Instant-drying slide sample sealing protection device

Abstract

The invention relates to the technical field of detection sample sealing, in particular to an instant-drying type slide sample sealing protection device which comprises a slide tray provided with a slide placing groove used for placing a slide; the linear driving module is connected with the slide tray and is used for driving the slide tray to linearly act; the glue adding module comprises a glue dripping head located above the moving path of the slide tray and is used for adding glue to the sample area of the slide; the glue scraping module comprises a scraping blade, and the scraping blade is located above the moving path of the slide tray and used for scraping glue on the slide; and the glue drying module is positioned on one side of the glue scraping module and is used for drying glue on the slide. According to the method, a brand new process is adopted, cover glass does not need to be placed on the slide, the problem of cover glass fragmentation and the problem of mounting medium pasting are avoided, the problem of mutual intersection of smear lamination storage is solved, the storage efficiency of a smear cabinet is improved, and rapid smear sealing can be achieved.

Description

Technical Field

[0001] This invention relates to the field of sample sealing technology, specifically to an instant-drying glass slide sample sealing and protection device. Background Technology

[0002] Cell mounting is the final crucial step in preparing cell slides for microscopic observation. Its purpose is to fix and protect the sample, enabling long-term preservation and obtaining clear microscopic images. The main process involves covering the prepared cell sample (on a slide) with a suitable mounting agent, then covering it with a coverslip to create a sealed, stable environment. This process includes: sample fixation (fixing the stained cells onto the slide to prevent displacement or detachment); and sample protection (isolating the sample from air to prevent drying, oxidation, fading, or contamination). Conventional resin-based mounting agents typically require a long time to fully harden, resulting in low mounting efficiency. If the slide is moved before the mounting agent is fully dry, the coverslip and slides may move relative to each other, and different slides may stick together. The utility model patent with authorization announcement number CN222419712U discloses a glass slide and cover glass adhesive structure, including a glass slide, a cover glass, and a photosensitive adhesive. The photosensitive adhesive is placed on the upper surface of the glass slide, and the cover glass is placed on the photosensitive adhesive. The glass slide, photosensitive adhesive, and cover glass can be bonded together by direct exposure of the photosensitive adhesive to ultraviolet light. In this patent, the use of ultraviolet light can quickly dry the photosensitive adhesive, which can improve the drying efficiency, but there are still some conventional problems: (1) the use of a cover glass can easily generate air bubbles if not handled properly; (2) the cover glass is also fragile, and once the cover glass breaks, it will inevitably affect the subsequent observation. Summary of the Invention

[0003] The purpose of this invention is to provide an instant-drying glass slide sample sealing and protection device to solve the problems of easy generation of air bubbles and fragility that exist in the sealing method using cover slips.

[0004] To achieve the above objectives, the present invention adopts the following technical solution:

[0005] A quick-drying glass slide sample sealing and protection device includes a glass slide tray with a glass slide placement groove for placing glass slides; A linear drive module, connected to the slide tray, is used to drive the slide tray in linear motion. The glue application module includes a glue dispensing head located above the slide tray movement path for applying glue to the sample area of ​​the slide; The adhesive scraping module includes a scraper, which is located above the slide tray movement path and is used to scrape the adhesive on the slide. The dry adhesive module, located on one side of the adhesive scraper module, is used to dry the adhesive on the glass slide.

[0006] Furthermore, one end of the slide placement groove is provided with a through-hole, and the tail of the slide is located at the through-hole.

[0007] Furthermore, the linear drive module employs a lead screw and nut mechanism, including a slider, which is connected to one end of the slide tray.

[0008] Furthermore, the depth of the glass slide placement groove is greater than the thickness of the glass slide.

[0009] Furthermore, the bottom of the scraper is a scraping part, the scraper is inclined, and the upper part of the scraper is hinged to the scraper seat; the scraping part has positioning notches on both sides, which are used to abut against the two sides of the glass slide placement groove in the width direction, and there is a gap between the scraping part and the upper side of the glass slide.

