High-throughput pharmacokinetic experiment sample residue removing machine

Abstract

The invention relates to the field of pharmacokinetics experimental equipment, in particular to a high-flux pharmacokinetics experimental sample residue removing machine which comprises a mounting frame, the mounting frame comprises a [-shaped frame, and an upper liquid inlet pipe, a lower liquid inlet pipe and a liquid outlet pipe are fixed in the [-shaped frame; and an outer cleaning assembly. Batch clamping of test tubes is facilitated through the clamping assembly, precise spraying of cleaning liquid is facilitated through cooperation of the outer cleaning assembly and the clamping assembly, resource waste is reduced, dead corners are broken through cleaning through arrangement of the inner cleaning assembly, dead-corner-free thorough cleaning of the test tubes is achieved, and the problems that in the prior art, the bottoms of most test tubes for experiments are of an arc-shaped structure, and cleaning is inconvenient are solved. Most of brush heads of existing cleaning equipment are of a straight structure, can only brush the side wall of a test tube and cannot be matched with the arc-shaped contour of the bottom of the test tube, so that an arc-shaped area at the bottom of the test tube becomes a cleaning dead angle, the spraying direction of cleaning liquid is not accurate enough, and a large amount of cleaning liquid does not directly act on the inner wall of the test tube.

Description

Technical Field

[0001] This invention relates to the field of pharmacokinetic experimental equipment technology, specifically to a high-throughput pharmacokinetic experimental sample residue removal machine. Background Technology

[0002] During pharmacokinetic experiments, a large number of test tubes containing experimental samples are generated. The inner walls and bottoms of these test tubes may contain residues of experimental samples, reagents, and other substances. If these residues are not thoroughly removed, they can lead to cross-contamination of subsequent experimental samples, affecting the accuracy and reliability of experimental data. Therefore, thorough cleaning of test tubes is a crucial step in the pharmacokinetic experimental process.

[0003] Currently, most tube cleaning equipment used in pharmacokinetic experiments suffers from low cleaning efficiency, incomplete cleaning, and significant waste of cleaning solution. On the one hand, existing equipment is mostly single-tube cleaning mode, which is insufficient to meet the rapid cleaning needs of a large number of tubes in high-throughput experiments. Even some equipment that can clean multiple tubes cannot achieve stable clamping and simultaneous, precise cleaning of multiple tubes. On the other hand, the direction of cleaning solution spraying is not precise enough, and a large amount of cleaning solution does not directly act on the inner wall of the tube, resulting in unnecessary waste of cleaning solution.

[0004] More importantly, the bottoms of experimental test tubes are mostly curved, while the brush heads of existing cleaning equipment are mostly straight. These brush heads can only clean the sides of the test tubes and cannot adapt to the curved contours of the bottom. This results in the curved area at the bottom of the test tube becoming a cleaning dead zone, making it difficult to completely remove residual samples. After long-term use, the residue will accumulate and solidify at the bottom of the test tubes, which not only further affects the cleaning effect but also shortens the lifespan of the test tubes, increases experimental costs, and inconveniences the smooth conduct of pharmacokinetic experiments.

[0005] Therefore, it is necessary to invent a high-throughput pharmacokinetic experiment sample residue removal machine to solve the above problems. Summary of the Invention

[0006] The purpose of this invention is to provide a high-throughput pharmacokinetic experimental sample residue removal machine. The clamping assembly facilitates batch clamping of test tubes, and the cooperation between the external cleaning assembly and the clamping assembly enables precise spraying of the cleaning solution, reducing resource waste. The internal cleaning assembly overcomes cleaning dead zones, achieving thorough cleaning of test tubes without any blind spots. This addresses the problem in existing technologies where the bottom of experimental test tubes is mostly curved, and the brush heads of existing cleaning equipment are mostly straight, only able to brush the side walls of the test tubes and unable to adapt to the curved contour of the bottom. This results in the curved area at the bottom of the test tube becoming a cleaning dead zone, the cleaning solution spraying direction being inaccurate, and a large amount of cleaning solution not directly acting on the inner wall of the test tube.

