Traditional Chinese medicine preparation for treating skin scald

Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, and discloses a traditional Chinese medicine preparation for treating skin scald. The invention discloses a traditional Chinese medicine preparation for treating skin scald. The traditional Chinese medicine preparation sequentially comprises a hydrogel bottom layer, a functional layer and a hydrogel covering layer from bottom to top. The traditional Chinese medicine preparation for treating skin scald provided by the invention has a good wound healing effect, has a remarkable inhibition effect on inflammatory response of tissues around a scald wound, and has an excellent inhibition effect on common pathogenic bacteria on the scald wound.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine preparations, and more specifically, to a traditional Chinese medicine preparation for treating skin burns. Background Technology

[0002] Burns are a common traumatic injury in clinical practice. They can be caused by a variety of factors, including high temperature, open flame, boiling water, and steam. After a burn, the skin barrier is damaged, making the wound prone to redness, swelling, exudation, and pain. It is also highly susceptible to bacterial infection. If not treated promptly or properly, it can lead to delayed wound healing, scar hyperplasia, and in severe cases, even systemic infection, tissue necrosis, and other complications, causing irreversible damage to the patient's skin appearance and physiological function. There is an urgent clinical need for safe, effective burn treatment agents with excellent wound repair effects.

[0003] Currently, clinically used preparations for treating skin burns are mainly divided into chemically synthesized and traditional Chinese medicine preparations. Although chemically synthesized preparations can have antibacterial and pain-relieving effects to a certain extent, they have problems such as strong wound irritation, easy development of drug resistance, and only single symptomatic treatment without addressing wound repair. Furthermore, long-term use may cause secondary damage to the skin. Traditional Chinese medicine burn preparations have become a research hotspot in burn treatment due to their natural ingredients, low toxicity and side effects, and the synergistic effect of multiple components in antibacterial, anti-inflammatory, and tissue-regenerating and wound-healing effects. However, they still have many technical shortcomings.

[0004] Existing traditional Chinese medicine (TCM) burn preparations are mostly in the form of ointments and powders, which suffer from problems such as difficulty in controlling the release rate of active ingredients and low bioavailability. Furthermore, some preparations use only a single extraction process for the raw materials, resulting in insufficient extraction of active ingredients and limited efficacy. Simultaneously, most TCM burn preparations lack optimized dosage form design, leading to poor wound adhesion, easy detachment, and an inability to continuously provide an effective environment for wound healing. This can also further increase the risk of wound infection due to external contamination. In addition, some TCM burn preparations lack scientific formulation, simply mixing herbs without classifying and extracting them according to their properties, failing to achieve comprehensive therapeutic effects such as anti-inflammatory, antibacterial, and tissue-regenerating wound healing, and thus failing to meet clinical needs for rapid wound healing and reduced scar formation.

[0005] Based on this, developing a traditional Chinese medicine burn preparation with scientific compatibility of Chinese herbs, sufficient extraction of effective components, and reasonable dosage form design, which can achieve synergistic effects of anti-inflammatory, antibacterial, and tissue regeneration and wound healing, as well as good wound adhesion, controllable release of effective components, and high bioavailability, has become a technical problem that urgently needs to be solved by those skilled in the art. Summary of the Invention

[0006] The purpose of this invention is to provide a traditional Chinese medicine preparation for treating skin burns.

[0007] To achieve the above objectives, the present invention provides the following technical solution: One of the technical solutions of this invention: A traditional Chinese medicine preparation for treating skin burns comprises, from bottom to top, a hydrogel bottom layer, an efficacy layer, and a hydrogel top layer.

[0008] Furthermore, the method for preparing the functional layer includes the following steps: S1. Extraction of compound traditional Chinese medicine extracts; S2. Prepare traditional Chinese medicine microcapsules using the composite traditional Chinese medicine extract obtained in step S1 as the core material; S3. Prepare the efficacy layer using the traditional Chinese medicine microcapsules obtained in step S2 as raw materials.

[0009] Furthermore, in step S1, the extraction of the compound traditional Chinese medicine extract specifically includes the following steps: 1) Weigh each raw material according to the following mass proportions: Rhubarb 75 parts, Coptis chinensis 25 parts, Honeysuckle 75 parts, Red peony root 25 parts, Saposhnikovia divaricata 75 parts, Angelica dahurica 45 parts, Angelica pubescens 10 parts, Notopterygium incisum 10 parts, Arisaema heterophyllum 20 parts, Ligusticum chuanxiong 25 parts, Sparganium stoloniferum 50 parts, Clematis chinensis 75 parts, Curcuma zedoaria 50 parts, Lindera strychnifolia 75 parts, Frankincense 100 parts, Cyperus rotundus 15 parts, Drynaria fortunei 25 parts, Cremastra appendiculata 75 parts, Prunus persica 25 parts, Cnidium monnieri 100 parts, Xanthium sibiricum 25 parts, Castor bean 50 parts, Phragmites communis 75 parts, Tangerine peel 25 parts, Green tangerine peel 25 parts 25 parts of Citrus reticulata peel, 50 parts of Gardenia jasminoides, 10 parts of Amomum villosum, 75 parts of Lycopus lucidus, 50 parts of Selaginella tamariscina, 50 parts of Eclipta prostrata, 75 parts of Artemisia capillaris, 50 parts of Nelumbo nucifera leaf, 225 parts of Chrysanthemum indicum, 50 parts of Carthamus tinctorius, 200 parts of Chimonanthus praecox, 25 parts of Typha orientalis pollen, 75 parts of Bombax ceiba bark, 25 parts of Paeonia suffruticosa bark, 100 parts of Sappanwood, 50 parts of Pinus tabuliformis knot, 100 parts of Tinospora sinensis, 10 parts of Pepper, 75 parts of Unnamed Herb, 75 parts of Herba Unnamed, 75 parts of Herba Artemisiae Laminariae, 75 parts of Herba Artemisiae Laminariae, 75 parts of Herba Artemisiae Laminariae, 100 parts of Rhizoma Lysimachiae, 50 parts of Polygonum hydropiper. 75 parts gold earrings, 75 parts arborvitae leaves, 100 parts sea breeze vine, 75 parts purslane, 44 parts large soapberry, 100 parts snake root, 100 parts two-sided needle, 100 parts sheep ear chrysanthemum, 75 parts large wind mugwort, 75 parts cinnabar root, 50 parts willow branches, 75 parts star-colored grass, 20 parts clove, 100 parts myrrh, 19 parts purple gromwell root, 50 parts large wind chrysanthemum, 100 parts processed strychnos nux-vomica, 10 parts cardamom, 15 parts nutmeg, 150 parts aloe vera, 15 parts long pepper, 25 parts ginger peel, 5 parts vitex leaves 0 parts, Lithospermum erythrorhizon 10 parts, Bletilla striata 25 parts, Shallots 150 parts, Garlic 150 parts, Panax notoginseng 10 parts, Bombax ceiba 125 parts, Kudzu flower 125 parts, Panax notoginseng ginger 100 parts, Eriocaulon buergerianum 75 parts, Basil basil 50 parts, Dragon's blood 100 parts, Amaranth 75 parts, Iron-clad gold 100 parts, Alum 5 parts, Eucalyptus oil 50 parts, Star anise oil 50 parts, Methyl salicylate 125 parts, Clove basil oil 45 parts, Turpentine oil 150 parts, Peppermint oil 160 parts, Cinnamon oil 5 parts, Borneol 200 parts; 2) Mix the rhubarb, coptis, honeysuckle flower, red peony root, divaricate saposhnikovia root, dahurian angelica root, pubescent angelica root, notopterygium root, jackinthepulpit tuber, chuanxiong rhizome, rhizoma sparganii, clematis root, zedoary tuber, combined spicebush root, frankincense, nutgrass galingale rhizome, drynaria rhizome, pseudobulbus cremastrae seu pleiones, peach kernel, fructus cnidii, fructus xanthii, castor bean, cleistocalyx operculatus, dried tangerine peel, green tangerine peel, excised tangerine peel, cape jasmine fruit, amomum fruit, Chinese thoroughwort, selaginella, eclipta prostrata, artemisia anomala, lotus leaf, wild chrysanthemum flower, safflower, wintersweet, cat-tail pollen, kapok bark, moutan bark, sappanwood, Chinese pine knot, suberect spatholobus stem, pepper, pyrolusite, acalypha hispida, Emilia sonchifolia, hypericum japonicum, auricularia cordata, Chinese loropetalum leaf, piper wallichii, inula cappa, blumea balsamifera, ardisia crenata, willow branch, commelina communis, clove, myrrh, gamboge, chaulmoogra oil, prepared strychnos nux-vomica, tsaoko amomum fruit, nutmeg, aloe, long pepper, ginger skin, vitex trifolia leaf and purple gromwell weighed in step 1) to obtain traditional Chinese medicine powder A, then place the traditional Chinese medicine powder A in 60% ethanol, perform ultrasonic-assisted extraction, and filter to obtain traditional Chinese medicine extract A; Among them, the material-liquid ratio of the traditional Chinese medicine powder A to 60% ethanol is (15-25) mL: 1 g; Among them, the ultrasonic-assisted extraction is specifically as follows: at 45 °C, control the ultrasonic power to be 300 W, the ultrasonic frequency to be 20 kHz, and perform ultrasonic-assisted extraction for 30-50 min; 3) Mix the bletilla striata, onion, garlic, notoginseng, kapok flower, flos puerariae lobatae, zingiber officinale roscoe, eriocaulon buergerianum, ocimum basilicum, dragon's blood, amaranthus spinosus, bauhinia championii and alum weighed in step 1) to obtain traditional Chinese medicine powder B, then place the traditional Chinese medicine powder B in water, perform reflux decoction, and filter to obtain traditional Chinese medicine extract B; Among them, the water-material ratio of the traditional Chinese medicine powder B to water is (10-20) mL: 1 g; Among them, the reflux decoction is specifically as follows: reflux decoct at 100 °C for 50-70 min; 4) Mix the traditional Chinese medicine extract A obtained in step 2) and the traditional Chinese medicine extract B obtained in step 3), and add the eucalyptus oil, star anise oil, methyl salicylate, clove oil, turpentine oil, peppermint oil, cinnamon oil and borneol weighed in step 1), perform vacuum concentration, spray drying, to obtain the composite traditional Chinese medicine extract; Among them, the vacuum concentration is specifically as follows: vacuum concentrate at 60 °C and 0.08 MPa to a relative density of 1.10; Among them, the parameters of the spray drying are: inlet air temperature 160-170 °C, outlet air temperature 75-85 °C, feed rate 8-12 mL / min, atomization pressure 0.25-0.35 MPa, dry until the water content ≤ 5%.