[0010] Furthermore, the front side of the scraper holder is provided with a hinge interface, the upper part of the scraper is provided with a hinge shaft, and a torsion spring is sleeved on the hinge shaft. The torsion spring is used to apply a downward flipping force to the scraper.

[0011] Furthermore, the scraping module includes the scraper holder, which is disposed on the lifting block of the lifting mechanism.

[0012] Furthermore, the lifting mechanism adopts a lead screw and nut mechanism, including the lifting block.

[0013] Furthermore, the adhesive application module is used to apply photosensitive adhesive onto the glass slide.

[0014] Furthermore, the dry adhesive module includes a light-based dry adhesive assembly or a heat-based dry adhesive assembly.

[0015] The beneficial effects of this invention are: This invention relates to a dry slide sample sealing and protection device. After applying adhesive to the slide, instead of using a conventional coverslip, a scraper module spreads the adhesive to form a protective layer, which is then rapidly dried using a drying module. This immediate drying process facilitates better slide reading and storage; it immediately protects samples from exposure, scratches, and detachment, preventing potential secondary contamination and enabling long-term sample preservation. Eliminating the need for a coverslip saves a step and improves efficiency. Furthermore, the absence of a coverslip eliminates the problem of coverslip fragments and sealing material adhesion, resolving the issue of overlapping and cross-contamination during slide storage and improving the storage efficiency of the slide cabinet. Attached Figure Description

[0016] Figure 1 This is an external view of the dry glass slide sample sealing and protection device of the present invention; Figure 2 This is an internal structural diagram of the dry glass slide sample sealing and protection device of the present invention; Figure 3It is a 3D view of the glass slide tray; Figure 4 This is a 3D view of the adhesive scraping module; Figure 5 This is a structural diagram of the combined scraper blade and scraper holder.

[0017] The names corresponding to each mark in the diagram: 1. Housing; 11. Slide storage compartment; 2. Slide tray; 21. Slide placement slot; 22. Clearance opening; 3. Slide; 4. Dispensing head; 5. Glue scraper module; 51. Scraper; 511. Glue scraping part; 512. Positioning notch; 513. Positioning ridge; 514. Limiting part; 52. Torsion spring; 53. Scraper seat; 54. Lifting block; 55. Second servo motor; 61. Slider; 62. First servo motor; 7. Dry glue module. Detailed Implementation

[0018] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.

[0019] Example: like Figures 1-5 As shown, a quick-drying slide sample sealing and protection device includes a housing 1, a slide tray 2, a linear drive module, an adhesive application module, an adhesive scraping module 5, and a dry adhesive module 7. It has a slide placement slot 21 for placing slides 3; the front of the housing has a passage opening through which the slide tray 2 can move in and out in the front-back direction. In the initial state, a portion of the slide tray 2 extends forward out of the housing 1, allowing slides 3 to be inserted from outside the housing 1.

[0020] like Figure 3 As shown, one end (front end) of the slide placement groove 21 is provided with a vertically extending clearance 22. The clearance 22 is an arc-shaped opening, and the tail of the slide 3 is located at the clearance 22. The clearance 22 is provided to facilitate manual handling of the slide 3.

[0021] like Figure 2 As shown, the linear drive module is connected to the slide tray 2 and is used to drive the slide tray 2 to move linearly. The linear drive module adopts a screw-nut mechanism, including a slider 61, which acts as the nut in the screw-nut mechanism and is connected to the rear end of the slide tray 2. The slider 61 is slidably mounted on a slide rail, the length of which is set along the front-to-back direction. The screw in the screw-nut mechanism is referred to as the first screw. One end of the first screw engages with the slider 61, and the other end is connected to the first servo motor 62. The first servo motor 62 drives the first screw to rotate, thereby driving the slider 61 to move linearly. During slide sealing, the slider 61 moves backward, and after sealing, the slider 61 moves forward. The first screw is located diagonally above the slide rail and does not interfere with other components.