[0007] To achieve the above objectives, the present invention provides the following technical solution: a high-throughput pharmacokinetic experiment sample residue removal machine, comprising: The mounting frame includes an inverted bracket, and an upper liquid inlet pipe, a lower liquid inlet pipe, and a liquid outlet pipe are fixed inside the inverted bracket. An external cleaning assembly includes a lifting electric actuator, which is installed on the top of a U-shaped frame. A sealing frame is fixedly connected to the output end of the lifting electric actuator, and multiple upper spray pipes communicating with the upper liquid inlet pipe are provided inside the sealing frame. A clamping assembly, comprising a support frame, a clamping frame fixedly connected to the bottom of the support frame, and multiple bases fixedly connected inside the support frame, wherein the bases have water inlet holes that cooperate with the upper spray pipe. An internal cleaning assembly includes a fixed frame with a partition below it. Multiple adjusting blocks are fixedly connected inside the fixed frame. Each adjusting block has a rotating seat rotatably connected inside it. An outer tube is fixedly connected to the top of the rotating seat. An inner tube is rotatably connected inside the outer tube. A lower diversion pipe is rotatably connected to the bottom of the inner tube. An inclined rod is fixedly connected to the top of the inner tube and is drivenly connected to the outer tube.

[0008] In a preferred embodiment of the present invention, the C-shaped frame is configured in the shape of a C, a cleaning tank is fixedly connected inside the C-shaped frame, the partition is fixedly connected to the inner side of the cleaning tank, the lower liquid inlet pipe is connected to the cleaning tank at a position above the partition, and the liquid outlet pipe is connected to the cleaning tank at a position below the partition.

[0009] As a preferred embodiment of the present invention, an upper buffer block is fixedly connected below the sealing frame, and multiple upper spray pipes are provided, all of which are connected to the upper liquid inlet pipe.

[0010] As a preferred embodiment of the present invention, the clamping frame has multiple placement frames fixedly connected inside, each placement frame has a fixed limiting block fixedly connected to its front and rear sides, and each placement frame has a movable clamping block movably connected to its left and right sides.

[0011] In a preferred embodiment of the present invention, a limiting rod is fixedly connected to the back of the movable clamping block, the end face of the limiting rod is inclined, a knob is rotatably connected to the end of the clamping frame, a lead screw is threadedly connected to the inside of the knob, a push rod is fixedly connected to the end of the lead screw, the push rod slides inside the clamping frame, a push block is fixedly connected to the side of the push rod, and the push block cooperates with the limiting rod.

[0012] As a preferred embodiment of the present invention, the movable clamping block has a movable groove inside, and an arc-shaped movable block is slidably connected inside the movable groove, with the outer side of the arc-shaped movable block being recessed.

[0013] As a preferred embodiment of the present invention, it further includes a lifting assembly, which includes four fixing blocks, the four fixing blocks being fixed at the four corners of the inner wall of the cleaning tank respectively, an elastic telescopic rod being fixedly connected to the top of the fixing blocks, a lifting frame being fixedly connected to the top of the elastic telescopic rod, a guide block being fixedly connected to the inner side of the lifting frame, and the guide block cooperating with the upper buffer block.

[0014] In a preferred embodiment of the present invention, the fixing frame is fixedly connected to the cleaning tank, a motor is installed on the outside of the cleaning tank, a protective groove is wrapped around the outside of the motor, a rotating rod is fixedly connected to the end of the motor through a coupling, the rotating rod passes through the interior of the fixing frame and is rotatably connected to the fixing frame, a worm gear is also fixedly connected to the outside of the rotating rod, a turbine is fixedly connected to the outside of the inner tube, the turbine is connected to the worm gear, a gear is also fixedly connected to the outside of the inner tube, a driven gear is rotatably connected inside the adjusting block, the gear meshes with the driven gear, an internal gear ring is fixedly connected to the inside of the rotating seat, the internal gear ring meshes with the driven gear, and a bearing is provided between the inner tube and the rotating seat.

[0015] As a preferred embodiment of the present invention, an inclined conical tooth is fixedly connected to the outer side of the inclined rod, an upper conical tooth is fixedly connected to the top of the outer tube, the inclined conical tooth and the upper conical tooth are meshed together, a lower spray pipe is connected to the top of the inclined rod, and brushes are fixedly connected to both the inclined conical tooth and the outer side of the outer tube.