[0010] Furthermore, in step S2, the preparation of the traditional Chinese medicine microcapsules specifically includes the following steps: 1) Place the compound Chinese herbal extract obtained in step S1 in phosphate buffer, add hyaluronic acid, and disperse by ultrasonication to obtain a core material suspension; The phosphate buffer solution has a concentration of 0.05 mol / L and a pH of 7.2. The ratio of the compound Chinese herbal extract to the phosphate buffer solution is (5-15) mL: 1g. The amount of the compound hyaluronic acid added is 1%wt; Specifically, the ultrasonic dispersion involves controlling the ultrasonic power to be 300W, the ultrasonic frequency to be 20kHz, and the ultrasonic dispersion time to be 5–15 minutes. 2) Mix the gelatin mother liquor and gum arabic mother liquor, and adjust the pH to 4.2 to obtain a composite wall material solution; The mass ratio of the gelatin to the gum arabic is 1:1. The gelatin mother liquor is prepared by mixing gelatin and water at a gelatin concentration of 5%wt. The gum arabic mother liquor is prepared by mixing gum arabic and water at a gum arabic concentration of 5%wt. 3) The core material suspension obtained in step 1) is added dropwise to the composite wall material solution obtained in step 2), and electrostatic self-assembly is performed to obtain a traditional Chinese medicine microcapsule suspension; Specifically, the dripping is performed as follows: under stirring conditions of 45°C and 300 r / min, the core material suspension is dripped into the composite wall material solution at a volume ratio of 1:1 between the core material suspension and the composite wall material solution. Specifically, the electrostatic self-assembly involves adding 0.5%wt sodium alginate and 0.3%wt chitosan quaternary ammonium salt to the mixture, electrostatically self-assembling at 10°C for 10–20 min, centrifuging, filtering, and then dispersing the filter residue in distilled water at pH 4.2 for 3–4 cycles. 4) Mix the traditional Chinese medicine microcapsule suspension obtained in step 3) with CaCl2 solution, perform ion cross-linking, and freeze-dry to obtain the traditional Chinese medicine microcapsules; The volume ratio of the traditional Chinese medicine microcapsule suspension to the CaCl2 solution is 1:1. Specifically, the ionic crosslinking involves ionic crosslinking at room temperature for 15–25 minutes. Specifically, the freeze-drying process involves freeze-drying at -50°C and 10 Pa for 12–24 hours.

[0011] Furthermore, in step S3, the preparation of the functional layer specifically includes the following steps: 1) N-isopropylacrylamide, acrylic acid and N,N'-methylenebisacrylamide were placed in water and deoxygenated with nitrogen to obtain a monomer prepolymer solution; The mass ratio of N-isopropylacrylamide, acrylic acid, N,N'-methylenebisacrylamide and water is 5:2:0.1:100. 2) The herbal microcapsules obtained in step S2 are placed in the monomer prepolymer solution obtained in step 1), ultrasonically dispersed, then ammonium persulfate is added to the dispersion, polymerized, and freeze-dried to obtain the efficacy layer; The ratio of the material to the liquid of the herbal microcapsule and the monomer prepolymer solution is (5-15) mL:1g. The amount of ammonium persulfate added is 0.1%wt; Specifically, the polymerization is carried out at 35°C for 4–6 hours; Specifically, the freeze-drying process involves freeze-drying at -50°C and 10 Pa for 10–14 hours.

[0012] Second technical solution of the present invention The preparation method of the above-mentioned traditional Chinese medicine preparation for treating skin burns includes the following steps: 1) Polyvinyl alcohol, sodium carboxymethyl cellulose, water and glycerol are mixed to obtain a hydrogel matrix; The material ratio of polyvinyl alcohol, sodium carboxymethyl cellulose, water and glycerin is 10g:2g:100mL:5mL. 2) Place the hydrogel matrix obtained in step 1) into a mold, allow it to stand to degas, and then freeze and thaw to obtain the hydrogel bottom layer; Specifically, the freeze-thaw process involves freezing at -20°C for 4 hours and thawing at room temperature for 4 hours. 3) Place the efficacy layer on the surface of the hydrogel bottom layer obtained in step 2), then add the hydrogel matrix obtained in step 1) to the surface of the efficacy layer, allow it to stand to defoam and freeze-thaw, and form a hydrogel covering layer on the surface of the efficacy layer to obtain the traditional Chinese medicine preparation for treating skin burns. Specifically, the freeze-thaw cycle involves freezing at -20°C for 4 hours, thawing at room temperature for 4 hours, and repeating the freeze-thaw cycle 3 times.

[0013] Compared with the prior art, the beneficial effects of the present invention are as follows: This invention provides a traditional Chinese medicine preparation for treating skin burns. For superficial second-degree burns, the wound healing rate is 81.2% in 7 days, 96.5% in 14 days, and 100.0% in 21 days. For deep second-degree burns, the wound healing rate is 69.5% in 7 days, 89.2% in 14 days, and 98.3% in 21 days, demonstrating good wound healing effects. This invention provides a traditional Chinese medicine preparation for treating skin burns. For superficial second-degree burns, the TNF-α content is 42.1 pg / mg and the IL-6 content is 40.3 pg / mg. For deep second-degree burns, the TNF-α content is 56.8 pg / mg and the IL-6 content is 52.5 pg / mg. It has a significant inhibitory effect on the inflammatory response of the tissues surrounding the burn wound. This invention provides a traditional Chinese medicine preparation for treating skin burns, specifically targeting superficial second-degree burns with a Staphylococcus aureus colony count of 0.35 × 10⁻⁶. 3 CFU / mL, E. coli colony count 0.42×10 3 CFU / mL, for deep second-degree burns, the Staphylococcus aureus colony count was 0.68 × 10⁻⁶. 3 CFU / mL, E. coli colony count 0.75×10⁻⁶ 3 CFU / mL, exhibits excellent inhibitory effects against common pathogens in scald wounds. Detailed Implementation

[0014] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as a limitation of the present invention, but rather as a more detailed description of certain aspects, features, and embodiments of the present invention. It should be understood that the terminology used in this invention is merely for describing particular embodiments and is not intended to limit the present invention.

[0015] Furthermore, regarding the numerical ranges in this invention, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. Every smaller range between any stated value or intermediate value within a stated range, and any other stated value or intermediate value within said range, is also included in this invention. The upper and lower limits of these smaller ranges may be independently included or excluded from the range.

[0016] Unless otherwise stated, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. While only preferred methods and materials have been described herein, any methods and materials similar or equivalent to those described herein may be used in the implementation or testing of this invention. All references to this specification are incorporated by way of citation to disclose and describe methods and / or materials associated with those references. In the event of any conflict with any incorporated reference, the content of this specification shall prevail.

[0017] Various modifications and variations can be made to the specific embodiments described in this specification without departing from the scope or spirit of the invention, as will be apparent to those skilled in the art. Other embodiments derived from this specification will also be apparent to those skilled in the art. This specification and embodiments are merely exemplary.

[0018] The terms “include,” “including,” “have,” “contain,” etc., used in this article are all open-ended terms, meaning that they include but are not limited to.

