Self-drying gel as well as preparation method and application thereof

Abstract

The invention relates to a self-drying gel. The self-drying gel is prepared from the following raw materials: cationic imidazolium salt, dopamine hydrochloride, a carboxyl ammonium zwitterionic monomer and carboxyl chitosan. The self-drying gel provided by the invention has the advantages of coating formation, in-situ self-drying, adhesion resistance, good biocompatibility and high immunocompatibility, so that secondary injury is not easily caused during clinical replacement, and wound repair can be promoted by adjusting immune response.

Description

Technical Field

[0001] This invention belongs to the field of medical gel dressing technology, and relates to a self-drying gel, its preparation method and application. Background Technology

[0002] Traditional wound dressings (such as gauze, cotton pads, and oil-soaked gauze) are mostly inert dressings, primarily serving to cover and protect the wound. However, their ability to absorb exudate is limited, and the dressings tend to adhere to the wound surface. When changing the dressing, the adhered dressing can easily cause further mechanical damage to the newly formed tissue, leading to pain, bleeding, and delayed wound healing.

[0003] Compared to the limitations of traditional solid dressings (such as gauze and sheet hydrocolloids) in conforming to irregular wound shapes, managing exudate, and avoiding the need for dressing changes, coatable self-drying flexible dressings (usually in hydrogel form) offer significant advantages. They form in situ, perfectly conforming to complex wound morphologies; the closed, moist environment they provide facilitates cell migration, accelerating healing and reducing pain; simultaneously, their good breathability and transparency allow for easy wound observation. For severe wounds such as burns, frequent mechanical debridement and dressing changes can easily cause secondary damage, while coatable dressings promise to reduce such damage.

[0004] Therefore, developing a novel gel dressing that combines properties such as coatability, in-situ self-drying, anti-adhesion, and good biocompatibility to achieve perfect fit and protection of the wound and minimize secondary damage during dressing changes has become an important research direction in the field of wound care. Summary of the Invention

[0005] The technical problem to be solved by the present invention is to overcome the shortcomings of the prior art and provide a self-drying gel, its preparation method and application. The self-drying gel provided by the present invention has the advantages of anti-adhesion and high immunocompatibility, which makes it less likely to cause secondary damage during clinical replacement. The self-drying gel flexible membrane prepared from the self-drying gel also has the advantages of strong plasticity, good adhesion and effective wound sealing.

[0006] To solve the above technical problems, the technical solution adopted by the present invention is as follows: The present invention provides a self-drying gel, wherein the raw materials for preparing the self-drying gel include: cationic imidazole salt, dopamine hydrochloride, carboxyam zwitterionic monomer and carboxychitosan.

[0007] Preferably, the cationic imidazole salt is selected from one or more of 1-butyl-2,3-dimethylimidazolium chloride, 1-ethyl-3-methylimidazolium chloride, 1-ethyl-3-methylimidazolium bromide, and 1-butyl-3-methylimidazolium chloride; And / or, the carboxyam zwitterionic monomer is selected from carboxylic acid betaine; And / or, the carboxylic acid betaine is selected from one or more of carboxymethyl methacrylate betaine and acryloylethyl carboxymethyl betaine; And / or, the carboxylated chitosan is selected from O-carboxymethyl chitosan, N-carboxymethyl chitosan and N,O-carboxymethyl chitosan.

[0008] Preferably, the raw material further includes: an initiator; And / or, the initiator is selected from aromatic ketone compounds; And / or, the aromatic ketone compound is selected from one or more of 2-hydroxy-2-methyl-1-phenyl-1-propanone and 2-hydroxy-4-(2-hydroxyethoxy)-2-methylphenylpropanone; And / or, the raw materials further include: a crosslinking agent; And / or, the crosslinking agent is selected from one or more of polyethylene glycol diacrylate and N,N′-methylenebisacrylamide.

[0009] Preferably, the molar ratio of the cationic imidazole salt, dopamine hydrochloride, carboxyam amphoteric monomer, and carboxychitosan is (1-2):(1-2):(5-15):(1-10). And / or, the cationic imidazole salt is added in the form of an aqueous solution, wherein the concentration of the cationic imidazole salt in the aqueous solution is 0.01 mol / L to 0.05 mol / L; And / or, the amount of the initiator is 0.1% to 0.5% of the molar amount of the carboxyam zwitterionic monomer and the cationic imidazole salt; And / or, the amount of the crosslinking agent is 0.1% to 0.5% of the molar amount of the carboxyam zwitterionic monomer and the carboxychitosan.

