphragm valve 15 is closed, the third pneumatic diaphragm valve 16 is closed, the fourth pneumatic diaphragm valve 20 and the fifth pneumatic diaphragm valve 21 are alternately opened and closed at intervals of 10 s, the sixth pneumatic diaphragm valve 22 is closed, and the flow regulating valve 23 is opened. The alkali washing filling time is set to 30 s. As shown in FIG. 6, the alkali solution in the buffer tank 10 enters the distributor 14 through the first connecting pipe 100, and then is discharged into the tail pipe 300 through the first connecting branch pipe 101 and the second connecting branch pipe 102. Figure 8 As shown by the middle red line, the alkali solution in the buffer tank 10 enters the distributor 14 through the first connecting pipe 100, and then is discharged into the tail pipe 300 through the first connecting branch pipe 101 and the second connecting branch pipe 102.

[0025] When the alkali soaking is performed, the first pneumatic control valve 2 is closed, the second pneumatic control valve 4 is closed, the third pneumatic control valve 6 is closed, the fourth pneumatic control valve 8 is closed, the fifth pneumatic control valve 48 is closed, the first pneumatic diaphragm valve 11 is opened, the rollers of the roller tube assembly 17 are opened, the bypass pinch valve 18 is opened, the filling pinch valve 19 is opened, the second pneumatic diaphragm valve 15 is closed, the third pneumatic diaphragm valve 16 is closed, the fourth pneumatic diaphragm valve 20 is opened, the fifth pneumatic diaphragm valve 21 is opened, the sixth pneumatic diaphragm valve 22 is closed, the flow regulating valve 23 is closed, and the alkali soaking time is set to 600 s. As shown in FIG. 6, the alkali solution in the buffer tank 10 enters the distributor 14 through the first connecting pipe 100, and then is discharged into the tail pipe 300 through the first connecting branch pipe 101 and the second connecting branch pipe 102. Figure 9The alkali solution is soaked in the buffer tank 10, the first connecting pipe 100, the distributor 14, the filling pump pipe 26, the filling outflow hose 28, the bypass cleaning hose 29, the bypass cleaning collecting pipe 31 and the filling needle box 38 as shown by the medium red line.

[0026] It can be understood that after the alkali solution cleaning is completed, the filling system needs to be aerated and purged to discharge the alkali solution, and then the filling system is cleaned with clean water, and after the clean water cleaning is completed, aerated and purged again. The specific steps of clean water cleaning and aerated and purged are as described above, and will not be repeated here.

[0027] In this embodiment, when the sterilization control is performed, the following steps are included: Step Y1, initial discharge of condensate: open the third pneumatic control valve 6 of the steam inlet 5, initially discharge the condensate, empty the buffer tank 10, the filling pump and the distributor 14, and preheat the sterilization pipeline at the same time, the time is set to 120s, the first pneumatic control valve 2 is closed, the second pneumatic control valve 4 is closed, the third pneumatic control valve 6 is opened, the fourth pneumatic control valve 8 is closed, the fifth pneumatic control valve 48 is closed, the first pneumatic diaphragm valve 11 is opened, the rollers of the roller pressure pipe assembly 17 are opened, the bypass pinch valve 18 is opened, the filling pinch valve 19 is opened, the second pneumatic diaphragm valve 15 and the third pneumatic diaphragm valve 16 are opened and closed alternately at intervals of 10s, the fourth pneumatic diaphragm valve 20 and the fifth pneumatic diaphragm valve 21 are opened and closed alternately at intervals of 10s, the sixth pneumatic diaphragm valve 22 and the second water valve 44 are closed, and the flow regulating valve 23 is opened. As shown in FIG. 2. Figure 10 As shown by the medium red line, high-temperature steam enters the buffer tank 10 from the steam inlet 5 and the third pneumatic control valve 6, part of the high-temperature steam is transported by the first connecting pipe 100 to the distributor 14, the filling pump pipe 26, the filling outflow hose 28, the bypass cleaning hose 29, the bypass cleaning collecting pipe 31 and the filling needle box 38, and flows into the second tail discharge branch pipe 302 from the upper discharge port 39 and the lower discharge port 41, and the other part of the high-temperature steam is discharged into the tail discharge pipe 300 through the first connecting branch pipe 101 and the second connecting branch pipe 102 after passing through the distributor 14, so as to complete the preheating of the entire filling system.