[0019] The following embodiments illustrate a method for preparing a traditional Chinese medicine preparation for treating skin burns, comprising the following steps: 1. Extraction of compound traditional Chinese medicine extracts 1) Weigh each raw material according to the following mass proportions: Rhubarb 75 parts, Coptis chinensis 25 parts, Honeysuckle 75 parts, Red peony root 25 parts, Saposhnikovia divaricata 75 parts, Angelica dahurica 45 parts, Angelica pubescens 10 parts, Notopterygium incisum 10 parts, Arisaema heterophyllum 20 parts, Ligusticum chuanxiong 25 parts, Sparganium stoloniferum 50 parts, Clematis chinensis 75 parts, Curcuma zedoaria 50 parts, Lindera strychnifolia 75 parts, Frankincense 100 parts, Cyperus rotundus 15 parts, Drynaria fortunei 25 parts, Cremastra appendiculata 75 parts, Prunus persica 25 parts, Cnidium monnieri 100 parts, Xanthium sibiricum 25 parts, Castor bean 50 parts, Phragmites communis 75 parts, Tangerine peel 25 parts, Green tangerine peel 25 parts 25 parts of Citrus reticulata peel, 50 parts of Gardenia jasminoides, 10 parts of Amomum villosum, 75 parts of Lycopus lucidus, 50 parts of Selaginella tamariscina, 50 parts of Eclipta prostrata, 75 parts of Artemisia capillaris, 50 parts of Nelumbo nucifera leaf, 225 parts of Chrysanthemum indicum, 50 parts of Carthamus tinctorius, 200 parts of Chimonanthus praecox, 25 parts of Typha orientalis pollen, 75 parts of Bombax ceiba bark, 25 parts of Paeonia suffruticosa bark, 100 parts of Sappanwood, 50 parts of Pinus tabuliformis knot, 100 parts of Tinospora sinensis, 10 parts of Pepper, 75 parts of Unnamed Herb, 75 parts of Herba Unnamed, 75 parts of Herba Artemisiae Laminariae, 75 parts of Herba Artemisiae Laminariae, 75 parts of Herba Artemisiae Laminariae, 100 parts of Rhizoma Lysimachiae, 50 parts of Polygonum hydropiper. 75 parts gold earrings, 75 parts arborvitae leaves, 100 parts sea breeze vine, 75 parts purslane, 44 parts large soapberry, 100 parts snake root, 100 parts two-sided needle, 100 parts sheep ear chrysanthemum, 75 parts large wind mugwort, 75 parts cinnabar root, 50 parts willow branches, 75 parts star-colored grass, 20 parts clove, 100 parts myrrh, 19 parts purple gromwell root, 50 parts large wind chrysanthemum, 100 parts processed strychnos nux-vomica, 10 parts cardamom, 15 parts nutmeg, 150 parts aloe vera, 15 parts long pepper, 25 parts ginger peel, 5 parts vitex leaves 0 parts, Lithospermum erythrorhizon 10 parts, Bletilla striata 25 parts, Shallots 150 parts, Garlic 150 parts, Panax notoginseng 10 parts, Bombax ceiba 125 parts, Kudzu flower 125 parts, Panax notoginseng ginger 100 parts, Eriocaulon buergerianum 75 parts, Basil basil 50 parts, Dragon's blood 100 parts, Amaranth 75 parts, Iron-clad gold 100 parts, Alum 5 parts, Eucalyptus oil 50 parts, Star anise oil 50 parts, Methyl salicylate 125 parts, Clove basil oil 45 parts, Turpentine oil 150 parts, Peppermint oil 160 parts, Cinnamon oil 5 parts, Borneol 200 parts; 2) Weigh the following herbs from step 1): rhubarb, coptis, honeysuckle, red peony root, saposhnikovia root, angelica root, angelica pubescens root, notopterygium root, arisaema rhizome, chuanxiong rhizome, sparganium rhizome, clematis root, turmeric rhizome, lindera root, frankincense, cyperus rhizome, drynaria rhizome, pseudobulb, peach kernel, cnidium fruit, cocklebur fruit, castor bean, water lily flower, tangerine peel, green tangerine peel, tangerine peel, gardenia fruit, amomum fruit, lycopus lucidus, selaginella tamariscina, eclipta prostrata, artemisia capillaris, lotus leaf, wild chrysanthemum, safflower, wintersweet flower, cattail pollen, kapok bark, peony bark, sappanwood, pine resin, broad-leaved vine, pepper, unnamed herb, *Gnaphalium affine*, *Hedyotis diffusa*, *Achyranthes bidentata*, *Lysimachia christinae*, *Polygonum hydropiper*, golden earring, arborvitae leaf, *Piper kadsura*, and purslane. The following herbs were mixed to obtain Chinese herbal powder A: Soapberry, snake, two-sided needle, sheep's ear chrysanthemum, big wind artemisia, cinnabar root, willow branch, star grass, clove, myrrh, purple gromwell, big wind seed, processed strychnos nux-vomica, cardamom, nutmeg, aloe vera, long pepper, ginger peel, vitex leaf and purple gromwell. Then, according to the material-liquid ratio of Chinese herbal powder A to 60% ethanol of (15-25) mL: 1g, Chinese herbal powder A was placed in 60% ethanol and extracted at 45℃ with ultrasonic power of 300W and ultrasonic frequency of 20kHz for 30-50min. The extract was then filtered through a 200-mesh filter cloth to obtain Chinese herbal extract A. 3) Mix the herbs weighed in step 1), including Bletilla striata, shallot, garlic, Panax notoginseng, Bombax ceiba, kudzu flower, Panax notoginseng ginger, Eriocaulon buergerianum, Basilica dioica, dragon's blood, Amaranth, Iron-clad Gold, and alum, to obtain Chinese herbal powder B. Then, according to the water-to-powder ratio of Chinese herbal powder B to water of (10-20) mL: 1g, place Chinese herbal powder B in water and reflux and boil at 100℃ for 50-70 minutes. Filter through a 200-mesh filter cloth to obtain Chinese herbal extract B. 4) Mix the herbal extract A obtained in step 2) and the herbal extract B obtained in step 3), and add the eucalyptus oil, star anise oil, methyl salicylate, clove basil oil, turpentine oil, peppermint oil, cinnamon oil and borneol weighed in step 1). Concentrate under reduced pressure at 60℃ and 0.08MPa to a relative density of 1.10 (60℃) to obtain a concentrated extract. Then spray dry the concentrated extract to obtain the compound herbal extract. The parameters for spray drying are as follows: inlet air temperature 160–170℃, outlet air temperature 75–85℃, feed rate 8–12 mL / min, atomization pressure 0.25–0.35 MPa, and drying to a moisture content ≤5%. 2. Preparation of Traditional Chinese Medicine Microcapsules 1) According to the material-liquid ratio of compound Chinese medicine extract to phosphate buffer of (5-15) mL:1g, place the compound Chinese medicine extract obtained in step 1 in 0.05mol / L phosphate buffer (pH 7.2), add 1%wt hyaluronic acid, control the ultrasonic power to be 300W, the ultrasonic frequency to be 20kHz, and ultrasonically disperse for 5-15min to obtain core material suspension; 2) Mix the gelatin mother liquor and gum arabic mother liquor at a mass ratio of 1:1 and adjust the pH to 4.2 to obtain a composite wall material solution; The gelatin mother liquor is prepared by mixing gelatin and water at a gelatin concentration of 5%wt. The gum arabic mother liquor is prepared by mixing gum arabic and water at a gum arabic concentration of 5%wt. 3) Under stirring conditions of 45℃ and 300r / min, the core material suspension obtained in step 1) is added dropwise to the composite wall material solution obtained in step 2) at a volume ratio of 1:1 to obtain a mixture. Then, 0.5%wt sodium alginate and 0.3%wt chitosan quaternary ammonium salt are added to the mixture. Electrostatic self-assembly is carried out at 10℃ for 10-20 min. After centrifugation and filtration, the filter residue is dispersed in distilled water at pH 4.2 and circulated 3-4 times to obtain a suspension of traditional Chinese medicine microcapsules. 4) The traditional Chinese medicine microcapsule suspension obtained in step 3) is mixed with 0.1 mol / L CaCl2 solution at a volume ratio of 1:1. The mixture is then subjected to ionic cross-linking at room temperature for 15-25 min, filtered, washed, and freeze-dried at -50℃ and 10 Pa for 12-24 h to obtain the traditional Chinese medicine microcapsules. 3. Preparation of the functional layer 1) According to the mass ratio of N-isopropylacrylamide, acrylic acid, N,N'-methylenebisacrylamide and water of 5:2:0.1:100, N-isopropylacrylamide, acrylic acid and N,N'-methylenebisacrylamide are placed in water and deoxygenated with nitrogen for 30 min to obtain monomer prepolymer solution; 2) According to the material-liquid ratio of the traditional Chinese medicine microcapsules and the monomer prepolymer solution of (5-15) mL:1g, the traditional Chinese medicine microcapsules obtained in step 2 are placed in the monomer prepolymer solution obtained in step 1) and ultrasonically dispersed for 5-15 min to obtain a dispersion. Then, 0.1%wt of ammonium persulfate is added to the dispersion, and polymerization is carried out at 35℃ for 4-6 h. After filtration, the mixture is freeze-dried at -50℃ and 10Pa for 10-14 h to obtain the efficacy layer. The thickness of the functional layer is 2-4 mm; 4. Preparation of traditional Chinese medicine preparations for treating skin burns 1) Polyvinyl alcohol, sodium carboxymethyl cellulose, water and glycerin were mixed in a material ratio of 10g:2g:100mL:5mL to obtain a hydrogel matrix; 2) Place the hydrogel matrix obtained in step 1) into a mold, let it stand to degas for 30 min, freeze at -20℃ for 4 h, and thaw at room temperature for 4 h to obtain the hydrogel bottom layer; The thickness of the hydrogel substrate is 1-3 mm; 3) Place the efficacy layer obtained in step 3 on the surface of the hydrogel bottom layer obtained in step 2), then add the hydrogel matrix obtained in step 1) to the surface of the efficacy layer, let it stand to degas for 30 minutes, and finally freeze it at -20℃ for 4 hours, thaw it at room temperature for 4 hours, and cycle the freeze-thaw cycle 3 times to form a hydrogel covering layer on the surface of the efficacy layer, thus obtaining the traditional Chinese medicine preparation for treating skin burns. The thickness of the hydrogel covering layer is 1 to 3 mm.

