Particle size separation and quantity mass quantification method of polystyrene nanoparticles

By combining a hollow fiber flow field separation system with nanoparticle tracking analysis and thermal pyrolysis-gas chromatography/mass spectrometry, efficient separation and multi-dimensional quantification of polystyrene nanoparticles in complex matrices are achieved. This solves the problem of simultaneously obtaining particle quantity and quality information in existing technologies and provides a comprehensive and reliable risk assessment method.

CN121783781APending Publication Date: 2026-04-03RES CENT FOR ECO ENVIRONMENTAL SCI THE CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-22
Publication Date
2026-04-03

AI Technical Summary

Technical Problem

Existing technologies are insufficient for efficiently separating polystyrene nanoparticles in complex matrices in a single analytical procedure, and simultaneously and accurately quantifying their particle size distribution, particle number concentration, and polymer mass concentration, thus failing to fully reflect the true characteristics of the particles.

Method used

A hollow fiber flow field separation system combined with a nanoparticle tracking analyzer and a pyrolysis-gas chromatography/mass spectrometry system was used to separate the particle size of polystyrene nanoparticles in the sample. The number concentration of particles was quantified by the nanoparticle tracking analyzer, and the mass concentration of polymer was quantified by the pyrolysis-gas chromatography/mass spectrometry system.

Benefits of technology

It achieves efficient separation of polystyrene nanoparticles by particle size in complex environments and biological matrices, and simultaneously acquires key data in multiple dimensions such as particle number concentration, particle size distribution and polymer mass concentration, providing a comprehensive and reliable risk assessment method.

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Abstract

The invention discloses a particle size separation and quantity and mass quantification method for polystyrene nanoparticles. The method comprises the following steps: firstly, enabling a sample to enter a hollow fiber flow field separation system along with a carrier liquid, and realizing online purification and separation according to particle sizes of particles by controlling focusing and elution processes; and then, sequentially carrying out quantitative analysis on particle number concentration and particle size distribution on the collected fractions in different particle size sections by adopting a nano-particle tracking analyzer, and carrying out quantitative analysis on polymer mass concentration by adopting a thermal cracking-gas chromatograph / mass spectrometer. According to the method, a physical separation technology and two complementary analysis technologies are combined for use, multi-dimensional information such as particle size distribution, number concentration and mass concentration of the polystyrene nanoparticles is synchronously and accurately obtained in one analysis process, and the problem that counting and weighing are difficult to consider at the same time in the prior art is solved; the method is suitable for reliable characterization of complex matrixes such as environmental water bodies and biological tissue homogenate.
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Citation Information

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