Pathological tissue sampling bottle for integrally limiting embedding box

Abstract

The invention belongs to the technical field of medical instruments, and discloses a pathological tissue sampling bottle for integral limiting of an embedding box, the pathological tissue sampling bottle comprises a lower cover and an upper cover, the central vertical section of the lower cover is cross-shaped, four side surface limiting ribs are arranged in the lower cover in a rectangular shape, two bottom supporting ribs are symmetrically arranged at the bottom in the lower cover, and the upper cover is provided with a lower cover. The two bottom supporting ribs are located in a surrounding range of the four side surface limiting ribs, and the bottom supporting ribs are matched with the side surface limiting ribs to place an embedding box together; after the lower cover and the upper cover are matched, the top of the embedding box is in contact with the inner top surface of the upper cover; the device is reliable in limiting, capable of tracing information, capable of guaranteeing sample quality and accurate management, optimizing operation and reagent efficiency, reducing medical care burden and sample loss, capable of strengthening sealing and pollution prevention, durable, economical and capable of meeting the long-term requirement of a laboratory.

Description

Technical Field

[0001] This invention belongs to the field of medical device technology, specifically relating to a pathological tissue sampling bottle for integrated embedding and positioning. Background Technology

[0002] In modern pathological diagnostic procedures, the processing of endoscopic biopsy tissues is a crucial preliminary step. The standardization of its collection, fixation, and transportation directly determines the accuracy of subsequent pathological section preparation and diagnostic results. Currently, the traditional processing method for biopsy tissues in clinical endoscopy rooms has formed a fixed procedure: medical staff first place the excised biopsy tissues one by one into a special small bag or filter. The small bag is usually made of paper or thin plastic, while the filter is usually made of metal or ordinary plastic woven structure. Then, formalin fixative is injected into the outer container of the small bag or filter containing the tissue to ensure that the fixative completely submerges the tissue, thereby achieving stable preservation of tissue cell morphology and laying the foundation for subsequent pathological analysis.

[0003] However, the aforementioned traditional processing methods have revealed many unavoidable technical flaws in practical applications, specifically in the following three aspects: First, the procedure is cumbersome and inefficient. Due to the small size and large quantity of biopsy tissues, medical staff must place each tissue into a small bag or filter in a sterile environment, taking extra care to avoid tissue loss. When injecting formalin, the amount of liquid must be controlled to prevent spillage. At the same time, a label must be attached to the outer wall of the container to record key data such as patient information, sampling site, and sampling time. The entire operation involves many steps and is time-consuming, especially when biopsy samples are concentrated, which can easily increase the workload of medical staff and poses a risk of operational errors.

[0004] Secondly, there is a high risk of cross-contamination. Traditional bags or filters have poor sealing performance. Paper bags are easily damaged by formalin, and gaps can easily appear at the seams of plastic bags or filters due to insufficient processing precision. During transportation or transfer, formalin fixative may carry tissue debris from different samples and seep between containers, or the bags / filters may be damaged, leading to direct contact between tissues and causing cross-contamination between samples from different patients. In severe cases, this may lead to incorrect diagnostic results and affect clinical treatment decisions.

[0005] Third, the tissue fixation is uneven and the information is easily confused. On the one hand, the tissue in the pouch or filter lacks an effective restraining structure. During transportation, it is easily affected by external forces such as bumps and tilting, and may float, slip, or accumulate. This results in some tissues not being able to fully contact formalin, causing uneven fixation, which in turn leads to changes in tissue cell morphology and affects pathological observation. On the other hand, sample information relies on the label recorded on the outer wall of the container. If the label is worn, falls off, or is misaligned with the container during transportation, it is easy for the sample and information to not match, resulting in information confusion and causing great trouble for subsequent pathological diagnosis.

[0006] In summary, existing methods of pathological tissue sampling and transportation are significantly inadequate in terms of ease of operation, contamination control, sample stability, and information traceability, and cannot meet the clinical requirements for high precision and high reliability in biopsy tissue processing. Summary of the Invention

[0007] In view of the problems mentioned in the background art above, the purpose of the present invention is to provide a pathological tissue sampling bottle for integrated embedding and positioning.