[0010] The present invention also provides a method for preparing the above-described self-drying gel, comprising the following steps: S1. Crosslinking of cationic imidazole salt, dopamine hydrochloride, carboxyam zwitterionic monomer, carboxy chitosan, initiator, and crosslinking agent to obtain a self-drying gel.

[0011] Preferably, step S1 further includes the following steps: S1a. Crosslinking cationic imidazole salt, dopamine hydrochloride, carboxyam amphoteric monomer, carboxy chitosan, initiator, and crosslinking agent to obtain a self-drying gel aqueous solution; adding the dried product of the self-drying gel aqueous solution to water and mixing, wherein the volume ratio of the dried product to water is 1:(0.5~2), to obtain a self-drying gel. And / or, the crosslinking reaction temperature is 40℃~60℃, and the reaction time is 1~5 hours; And / or, the crosslinking is carried out under light irradiation, wherein the light irradiation is ultraviolet light with a wavelength of 260nm~390nm; And / or, in step S1a, the drying is to dry the self-drying gel aqueous solution to a water content of less than 3%.

[0012] The present invention also provides a self-drying gel flexible membrane, wherein the preparation method of the self-drying gel flexible membrane includes the following steps: S2. Coating and drying the self-drying gel prepared by any of the above-described self-drying gel preparation methods to obtain a self-drying gel flexible film.

[0013] Preferably, in step S2, the drying conditions are a temperature of 30°C to 40°C and a relative humidity of 60% to 80%. And / or, in step S2, the drying is to dry the self-drying gel to a water content of less than 10%; And / or, the maximum strain of the self-drying gel flexible membrane is 621% to 852%; And / or, the maximum stress of the self-drying gel flexible membrane is 3252 kPa to 269 kPa.

[0014] Preferably, step S2 further includes the following steps: The self-drying gel prepared by any of the above-described self-drying gel methods is dried at a temperature of 37°C and a relative humidity of 70% to form a self-drying gel flexible film with a water content of less than 5%.

[0015] The present invention also provides the application of the self-drying gel described in any one of the above claims, or the self-drying gel obtained by any one of the above claims, or the self-drying gel flexible membrane described in any one of the above claims, in the preparation of medical wound dressings.

[0016] Due to the adoption of the above technical solutions, the present invention has the following advantages compared with the prior art: The self-drying gel provided by this invention combines the advantages of being coatable and moldable, self-drying in situ, anti-adhesion, good biocompatibility, and high immunocompatibility, making it less likely to cause secondary damage during clinical use and promoting wound healing by regulating the immune response. The self-drying gel flexible membrane prepared from this gel also possesses high plasticity, good adhesion, effectively seals wounds, and has good tensile properties, allowing it to move with body tissues after being applied to the wound surface. Attached Figure Description

[0017] Figure 1 The self-drying gel sample prepared in Example 1; Figure 2The sample of the self-drying gel prepared in Example 1 was left to stand naturally for 2 hours at a temperature of 37°C and a relative humidity of 70%. Figure 3 To test the effects of the self-drying gel prepared in Example 1 of Test Example 2 and the chitosan gel prepared in Comparative Example 1 on four pro-inflammatory cytokines: TNF-α, CCR-7, IL-6, and IL-17. Detailed Implementation

[0018] To make the technical solution and beneficial effects of the present invention more apparent and understandable, a detailed description is provided below in conjunction with the accompanying drawings and specific embodiments. The drawings are not necessarily drawn to scale, and local features may be enlarged or reduced to more clearly show the details of the local features; unless otherwise defined, the technical and scientific terms used herein have the same meanings as those in the technical field to which this application pertains.

[0019] The present invention provides a self-drying gel, wherein the raw materials for preparing the self-drying gel include: cationic imidazole salt, dopamine hydrochloride, carboxyam zwitterionic monomer and carboxychitosan.