[0022] The adhesive dispensing module includes a dispensing head 4 located above the moving path of the slide tray 2, used to apply adhesive to the sample area of ​​the slide. The dispensing module is used to dispense photosensitive adhesive onto the slide 3; in this embodiment, existing photosensitive adhesive is used. The dispensing module also includes an adhesive container, tubing, and an adhesive pump. Existing technologies can be used for the dispensing module, and details are omitted here. Only the position and dispensing amount of the dispensing head 4 need to be adjusted according to the scenario of this embodiment. The dispensing head 4 is located above the slide rail. After the slide 3 moves to the set position, dispensing begins. After dispensing is completed, the slide 3 continues to move backward under the drive of the linear drive module.

[0023] like Figure 2 As shown, the adhesive scraping module 5 includes a scraper 51, which is located above the moving path of the slide tray 2 and is used to scrape the adhesive on the slide 3.

[0024] like Figure 4 and 5 As shown, the scraper blade 51 is inclined, and its upper part is hinged to the scraper blade seat 53. The front side of the scraper blade seat 53 has a hinge interface, and the upper part of the scraper blade has a hinge shaft. The scraper blade 51 can rotate along the hinge shaft within a small angle range. A torsion spring 52 is sleeved on the hinge shaft, and the torsion spring 52 applies a downward flipping force to the scraper blade 51. The upper part of the scraper blade 51 also has a limiting part 514, which cooperates with the scraper blade seat 53 to limit the downward flipping angle of the scraper blade 51. That is, the maximum downward flipping angle of the scraper blade 51 is limited, so that the scraper blade 51 can maintain a specific tilt angle only under the force of the torsion spring 52 when no other external force is applied.

[0025] The bottom of the scraper 51 is a scraping part 511. During the backward movement of the slide, the scraping part 511 of the scraper 51 can be used to scrape away the adhesive on the slide, forming an adhesive layer that seals the sample on the slide. The depth of the slide placement groove 21 is greater than the thickness of the slide. Positioning notches 512 are provided on both sides of the scraping part 511. The positioning edges 513 of the positioning notches 512 are used to abut against both sides of the slide placement groove 21 in the width direction. That is, the positioning edges 513 contact the slide placement groove 21 but not the slide itself, and there is a certain gap between the positioning edges 513 and the upper side of the slide. During the backward movement of the slide, the positioning edges 513 can be pressed against both sides of the slide placement groove 21 under the force of the torsion spring 52, playing a positioning role and ensuring a fixed gap between the scraping part 511 and the upper side of the slide, thus making the scraping more uniform. By designing the size of the positioning notch 512, the distance between the positioning ridge 513 and the upper side of the glass slide can be changed, which changes the size of the gap between the adhesive scraping part 511 and the upper side of the glass slide. The gap size can be designed to be about 1 mm as needed.

[0026] The scraper holder 53 is raised and lowered by a lifting mechanism, which employs a screw and nut mechanism and includes a lifting block 54. The scraper holder 53 is mounted on the lifting block of the lifting mechanism. The lifting block 54 forms the nut in the screw and nut mechanism, and the screw in the screw and nut mechanism is driven by a second servo motor 55.

[0027] The dry adhesive module 7, located on one side of the adhesive scraping module 5, is used to dry the adhesive on the glass slide. The dry adhesive module 7 includes a light-based dry adhesive assembly or a heat-based dry adhesive assembly. In this embodiment, the dry adhesive module 7 preferably uses a light-based dry adhesive assembly, which irradiates the photosensitive adhesive on the glass slide using a UV lamp. The photosensitive adhesive dries in a few seconds; the drying time is related to the power of the UV lamp, and a UV lamp of appropriate power can be selected.

[0028] The UV lamp consists of a UV lamp tube and an outer lamp cover. The vertical distance between the lamp cover and the glass slide tray 2 is small, ensuring that the ultraviolet light generated by the UV lamp tube directly illuminates the photosensitive adhesive on the glass slide below the lamp cover, preventing the UV lamp tube from scattering light to other areas. The lamp cover has an opening at the bottom, and the inner wall of the lamp cover can be made into a mirror, which has a reflective effect and improves the utilization rate of the UV lamp tube.