[0028] Step Y2, sterilization: sterilization pressure is set to 2.0 bar, sterilization temperature is set to 121℃; the temperature of the filling system is raised to greater than 121℃, and the sterilization time starting point definition phase is entered. Specifically, if the temperature of the filling system remains greater than 121℃ within 180s, the sterilization starts timing, and the equipment enters the sterilization phase; if the temperature of the filling system fails to remain for the set time, the timing is restarted until the temperature of the filling system remains continuously for more than 210s, and the sterilization phase is entered. The first pneumatic control valve 2 is closed, the second pneumatic control valve 4 is closed, the third pneumatic control valve 6 is opened, the fourth pneumatic control valve 8 is closed, the fifth pneumatic control valve 48 is closed, the first pneumatic diaphragm valve 11 is opened, the rollers of the roller tube assembly 17 are opened, the bypass pinch valve 18 is opened, the filling pinch valve 19 is opened, the second pneumatic diaphragm valve 15 is closed, the third pneumatic diaphragm valve 16 is opened, the fourth pneumatic diaphragm valve 20 and the fifth pneumatic diaphragm valve 21 are alternately opened and closed at intervals of 10s, the sixth pneumatic diaphragm valve 22 is opened, and the flow regulating valve 23 is closed; the sterilization time is set to 1800s. As shown in FIG. 8, when the sterilization time is up, the first pneumatic diaphragm valve 11 is closed, the second pneumatic diaphragm valve 15 is opened, the third pneumatic diaphragm valve 16 is closed, the fourth pneumatic diaphragm valve 20 is opened, the fifth pneumatic diaphragm valve 21 is closed, the sixth pneumatic diaphragm valve 22 is closed, and the flow regulating valve 23 is opened. Figure 11 As shown by the middle red line, high-temperature steam enters the buffer tank 10 from the steam inlet 5 and the third pneumatic control valve 6, a part of the high-temperature steam is transported by the first connecting pipe 100 to the distributor 14, the filling pump pipe 26, the filling liquid outlet hose 28, the bypass cleaning hose 29, the bypass cleaning collection pipe 31, and the needle filling box 38, and flows into the first tail discharge branch pipe 301 from the upper discharge port 39 and the lower discharge port 41, and another part of the high-temperature steam is discharged to the tail discharge pipe 300 through the second connecting branch pipe 102 after passing through the distributor 14, so as to complete the online sterilization of the entire filling system.

[0029] Step Y3, pressure relief: after the sterilization is completed, the third pneumatic control valve 6 of the steam inlet 5 is closed, the flow regulating valve 23 is opened, and the pressure relief is performed; when the pressure detection is 0.1 bar, the sixth pneumatic diaphragm valve 22 and the flow regulating valve 23 are closed.

[0030] Step Y4: Use air purging for cooling. Set the purging pressure in the buffer tank to a lower limit of 2.5 bar and an upper limit of 3.0 bar. Automatically replenish air and reduce the set temperature to 30℃. The first pneumatic control valve 2 is closed, the second pneumatic control valve 4 is closed, the third pneumatic control valve 6 is closed, the fourth pneumatic control valve 8 is closed, the fifth pneumatic control valve 48 is open, the first pneumatic diaphragm valve 11 is open, the rollers of the roller clamping assembly 17 are opened, the bypass clamp valve 18 is opened, and the filling clamp valve 19 is opened. The second pneumatic diaphragm valve 15 and the third pneumatic diaphragm valve 16 cycle between opening for 10 seconds and closing for 50 seconds. The fourth pneumatic diaphragm valve 20 and the fifth pneumatic diaphragm valve 21 alternate between opening and closing at 10-second intervals. The sixth pneumatic diaphragm valve 22 is closed, and the flow regulating valve 23 is open. When the temperature drops to 30°C, the fifth pneumatic control valve 48 is closed. When the pressure is detected at 0.1 bar, the second pneumatic diaphragm valve 15, the third pneumatic diaphragm valve 16, the sixth pneumatic diaphragm valve 22, and the flow regulating valve 23 are closed.