[0020] Example 1 1. Extraction of compound traditional Chinese medicine extracts 1) Weigh each raw material according to the following mass proportions: Rhubarb 75 parts, Coptis chinensis 25 parts, Honeysuckle 75 parts, Red peony root 25 parts, Saposhnikovia divaricata 75 parts, Angelica dahurica 45 parts, Angelica pubescens 10 parts, Notopterygium incisum 10 parts, Arisaema heterophyllum 20 parts, Ligusticum chuanxiong 25 parts, Sparganium stoloniferum 50 parts, Clematis chinensis 75 parts, Curcuma zedoaria 50 parts, Lindera strychnifolia 75 parts, Frankincense 100 parts, Cyperus rotundus 15 parts, Drynaria fortunei 25 parts, Cremastra appendiculata 75 parts, Prunus persica 25 parts, Cnidium monnieri 100 parts, Xanthium sibiricum 25 parts, Castor bean 50 parts, Phragmites communis 75 parts, Tangerine peel 25 parts, Green tangerine peel 25 parts 25 parts of Citrus reticulata peel, 50 parts of Gardenia jasminoides, 10 parts of Amomum villosum, 75 parts of Lycopus lucidus, 50 parts of Selaginella tamariscina, 50 parts of Eclipta prostrata, 75 parts of Artemisia capillaris, 50 parts of Nelumbo nucifera leaf, 225 parts of Chrysanthemum indicum, 50 parts of Carthamus tinctorius, 200 parts of Chimonanthus praecox, 25 parts of Typha orientalis pollen, 75 parts of Bombax ceiba bark, 25 parts of Paeonia suffruticosa bark, 100 parts of Sappanwood, 50 parts of Pinus tabuliformis knot, 100 parts of Tinospora sinensis, 10 parts of Pepper, 75 parts of Unnamed Herb, 75 parts of Herba Unnamed, 75 parts of Herba Artemisiae Laminariae, 75 parts of Herba Artemisiae Laminariae, 75 parts of Herba Artemisiae Laminariae, 100 parts of Rhizoma Lysimachiae, 50 parts of Polygonum hydropiper. 75 parts gold earrings, 75 parts arborvitae leaves, 100 parts sea breeze vine, 75 parts purslane, 44 parts large soapberry, 100 parts snake root, 100 parts two-sided needle, 100 parts sheep ear chrysanthemum, 75 parts large wind mugwort, 75 parts cinnabar root, 50 parts willow branches, 75 parts star-colored grass, 20 parts clove, 100 parts myrrh, 19 parts purple gromwell root, 50 parts large wind chrysanthemum, 100 parts processed strychnos nux-vomica, 10 parts cardamom, 15 parts nutmeg, 150 parts aloe vera, 15 parts long pepper, 25 parts ginger peel, 5 parts vitex leaves 0 parts, Lithospermum erythrorhizon 10 parts, Bletilla striata 25 parts, Shallots 150 parts, Garlic 150 parts, Panax notoginseng 10 parts, Bombax ceiba 125 parts, Kudzu flower 125 parts, Panax notoginseng ginger 100 parts, Eriocaulon buergerianum 75 parts, Basil basil 50 parts, Dragon's blood 100 parts, Amaranth 75 parts, Iron-clad gold 100 parts, Alum 5 parts, Eucalyptus oil 50 parts, Star anise oil 50 parts, Methyl salicylate 125 parts, Clove basil oil 45 parts, Turpentine oil 150 parts, Peppermint oil 160 parts, Cinnamon oil 5 parts, Borneol 200 parts; 2) Weigh the following ingredients from step 1): rhubarb, coptis, honeysuckle, red peony root, saposhnikovia root, angelica root, angelica pubescens root, notopterygium root, arisaema rhizome, chuanxiong rhizome, sparganium rhizome, clematis root, turmeric rhizome, lindera root, frankincense, cyperus rhizome, drynaria rhizome, pseudobulb of cremastra, peach kernel, cnidium fruit, cocklebur fruit, castor bean, water lily flower, tangerine peel, green tangerine peel, tangerine peel, gardenia fruit, amomum fruit, lycopus lucidus, selaginella tamariscina, eclipta prostrata, artemisia capillaris, lotus leaf, wild chrysanthemum, safflower, wintersweet flower, cattail pollen, kapok bark, peony bark, sappanwood, pine resin, broad-leaved vine, pepper, unnamed herb, *Gynostemma pentaphyllum*, *Hedyotis diffusa*, *Aristolochia debilis*, *Polygonum hydropiper*, golden earring, arborvitae leaf, and *Piper kadsura*. The following herbs were mixed to obtain herbal powder A: purslane, soapberry, snake root, two-sided needle, sheep ear chrysanthemum, artemisia argyi, cinnabar root, willow branch, starflower, clove, myrrh, purple gromwell root, houttuynia cordata, processed strychnos nux-vomica, cardamom, nutmeg, aloe vera, long pepper, ginger peel, vitex leaf, and purple gromwell root. Herbal powder A was then placed in 60% ethanol at a ratio of 15 mL to 1 g, and extracted at 45°C with an ultrasonic power of 300 W and an ultrasonic frequency of 20 kHz for 30 minutes. The extract was then filtered through a 200-mesh filter to obtain herbal extract A. 3) Mix the Bletilla striata, shallot, garlic, Panax notoginseng, Bombax ceiba, kudzu flower, Panax notoginseng ginger, Eriocaulon buergerianum, Basilica sinensis, dragon's blood, Amaranth, Iron-clad Gold and alum weighed in step 1) to obtain Chinese medicine powder B. Then, according to the water-to-powder ratio of Chinese medicine powder B to water of 10mL:1g, put Chinese medicine powder B into water and reflux and boil at 100℃ for 50min. Filter through a 200-mesh filter cloth to obtain Chinese medicine extract B. 4) Mix the herbal extract A obtained in step 2) and the herbal extract B obtained in step 3), and add the eucalyptus oil, star anise oil, methyl salicylate, clove basil oil, turpentine oil, peppermint oil, cinnamon oil and borneol weighed in step 1). Concentrate under reduced pressure at 60℃ and 0.08MPa to a relative density of 1.10 (60℃) to obtain a concentrated extract. Then spray dry the concentrated extract to obtain the compound herbal extract. The parameters for spray drying are as follows: inlet air temperature 160℃, outlet air temperature 75℃, feed rate 8mL / min, atomization pressure 0.25MPa, and drying to a moisture content ≤5%. 2. Preparation of Traditional Chinese Medicine Microcapsules 1) According to the material-liquid ratio of compound Chinese medicine extract to phosphate buffer of 5mL:1g, place the compound Chinese medicine extract obtained in step 1 into 0.05mol / L phosphate buffer (pH 7.2), add 1%wt hyaluronic acid, control the ultrasonic power to 300W, the ultrasonic frequency to 20kHz, and ultrasonically disperse for 5min to obtain core material suspension. 2) Mix the gelatin mother liquor and gum arabic mother liquor at a mass ratio of 1:1 and adjust the pH to 4.2 to obtain a composite wall material solution; The gelatin mother liquor is prepared by mixing gelatin and water at a gelatin concentration of 5%wt. The gum arabic mother liquor is prepared by mixing gum arabic and water at a gum arabic concentration of 5%wt. 3) Under stirring conditions of 45℃ and 300r / min, the core material suspension obtained in step 1) was added dropwise to the composite wall material solution obtained in step 2) at a volume ratio of 1:1 to obtain a mixture. Then, 0.5%wt sodium alginate and 0.3%wt chitosan quaternary ammonium salt were added to the mixture. The mixture was electrostatically self-assembled at 10℃ for 10min, centrifuged, filtered, and the filter residue was dispersed in distilled water at pH 4.2 and circulated 3 times to obtain a suspension of traditional Chinese medicine microcapsules. 4) The traditional Chinese medicine microcapsule suspension obtained in step 3) was mixed with 0.1 mol / L CaCl2 solution at a volume ratio of 1:1. The mixture was then subjected to ion crosslinking at room temperature for 15 min, filtered, washed, and freeze-dried at -50℃ and 10 Pa for 12 h to obtain the traditional Chinese medicine microcapsules. 3. Preparation of the functional layer 1) According to the mass ratio of N-isopropylacrylamide, acrylic acid, N,N'-methylenebisacrylamide and water of 5:2:0.1:100, N-isopropylacrylamide, acrylic acid and N,N'-methylenebisacrylamide are placed in water and deoxygenated with nitrogen for 30 min to obtain monomer prepolymer solution; 2) According to the material-liquid ratio of traditional Chinese medicine microcapsules to monomer prepolymer solution of 5mL:1g, the traditional Chinese medicine microcapsules obtained in step 2 are placed in the monomer prepolymer solution obtained in step 1), ultrasonically dispersed for 5min to obtain dispersion solution, then 0.1%wt of ammonium persulfate is added to dispersion solution, polymerized at 35℃ for 4h, filtered, and freeze-dried at -50℃ and 10Pa for 10h to obtain the efficacy layer; The thickness of the functional layer is 2 mm; 4. Preparation of traditional Chinese medicine preparations for treating skin burns 1) Polyvinyl alcohol, sodium carboxymethyl cellulose, water and glycerin were mixed in a material ratio of 10g:2g:100mL:5mL to obtain a hydrogel matrix; 2) Place the hydrogel matrix obtained in step 1) into a mold, let it stand to degas for 30 min, freeze at -20℃ for 4 h, and thaw at room temperature for 4 h to obtain the hydrogel bottom layer; The thickness of the hydrogel substrate is 1 mm; 3) Place the efficacy layer obtained in step 3 on the surface of the hydrogel bottom layer obtained in step 2), then add the hydrogel matrix obtained in step 1) to the surface of the efficacy layer, let it stand to degas for 30 minutes, and finally freeze it at -20℃ for 4 hours, thaw it at room temperature for 4 hours, and cycle the freeze-thaw cycle 3 times to form a hydrogel covering layer on the surface of the efficacy layer, thus obtaining the traditional Chinese medicine preparation for treating skin burns. The thickness of the hydrogel covering layer is 1 mm.