[0008] To achieve the above-mentioned technical objectives, the technical solution adopted by the present invention is as follows: A pathological tissue sampling bottle for integrated embedding cassette positioning includes a lower cover and an upper cover. The lower cover has a cross-shaped vertical cross section at its center. The interior of the lower cover is rectangular and has four side limiting ribs. The bottom of the lower cover has two symmetrical bottom support ribs. The two bottom support ribs are located within the enclosed area of ​​the four side limiting ribs. The embedding cassette is placed on the bottom support ribs together with the side limiting ribs. After the lower cover and the upper cover are fitted together, the top of the embedding box contacts the inner top surface of the upper cover; The embedding box includes a box body, a box cover hinged to the box body, the box cover being fastened to the box body, both the box body and the box cover having permeation holes, a scratch strip installed in the middle of the bottom of the box body, and a QR code affixed to the top of the outer side of the box cover.

[0009] Further specified, the lower cover and the upper cover are threadedly connected, and the outer side of the upper cover is provided with friction texture. The threaded connection has high strength, and the friction texture is conducive to the rotation of the upper cover.

[0010] Furthermore, both the side limiting ribs and the bottom supporting ribs are integrally connected with reinforcing ribs to enhance the supporting strength, thereby strengthening the overall structural strength and ensuring service life.

[0011] Furthermore, the scraping strip has barbs on both sides, which can effectively hang and pull the endoscopic tissue, facilitating rapid placement and detachment.

[0012] Furthermore, the permeation holes are square and evenly distributed in an array on the box body and the box lid. The even arrangement facilitates subsequent cleaning of the pores while also improving the overall appearance.

[0013] Furthermore, the QR code is waterproof and immersion-resistant, and will not be lost or blurred in a formalin environment, which is beneficial for subsequent identification.

[0014] Furthermore, both the box body and the lid are made of polypropylene, which has good chemical stability and weather resistance.

[0015] Furthermore, the total area of ​​the permeation holes accounts for half of the surface area of ​​the box body and the box cover to ensure the permeation efficiency of the reagent.

[0016] Furthermore, the top of the inner surface of the box lid is provided with raised ridges in a grid shape to ensure a pressing and resisting effect on the box lid.

[0017] Furthermore, the internal groove of the box is shaped like an inverted frustum, which meets the operational requirements of pathological tissue sampling and can simultaneously improve the convenience of tissue placement, reagent efficiency, and the safety of subsequent processing.

[0018] The beneficial effects of using the present invention are as follows: This sampling bottle securely fixes the embedding cassette through the coordinated positioning of the side limiting ribs on the lower cap, the bottom supporting ribs, and the upper cap. This completely avoids the problems of tissue floating and slipping during traditional transportation, ensuring that the tissue is always fully immersed in the fixative and guaranteeing uniform fixation. At the same time, the waterproof QR code on the embedding cassette cap can directly store key information such as patient and sampling details. This information can be synchronized to the hospital system by scanning the code, eliminating information confusion caused by wear and tear or detachment of traditional labels. This enables accurate traceability of sample information and provides an accurate sample and information foundation for pathological diagnosis.

[0019] In this invention, the inverted equilateral frustum-shaped groove inside the embedding box is wider at the top and narrower at the bottom. This not only expands the tissue insertion opening for quick sample placement by medical staff, but also reduces the bottom space to facilitate precise tweezers handling, reducing tissue drop and breakage. At the same time, the inclined inner wall of the frustum has no dead angles, and together with the permeation holes in the box, it can accelerate the injection and drainage of fixation fluid, avoid air bubbles or reagent residue, significantly improve reagent efficiency, and eliminate the need to process traditional small bag labels one by one, simplifying the operation process and effectively reducing the workload of medical staff.

[0020] In this invention, the lower and upper caps of the sampling bottle are connected by a threaded seal, and together with the independent snap-fit ​​structure of the embedding box, a double isolation space is formed, which completely blocks cross-contamination caused by the breakage of traditional small bags / filters. Furthermore, the limiting ribs of the lower cap and the bottom support ribs are reinforced. The embedding box and the main body of the sampling bottle are made of chemically resistant and autoclaved materials, which are durable and not easily deformed, and are suitable for repeated sterilization and use. Compared with traditional disposable consumables, this reduces waste, significantly reduces the long-term use cost of the laboratory, and meets the stringent requirements of pathological scenarios. Attached Figure Description

