Process for the preparation of a medium-chain triglyceride composition and medium-chain triglyceride composition

By introducing specifically surface-modified inorganic nano-silica hybrid materials into medium-chain triglycerides, a stable lipid carrier platform was constructed, solving the problems of stability and drug loading capacity of medium-chain triglycerides in biopharmaceuticals, and achieving efficient and safe drug delivery and targeting functions.

CN121818940BActive Publication Date: 2026-06-19HUBEI CHUYI NEW MATERIAL CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HUBEI CHUYI NEW MATERIAL CO LTD
Filing Date
2026-03-11
Publication Date
2026-06-19

AI Technical Summary

Technical Problem

Existing medium-chain triglycerides face challenges in biopharmaceutical applications, including insufficient physical stability, limited drug loading capacity, and the need to improve biocompatibility, making it difficult to meet the high-requirement formulation needs.

Method used

By introducing a specifically surface-modified inorganic nano-silica hybrid material and combining it with a medium-chain triglyceride lipid matrix, a kinetically stable dispersion system is formed. The multifunctional groups of the modified material generate various interactions with drug molecules, thus constructing a stable lipid carrier platform.

Benefits of technology

This study improved the physicochemical stability of medium-chain triglyceride compositions under long-term storage and temperature fluctuation conditions, broadened the drug loading capacity for different drugs, optimized biocompatibility, and provided flexible functional upgrade capabilities.

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Abstract

This invention belongs to the field of biopharmaceutical carrier materials, specifically relating to a preparation process and composition of a medium-chain triglyceride composition. The composition comprises basic medium-chain and medium-to-long-chain triglycerides, two types of inorganic modified silica, an interface stabilizer, an antioxidant, and a flow modifier. The core of the process involves first preparing two types of modified silica: one is the grafting of ethylenediaminetetraacetic acid (EDTA) onto the surface of mesoporous silica via silanization and subsequent amidation; the other is the hydrolysis of glycidyl etheroxypropyltrimethoxysilane under acetic acid catalysis, followed by a ring-opening reaction with decenol, while the silane portion condenses with the surface of fumed silica. Finally, the two modified materials are mixed with lipids and other components, and the final product is obtained through dispersion and grinding processes. This invention significantly improves the physical stability and functional applicability of the composition by introducing inorganic modified components with specific structures, making it suitable for the food, pharmaceutical, or cosmetic fields.
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