[0021] Example 2 1. Extraction of compound traditional Chinese medicine extracts 1) Weigh each raw material according to the following mass proportions: Rhubarb 75 parts, Coptis chinensis 25 parts, Honeysuckle 75 parts, Red peony root 25 parts, Saposhnikovia divaricata 75 parts, Angelica dahurica 45 parts, Angelica pubescens 10 parts, Notopterygium incisum 10 parts, Arisaema heterophyllum 20 parts, Ligusticum chuanxiong 25 parts, Sparganium stoloniferum 50 parts, Clematis chinensis 75 parts, Curcuma zedoaria 50 parts, Lindera strychnifolia 75 parts, Frankincense 100 parts, Cyperus rotundus 15 parts, Drynaria fortunei 25 parts, Cremastra appendiculata 75 parts, Prunus persica 25 parts, Cnidium monnieri 100 parts, Xanthium sibiricum 25 parts, Castor bean 50 parts, Phragmites communis 75 parts, Tangerine peel 25 parts, Green tangerine peel 25 parts 25 parts of Citrus reticulata peel, 50 parts of Gardenia jasminoides, 10 parts of Amomum villosum, 75 parts of Lycopus lucidus, 50 parts of Selaginella tamariscina, 50 parts of Eclipta prostrata, 75 parts of Artemisia capillaris, 50 parts of Nelumbo nucifera leaf, 225 parts of Chrysanthemum indicum, 50 parts of Carthamus tinctorius, 200 parts of Chimonanthus praecox, 25 parts of Typha orientalis pollen, 75 parts of Bombax ceiba bark, 25 parts of Paeonia suffruticosa bark, 100 parts of Sappanwood, 50 parts of Pinus tabuliformis knot, 100 parts of Tinospora sinensis, 10 parts of Pepper, 75 parts of Unnamed Herb, 75 parts of Herba Unnamed, 75 parts of Herba Artemisiae Laminariae, 75 parts of Herba Artemisiae Laminariae, 75 parts of Herba Artemisiae Laminariae, 100 parts of Rhizoma Lysimachiae, 50 parts of Polygonum hydropiper. 75 parts gold earrings, 75 parts arborvitae leaves, 100 parts sea breeze vine, 75 parts purslane, 44 parts large soapberry, 100 parts snake root, 100 parts two-sided needle, 100 parts sheep ear chrysanthemum, 75 parts large wind mugwort, 75 parts cinnabar root, 50 parts willow branches, 75 parts star-colored grass, 20 parts clove, 100 parts myrrh, 19 parts purple gromwell root, 50 parts large wind chrysanthemum, 100 parts processed strychnos nux-vomica, 10 parts cardamom, 15 parts nutmeg, 150 parts aloe vera, 15 parts long pepper, 25 parts ginger peel, 5 parts vitex leaves 0 parts, Lithospermum erythrorhizon 10 parts, Bletilla striata 25 parts, Shallots 150 parts, Garlic 150 parts, Panax notoginseng 10 parts, Bombax ceiba 125 parts, Kudzu flower 125 parts, Panax notoginseng ginger 100 parts, Eriocaulon buergerianum 75 parts, Basil basil 50 parts, Dragon's blood 100 parts, Amaranth 75 parts, Iron-clad gold 100 parts, Alum 5 parts, Eucalyptus oil 50 parts, Star anise oil 50 parts, Methyl salicylate 125 parts, Clove basil oil 45 parts, Turpentine oil 150 parts, Peppermint oil 160 parts, Cinnamon oil 5 parts, Borneol 200 parts; 2) Weigh the following ingredients from step 1): rhubarb, coptis, honeysuckle, red peony root, saposhnikovia root, angelica root, angelica pubescens root, notopterygium root, arisaema rhizome, chuanxiong rhizome, sparganium rhizome, clematis root, turmeric rhizome, lindera root, frankincense, cyperus rhizome, drynaria rhizome, pseudobulb of cremastra, peach kernel, cnidium fruit, cocklebur fruit, castor bean, water lily flower, tangerine peel, green tangerine peel, tangerine peel, gardenia fruit, amomum fruit, lycopus lucidus, selaginella tamariscina, eclipta prostrata, artemisia capillaris, lotus leaf, wild chrysanthemum, safflower, wintersweet flower, cattail pollen, kapok bark, peony bark, sappanwood, pine resin, broad-leaved vine, pepper, unnamed herb, *Gynostemma pentaphyllum*, *Hedyotis diffusa*, *Aristolochia debilis*, *Polygonum hydropiper*, golden earring, arborvitae leaf, and *Piper kadsura*. The following herbs were mixed to obtain herbal powder A: purslane, soapberry, snake root, two-sided needle, sheep's ear chrysanthemum, artemisia argyi, cinnabar root, willow branch, starflower, clove, myrrh, purple gromwell root, houttuynia cordata, processed strychnos nux-vomica, cardamom, nutmeg, aloe vera, long pepper, ginger peel, vitex leaf, and purple gromwell root. Herbal powder A was then placed in 60% ethanol at a ratio of 20 mL to 1 g, and extracted at 45°C with an ultrasonic power of 300 W and an ultrasonic frequency of 20 kHz for 40 minutes. The extract was then filtered through a 200-mesh filter to obtain herbal extract A. 3) Mix the herbs weighed in step 1), including Bletilla striata, shallot, garlic, Panax notoginseng, Bombax ceiba, kudzu flower, Panax notoginseng ginger, Eriocaulon buergerianum, Basilica dioica, dragon's blood, Amaranth, Iron-clad Gold, and alum, to obtain Chinese herbal powder B. Then, according to the water-to-powder ratio of Chinese herbal powder B to water of 15mL:1g, place Chinese herbal powder B in water and reflux and boil at 100℃ for 60min. Filter through a 200-mesh filter cloth to obtain Chinese herbal extract B. 4) Mix the herbal extract A obtained in step 2) and the herbal extract B obtained in step 3), and add the eucalyptus oil, star anise oil, methyl salicylate, clove basil oil, turpentine oil, peppermint oil, cinnamon oil and borneol weighed in step 1). Concentrate under reduced pressure at 60℃ and 0.08MPa to a relative density of 1.10 (60℃) to obtain a concentrated extract. Then spray dry the concentrated extract to obtain the compound herbal extract. The parameters for spray drying are as follows: inlet air temperature 165℃, outlet air temperature 80℃, feed rate 10mL / min, atomization pressure 0.35MPa, and drying to a moisture content ≤5%. 2. Preparation of Traditional Chinese Medicine Microcapsules 1) According to the material-liquid ratio of compound Chinese medicine extract to phosphate buffer of 10mL:1g, the compound Chinese medicine extract obtained in step 1 was placed in 0.05mol / L phosphate buffer (pH 7.2), and 1%wt hyaluronic acid was added. The ultrasonic power was controlled at 300W, the ultrasonic frequency was 20kHz, and the ultrasonic dispersion was carried out for 10min to obtain the core material suspension. 2) Mix the gelatin mother liquor and gum arabic mother liquor at a mass ratio of 1:1 and adjust the pH to 4.2 to obtain a composite wall material solution; The gelatin mother liquor is prepared by mixing gelatin and water at a gelatin concentration of 5%wt. The gum arabic mother liquor is prepared by mixing gum arabic and water at a gum arabic concentration of 5%wt. 3) Under stirring conditions of 45℃ and 300r / min, the core material suspension obtained in step 1) was added dropwise to the composite wall material solution obtained in step 2) at a volume ratio of 1:1 to obtain a mixture. Then, 0.5%wt sodium alginate and 0.3%wt chitosan quaternary ammonium salt were added to the mixture. The mixture was electrostatically self-assembled at 10℃ for 15min, centrifuged, filtered, and the filter residue was dispersed in distilled water at pH 4.2 and circulated 4 times to obtain a suspension of traditional Chinese medicine microcapsules. 4) The traditional Chinese medicine microcapsule suspension obtained in step 3) was mixed with 0.1 mol / L CaCl2 solution at a volume ratio of 1:1. The mixture was then subjected to ion crosslinking at room temperature for 20 min, filtered, washed, and freeze-dried at -50℃ and 10 Pa for 18 h to obtain the traditional Chinese medicine microcapsules. 3. Preparation of the functional layer 1) According to the mass ratio of N-isopropylacrylamide, acrylic acid, N,N'-methylenebisacrylamide and water of 5:2:0.1:100, N-isopropylacrylamide, acrylic acid and N,N'-methylenebisacrylamide are placed in water and deoxygenated with nitrogen for 30 min to obtain monomer prepolymer solution; 2) According to the material-liquid ratio of traditional Chinese medicine microcapsules to monomer prepolymer liquid of 10mL:1g, the traditional Chinese medicine microcapsules obtained in step 2 are placed in the monomer prepolymer liquid obtained in step 1), ultrasonically dispersed for 10min to obtain a dispersion, then 0.1%wt of ammonium persulfate is added to the dispersion, polymerized at 35℃ for 5h, filtered, and freeze-dried at -50℃ and 10Pa for 12h to obtain the efficacy layer; The thickness of the functional layer is 3mm; 4. Preparation of traditional Chinese medicine preparations for treating skin burns 1) Polyvinyl alcohol, sodium carboxymethyl cellulose, water and glycerin were mixed in a material ratio of 10g:2g:100mL:5mL to obtain a hydrogel matrix; 2) Place the hydrogel matrix obtained in step 1) into a mold, let it stand to degas for 30 min, freeze at -20℃ for 4 h, and thaw at room temperature for 4 h to obtain the hydrogel bottom layer; The thickness of the hydrogel substrate is 2 mm; 3) Place the efficacy layer obtained in step 3 on the surface of the hydrogel bottom layer obtained in step 2), then add the hydrogel matrix obtained in step 1) to the surface of the efficacy layer, let it stand to degas for 30 minutes, and finally freeze it at -20℃ for 4 hours, thaw it at room temperature for 4 hours, and cycle the freeze-thaw cycle 3 times to form a hydrogel covering layer on the surface of the efficacy layer, thus obtaining the traditional Chinese medicine preparation for treating skin burns. The thickness of the hydrogel covering layer is 2 mm.