[0021] The present invention can be further illustrated by the non-limiting embodiments given in the accompanying drawings; Figure 1 This is a schematic diagram of an embodiment of a pathological tissue sampling bottle for integrated embedding and positioning of an embedding cassette according to the present invention. Figure 2 This is an exploded structural diagram of an embodiment of a pathological tissue sampling bottle for integrated embedding and positioning according to the present invention. Figure 3This is a schematic diagram of the flat structure of a pathological tissue sampling bottle for integrated embedding and positioning according to an embodiment of the present invention. Figure 4 This is a schematic diagram of the embedding box structure of a pathological tissue sampling bottle for integrated embedding box positioning according to an embodiment of the present invention. Figure 5 This is a cross-sectional structural schematic diagram of an embodiment of a pathological tissue sampling bottle for integrated positioning of an embedding box according to the present invention. The symbols for the main components are explained below: 1. Lower cover; 2. Upper cover; 3. Side limiting rib; 4. Bottom support rib; 5. Embedding box; 6. Reinforcing rib; 51. Box body; 52. Box lid; 53. Permeability hole; 54. Scratch strip; 55. QR code; 56. Raised edge. Detailed Implementation

[0022] To enable those skilled in the art to better understand the present invention, the technical solution of the present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0023] like Figures 1-5 As shown, a pathological tissue sampling bottle for integrated embedding cassette positioning according to the present invention includes a lower cover 1 and an upper cover 2. The central vertical cross section of the lower cover 1 is cross-shaped. The interior of the lower cover 1 is rectangular and has four side limiting ribs 3. The bottom of the lower cover 1 is symmetrically provided with two bottom support ribs 4. The two bottom support ribs 4 are located within the enclosed area of ​​the four side limiting ribs 3. The embedding cassette 5 is placed together with the bottom support ribs 4 and the side limiting ribs 3. After the lower cover 1 and the upper cover 2 are assembled, the top of the embedding box 5 contacts the inner top surface of the upper cover 2; The embedding box 5 includes a box body 51, a box cover 52 is hinged to the box body 51, the box cover 52 is fastened to the box body 51, both the box body 51 and the box cover 52 are provided with permeation holes 53, a scratch strip 54 is installed in the middle of the bottom inside the box body 51, and a QR code 55 is affixed to the top outside the box cover 52.

[0024] In this implementation case, when using a pathological tissue sampling bottle with integrated embedding cassette positioning, the lower cover 1 is manufactured using injection molding. Its central vertical cross-section is designed in a cross shape. This structure can reduce material usage while ensuring the overall strength of the lower cover, and the outwardly protruding ring facilitates placement and positioning and clamping support for automated equipment. The four side limiting ribs 3 inside the lower cover 1 are evenly distributed along the rectangular inner wall. Each side limiting rib 3 is perpendicularly connected to the inner wall of the lower cover 1, and its height is slightly lower than the depth of the lower cover 1. The four limiting ribs together form a... The rectangular space that fits the outer wall of the embedding cassette 5 precisely restricts the lateral movement of the embedding cassette 5; the two elongated and parallel bottom support ribs 4 inside the bottom of the lower cover 1 are symmetrically arranged on both sides of the bottom of the rectangular enclosed area, which just supports the bottom edge of the embedding cassette 5, keeping the bottom of the embedding cassette 5 and the inner bottom of the lower cover 1 in a gap to facilitate the flow of fixative fluid; this design significantly optimizes the cumbersome process in the prior art that requires placing the endoscopic tissue into the filter bag and then into the embedding cassette; in actual operation, medical staff can directly insert the tiny tissue obtained by endoscopic biopsy through the opening of the cassette 51. The embedding box 5 is placed inside without the need for a filter bag as an intermediate carrier. The box, with its lid 52 fastened, is then placed directly within the space formed by the side limiting ribs 3 and the bottom supporting ribs 4. This reduces the unnecessary steps of "placing the filter bag → transferring the tissue to the filter bag → placing the filter bag into the embedding box." After the embedding box 5 is placed, the lower cover 1 and the upper cover 2 are closed by a threaded connection. At this point, the inner top surface of the upper cover 2 is in contact with the top of the embedding box 5, forming a vertical constraint. The embedding box 5 is further constrained by the lateral restraint of the side limiting ribs 3, the vertical support of the bottom supporting ribs 4, and the top of the upper cover 2. Next, the three components work together to firmly lock the embedding cassette 5 inside the sampling bottle, ensuring that the embedding cassette 5 does not shake or shift during transportation. At the same time, the body 51 of the embedding cassette 5 and the lid 52 are fastened together to form a closed space. With the permeation holes 53 of both, the external fixative can fully enter the cassette to soak the tissue without relying on the permeation function of the filter bag. This not only solves the problem of tissue floating with the filter bag and uneven fixation in the traditional method, but also reduces the risk of contamination caused by tissue being trapped in the gaps of the filter bag or the filter bag being damaged by eliminating the filter bag, thus greatly improving sample stability and operational efficiency.