[0031] In this embodiment, after sterilization and purging are completed, the filling system can be pressurized again. Specifically, when the temperature of the filling system drops below 30°C, the pressurization time can be extended to the next stage of production; the first pneumatic control valve 2 is closed, the second pneumatic control valve 4 is closed, the third pneumatic control valve 6 is closed, the fourth pneumatic control valve 8 is closed, the fifth pneumatic control valve 48 is open, the first pneumatic diaphragm valve 11 is open, the rollers of the roller clamping assembly 17 are opened, the bypass clamp valve 18 is open, the filling clamp valve 19 is open, the second pneumatic diaphragm valve 15 is closed, the third pneumatic diaphragm valve 16 is closed, the fourth pneumatic diaphragm valve 20 is open, the fifth pneumatic diaphragm valve 21 is open, the sixth pneumatic diaphragm valve 22 is closed, and the flow regulating valve 23 is closed to maintain system pressure. When the pressure is detected at 0.5 bar, the fifth pneumatic control valve 48 is closed.

[0032] In this embodiment, before production, the SIP machine is degassed. The first pneumatic control valve 2 is closed, the second pneumatic control valve 4 is closed, the third pneumatic control valve 6 is closed, the fourth pneumatic control valve 8 is closed, the fifth pneumatic control valve 48 is closed, the first pneumatic diaphragm valve 11 is open, the rollers of the roller clamping assembly 17 are opened, the bypass clamp valve 18 is open, the filling clamp valve 19 is open, the second pneumatic diaphragm valve 15 is closed, the third pneumatic diaphragm valve 16 is closed, the fourth pneumatic diaphragm valve 20 is open, the fifth pneumatic diaphragm valve 21 is open, the sixth pneumatic diaphragm valve 22 is closed, and the flow regulating valve 23 is open. When the pressure is detected to be 0.1 bar, the flow regulating valve 23 is closed.

[0033] The above merely describes the preferred embodiments of the present application, and the protection scope of the present application is not limited to the above-described embodiments. Any technical solution falling within the concept of the present application shall fall within the protection scope of the present application. It should be noted that, for ordinary skilled persons in the art, some improvements and refinements without departing from the principles of the present application shall also be considered as falling within the protection scope of the present application.

Claims

1. A hose pump filling system with CIP and SIP functions, characterized in that, include: Buffer tank (10), dispenser (14), roller clamping assembly (17), bypass clamp valve (18), filling clamp valve (19), filling pump pipe (26), filling outlet hose (28), bypass cleaning hose (29), bypass cleaning collection pipe (31) and filling syringe box (38). The buffer tank (10) is connected to the distributor (14) through the first connecting pipe (100). The distributor (14) has multiple filling pump pipes (26) at its outlet end. The filling pump pipes (26) have roller pressing pipe assemblies (17) on their outer sides. The filling pump pipes (26) have parallel filling outlet hoses (28) and bypass cleaning hoses (29) at their outlet end. The filling outlet hoses (28) are connected to the injection box (38). The bypass cleaning hoses (29) are connected to the injection box (38) through the bypass cleaning collection pipe (31). The top of the injection box (38) is provided with an upper discharge port (39), and the bottom of the injection box (38) is provided with a lower discharge port (41). The upper discharge port (39) is connected to the tail drain pipe (300) through a second connecting pipe (201), and the lower discharge port (41) is connected to the tail drain pipe (300) through a third connecting pipe (202). The second connecting pipe (201) and the third connecting pipe (202) are arranged in parallel.

2. The hose pump filling system with CIP and SIP functions according to claim 1, characterized in that, The buffer tank (10) is provided with an alkali inlet (1) with a first pneumatic control valve (2), a water inlet (3) with a second pneumatic control valve (4), a steam inlet (5) with a third pneumatic control valve (6), a medicine inlet (7) with a fourth pneumatic control valve (8), and a compressed air inlet (47) with a fifth pneumatic control valve (48); the alkali inlet (1), water inlet (3) and compressed air inlet (47) are connected in parallel on the same feed pipe, and a cleaning ball (9) is provided at the outlet of the feed pipe.

3. The hose pump filling system with CIP and SIP functions according to claim 1, characterized in that, The first connecting pipe (100) is provided with a first pneumatic diaphragm valve (11), a temperature sensor (12) and a pressure sensor (13); the first connecting pipe (100) runs through the distributor (14) and is connected to the inlet of the liquid inlet connecting pipe (24) in the distributor (14), and the outlet of the liquid inlet connecting pipe (24) is connected to the filling pump pipe (26); the first connecting pipe (100) is provided with a first connecting branch pipe (101) and a second connecting branch pipe (102) in parallel at the outlet outside the distributor (14), and the first connecting branch pipe (101) and the second connecting branch pipe (102) are both connected to the tail drain pipe (300), the first connecting branch pipe (101) is provided with a second pneumatic diaphragm valve (15), and the second connecting branch pipe (102) is provided with a third pneumatic diaphragm valve (16).