[0022] Example 3 1. Extraction of compound traditional Chinese medicine extracts 1) Weigh each raw material according to the following mass proportions: Rhubarb 75 parts, Coptis chinensis 25 parts, Honeysuckle 75 parts, Red peony root 25 parts, Saposhnikovia divaricata 75 parts, Angelica dahurica 45 parts, Angelica pubescens 10 parts, Notopterygium incisum 10 parts, Arisaema heterophyllum 20 parts, Ligusticum chuanxiong 25 parts, Sparganium stoloniferum 50 parts, Clematis chinensis 75 parts, Curcuma zedoaria 50 parts, Lindera strychnifolia 75 parts, Frankincense 100 parts, Cyperus rotundus 15 parts, Drynaria fortunei 25 parts, Cremastra appendiculata 75 parts, Prunus persica 25 parts, Cnidium monnieri 100 parts, Xanthium sibiricum 25 parts, Castor bean 50 parts, Phragmites communis 75 parts, Tangerine peel 25 parts, Green tangerine peel 25 parts 25 parts of Citrus reticulata peel, 50 parts of Gardenia jasminoides, 10 parts of Amomum villosum, 75 parts of Lycopus lucidus, 50 parts of Selaginella tamariscina, 50 parts of Eclipta prostrata, 75 parts of Artemisia capillaris, 50 parts of Nelumbo nucifera leaf, 225 parts of Chrysanthemum indicum, 50 parts of Carthamus tinctorius, 200 parts of Chimonanthus praecox, 25 parts of Typha orientalis pollen, 75 parts of Bombax ceiba bark, 25 parts of Paeonia suffruticosa bark, 100 parts of Sappanwood, 50 parts of Pinus tabuliformis knot, 100 parts of Tinospora sinensis, 10 parts of Pepper, 75 parts of Unnamed Herb, 75 parts of Herba Unnamed, 75 parts of Herba Artemisiae Laminariae, 75 parts of Herba Artemisiae Laminariae, 75 parts of Herba Artemisiae Laminariae, 100 parts of Rhizoma Lysimachiae, 50 parts of Polygonum hydropiper. 75 parts gold earrings, 75 parts arborvitae leaves, 100 parts sea breeze vine, 75 parts purslane, 44 parts large soapberry, 100 parts snake root, 100 parts two-sided needle, 100 parts sheep ear chrysanthemum, 75 parts large wind mugwort, 75 parts cinnabar root, 50 parts willow branches, 75 parts star-colored grass, 20 parts clove, 100 parts myrrh, 19 parts purple gromwell root, 50 parts large wind chrysanthemum, 100 parts processed strychnos nux-vomica, 10 parts cardamom, 15 parts nutmeg, 150 parts aloe vera, 15 parts long pepper, 25 parts ginger peel, 5 parts vitex leaves 0 parts, Lithospermum erythrorhizon 10 parts, Bletilla striata 25 parts, Shallots 150 parts, Garlic 150 parts, Panax notoginseng 10 parts, Bombax ceiba 125 parts, Kudzu flower 125 parts, Panax notoginseng ginger 100 parts, Eriocaulon buergerianum 75 parts, Basil basil 50 parts, Dragon's blood 100 parts, Amaranth 75 parts, Iron-clad gold 100 parts, Alum 5 parts, Eucalyptus oil 50 parts, Star anise oil 50 parts, Methyl salicylate 125 parts, Clove basil oil 45 parts, Turpentine oil 150 parts, Peppermint oil 160 parts, Cinnamon oil 5 parts, Borneol 200 parts; 2) Weigh the following ingredients from step 1): rhubarb, coptis, honeysuckle, red peony root, saposhnikovia root, angelica root, angelica pubescens root, notopterygium root, arisaema rhizome, chuanxiong rhizome, sparganium rhizome, clematis root, turmeric rhizome, lindera root, frankincense, cyperus rhizome, drynaria rhizome, pseudobulb of cremastra, peach kernel, cnidium fruit, cocklebur fruit, castor bean, water lily flower, tangerine peel, green tangerine peel, tangerine peel, gardenia fruit, amomum fruit, lycopus lucidus, selaginella tamariscina, eclipta prostrata, artemisia capillaris, lotus leaf, wild chrysanthemum, safflower, wintersweet flower, cattail pollen, kapok bark, peony bark, sappanwood, pine resin, broad-leaved vine, pepper, unnamed herb, *Gynostemma pentaphyllum*, *Hedyotis diffusa*, *Aristolochia debilis*, *Polygonum hydropiper*, golden earring, arborvitae leaf, and *Piper kadsura*. The following herbs were mixed to obtain herbal powder A: purslane, soapberry, snake root, two-sided needle, sheep ear chrysanthemum, artemisia argyi, cinnabar root, willow branch, starflower, clove, myrrh, purple gromwell root, houttuynia cordata, processed strychnos nux-vomica, cardamom, nutmeg, aloe vera, long pepper, ginger peel, vitex leaf, and purple gromwell root. Herbal powder A was then placed in 60% ethanol at a ratio of 25 mL to 1 g, and extracted at 45°C with an ultrasonic power of 300 W and an ultrasonic frequency of 20 kHz for 50 minutes. The extract was then filtered through a 200-mesh filter to obtain herbal extract A. 3) Mix the herbs weighed in step 1), including Bletilla striata, shallot, garlic, Panax notoginseng, Bombax ceiba, kudzu flower, Panax notoginseng ginger, Eriocaulon buergerianum, Basilica dioica, dragon's blood, Amaranth, Iron-clad Gold, and alum, to obtain Chinese herbal powder B. Then, according to the water-to-powder ratio of Chinese herbal powder B to water of 20mL:1g, place Chinese herbal powder B in water and reflux and boil at 100℃ for 70min. Filter through a 200-mesh filter cloth to obtain Chinese herbal extract B. 4) Mix the herbal extract A obtained in step 2) and the herbal extract B obtained in step 3), and add the eucalyptus oil, star anise oil, methyl salicylate, clove basil oil, turpentine oil, peppermint oil, cinnamon oil and borneol weighed in step 1). Concentrate under reduced pressure at 60℃ and 0.08MPa to a relative density of 1.10 (60℃) to obtain a concentrated extract. Then spray dry the concentrated extract to obtain the compound herbal extract. The parameters for spray drying are as follows: inlet air temperature 170℃, outlet air temperature 85℃, feed rate 12mL / min, atomization pressure 0.35MPa, and drying to a moisture content ≤5%. 2. Preparation of Traditional Chinese Medicine Microcapsules 1) According to the material-liquid ratio of compound Chinese medicine extract to phosphate buffer of 15mL:1g, the compound Chinese medicine extract obtained in step 1 was placed in 0.05mol / L phosphate buffer (pH 7.2), and 1%wt hyaluronic acid was added. The ultrasonic power was controlled at 300W, the ultrasonic frequency was 20kHz, and the ultrasonic dispersion was carried out for 15min to obtain the core material suspension. 2) Mix the gelatin mother liquor and gum arabic mother liquor at a mass ratio of 1:1 and adjust the pH to 4.2 to obtain a composite wall material solution; The gelatin mother liquor is prepared by mixing gelatin and water at a gelatin concentration of 5%wt. The gum arabic mother liquor is prepared by mixing gum arabic and water at a gum arabic concentration of 5%wt. 3) Under stirring conditions of 45℃ and 300r / min, the core material suspension obtained in step 1) was added dropwise to the composite wall material solution obtained in step 2) at a volume ratio of 1:1 to obtain a mixture. Then, 0.5%wt sodium alginate and 0.3%wt chitosan quaternary ammonium salt were added to the mixture. The mixture was electrostatically self-assembled at 10℃ for 20min, centrifuged, filtered, and the filter residue was dispersed in distilled water at pH 4.2 and circulated 4 times to obtain a suspension of traditional Chinese medicine microcapsules. 4) The traditional Chinese medicine microcapsule suspension obtained in step 3) was mixed with 0.1 mol / L CaCl2 solution at a volume ratio of 1:1. The mixture was then subjected to ion crosslinking at room temperature for 25 min, filtered, washed, and freeze-dried at -50℃ and 10 Pa for 24 h to obtain the traditional Chinese medicine microcapsules. 3. Preparation of the functional layer 1) According to the mass ratio of N-isopropylacrylamide, acrylic acid, N,N'-methylenebisacrylamide and water of 5:2:0.1:100, N-isopropylacrylamide, acrylic acid and N,N'-methylenebisacrylamide are placed in water and deoxygenated with nitrogen for 30 min to obtain monomer prepolymer solution; 2) The traditional Chinese medicine microcapsules obtained in step 2 were placed in the monomer prepolymer obtained in step 1) according to the material-liquid ratio of 15 mL: 1 g. The microcapsules were ultrasonically dispersed for 15 min to obtain a dispersion. Then, 0.1% wt ammonium persulfate was added to the dispersion, and polymerization was carried out at 35 °C for 6 h. After filtration, the mixture was freeze-dried at -50 °C and 10 Pa for 14 h to obtain the efficacy layer. The thickness of the functional layer is 4 mm; 4. Preparation of traditional Chinese medicine preparations for treating skin burns 1) Polyvinyl alcohol, sodium carboxymethyl cellulose, water and glycerin were mixed in a material ratio of 10g:2g:100mL:5mL to obtain a hydrogel matrix; 2) Place the hydrogel matrix obtained in step 1) into a mold, let it stand to degas for 30 min, freeze at -20℃ for 4 h, and thaw at room temperature for 4 h to obtain the hydrogel bottom layer; The thickness of the hydrogel substrate is 3 mm; 3) Place the efficacy layer obtained in step 3 on the surface of the hydrogel bottom layer obtained in step 2), then add the hydrogel matrix obtained in step 1) to the surface of the efficacy layer, let it stand to degas for 30 minutes, and finally freeze it at -20℃ for 4 hours, thaw it at room temperature for 4 hours, and cycle the freeze-thaw cycle 3 times to form a hydrogel covering layer on the surface of the efficacy layer, thus obtaining the traditional Chinese medicine preparation for treating skin burns. The thickness of the hydrogel covering layer is 3 mm.

[0023] Comparative Example 1 Same as Example 2, except that the extraction of the compound Chinese medicine extract in step 1 is as follows: 1) Weigh each raw material according to the following mass proportions: Rhubarb 75 parts, Coptis chinensis 25 parts, Honeysuckle 75 parts, Red peony root 25 parts, Saposhnikovia divaricata 75 parts, Angelica dahurica 45 parts, Angelica pubescens 10 parts, Notopterygium incisum 10 parts, Arisaema heterophyllum 20 parts, Ligusticum chuanxiong 25 parts, Sparganium stoloniferum 50 parts, Clematis chinensis 75 parts, Curcuma zedoaria 50 parts, Lindera strychnifolia 75 parts, Frankincense 100 parts, Cyperus rotundus 15 parts, Drynaria fortunei 25 parts, Cremastra appendiculata 75 parts, Prunus persica 25 parts, Cnidium monnieri 100 parts, Xanthium sibiricum 25 parts, Castor bean 50 parts, Phragmites communis 75 parts, Tangerine peel 25 parts, Green tangerine peel 25 parts 25 parts of Citrus reticulata peel, 50 parts of Gardenia jasminoides, 10 parts of Amomum villosum, 75 parts of Lycopus lucidus, 50 parts of Selaginella tamariscina, 50 parts of Eclipta prostrata, 75 parts of Artemisia capillaris, 50 parts of Nelumbo nucifera leaf, 225 parts of Chrysanthemum indicum, 50 parts of Carthamus tinctorius, 200 parts of Chimonanthus praecox, 25 parts of Typha orientalis pollen, 75 parts of Bombax ceiba bark, 25 parts of Paeonia suffruticosa bark, 100 parts of Sappanwood, 50 parts of Pinus tabuliformis knot, 100 parts of Tinospora sinensis, 10 parts of Pepper, 75 parts of Unnamed Herb, 75 parts of Herba Unnamed, 75 parts of Herba Artemisiae Laminariae, 75 parts of Herba Artemisiae Laminariae, 75 parts of Herba Artemisiae Laminariae, 100 parts of Rhizoma Lysimachiae, 50 parts of Polygonum hydropiper. 75 parts gold earrings, 75 parts arborvitae leaves, 100 parts sea breeze vine, 75 parts purslane, 44 parts large soapberry, 100 parts snake root, 100 parts two-sided needle, 100 parts sheep ear chrysanthemum, 75 parts large wind mugwort, 75 parts cinnabar root, 50 parts willow branches, 75 parts star-colored grass, 20 parts clove, 100 parts myrrh, 19 parts purple gromwell root, 50 parts large wind chrysanthemum, 100 parts processed strychnos nux-vomica, 10 parts cardamom, 15 parts nutmeg, 150 parts aloe vera, 15 parts long pepper, 25 parts ginger peel, 5 parts vitex leaves 0 parts, Lithospermum erythrorhizon 10 parts, Bletilla striata 25 parts, Shallots 150 parts, Garlic 150 parts, Panax notoginseng 10 parts, Bombax ceiba 125 parts, Kudzu flower 125 parts, Panax notoginseng ginger 100 parts, Eriocaulon buergerianum 75 parts, Basil basil 50 parts, Dragon's blood 100 parts, Amaranth 75 parts, Iron-clad gold 100 parts, Alum 5 parts, Eucalyptus oil 50 parts, Star anise oil 50 parts, Methyl salicylate 125 parts, Clove basil oil 45 parts, Turpentine oil 150 parts, Peppermint oil 160 parts, Cinnamon oil 5 parts, Borneol 200 parts; 2) Weigh the following herbs from step 1): rhubarb, coptis, honeysuckle, red peony root, saposhnikovia root, angelica root, angelica pubescens root, notopterygium root, arisaema rhizome, chuanxiong rhizome, sparganium rhizome, clematis root, turmeric rhizome, lindera root, frankincense, cyperus rhizome, drynaria rhizome, cremastra appendiculata root, peach kernel, cnidium fruit, cocklebur fruit, castor bean, water lily flower, tangerine peel, green tangerine peel, citrus peel, gardenia fruit, amomum fruit, lycopus lucidus, selaginella tamariscina, eclipta prostrata, artemisia capillaris, lotus leaf, wild chrysanthemum, safflower, wintersweet flower, cattail pollen, kapok bark, peony bark, sappanwood, pine resin, broad-leaved vine, pepper, unnamed herb, *Gnaphalium affine*, *Hedyotis diffusa*, *Aristolochia debilis*, *Polygonum hydropiper*, *Gynostemma pentaphyllum*, arborvitae leaf, *Piper kadsura*, *Gnaphalium affine*, *Gnaphalium affine*, *Gnaphalium affine*, *Gnaphalium affine*, *Zanthoxylum nitidum*, and *Chrysanthemum indicum*. The following herbs were mixed to obtain a traditional Chinese medicine powder: Artemisia argyi, Cinnamomum cassia root, Willow branch, Starflower, Clove, Myrrh, Lithospermum erythrorhizon, Hydnocarpus macrocarpa, Prepared Strychnos nux-vomica, Amomum villosum, Nutmeg, Aloe vera, Piper longum, Ginger peel, Vitex trifolia leaf, Lithospermum erythrorhizon, Bletilla striata, Scallion, Garlic, Panax notoginseng, Bombax ceiba flower, Pueraria lobata flower, Panax notoginseng ginger, Eriocaulon buergerianum, Basilica sinensis, Dragon's blood, Amaranth, Iron-clad gold, and Alum. Then, the powder was placed in 60% ethanol at a ratio of 20 mL to 1 g, and ultrasonic-assisted extraction was performed at 45°C with an ultrasonic power of 300 W and an ultrasonic frequency of 20 kHz for 40 min. The extract was then filtered through a 200-mesh filter to obtain the traditional Chinese medicine extract. 3) Add the eucalyptus oil, star anise oil, methyl salicylate, clove basil oil, turpentine oil, peppermint oil, cinnamon oil and borneol weighed in step 1) to the Chinese herbal extract obtained in step 2), and then concentrate it under reduced pressure at 60℃ and 0.08MPa to a relative density of 1.10 (60℃) to obtain a concentrated extract. Then spray dry the concentrated extract to obtain the compound Chinese herbal extract. The parameters for spray drying are as follows: inlet air temperature 165℃, outlet air temperature 80℃, feed rate 10mL / min, atomization pressure 0.35MPa, and drying to a moisture content ≤5%.