[0029] In other embodiments, the heated dry adhesive assembly can use an electric heater, drawing on the principle of a reflective electric heater (commonly known as a small sun heater), to quickly heat the adhesive on the glass slide and allow it to dry rapidly. Alternatively, a cover can be used so that the heat is concentrated and directed downwards towards the glass slide.

[0030] The working principle of this invention, namely the dry glass slide sample sealing and protection device: A glass slide with the sample is placed into the slide placement slot 21 of the slide tray 2, with the tail of the slide facing forward. The wall of the slide placement slot 21 can limit the slide, preventing it from falling out during subsequent movement. The first servo motor 62 is activated, moving the slide tray 2 backward to the dispensing station. The dispensing module starts and dispenses dispensing adhesive onto the slide. After completion, the first servo motor 62 moves the slide tray 2 further backward. At this time, the bottom of the scraper of the scraper module 5 is in contact with the slide tray 2. During the backward movement of the slide, the scraping part 511 of the scraper scrapes the adhesive on the slide, forming an adhesive layer that seals the sample on the slide. The slide tray 2 moves backward to the drying station and stays for 5 to 10 seconds, using a UV lamp to irradiate the photosensitive adhesive on the slide until it dries. Under the control of the lifting mechanism, the scraper module 5 rises a certain distance, avoiding the slide tray 2. The first servo motor 62 moves the slide tray 2 forward to its initial position, with a portion of the slide tray 2 protruding from the housing 1, allowing the slide to be removed.

[0031] The housing 1 is also provided with several glass slide storage compartments 11, in which glass slides before being coated with adhesive can be placed.

[0032] This invention is not limited to the preferred embodiments described above. Anyone can derive other products in various forms under the guidance of this invention. However, regardless of any changes in shape or structure, any technical solution that is the same as or similar to this application falls within the protection scope of this invention.

Claims

1. A dry-slide sample mounting protection device, characterized by: The glass slide tray comprises glass slide placing grooves for placing glass slides; The linear driving module is connected with the glass slide tray and is used for driving the glass slide tray to move linearly; The glue adding module comprises a glue dropping head above the moving path of the glass slide tray and is used for adding glue to the sample area of the glass slide; The glue scraping module comprises a scraping piece above the moving path of the glass slide tray and is used for scraping the glue on the glass slide; The glue drying module is located on one side of the glue scraping module and is used for drying the glue on the glass slide.

2. The dried slide sample mounting device of claim 1, wherein: One end of the glass slide placing groove is provided with an up-and-down through gap, and the tail of the glass slide is located at the position of the gap.

3. The dried slide sample mounting device of claim 1, wherein: The linear driving module adopts a screw nut mechanism and comprises a sliding block connected with one end of the glass slide tray.

4. The dry-slide sample mounting device of claim 1, wherein: The depth of the glass slide placing groove is greater than the thickness of the glass slide.

5. The dry slide sample mounting device of claim 4, wherein: The bottom of the scraping piece is a glue scraping part, the scraping piece is obliquely arranged, the upper part of the scraping piece is hinged to a scraping piece seat, both sides of the glue scraping part are provided with positioning notches for abutting against both sides of the glass slide placing groove in the width direction, and a gap is formed between the glue scraping part and the upper side of the glass slide.

6. The dry slide sample mounting device of claim 5, wherein: The front side of the scraping piece seat is provided with a hinge joint, the upper part of the scraping piece is provided with a hinge shaft, a torsional spring is sleeved on the hinge shaft, and the torsional spring is used for applying a downward turning force to the scraping piece.

7. The dry slide sample mounting device of claim 5, wherein: The glue scraping module comprises the scraping piece seat arranged on the lifting block of the lifting mechanism.

8. The dried slide sample mounting device of claim 7, wherein: The lifting mechanism adopts a screw nut mechanism and comprises the lifting block.

9. The dry slide sample mounting device of claim 1, wherein: The glue adding module is used for dropping photosensitive glue on the glass slide.

10. The dry-slide sample mounting device of claim 1, wherein: The glue drying module comprises a light irradiation type glue drying assembly or a heating type glue drying assembly.

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