[0020] In some embodiments, the cationic imidazole salt is selected from one or more of 1-butyl-2,3-dimethylimidazolium chloride, 1-ethyl-3-methylimidazolium chloride, 1-ethyl-3-methylimidazolium bromide, and 1-butyl-3-methylimidazolium chloride.

[0021] In some embodiments, the cationic imidazole salt is selected from 1-butyl-2,3-dimethylimidazolium chloride.

[0022] In some embodiments, the carboxyam zwitterionic monomer is selected from carboxylic acid betaine.

[0023] In some embodiments, the carboxylic acid betaine is selected from one or more of carboxymethyl methacrylate betaine and acryloylethyl carboxymethyl betaine.

[0024] In some embodiments, the carboxylated chitosan is selected from O-carboxymethyl chitosan, N-carboxymethyl chitosan, and N,O-carboxymethyl chitosan.

[0025] In some embodiments, the carboxylated chitosan is selected from N-carboxymethyl chitosan.

[0026] In some embodiments, the raw material further includes an initiator.

[0027] In some embodiments, the initiator is selected from aromatic ketone compounds.

[0028] In some embodiments, the aromatic ketone compound is selected from one or more of 2-hydroxy-2-methyl-1-phenyl-1-propanone and 2-hydroxy-4-(2-hydroxyethoxy)-2-methylphenylpropanone.

[0029] In some embodiments, the aromatic ketone compound is selected from 2-hydroxy-2-methyl-1-phenyl-1-propanone.

[0030] In some embodiments, the raw material further includes a crosslinking agent.

[0031] In some embodiments, the crosslinking agent is selected from one or more of polyethylene glycol diacrylate and N,N′-methylenebisacrylamide.

[0032] In some embodiments, the crosslinking agent is selected from N,N′-methylenebisacrylamide.

[0033] In some embodiments, the molar ratio of the cationic imidazole salt, dopamine hydrochloride, carboxyamium zwitterionic monomer, and carboxychitosan is (1-2):(1-2):(5-15):(1-10), for example, 1:1:5:1, 1:1:5:2, 1:1:5:3, 1:1:5:4, 1:1:5:5, 1:1:5:6, 1:1:5:7, 1:1:5:8, 1:1:5:9, 1:1:5:10, 1:1:6:1, 1:1:6:2, 1:1:6:3, 1:1:6:4, 1:1:6:5, 1:1:6:6, 1:1:6:7, 1:1:6:8, 1:1:6:9, 1:1:6:10, 1:1:7:1, 1:1:7: 2, 1:1:7:3, 1:1:7:4, 1:1:7:5, 1:1:7:6, 1:1:7:7, 1:1:7:8, 1:1:7:9, 1:1:7:10, 1:1:8:1, 1:1:8:2, 1:1:8:3, 1:1:8:4, 1:1:8:5, 1:1:8:6, 1:1:8:7, 1 :1:8:8、1:1:8:9、1:1:8:10、1:1:9:1、1:1:9:2、1:1:9:3、1:1:9:4、1:1:9:5、1:1:9:6、1:1:9:7、1:1:9:8、1:1:9:9、1:1:9:10、1:1:10:1、1:1:10:2、1: 1:10:3, 1:1:10:4, 1:1:10:5, 1:1:10:6, 1:1:10:7, 1:1:10:8, 1:1:10:9, 1:1:10:10, 1:1:11:1, 1:1:11:2, 1:1:11:3, 1:1:11:4, 1:1:11:5, 1:1:11:6 1:1:11:7, 1:1:11:8, 1:1:11:9, 1:1:11:10, 1:1:12:1, 1:1:12:2, 1:1:12:3, 1:1:12:4, 1:1:12:5, 1:1:12:6, 1:1:12:7, 1:1:12:8, 1:1:12:9, 1:1:12 :10、1:1:13:1、1:1:13:2、1:1:13:3、1:1:13:4、1:1:13:5、1:1:13:6、1:1:13:7、1:1:13:8、1:1:13:9、1:1:13:10、1:1:14:1、1:1:14:2、1:1:14:3、1: 1:14:4, 1:1:14:5, 1:1:14:6, 1:1:14:7, 1:1:14:8, 1:1:14:9, 1:1:14:10, 1:1:15:1, 1:1:15:2, 1:1:15:3, 1:1:15:4, 1:1:15:5, 1:1:15:6, 1:1:15:71:1:15:8, 1:1:15:9, 1:1:15:10, 2:2:5:1, 2:2:5:2, 2:2:5:3, 2:2:5:4, 2:2:5:5, 2:2:5:6, 2:2:5:7, 2:2:5:8, 2:2:5:9, 2:2:5:10, 2:2:15:1, 2:2:15:2, 2:2:15:3, 2:2:15:4, 2:2:15:5, 2:2:15:6, 2:2:15:7, 2:2:15:8, 2:2:15:9, 2:2:15:10, etc.