[0016] Compared with the prior art, the technical effects and advantages provided by the present invention in the above technical solution are as follows: By simultaneously and stably clamping multiple test tubes, simultaneous internal and external cleaning of multiple test tubes can be achieved, which greatly improves the efficiency of test tube cleaning in pharmacokinetic experiments. It effectively solves the problems of low cleaning efficiency and inability to adapt to high-throughput experiments of existing equipment, and saves experimental time and labor costs. Precise spraying of cleaning solution reduces resource waste: The cleaning structure designed in this invention allows the cleaning solution to be directly aimed at the inner wall of the test tube and the area to be cleaned, avoiding waste caused by spray deviation. While ensuring the cleaning effect, it reduces the cost of experimental consumables and is more energy-efficient and environmentally friendly. Breaking through cleaning dead angles, achieving thorough cleaning of test tubes without any blind spots: The inclined conical end is equipped with an inclined brush that can rotate, brushing the side walls of the test tube while precisely adapting to the curved contour of the bottom of the test tube. It can clean the curved part of the bottom of the test tube from all angles without dead angles, solving the technical problem of existing equipment where straight brush heads cannot clean the curved area at the bottom of the test tube and the residue is difficult to remove. The test tube is thoroughly cleaned, effectively avoiding cross-contamination of samples in subsequent experiments, ensuring the accuracy and reliability of experimental data. By thoroughly cleaning the inner wall and the curved area at the bottom of the test tube, it can avoid the corrosion and damage caused by the accumulation and solidification of residual substances, extend the number of times the test tube can be reused, further reduce the consumable costs of pharmacokinetic experiments, and improve the practicality and economy of the equipment. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this invention. For those skilled in the art, other drawings can be obtained based on these drawings.

[0018] Figure 1 This is a schematic diagram of the overall structure of the present invention; Figure 2 This is a schematic diagram of the internal structure of the cleaning tank of the present invention; Figure 3 This is a schematic diagram of the external cleaning component structure of the present invention; Figure 4 This is a first-view structural diagram of the clamping assembly of the present invention; Figure 5 This is a second-view structural diagram of the clamping assembly of the present invention; Figure 6 This is a schematic diagram of the cross-sectional structure of the clamping component of the present invention; Figure 7 For the present invention Figure 6 Enlarged structural diagram at point A in the middle; Figure 8 This is a schematic diagram of the internal cleaning component structure of the present invention; Figure 9 This is a partial structural diagram of the internal cleaning component of the present invention; Figure 10 This is a schematic diagram of the internal structure of the rotating seat of the present invention; Figure 11 This is a schematic diagram of the connection structure between the outer tube and the inclined bevel teeth of the present invention.

[0019] Explanation of reference numerals in the attached figures: 001. Mounting bracket; 002. External cleaning assembly; 003. Clamping assembly; 004. Lifting assembly; 005. Internal cleaning assembly; 101. C-shaped frame; 102. Upper inlet pipe; 103. Lower inlet pipe; 104. Outlet pipe; 105. Cleaning tank; 106. Protective tank; 201. Lifting electric actuator; 202. Sealing frame; 203. Upper spray pipe; 204. Upper buffer block; 301. Support frame; 302. Base; 303. Water inlet; 304. Clamping frame; 305. Placement frame; 306. Fixed limit block; 307. Movable clamping block; 308. Arc-shaped movable block; 309. Limiting rod; 310. Knob; 311. Lead screw; 312. Push rod; 313. Push block; 314. Movable groove; 401. Fixed block; 402. Elastic telescopic rod; 403. Lifting frame; 404. Guide block; 501. Fixed frame; 502. Motor; 503. Rotating rod; 504. Adjusting block; 505. Lower distributor pipe; 506. Inner pipe; 507. Rotating seat; 508. Outer pipe; 509. Upper bevel gear; 510. Inclined rod; 511. Inclined bevel gear; 512. Lower spray pipe; 513. Brush; 514. Turbine; 515. Gear; 516. Driven gear; 517. Internal gear ring; 518. Bearing. Detailed Implementation

[0020] To enable those skilled in the art to better understand the technical solution of the present invention, the present invention will be further described in detail below with reference to the accompanying drawings.