[0025] Preferably, the lower cover 1 and the upper cover 2 are threaded together, and the outer side of the upper cover 2 is provided with friction texture.

[0026] In this implementation case, the lower cover 1 has an external thread on its top outer periphery, and the upper cover 2 has a matching internal thread on its inner wall. The thread has a fine tooth structure to ensure a tight connection. The friction texture on the outer side of the upper cover 2 is designed as a ring tooth shape, evenly distributed along the outer periphery of the upper cover. The fine tooth thread has a large number of mating turns, resulting in high connection strength and good sealing performance, which can effectively prevent the fixative fluid from leaking. The friction texture increases the friction between the hand and the upper cover, making it easier for medical staff to quickly tighten or open the upper cover and improve operating efficiency.

[0027] Preferably, the side limiting rib 3 and the bottom supporting rib 4 are both integrally connected with the reinforcing rib 6.

[0028] In this embodiment, the reinforcing ribs 6 of the side limiting ribs 3 and the bottom supporting ribs 4 are arranged in a triangular support structure. Two reinforcing ribs 6 are connected between the outer wall of each side limiting rib 3 and the inner wall of the lower cover 1, and are evenly distributed at the upper and middle positions in the height direction of the limiting rib. One reinforcing rib 6 is connected between the bottom of each bottom supporting rib 4 and the inner bottom of the lower cover 1, located in the middle of the length direction of the supporting rib. The thickness of the reinforcing rib 6 is the same as that of the limiting rib and the supporting rib, and they are integrally formed by injection molding. The triangular reinforcing ribs can disperse the force on the limiting ribs and the supporting ribs, significantly enhance the structural strength of both, and avoid deformation and breakage during long-term use or under stress, thereby extending the service life of the sampling bottle.

[0029] The preferred scraper strip 54 has barbs on both sides.

[0030] In this implementation, the scraping strip 54 is perpendicular to the bottom of the box 51, and the barbs on both sides are inclined upward at a 45° angle, with smooth tips without burrs. The barb-like structure can easily catch the tiny tissues obtained by endoscopic biopsy, making it easy to quickly place the tissues into the box 51. At the same time, when picking up and putting down the tissues, the tilting angle of the barbs can guide the tissues to detach smoothly, reducing the adhesion between the tissues and the scraping strip and reducing sample loss.

[0031] Preferably, the permeation holes 53 are square and evenly distributed in an array on the box body 51 and the box cover 52.

[0032] In this embodiment, the permeation holes 53 on the box body 51 and the box cover 52 are all squares with a side length of 2-3 mm. They are evenly arranged in a 3×4 array on the bottom and sides of the box body and the top of the box cover, with a hole spacing of 2 mm. The square holes have flat edges, which facilitates injection molding. The evenly distributed array allows the fixative to enter the box from multiple directions, ensuring that all parts of the tissue are in full contact with the reagent. At the same time, the neat arrangement reduces cleaning dead corners, makes it easy to rinse off residual tissue debris after use, and the overall appearance is neat, improving the product quality.

[0033] QR code 55 is the preferred one as it is waterproof and immersion-resistant.

[0034] In this implementation case, a waterproof label made of PET substrate is selected and affixed to the top of the box lid 52 with chemically resistant adhesive. The QR code information is produced by laser etching or UV printing to ensure clear patterns. In corrosive fixative environments such as formalin, the label will not fall off or the text will become blurred, maintaining the integrity of the information for a long time. This facilitates the rapid reading of key information such as patient information and sampling sites through scanning devices, avoiding information confusion.

[0035] Preferably, both the box body 51 and the box lid 52 are made of polypropylene.

[0036] In this implementation case, food-grade polypropylene raw material was selected for injection molding, with a wall thickness of 1.5-2mm. Polypropylene has excellent chemical stability, is resistant to corrosion by pathological reagents such as formalin, and has good high and low temperature resistance, making it suitable for sterilization methods such as high-pressure steam sterilization. At the same time, the material has moderate toughness, is not easy to break, and can meet the needs of repeated use in pathology laboratories.

[0037] Preferably, the total area of ​​the permeation holes 53 is half the surface area of ​​the box body 51 and the box cover 52.