[0034] In some embodiments, the cationic imidazole salt is added in the form of an aqueous solution, wherein the concentration of the cationic imidazole salt in the aqueous solution is 0.01 mol / L to 0.05 mol / L, for example, 0.01 mol / L, 0.02 mol / L, 0.03 mol / L, 0.04 mol / L, 0.05 mol / L, etc.

[0035] In some embodiments, the cationic imidazole salt is added in the form of an aqueous solution, wherein the concentration of the cationic imidazole salt in the aqueous solution is 0.01 mol / L.

[0036] In some embodiments, the amount of the initiator is 0.1% to 0.5% of the molar amount of the carboxyam zwitterionic monomer and the cationic imidazole salt, for example, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, etc.

[0037] In some embodiments, the amount of the initiator is 0.1% of the molar amount of the carboxyam zwitterionic monomer and the cationic imidazole salt.

[0038] In some embodiments, the amount of the crosslinking agent is 0.1% to 0.5% of the molar amount of the carboxyam amphoteric monomer and the carboxychitosan, for example, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, etc.

[0039] In some embodiments, the amount of the crosslinking agent is 0.1% of the molar amount of the carboxyam amphoteric monomer and the carboxychitosan.

[0040] The present invention also provides a method for preparing the above-described self-drying gel, comprising the following steps: S1. Crosslinking of cationic imidazole salt, dopamine hydrochloride, carboxyam zwitterionic monomer, carboxy chitosan, initiator, and crosslinking agent to obtain a self-drying gel.

[0041] In some embodiments, step S1 further includes the following steps: S1a. Crosslinking is performed on cationic imidazole salt, dopamine hydrochloride, carboxyam amphoteric monomer, carboxylated chitosan, initiator, and crosslinking agent to obtain a self-drying gel aqueous solution. The dried product of the self-drying gel aqueous solution is then added to water and mixed, with the volume ratio of the dried product to water being 1:(0.5~2), to obtain a self-drying gel. The step of adding the dried product of the self-drying gel aqueous solution to water is primarily for accurately measuring the amount of water used and controlling the ratio of the dried product to water, facilitating the preparation of a coatable self-drying gel flexible membrane.

[0042] In some embodiments, in step S1a, the drying is oven drying, natural drying, or freeze drying.

[0043] In some embodiments, the drying in step S1a is oven drying.

[0044] In some embodiments, the crosslinking reaction temperature is 40°C to 60°C, for example, 40°C, 45°C, 50°C, 55°C, 60°C, etc.; the reaction time is 1 to 5 hours, for example, 1 hour, 2 hours, 3 hours, 4 hours, 5 hours, etc.

[0045] In some embodiments, the crosslinking is carried out under light irradiation, which is ultraviolet light with a wavelength of 260nm to 390nm, such as 260nm, 270nm, 280nm, 290nm, 300nm, 310nm, 320nm, 330nm, 340nm, 350nm, 360nm, 370nm, 380nm, 390nm, etc.

[0046] In some embodiments, the crosslinking is carried out under light irradiation, wherein the light irradiation is ultraviolet light with a wavelength of 350 nm to 370 nm.

[0047] In some embodiments, the crosslinking is carried out under light irradiation, wherein the light irradiation is ultraviolet light at a wavelength of 360 nm.

[0048] In some embodiments, in step S1a, the drying is to dry the self-drying gel aqueous solution to a water content of less than 3%, for example, 3%, 2.5%, 2%, 1.5%, 1%, etc.