[0021] This invention provides, for example Figure 1-11The high-throughput pharmacokinetic experiment sample residue removal machine shown includes: a mounting frame 001, which includes a U-shaped frame 101, with an upper inlet pipe 102, a lower inlet pipe 103, and an outlet pipe 104 fixed inside the U-shaped frame 101; an external cleaning assembly 002, which includes a lifting electric actuator 201, which is mounted on the top of the U-shaped frame 101, and a sealing frame 202 is fixedly connected to the output end of the lifting electric actuator 201, with multiple upper spray pipes 203 communicating with the upper inlet pipe 102 inside the sealing frame 202; and a clamping assembly 003, which includes a support frame 301, with a clamping frame 304 fixedly connected to the bottom of the support frame 301. Multiple bases 302 are fixedly connected inside 301. The bases 302 have water inlet holes 303 that cooperate with the upper spray pipe 203. The internal cleaning component 005 includes a fixing frame 501. A perforated partition is provided below the fixing frame 501. Multiple adjusting blocks 504 are fixedly connected inside the fixing frame 501. A rotating seat 507 is rotatably connected inside each adjusting block 504. An outer pipe 508 is fixedly connected to the top of the rotating seat 507. An inner pipe 506 is rotatably connected inside the outer pipe 508. A lower diverter pipe 505 is rotatably connected to the bottom of the inner pipe 506. An inclined rod 510 is fixedly connected to the top of the inner pipe 506. The inclined rod 510 is connected to the outer pipe 508 in a transmission connection.

[0022] like Figure 4 As shown, the support frame 301 has handles on both sides, allowing the user to remove it by holding the clamping assembly 003. The support frame 301 is placed downwards, and the clamping frame 304 upwards. The test tube to be cleaned is then placed between the two fixed limiting blocks 306 and the two movable clamping blocks 307. The knob 310 is then turned to clamp the test tube. Next, the user holds the handles on both sides of the support frame 301 and inverts the clamping assembly 003, holding the test tube, onto the top of the cleaning tank 105. The lifting electric actuator 201 is then activated, causing the sealing frame 202 to gradually approach the test tube inside the clamping assembly 003, thus sealing the cleaning tank 105. Meanwhile, the external cleaning assembly 002 lowers the clamping assembly 003 and the test tube. The outer tube 508 is inserted into the test tube, and then the inner cleaning component 005 is activated to clean the inside of the test tube. The outer tube 508 and the inclined conical teeth 511 clean the inner side wall and inner bottom wall of the test tube respectively, improving the cleaning efficiency. The outer cleaning component 002 can clean the outer wall of the test tube. After cleaning, the lifting electric push rod 201 is activated to raise the sealing frame 202, and then the wastewater is discharged. Then the clamping component 003 is taken out to facilitate the removal of the clean test tube. Multiple clamping components 003 can be set. When one is cleaning, the others can be clamped or stored, which is convenient for batch clamping of test tubes and batch cleaning. Multiple test tubes can be cleaned at one time, and the clamping components 003 can also be used to collect test tubes.

[0023] As a further optimization of the present invention, such as Figure 1 and Figure 3 As shown, the C-shaped frame 101 is configured in the shape of a C-shape, and a cleaning tank 105 is fixedly connected inside the C-shaped frame 101. A partition is fixedly connected to the inside of the cleaning tank 105. The lower liquid inlet pipe 103 is connected to the cleaning tank 105 at the position above the partition, and the liquid outlet pipe 104 is connected to the cleaning tank 105 at the position below the partition. The upper buffer block 204 is also fixedly connected to the lower part of the sealing frame 202. Multiple upper spray pipes 203 are provided, and all of the multiple upper spray pipes 203 are connected to the upper liquid inlet pipe 102.

[0024] The upper inlet pipe 102 is connected to an external water pump to pump the cleaning solution into the upper spray pipe 203. The lower inlet pipe 103 is connected to multiple lower branch pipes 505. The lower inlet pipe 103 is connected to an external water pump to pump the cleaning solution into the lower branch pipes 505. The cleaning solution enters the inner tube 506 through the lower branch pipes 505 to clean the inside of the test tube. The waste liquid after cleaning flows out through the perforated baffle and is discharged to the outside of the cleaning tank 105 through the outlet pipe 104.