4. The hose pump filling system with CIP and SIP functions according to any one of claims 1 to 3, characterized in that, The bypass cleaning collection pipe (31) is equipped with a first temperature transmitter (30); the injection box (38) is equipped with a second temperature transmitter (40) on its side; the second connecting pipe (201) is equipped with a fifth pneumatic diaphragm valve (21); and the third connecting pipe (202) is equipped with a fourth pneumatic diaphragm valve (20).

5. The hose pump filling system with CIP and SIP functions according to any one of claims 1 to 3, characterized in that, The tailpipe (300) is provided with a first tailpipe branch pipe (301) and a second tailpipe branch pipe (302) connected in parallel. The front end of the first tailpipe branch pipe (301) and the second tailpipe branch pipe (302) is provided with a pressure transmitter (42) and a third temperature transmitter (43). The rear end of the first tailpipe branch pipe (301) and the second tailpipe branch pipe (302) is provided with a conductivity detector (33) and a sampling valve (34). The outlet of the tailpipe (300) is connected to a floor drain (45).

6. A control method for a hose pump filling system with CIP and SIP functions according to any one of claims 1 to 5, characterized in that, The control method includes cleaning control, which includes the following steps when performing cleaning control: Step S1, Pressure Holding and Leak Detection: The pressure holding value is set to 2.0±0.2 bar, the pressure holding time is set to 180±10 s, the first pneumatic control valve (2) is closed, the second pneumatic control valve (4) is closed, the third pneumatic control valve (6) is closed, the fourth pneumatic control valve (8) is closed, the fifth pneumatic control valve (48) is opened, the first pneumatic diaphragm valve (11) is opened, the roller of the roller clamping assembly (17) is opened, the bypass clamp valve (18) is opened, the filling clamp valve (19) is opened, the second pneumatic diaphragm valve (15) is closed, the fourth pneumatic diaphragm valve (20) is opened, the fifth pneumatic diaphragm valve (21) is opened, the sixth pneumatic diaphragm valve (22) is closed, the flow regulating valve (23) is closed, and the third pneumatic diaphragm valve (16) is closed; after the pressure holding is completed, the flow regulating valve (23) is opened, the pressure reduction time is set to 30±2 s, and when the pressure detection is 0, the flow regulating valve (23) is closed; Step S2: Rinse the buffer tank (10) and separator (14) with clean water or alkaline solution. Step S3: The pump pipeline and injection box (38) are cleaned online with clean water or alkaline solution. Step S4, purge residue with air: Purge with air to empty the tank. The purging pressure in the buffer tank (10) is set to a lower limit of 2.5±0.2 bar and an upper limit of 3.0±0.2 bar. Air is automatically replenished, and the time is set to 1200±10 s. The first pneumatic control valve (2) is closed, the second pneumatic control valve (4) is closed, the third pneumatic control valve (6) is closed, the fourth pneumatic control valve (8) is closed, the fifth pneumatic control valve (48) is open, the first pneumatic diaphragm valve (11) is open, the roller of the roller clamping assembly (17) is opened, the bypass clamp valve (18) is opened, the filling clamp valve (19) is opened, the second pneumatic diaphragm valve (15) and the third pneumatic diaphragm valve (16) cycle open for 10s and close for 50s, the fourth pneumatic diaphragm valve (20) and the fifth pneumatic diaphragm valve (21) alternately open and close at 10s intervals, the sixth pneumatic diaphragm valve (22) is closed, and the flow regulating valve (23) is open.