[0049] In some embodiments, in step S1a, the drying is to dry the self-drying gel aqueous solution to a water content of less than 1%.

[0050] In some embodiments, in step S1a, the drying is oven drying, natural drying, or freeze drying.

[0051] The present invention also provides a self-drying gel flexible membrane, wherein the preparation method of the self-drying gel flexible membrane includes the following steps: S2. Coating and drying the self-drying gel prepared by any of the above-described self-drying gel preparation methods to obtain a self-drying gel flexible film.

[0052] In some embodiments, in step S2, the drying conditions are a temperature of 30°C to 40°C, for example, 30°C, 31°C, 32°C, 33°C, 34°C, 35°C, 36°C, 37°C, 38°C, 39°C, 40°C, etc.; and a relative humidity of 60% to 80%, for example, 60%, 65%, 70%, 75%, 80%, etc.

[0053] In some embodiments, in step S2, the drying conditions are a temperature of 35°C to 39°C and a relative humidity of 65% to 75%.

[0054] In some embodiments, in step S2, the drying is to dry the self-drying gel to a moisture content of less than 10%, for example, 10%, 9%, 8%, 7%, 6%, 5%, 4%, 3%, 2%, 1%, etc.

[0055] In some embodiments, in step S2, the drying process involves drying the self-drying gel to a moisture content of less than 5%.

[0056] In some embodiments, in step S2, the drying is oven drying, natural drying, or freeze drying.

[0057] In some embodiments, the maximum strain of the self-drying gel flexible membrane is 621% to 852%.

[0058] In some embodiments, the maximum stress of the self-drying gel flexible membrane is 3252 kPa to 269 kPa.

[0059] In some embodiments, step S2 further includes the following steps: The self-drying gel prepared by any of the above-described self-drying gel methods is dried at a temperature of 37°C and a relative humidity of 70% to form a self-drying gel flexible film with a water content of less than 5%.

[0060] The present invention also provides the application of the self-drying gel described in any one of the above claims, or the self-drying gel obtained by any one of the above claims, or the self-drying gel flexible membrane described in any one of the above claims, in the preparation of medical wound dressings.

[0061] It should be understood that these embodiments are for illustrative purposes only and are not intended to limit the scope of the invention. Experimental methods in the following embodiments, unless otherwise specified, are generally performed under conventional experimental conditions. Unless otherwise specified, all reagents and raw materials used in this invention are commercially available.

[0062] Example 1 Step S11: Weigh 0.189 g of 1-butyl-2,3-dimethylimidazolium chloride (0.001 mol), add 100 mL of water to prepare a 0.01 mol / L solution, add 0.19 g of dopamine hydrochloride (0.001 mol), 2.59 g of the zwitterionic monomer carboxybetaine methacrylate (0.011 mol), 2.1 g of N-carboxymethyl chitosan (0.004 mol), 0.0155 g of N,N'-methylenebisacrylamide (1% of the molar amount of the zwitterionic monomer), and 0.016 g of... 2-Hydroxy-2-methyl-1-phenyl-1-propanone (1% of the molar amount of the zwitterionic monomer) was placed in a 25 mL beaker, stirred, irradiated with a 360 nm UV lamp, reacted at 60 °C for 2 hours to obtain a self-drying gel aqueous solution; the self-drying gel aqueous solution was dried to a water content of less than 1%, and then mixed with water at a volume ratio of 1:0.5 to obtain a self-drying gel.

[0063] Step S12: Inject the self-drying gel into two 5*2cm glass plates using a syringe, with a thickness of 2mm between the glass plates. After injection, dry the gel at 37℃ and 70% relative humidity for 30 minutes until a self-drying gel flexible film with a moisture content of less than 5% is formed.

[0064] Example 2 Step S21: Weigh 0.189 g of 1-butyl-2,3-dimethylimidazolium chloride (0.001 mol), add 100 mL of water to prepare a 0.01 mol / L solution, add 0.19 g of dopamine hydrochloride (0.001 mol), 2.59 g of zwitterionic monomer carboxybetaine methacrylate (0.011 mol), 2.1 g of N-carboxymethyl chitosan (0.004 mol), 0.0155 g of N,N'-methylenebisacrylamide (1% of the molar amount of the zwitterionic monomer), and 0.016 g of... 2-Hydroxy-2-methyl-1-phenyl-1-propanone (1% of the molar amount of the zwitterionic monomer) was placed in a 25 mL beaker, stirred, irradiated with a 360 nm UV lamp, reacted at 60 °C for 2 hours to obtain a self-drying gel aqueous solution; the self-drying gel aqueous solution was dried to a water content of less than 1%, and then mixed with water at a volume ratio of 1:2 to obtain a self-drying gel.