[0025] In the above structure, multiple placement racks 305 are fixedly connected inside the clamping frame 304. Each placement rack 305 has a fixed limiting block 306 fixedly connected to its front and rear sides, and a movable clamping block 307 movably connected to its left and right sides. A limiting rod 309 is fixedly connected to the back of each movable clamping block 307, with the end face of the limiting rod 309 inclined. A knob 310 is rotatably connected to the end of the clamping frame 304, and a lead screw 311 is threaded internally connected to the knob 310. The end of the lead screw 311... A push rod 312 is fixedly connected to the part, and the push rod 312 slides inside the clamping frame 304. A push block 313 is fixedly connected to the side of the push rod 312. The push block 313 slides with the limiting rod 309. A sliding groove is provided inside the push block 313. A slider that slides inside the sliding groove is fixedly connected to the end of the limiting rod 309. Furthermore, an movable groove 314 is opened inside the movable clamping block 307. An arc-shaped movable block 308 is slidably connected inside the movable groove 314. The outer side of the arc-shaped movable block 308 is recessed.

[0026] The user can remove the clamping component 003 by hand, placing the support frame 301 downwards and the clamping frame 304 upwards. Then, the test tube to be cleaned is placed between the two fixed limiting blocks 306 and the two movable clamping blocks 307. The bottom of the test tube naturally falls into the water inlet 303 inside the base 302. After each water inlet 303 has a test tube inside, the knob 310 is manually turned. The knob 310 drives the lead screw 311 to extend inwards. 311 drives push rod 312 to slide, push rod 312 drives push block 313 to move synchronously, push block 313 pushes limit rod 309 to extend, limit rod 309 clamps and fixes the internal test tube through movable clamping block 307 and arc-shaped movable block 308, wherein arc-shaped movable block 308 is adapted to the test tube. Then, the clamping assembly 003 is inverted so that the test tube is placed inside the cleaning tank 105. When the test tube is inverted, the arc-shaped movable block 308 clamping the test tube descends under the action of gravity. The arc-shaped movable block 308 descends inside the movable clamping block 307, so that the bottom of the test tube leaves the water inlet hole 303, which facilitates the spraying of cleaning solution.

[0027] As a further optimization of the present invention, a lifting assembly 004 is also included. The lifting assembly 004 includes four fixing blocks 401, which are respectively fixed at the four corners of the inner wall of the cleaning tank 105. An elastic telescopic rod 402 is fixedly connected to the top of the fixing block 401, and a lifting frame 403 is fixedly connected to the top of the elastic telescopic rod 402. A guide block 404 is fixedly connected to the inner side of the lifting frame 403, and the guide block 404 cooperates with the upper buffer block 204.

[0028] The guide block 404 has a gap in the middle, which cooperates with the knob 310. The guide block 404 is inclined to facilitate the positioning of the clamping assembly 003. Then, the clamping assembly 003 is placed on the platform of the guide block 404. The lifting electric actuator 201 is activated, which drives the sealing frame 202 to descend. The upper buffer block 204 at the bottom of the sealing frame 202 descends and cooperates with the guide block 404, pressing down on the top of the clamping frame 304 to fix the clamping assembly 003. This causes the elastic telescopic rod 402 to retract, allowing the test tube to... As the tube gradually approaches the inner cleaning component 005, the upper spray pipe 203 is inserted into the water inlet 303 and positioned directly above the test tube, thus accurately spraying the cleaning fluid, reducing resource waste, and ensuring that the cleaning fluid is directly aimed at the outer wall of the test tube, avoiding waste caused by spray deviation. While ensuring the cleaning effect, it reduces the cost of experimental consumables and is more energy-efficient and environmentally friendly. As the outer cleaning component 002 gradually rises, the lifting frame 403 gradually rises under the action of the elastic telescopic rod 402, lifting the clamping component 003 and the test tube for easy discharge.