7. The control method according to claim 6, characterized in that, The control method further includes sterilization control, which includes the following steps when performing sterilization control: Step Y1, Initial condensate drainage: Open the third pneumatic control valve (6) of the steam inlet (5) to initially drain the condensate, empty the buffer tank (10), filling pump and distributor (14), and preheat the sterilization pipeline at the same time. Set the time to 120±10s. Close the first pneumatic control valve (2), close the second pneumatic control valve (4), open the third pneumatic control valve (6), close the fourth pneumatic control valve (8), close the fifth pneumatic control valve (48), and close the first... The pneumatic diaphragm valve (11) is open, the rollers of the roller clamping assembly (17) are opened, the bypass clamp valve (18) is open, the filling clamp valve (19) is open, the second pneumatic diaphragm valve (15) and the third pneumatic diaphragm valve (16) are opened and closed in a cycle at 10s intervals, the fourth pneumatic diaphragm valve (20) and the fifth pneumatic diaphragm valve (21) are opened and closed alternately at 10s intervals, the sixth pneumatic diaphragm valve (22) is closed, and the flow regulating valve (23) is open. Step Y2, Sterilization: The sterilization pressure is set to 2.0±0.1 bar, and the sterilization temperature is set to 120±5℃; the temperature is raised until the filling system temperature is greater than the preset value, and the sterilization time start point definition stage is entered. The sterilization time is set to 1800±10s; the first pneumatic control valve (2) is closed, the second pneumatic control valve (4) is closed, the third pneumatic control valve (6) is open, the fourth pneumatic control valve (8) is closed, the fifth pneumatic control valve (48) is closed, the first pneumatic diaphragm valve (11) is open, the roller of the roller pressing tube assembly (17) is opened, the bypass clamp valve (18) is opened, the filling clamp valve (19) is opened, the second pneumatic diaphragm valve (15) is closed, the third pneumatic diaphragm valve (16) is open, the fourth pneumatic diaphragm valve (20) and the fifth pneumatic diaphragm valve (21) are opened and closed alternately at 10s intervals, the sixth pneumatic diaphragm valve (22) is opened, and the flow regulating valve (23) is closed; Step Y3, depressurization: After sterilization, close the third pneumatic control valve (6) of the steam inlet (5), open the flow regulating valve (23) to depressurize, and close the sixth pneumatic diaphragm valve (22) and the flow regulating valve (23) when the pressure is detected to be 0.1 bar. Step Y4: Use air purging to cool down. The purging pressure in the buffer tank (10) is set to a lower limit of 2.5±0.2 bar and an upper limit of 3.0±0.2 bar. Automatic air replenishment is performed, and the set temperature is reduced to 30±2℃. The first pneumatic control valve (2) is closed, the second pneumatic control valve (4) is closed, the third pneumatic control valve (6) is closed, the fourth pneumatic control valve (8) is closed, the fifth pneumatic control valve (48) is opened, the first pneumatic diaphragm valve (11) is opened, the rollers of the roller clamping assembly (17) are opened, the bypass clamping valve (18) is opened, and the filling clamping valve (19) is opened. When the temperature drops to 30°C, the fifth pneumatic control valve (48) is closed. When the pressure is detected to be 0.1 bar, the second pneumatic diaphragm valve (15), the third pneumatic diaphragm valve (16), the sixth pneumatic diaphragm valve (22), and the flow regulating valve (23) are closed.

8. The control method according to claim 6, characterized in that, In step S2, when rinsing with clean water, the cleaning ball (9) in the buffer tank (10) sprays clean water, the first pneumatic control valve (2) is closed, the second pneumatic control valve (4) is open, the third pneumatic control valve (6) is closed, the fourth pneumatic control valve (8) is closed, the fifth pneumatic control valve (48) is closed, the first pneumatic diaphragm valve (11) is open, the roller of the roller pressing assembly (17) is closed, the bypass clamp valve (18) is closed, the filling clamp valve (19) is closed, the second pneumatic diaphragm valve (15) is open, the fourth pneumatic diaphragm valve (20) is closed, the fifth pneumatic diaphragm valve (21) is closed, the sixth pneumatic diaphragm valve (22) is closed, the flow regulating valve (23) is closed, and the third pneumatic diaphragm valve (16) is open; the rinsing time is set to 300±10s, the conductivity is set to 2.0±0.1us / cm, if the conductivity judgment fails, the rinsing is repeated until the conductivity reaches the set requirement; When performing alkaline cleaning, the cleaning ball (9) in the buffer tank (10) sprays alkaline cleaning solution. The first pneumatic control valve (2) is open, the second pneumatic control valve (4) is closed, the third pneumatic control valve (6) is closed, the fourth pneumatic control valve (8) is closed, the fifth pneumatic control valve (48) is closed, and the first pneumatic diaphragm valve (11) is closed. The cleaning liquid level is set to 80% of the volume of the buffer tank (10). The alkaline solution is not discharged. After reaching the preset liquid level, the spraying of alkaline solution stops. The purging pressure in the buffer tank (10) is set to a lower limit of 2.5±0.2 bar and an upper limit of 3.0±0.2 bar. Automatic air replenishment is performed. The first pneumatic control valve (2) is closed, the second pneumatic control valve (4) is closed, the third pneumatic control valve (6) is closed, the fourth pneumatic control valve (8) is closed, the fifth pneumatic control valve (48) is opened, the first pneumatic diaphragm valve (11) is opened, the roller of the roller pressure tube assembly (17) is closed, the bypass clamp valve (18) is closed, the filling clamp valve (19) is closed, the second pneumatic diaphragm valve (15) is opened, the third pneumatic diaphragm valve (16) is opened, the fourth pneumatic diaphragm valve (20) is closed, the fifth pneumatic diaphragm valve (21) is closed, the sixth pneumatic diaphragm valve (22) is closed, and the flow regulating valve (23) is closed. The alkaline washing filling time is set to 30±2s.