[0065] Step S22: Inject the self-drying gel into two 5*2cm glass plates using a syringe, with a thickness of 2mm between the glass plates. After injection, dry the gel at 37℃ and 70% relative humidity for 30 minutes until a self-drying gel flexible film with a moisture content of less than 5% is formed.

[0066] Comparative Example 1 Weigh 0.189 g of 1-butyl-2,3-dimethylimidazolium chloride (0.001 mol), add 100 mL of water to prepare a 0.01 mol / L solution, add 0.19 g of dopamine hydrochloride (0.001 mol), 2.1 g of N-carboxymethyl chitosan (0.004 mol), 0.155 g of N,N'-methylenebisacrylamide, and 0.016 g of 2-hydroxy-2-methyl-1-phenyl-1-propanone, place in a 25 mL beaker, stir, irradiate with a 360 nm UV lamp, react at 60 °C for 2 hours to obtain a self-drying gel aqueous solution; dry the self-drying gel aqueous solution to a water content of less than 1%, add it to water and mix, with a volume ratio of dried product to water of 1:0.5, to obtain chitosan gel.

[0067] Test Example 1 The self-drying gel flexible membranes prepared in Examples 1 and 2 were subjected to tensile property tests according to ASTM D882 standard. The equipment was a stress-strain testing machine equipped with clamps to fix the membrane. Before the test, the self-drying gel flexible membranes were cut into dumbbell-shaped specimens of 50mm*20mm*2mm and left to stand for 40 hours under standard temperature and humidity conditions (usually 23±2℃, relative humidity 50±10%).

[0068] The test results are shown in Table 1. The self-drying gel flexible membranes prepared in Examples 1 and 2 have a maximum strain of 621% to 852% and a maximum stress of 3252 kPa to 269 kPa. They have good tensile properties and can move with the body tissue after being covered on the wound surface.

[0069] Table 1 Tensile property test results

[0070] Test Example 2 The self-drying gel prepared in Example 1 and the chitosan gel prepared in Comparative Example 1 were injected subcutaneously into the backs of two-week-old mice (n=5), with each mouse receiving 20 μL. Inflammation was assessed two weeks later. Specifically, immunohistochemical analysis of four typical pro-inflammatory cytokines—TNF-α, CCR-7, IL-6, and IL-17—was performed on mouse tissues. Higher expression levels of pro-inflammatory cytokines indicated more severe inflammation.

[0071] like Figure 3As shown, compared with the unmodified chitosan gel prepared in Comparative Example 1, the self-drying gel of Example 1 induced a significantly lower release of pro-inflammatory cytokines than the unmodified chitosan gel, indicating that the self-drying gel of Example 1 of this invention has superior immunocompatibility. This self-drying gel exerts an anti-inflammatory effect during wound healing and can promote wound repair by regulating the immune response.

[0072] It should be understood that the above embodiments are exemplary and are not intended to encompass all possible implementations included in the claims. Various modifications and changes can be made to the above embodiments without departing from the scope of this disclosure. Similarly, the various technical features of the above embodiments can be arbitrarily combined to form other embodiments of the present invention that may not be explicitly described. Therefore, the above embodiments only illustrate several implementations of the present invention and do not limit the scope of protection of this patent.

Claims

1. A self-drying gel, characterized in that, The raw materials for preparing the self-drying gel include: cationic imidazole salt, dopamine hydrochloride, carboxyam amphoteric monomers, and carboxylated chitosan.