[0038] In this implementation case, after calculating the total surface area based on the dimensions of the box body and lid, square holes of corresponding quantity and size are set to ensure that the total area of ​​the openings accounts for 50%. This ratio maximizes the flow efficiency of the fixative while ensuring the structural strength of the box body and lid, allowing the reagent to quickly penetrate into every corner of the box and ensuring uniform and sufficient tissue fixation.

[0039] The inner top of the preferred box lid 52 has a raised ridge 56 in a grid shape.

[0040] In this embodiment, the protruding ribs 56 are distributed in a "well" shape on the inner top surface of the box lid, with the intersection point aligned with the center of the box lid. The well-shaped structure can evenly distribute pressure. When the box lid 52 and the box body 51 are fastened together, the protruding ribs 56 can closely contact the tissue inside the box or the bottom of the box body, effectively preventing the tissue from shifting due to shaking during transportation and enhancing the compression and fixation effect on the tissue.

[0041] The internal groove of the preferred box 51 is shaped like an inverted frustum.

[0042] In this implementation case, the top opening of the groove is larger than the bottom opening, the angle between the side of the cone and the bottom is 60° to 70°, and the inner wall is smooth and burr-free. The "wide" top opening makes it easy for medical staff to quickly place small tissues with tweezers, reducing operational errors. The "narrow" bottom can automatically gather tissues and avoid dispersion. The inclined inner wall has no right angle dead corners, which facilitates the rapid flow and emptying of fixative, improves reagent efficiency, and facilitates subsequent tissue handling and reduces the risk of sample damage.

[0043] The above embodiments are merely illustrative of the principles and effects of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by those skilled in the art without departing from the spirit and technical concept disclosed in the present invention should still be covered by the claims of the present invention.

Claims

1. A pathological tissue sampling bottle for integrated embedding and positioning, comprising a lower cap (1) and an upper cap (2), wherein the central vertical cross-section of the lower cap (1) is cross-shaped, characterized in that: The lower cover (1) has a rectangular interior with four side limiting ribs (3). The bottom of the lower cover (1) has two bottom support ribs (4) symmetrically arranged. The two bottom support ribs (4) are located within the enclosed area of ​​the four side limiting ribs (3). The bottom support ribs (4) are placed together with the side limiting ribs (3) to form an embedding box (5). After the lower cover (1) and the upper cover (2) are fitted together, the top of the embedding box (5) contacts the inner top surface of the upper cover (2); The embedding box (5) includes a box body (51), a box cover (52) is hinged to the box body (51), the box cover (52) is fastened to the box body (51), both the box body (51) and the box cover (52) are provided with permeation holes (53), a scraping strip (54) is installed in the middle of the bottom of the box body (51), and a QR code (55) is affixed to the top of the outer side of the box cover (52).

2. A pathological tissue sampling bottle for integrated embedding and positioning according to claim 1, characterized in that: The lower cover (1) and the upper cover (2) are threaded together, and the outer side of the upper cover (2) is provided with friction texture.

3. A pathological tissue sampling bottle for integrated embedding and positioning according to claim 1, characterized in that: The side limiting rib (3) and the bottom supporting rib (4) are both integrally connected with reinforcing ribs (6).

4. A pathological tissue sampling bottle for integrated embedding and positioning according to claim 1, characterized in that: The scraping strip (54) has barbs on both sides.

5. A pathological tissue sampling bottle for integrated embedding and positioning according to claim 1, characterized in that: The permeation holes (53) are square and evenly distributed in an array on the box body (51) and the box cover (52).

6. A pathological tissue sampling bottle for integrated embedding and positioning according to claim 1, characterized in that: The QR code (55) is a waterproof and immersion-resistant QR code.

7. A pathological tissue sampling bottle for integrated embedding and positioning according to claim 1, characterized in that: Both the box body (51) and the box lid (52) are made of polypropylene.

8. A pathological tissue sampling bottle for integrated embedding and positioning according to claim 1, characterized in that: The total area of ​​the permeation holes (53) accounts for half of the surface area of ​​the box body (51) and the box cover (52).

9. A pathological tissue sampling bottle for integrated embedding and positioning according to claim 1, characterized in that: The top of the inner lid (52) is provided with raised ridges (56) in a grid shape.

10. A pathological tissue sampling bottle for integrated embedding and positioning according to claim 1, characterized in that: The internal groove of the box (51) is in the shape of an inverted frustum.

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