A non-natural 3apos; untranslated regions and applications thereof

By designing non-natural 3'UTR structures and adding capping modifications, the stability and translation efficiency of mRNA are optimized, solving the problem of unstable protein expression in existing mRNA therapies. This enables efficient protein synthesis and expression, making it suitable for cancer immunotherapy and stem cell research.

CN121889503APending Publication Date: 2026-04-17HANMI PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HANMI PHARM CO LTD
Filing Date
2024-09-27
Publication Date
2026-04-17

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Abstract

Provided are: a transmission ribonucleic acid which comprises a non-natural 3'non-translated region (3 'UTR) and has excellent activity for improving the synthesis yield of a transmission ribonucleic acid (mRNA) of a gene; a composition comprising the transmission ribonucleic acid; a composition for delivering the signaling ribonucleic acid or polypeptide to a subject comprising the signaling ribonucleic acid; and a desoxyribonucleic acid encoding the signaling ribonucleic acid.
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