9. The control method according to claim 6, characterized in that, In step S3, when performing water rinsing, the rinsing liquid level of the buffer tank (10) is set to 30% of the volume of the buffer tank (10), the purging pressure in the buffer tank (10) is set to a lower limit of 2.5±0.2 bar and an upper limit of 3.0±0.2 bar, water and air are automatically replenished, the rinsing time is set to 300±10s, the first pneumatic control valve (2) is closed, the second pneumatic control valve (4) is opened, the third pneumatic control valve (6) is closed, the fourth pneumatic control valve (8) is closed, the fifth pneumatic control valve (48) is opened, and the first pneumatic diaphragm valve... (11) Open the rollers of the roller clamping assembly (17), open the bypass clamp valve (18), open the filling clamp valve (19), close the second pneumatic diaphragm valve (15), close the third pneumatic diaphragm valve (16), open the fourth pneumatic diaphragm valve (20) and the fifth pneumatic diaphragm valve (21) alternately at 10s intervals, close the sixth pneumatic diaphragm valve (22), and open the flow regulating valve (23); the conductivity is set to 2.0±0.1us / cm. If the conductivity judgment fails, clean again until the conductivity reaches the set requirement. When performing alkaline cleaning, the purging pressure in the buffer tank (10) is set to a lower limit of 2.5±0.2 bar and an upper limit of 3.0±0.2 bar. Automatic air replenishment is performed. The first pneumatic control valve (2) is closed, the second pneumatic control valve (4) is closed, the third pneumatic control valve (6) is closed, the fourth pneumatic control valve (8) is closed, the fifth pneumatic control valve (48) is opened, the first pneumatic diaphragm valve (11) is opened, the rollers of the roller clamping assembly (17) are opened, the bypass clamp valve (18) is opened, the filling clamp valve (19) is opened, the second pneumatic diaphragm valve (15) is closed, the third pneumatic diaphragm valve (16) is closed, the fourth pneumatic diaphragm valve (20) and the fifth pneumatic diaphragm valve (21) alternately open and close at 10s intervals, the sixth pneumatic diaphragm valve (22) is closed, and the flow regulating valve (23) is opened. The alkaline cleaning filling time is set to 30±2s. During alkaline soaking, the first pneumatic control valve (2) is closed, the second pneumatic control valve (4) is closed, the third pneumatic control valve (6) is closed, the fourth pneumatic control valve (8) is closed, the fifth pneumatic control valve (48) is closed, the first pneumatic diaphragm valve (11) is opened, the rollers of the roller clamping assembly (17) are opened, the bypass clamp valve (18) is opened, the filling clamp valve (19) is opened, the second pneumatic diaphragm valve (15) is closed, the third pneumatic diaphragm valve (16) is closed, the fourth pneumatic diaphragm valve (20) is opened, the fifth pneumatic diaphragm valve (21) is opened, the sixth pneumatic diaphragm valve (22) is closed, and the flow regulating valve (23) is closed. The alkaline soaking time is set to 600±10s.

10. The control method according to claim 7, characterized in that, In step Y2, if the temperature of the filling system remains above the preset temperature within 180s, the sterilization timer starts and the equipment enters the sterilization stage; if the temperature of the filling system fails to be maintained for the set time, the timer restarts until the temperature of the filling system is maintained continuously for more than 210s, at which point the sterilization stage begins.