[0024] Comparative Example 2 Same as Example 2, except that step 2, which involves the preparation of the herbal microcapsules, is omitted, and the efficacy layer is prepared directly using the compound herbal extract as the raw material.

[0025] Comparative Example 3 Same as Example 2, except that the preparation of the herbal microcapsules in step 2 is as follows: 1) According to the material-liquid ratio of compound Chinese medicine extract to phosphate buffer of 10mL:1g, the compound Chinese medicine extract obtained in step 1 was placed in 0.05mol / L phosphate buffer (pH 7.2), and 1%wt hyaluronic acid was added. The ultrasonic power was controlled at 300W, the ultrasonic frequency was 20kHz, and the ultrasonic dispersion was carried out for 10min to obtain the core material suspension. 2) Mix the gelatin mother liquor and gum arabic mother liquor at a mass ratio of 1:1 and adjust the pH to 4.2 to obtain a composite wall material solution; The gelatin mother liquor is prepared by mixing gelatin and water at a gelatin concentration of 5%wt. The gum arabic mother liquor is prepared by mixing gum arabic and water at a gum arabic concentration of 5%wt. 3) Under stirring conditions of 45℃ and 300r / min, the core material suspension obtained in step 1) was added dropwise to the composite wall material solution obtained in step 2) at a volume ratio of 1:1 between the core material suspension and the composite wall material solution to obtain a mixed solution. Then, the mixed solution and 0.1mol / L CaCl2 solution were mixed at a volume ratio of 1:1 between the mixed solution and the CaCl2 solution. The mixture was ion crosslinked at room temperature for 20min, filtered, washed, and freeze-dried at -50℃ and 10Pa for 18h to obtain the traditional Chinese medicine microcapsules.

[0026] Comparative Example 4 Same as Example 2, except that the preparation of the herbal microcapsules in step 2 is as follows: 1) According to the material-liquid ratio of compound Chinese medicine extract to phosphate buffer of 10mL:1g, the compound Chinese medicine extract obtained in step 1 was placed in 0.05mol / L phosphate buffer (pH 7.2), and 1%wt hyaluronic acid was added. The ultrasonic power was controlled at 300W, the ultrasonic frequency was 20kHz, and the ultrasonic dispersion was carried out for 10min to obtain the core material suspension. 2) Mix the gelatin mother liquor and gum arabic mother liquor at a mass ratio of 1:1 and adjust the pH to 4.2 to obtain a composite wall material solution; The gelatin mother liquor is prepared by mixing gelatin and water at a gelatin concentration of 5%wt. The gum arabic mother liquor is prepared by mixing gum arabic and water at a gum arabic concentration of 5%wt. 3) Under stirring conditions of 45℃ and 300r / min, the core material suspension obtained in step 1) was added dropwise to the composite wall material solution obtained in step 2) at a volume ratio of 1:1 to obtain a mixture. Then, 0.5%wt sodium alginate and 0.3%wt chitosan quaternary ammonium salt were added to the mixture. The mixture was electrostatically self-assembled at 10℃ for 15min, centrifuged, filtered, and the filter residue was dispersed in distilled water at pH 4.2. The mixture was circulated 4 times (the filter residue was not dispersed in distilled water at pH 4.2 in the 4th cycle) to obtain the traditional Chinese medicine microcapsules.

[0027] Comparative Example 5 Same as Example 2, except that in step 2, in the preparation of the herbal microcapsules, step 4) is: The traditional Chinese medicine microcapsule suspension and CaCl2 solution were mixed in a volume ratio of 1:1. The traditional Chinese medicine microcapsule suspension obtained in step 3) was mixed with 0.1 mol / L CaCl2 solution, and the mixture was ion crosslinked at room temperature for 20 min. The mixture was then filtered, washed, and dried with hot air at 40°C for 12 h to obtain the traditional Chinese medicine microcapsules.

[0028] Comparative Example 6 Steps 1 and 2 are the same as in Example 2. 3. Preparation of traditional Chinese medicine preparations for treating skin burns 1) Polyvinyl alcohol, sodium carboxymethyl cellulose, water and glycerin were mixed in a material ratio of 10g:2g:100mL:5mL to obtain a hydrogel matrix; 2) According to the mass-volume ratio of traditional Chinese medicine microcapsules to hydrogel matrix of 10mL:1g (equivalent to the amount used in Example 2), the traditional Chinese medicine microcapsules obtained in step 2 are placed in the hydrogel matrix obtained in step 1), mixed well, allowed to stand for 30min to defoam, and finally frozen at -20℃ for 4h, thawed at room temperature for 4h, and the freeze-thaw cycle was repeated 3 times to obtain the traditional Chinese medicine preparation for treating skin burns. The thickness of the traditional Chinese medicine preparation used to treat skin burns is 5 mm.

[0029] Effect verification I. Wound Healing Inspection Mice with superficial second-degree burns and deep second-degree burns were constructed and administered the traditional Chinese medicine preparations for treating skin burns prepared in Examples 1-3 and Comparative Examples 1-6, once daily for 21 consecutive days (directly applied to the burned skin surface). Wound area measurements were taken on days 7, 14, and 21 after administration, and the wound healing rate was calculated. The formula for calculating the wound healing rate is as follows: Wound healing rate = (initial wound area - wound area at each time point) / initial wound area × 100%; The results of wound healing rate calculations are shown in Tables 1-3. Table 1. Calculation results of wound healing rate (day 7)

[0030] Table 2. Calculation results of wound healing rate (day 14)

[0031] Table 3. Calculation results of wound healing rate (day 21)

[0032] As shown in Tables 1-3, the traditional Chinese medicine preparation for treating skin burns provided by this invention has a wound healing rate of 81.2% in 7 days, 96.5% in 14 days, and 100.0% in 21 days for superficial second-degree burns. For deep second-degree burns, the wound healing rate is 69.5% in 7 days, 89.2% in 14 days, and 98.3% in 21 days, demonstrating good wound healing effects.

[0033] II. Anti-inflammatory effect test On day 7 after drug administration, tissue around the wound of rats was collected to detect the levels of inflammatory factors tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6); The results of the anti-inflammatory effect test are shown in Table 4; Table 4 Anti-inflammatory effect test

[0034] As shown in Table 4, the traditional Chinese medicine preparation for treating skin burns provided by this invention has the following effects: for superficial second-degree burns, the TNF-α content is 42.1 pg / mg and the IL-6 content is 40.3 pg / mg; for deep second-degree burns, the TNF-α content is 56.8 pg / mg and the IL-6 content is 52.5 pg / mg. It has a significant inhibitory effect on the inflammatory response of the tissues surrounding the burn wound.

[0035] III. Antibacterial Efficacy Test On the 7th day after administration, wound secretions were collected, inoculated into the corresponding bacterial culture medium, and incubated at 37℃ for 24 hours to observe colony growth. The results of the antibacterial effect test are shown in Table 5; Table 5 Antibacterial Efficacy Test

[0036] As shown in Table 5, the traditional Chinese medicine preparation for treating skin burns provided by this invention has a Staphylococcus aureus colony count of 0.35 × 10⁻⁶ for superficial second-degree burns. 3 CFU / mL, E. coli colony count 0.42×10 3 CFU / mL, for deep second-degree burns, the Staphylococcus aureus colony count was 0.68 × 10⁻⁶. 3 CFU / mL, E. coli colony count 0.75×10⁻⁶ 3 CFU / mL, exhibits excellent inhibitory effects against common pathogens in scald wounds.

[0037] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit it. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art should understand that modifications or equivalent substitutions can still be made to the specific implementation of the present invention. Any modifications or equivalent substitutions that do not depart from the spirit and scope of the present invention should be covered within the scope of protection of the claims of the present invention.

Claims

1. A traditional Chinese medicine preparation for treating skin burns, characterized in that, The traditional Chinese medicine preparation for treating skin burns comprises, from bottom to top, a hydrogel bottom layer, an efficacy layer, and a hydrogel top layer.

2. The traditional Chinese medicine preparation for treating skin burns according to claim 1, characterized in that, The method for preparing the functional layer includes the following steps: S1. Extraction of compound traditional Chinese medicine extracts; S2. Prepare traditional Chinese medicine microcapsules using the composite traditional Chinese medicine extract obtained in step S1 as the core material; S3. Prepare the efficacy layer using the traditional Chinese medicine microcapsules obtained in step S2 as raw materials.