2. The self-drying gel according to claim 1, characterized in that, The cationic imidazole salt is selected from one or more of 1-butyl-2,3-dimethylimidazolium chloride, 1-ethyl-3-methylimidazolium chloride, 1-ethyl-3-methylimidazolium bromide and 1-butyl-3-methylimidazolium chloride; And / or, the carboxyam zwitterionic monomer is selected from carboxylic acid betaine; And / or, the carboxylic acid betaine is selected from one or more of carboxymethyl methacrylate betaine and acryloylethyl carboxymethyl betaine; And / or, the carboxylated chitosan is selected from O-carboxymethyl chitosan, N-carboxymethyl chitosan and N,O-carboxymethyl chitosan.

3. The self-drying gel according to claim 1, characterized in that, The raw materials also include: an initiator; And / or, the initiator is selected from aromatic ketone compounds; And / or, the aromatic ketone compound is selected from one or more of 2-hydroxy-2-methyl-1-phenyl-1-propanone and 2-hydroxy-4-(2-hydroxyethoxy)-2-methylphenylpropanone; And / or, the raw materials further include: a crosslinking agent; And / or, the crosslinking agent is selected from one or more of polyethylene glycol diacrylate and N,N′-methylenebisacrylamide.

4. The self-drying gel according to claim 3, characterized in that, The molar ratio of the cationic imidazole salt, dopamine hydrochloride, carboxyam amphoteric monomer and carboxy chitosan is (1-2):(1-2):(5-15):(1-10). And / or, the cationic imidazole salt is added in the form of an aqueous solution, wherein the concentration of the cationic imidazole salt in the aqueous solution is 0.01 mol / L to 0.05 mol / L; And / or, the amount of the initiator is 0.1% to 0.5% of the molar amount of the carboxyam zwitterionic monomer and the cationic imidazole salt; And / or, the amount of the crosslinking agent is 0.1% to 0.5% of the molar amount of the carboxyam zwitterionic monomer and the carboxychitosan.

5. The method for preparing the self-drying gel according to any one of claims 1 to 4, characterized in that, Includes the following steps: S1. Crosslinking of cationic imidazole salt, dopamine hydrochloride, carboxyam zwitterionic monomer, carboxy chitosan, initiator, and crosslinking agent to obtain a self-drying gel.

6. The preparation method according to claim 5, characterized in that, Step S1 further includes the following steps: S1a. Crosslinking cationic imidazole salt, dopamine hydrochloride, carboxyam amphoteric monomer, carboxy chitosan, initiator, and crosslinking agent to obtain a self-drying gel aqueous solution; adding the dried product of the self-drying gel aqueous solution to water and mixing, wherein the volume ratio of the dried product to water is 1:(0.5~2), to obtain a self-drying gel. And / or, the crosslinking reaction temperature is 40℃~60℃, and the reaction time is 1~5 hours; And / or, the crosslinking is carried out under light irradiation, wherein the light irradiation is ultraviolet light with a wavelength of 260nm~390nm; And / or, in step S1a, the drying is to dry the self-drying gel aqueous solution to a water content of less than 3%.

7. A self-drying gel flexible membrane, characterized in that, The method for preparing the self-drying gel flexible membrane includes the following steps: S2. The self-drying gel prepared by the self-drying gel preparation method according to any one of claims 1 to 4 or any one of claims 5 to 6 is coated and dried to obtain a self-drying gel flexible film.

8. The self-drying gel flexible membrane according to claim 7, characterized in that, In step S2, the drying conditions are a temperature of 30°C to 40°C and a relative humidity of 60% to 80%. And / or, in step S2, the drying is to dry the self-drying gel to a water content of less than 10%; And / or, the maximum strain of the self-drying gel flexible membrane is 621% to 852%; And / or, the maximum stress of the self-drying gel flexible membrane is 3252 kPa to 269 kPa.

9. The self-drying gel flexible membrane according to claim 8, characterized in that, Step S2 further includes the following steps: The self-drying gel prepared by the self-drying gel preparation method according to any one of claims 1 to 4 or according to any one of claims 5 to 6 is dried at a temperature of 37°C and a relative humidity of 70% to form a self-drying gel flexible film with a water content of less than 5%.

10. The use of the self-drying gel according to any one of claims 1 to 4, or the self-drying gel obtained by the preparation method according to any one of claims 5 to 6, or the self-drying gel flexible membrane according to any one of claims 7 to 9, in the preparation of medical wound dressings.

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