3. A traditional Chinese medicine preparation for treating skin burns according to claim 2, characterized in that, In step S1, the extraction of the compound traditional Chinese medicine extract specifically includes the following steps: 1) Weigh each raw material according to the following mass proportions: Rhubarb 75 parts, Coptis chinensis 25 parts, Honeysuckle 75 parts, Red peony root 25 parts, Saposhnikovia divaricata 75 parts, Angelica dahurica 45 parts, Angelica pubescens 10 parts, Notopterygium incisum 10 parts, Arisaema heterophyllum 20 parts, Ligusticum chuanxiong 25 parts, Sparganium stoloniferum 50 parts, Clematis chinensis 75 parts, Curcuma zedoaria 50 parts, Lindera strychnifolia 75 parts, Frankincense 100 parts, Cyperus rotundus 15 parts, Drynaria fortunei 25 parts, Cremastra appendiculata 75 parts, Prunus persica 25 parts, Cnidium monnieri 100 parts, Xanthium sibiricum 25 parts, Castor bean 50 parts, Phragmites communis 75 parts, Tangerine peel 25 parts, Green tangerine peel 25 parts 25 parts of Citrus reticulata peel, 50 parts of Gardenia jasminoides, 10 parts of Amomum villosum, 75 parts of Lycopus lucidus, 50 parts of Selaginella tamariscina, 50 parts of Eclipta prostrata, 75 parts of Artemisia capillaris, 50 parts of Nelumbo nucifera leaf, 225 parts of Chrysanthemum indicum, 50 parts of Carthamus tinctorius, 200 parts of Chimonanthus praecox, 25 parts of Typha orientalis pollen, 75 parts of Bombax ceiba bark, 25 parts of Paeonia suffruticosa bark, 100 parts of Sappanwood, 50 parts of Pinus tabuliformis knot, 100 parts of Tinospora sinensis, 10 parts of Pepper, 75 parts of Unnamed Herb, 75 parts of Herba Unnamed, 75 parts of Herba Artemisiae Laminariae, 75 parts of Herba Artemisiae Laminariae, 75 parts of Herba Artemisiae Laminariae, 100 parts of Rhizoma Lysimachiae, 50 parts of Polygonum hydropiper. 75 parts gold earrings, 75 parts arborvitae leaves, 100 parts sea breeze vine, 75 parts purslane, 44 parts large soapberry, 100 parts snake root, 100 parts two-sided needle, 100 parts sheep ear chrysanthemum, 75 parts large wind mugwort, 75 parts cinnabar root, 50 parts willow branches, 75 parts star-colored grass, 20 parts clove, 100 parts myrrh, 19 parts purple gromwell root, 50 parts large wind chrysanthemum, 100 parts processed strychnos nux-vomica, 10 parts cardamom, 15 parts nutmeg, 150 parts aloe vera, 15 parts long pepper, 25 parts ginger peel, 5 parts vitex leaves 0 parts, Lithospermum erythrorhizon 10 parts, Bletilla striata 25 parts, Shallots 150 parts, Garlic 150 parts, Panax notoginseng 10 parts, Bombax ceiba 125 parts, Kudzu flower 125 parts, Panax notoginseng ginger 100 parts, Eriocaulon buergerianum 75 parts, Basil basil 50 parts, Dragon's blood 100 parts, Amaranth 75 parts, Iron-clad gold 100 parts, Alum 5 parts, Eucalyptus oil 50 parts, Star anise oil 50 parts, Methyl salicylate 125 parts, Clove basil oil 45 parts, Turpentine oil 150 parts, Peppermint oil 160 parts, Cinnamon oil 5 parts, Borneol 200 parts; 2) Mix the rhubarb, coptis, honeysuckle, red peony root, divaricate saposhnikovia root, dahurian angelica root, pubescent angelica root, jackinthepulpit tuber, chuanxiong rhizome, rhizoma sparganii, clematis root, zedoary tuber, combined spicebush root, frankincense, nutgrass galingale rhizome, drynaria rhizome, common falsebutton orchid, peach kernel, fructus cnidii, fructus xanthii, castor bean, water wattle flower, tangerine peel, green tangerine peel, excised tangerine peel, gardenia fruit, amomum fruit, Chinese thorowax, selaginella, eclipta, artemisia anomala, lotus leaf, wild chrysanthemum flower, safflower, wintersweet, cattail pollen, kapok bark, tree peony bark, sappan wood, Chinese pine node, caulis sinomenii, pepper, pyrolusite, acalypha australis, emilia sonchifolia, hepaticae, auricularia, oriental arborvitae leaf, piper hancei, purslane, Chinese honey locust, hygrophila salicifolia, zanthoxylum nitidum, inula cappa, blumea balsamifera, ardisia crenata, willow branch, commelina communis, clove, myrrh, gamboge, chaulmoogra oil, prepared strychnos, tsaoko amomum fruit, nutmeg, aloe, long pepper, ginger skin, vitex trifolia leaf and purple gromwell weighed in step 1) to obtain traditional Chinese medicine powder A, and then place the traditional Chinese medicine powder A in 60% ethanol, perform ultrasonic-assisted extraction, and filter to obtain traditional Chinese medicine extract A; 3) Mix the bletilla striata, onion, garlic, notoginseng, kapok flower, kudzu flower, zingiber officinale, eriocaulon buergerianum, basil, dragon's blood, amaranthus spinosus, litsea cubeba and alum weighed in step 1) to obtain traditional Chinese medicine powder B, and then place the traditional Chinese medicine powder B in water, perform reflux decoction, and filter to obtain traditional Chinese medicine extract B; 4) Mix the traditional Chinese medicine extract A obtained in step 2) and the traditional Chinese medicine extract B obtained in step 3), and add the eucalyptus oil, star anise oil, methyl salicylate, clove basil oil, turpentine, peppermint oil, cinnamon oil and borneol weighed in step 1), perform vacuum concentration and spray drying to obtain the composite traditional Chinese medicine extract.

4. A traditional Chinese medicine preparation for treating skin burns according to claim 3, wherein in step 2), the material-liquid ratio of the traditional Chinese medicine powder A to 60% ethanol is (15-25) mL:1 g; the ultrasonic-assisted extraction specifically is: at 45 °C, control the ultrasonic power to be 300 W, the ultrasonic frequency to be 20 kHz, and perform ultrasonic-assisted extraction for 30-50 min; in step 3), the water-material ratio of the traditional Chinese medicine powder B to water is (10-20) mL:1 g; the reflux decoction specifically is: reflux decoct at 100 °C for 50-70 min; in step 4), the vacuum concentration specifically is: vacuum concentrate to a relative density of 1.10 at 60 °C and 0.08 MPa; the parameters of the spray drying are: inlet air temperature 160-17℃, outlet air temperature 75-85℃, feed rate 8-12 mL / min, atomization pressure 0.25-0.35 MPa, and dry until the water content ≤ 5%.

5. A traditional Chinese medicine preparation for treating skin burns according to claim 2, characterized in that, In step S2, the preparation of the traditional Chinese medicine microcapsules specifically includes the following steps: 1) Place the composite traditional Chinese medicine extract obtained in step S1 in a phosphate buffer solution, add hyaluronic acid, and perform ultrasonic dispersion to obtain a core material suspension; 2) Mix the gelatin mother liquor and the gum arabic mother liquor, and adjust the pH to 4.2 to obtain a composite wall material solution; 3) Drop the core material suspension obtained in step 1) into the composite wall material solution obtained in step 2), and perform electrostatic self-assembly to obtain a traditional Chinese medicine microcapsule suspension; 4) Mix the Chinese medicine microcapsule suspension obtained in step 3) with CaCl2 solution, perform ion cross-linking, and freeze-dry to obtain the Chinese medicine microcapsules.

6. A traditional Chinese medicine preparation for treating skin burns according to claim 5, characterized in that, In step 1), the ratio of the compound Chinese herbal extract to the phosphate buffer is (5-15) mL:1g; the amount of added hyaluronic acid is 1%wt; the ultrasonic dispersion is specifically controlled as follows: the ultrasonic power is 300W, the ultrasonic frequency is 20kHz, and the ultrasonic dispersion is carried out for 5-15 minutes. In step 2), the mass ratio of gelatin to gum arabic is 1:1; In step 3), the dripping is specifically as follows: under stirring conditions of 45℃ and 300r / min, the core material suspension is dripped into the composite wall material solution at a volume ratio of 1:

1. The electrostatic self-assembly is specifically as follows: 0.5%wt sodium alginate and 0.3%wt chitosan quaternary ammonium salt are added to the mixture, and electrostatic self-assembly is performed at 10℃ for 10-20 min. After centrifugation and filtration, the filter residue is dispersed in distilled water at pH 4.2 and circulated 3-4 times. In step 4), the volume ratio of the traditional Chinese medicine microcapsule suspension to the CaCl2 solution is 1:1; the ion crosslinking is specifically carried out at room temperature for 15-25 min; the freeze-drying is specifically carried out at -50℃ and 10 Pa for 12-24 h.

7. A traditional Chinese medicine preparation for treating skin burns according to claim 2, characterized in that, In step S3, the preparation of the functional layer specifically includes the following steps: 1) N-isopropylacrylamide, acrylic acid and N,N'-methylenebisacrylamide were placed in water and deoxygenated with nitrogen to obtain a monomer prepolymer solution; 2) Place the herbal microcapsules obtained in step S2 into the monomer prepolymer solution obtained in step 1), disperse by ultrasonication, then add ammonium persulfate to the dispersion, polymerize, freeze dry, and obtain the efficacy layer.

8. A traditional Chinese medicine preparation for treating skin burns according to claim 2, characterized in that, In step 1), the mass ratio of N-isopropylacrylamide, acrylic acid, N,N'-methylenebisacrylamide and water is 5:2:0.1:100; In step 2), the ratio of the traditional Chinese medicine microcapsules to the monomer prepolymer solution is (5-15) mL:1g; the amount of ammonium persulfate added is 0.1%wt; the polymerization is specifically carried out at 35℃ for 4-6 hours; the freeze drying is specifically carried out at -50℃ and 10Pa for 10-14 hours.

9. The method for preparing a traditional Chinese medicine preparation for treating skin burns as described in any one of claims 1 to 8, characterized in that, Includes the following steps: 1) Polyvinyl alcohol, sodium carboxymethyl cellulose, water and glycerol are mixed to obtain a hydrogel matrix; 2) Place the hydrogel matrix obtained in step 1) into a mold, allow it to stand to degas, and then freeze and thaw to obtain the hydrogel bottom layer; 3) Place the efficacy layer on the surface of the hydrogel bottom layer obtained in step 2), then add the hydrogel matrix obtained in step 1) to the surface of the efficacy layer, allow it to stand to defoam and freeze-thaw, and form a hydrogel covering layer on the surface of the efficacy layer to obtain the traditional Chinese medicine preparation for treating skin burns.

10. The preparation method according to claim 9, characterized in that, In step 1), the material ratio of polyvinyl alcohol, sodium carboxymethyl cellulose, water and glycerin is 10g:2g:100mL:5mL; In step 2), the freeze-thaw process specifically involves freezing at -20°C for 4 hours and thawing at room temperature for 4 hours. In step 3), the freeze-thaw cycle specifically involves freezing at -20°C for 4 hours, thawing at room temperature for 4 hours, and repeating the freeze-thaw cycle 3 times.

Images