[0029] In the above structure, the fixing frame 501 is fixedly connected to the cleaning tank 105. A motor 502 is installed on the outside of the cleaning tank 105. The motor 502 is surrounded by a protective groove 106. A rotating rod 503 is fixedly connected to the end of the motor 502 via a coupling. The rotating rod 503 passes through the inside of the fixing frame 501 and is rotatably connected to the fixing frame 501. A worm gear is also fixedly connected to the outside of the rotating rod 503. A turbine 514 is fixedly connected to the outside of the inner tube 506. The turbine 514 is connected to the worm gear. A gear 515 is also fixedly connected to the outside of the inner tube 506. The internal rotating connection of the adjusting block 504 is... A driven tooth 516 is connected, and a gear 515 meshes with the driven tooth 516. An internal gear ring 517 is fixedly connected to the inner side of the rotating seat 507, and the internal gear ring 517 meshes with the driven tooth 516. A bearing 518 is provided between the inner tube 506 and the rotating seat 507. An inclined bevel tooth 511 is fixedly connected to the outer side of the inclined rod 510, and an upper bevel tooth 509 is fixedly connected to the top of the outer tube 508. The inclined bevel tooth 511 meshes with the upper bevel tooth 509. A lower spray pipe 512 is connected to the top of the inclined rod 510. Brushes 513 are fixedly connected to both the inclined bevel tooth 511 and the outer side of the outer tube 508.

[0030] After the test tube is positioned, the inner wall of the test tube needs to be cleaned. The cleaning solution is pumped into the interior of multiple lower distribution pipes 505 through the lower inlet pipe 103 by a water pump, and then enters the interior of the inner tube 506 through the lower distribution pipes 505. Then, the inner bottom wall of the test tube is sprayed through the lower spray pipe 512. At the same time, the motor 502 is started. The motor 502 drives the rotating rod 503 and the worm gear to rotate. The worm gear drives the inner tube 506 to rotate through the turbine 514. The inner tube 506 drives the driven gear 516 to rotate through the gear 515. The driven gear 516 drives the rotating seat 507 to rotate through the internal gear ring 517. The rotating seat 507 drives the outer tube 508 to rotate, so that the outer tube 508 and the inner tube 506 rotate in opposite directions through the bearing 518. The outer tube 508 drives the upper bevel gear 509 to rotate, and the inner tube 506 drives the inclined rod 510 and the inclined bevel gear 511 to rotate in opposite directions. The upper bevel gear 509 and the inclined bevel gear 511 are meshed and connected, thereby driving the inclined bevel gear 511 to rotate on its own axis during the revolution. Because the inclined bevel gear 511 is inclined, the brush 513 on the outside of the inclined bevel gear 511 can contact the bottom of the test tube. Since the inclined bevel gear 511 can rotate on its own axis, the bottom of the test tube can be thoroughly cleaned. The brush 513 on the side wall of the inner tube 506 can clean the side wall of the test tube. With the spraying of the lower spray pipe 512, the cleaning can be further carried out.

[0031] The inclined conical teeth 511 are set at an angle, and the brush 513 on the outer side of the inclined conical teeth 511 can rotate. While brushing the side wall of the test tube, it can accurately adapt to the arc-shaped contour of the bottom of the test tube, and perform all-round, no dead angle brushing of the arc-shaped part at the bottom of the test tube, ensuring that the test tube is thoroughly cleaned, effectively avoiding cross-contamination of samples in subsequent experiments, and can break through cleaning dead angles to achieve thorough cleaning of the test tube without dead angles.

[0032] The foregoing has only described certain exemplary embodiments of the present invention by way of illustration. Undoubtedly, those skilled in the art can modify the described embodiments in various ways without departing from the spirit and scope of the present invention. Therefore, the foregoing drawings and descriptions are illustrative in nature and should not be construed as limiting the scope of protection of the claims of the present invention.

Claims

1. A high-throughput pharmacokinetic experiment sample residue removal device, characterized in that: include: Mounting bracket (001), the mounting bracket (001) includes an inverted bracket (101), the inverted bracket (101) has an upper liquid inlet pipe (102), a lower liquid inlet pipe (103) and an outlet pipe (104) fixed inside. An external cleaning assembly (002) includes a lifting electric actuator (201), which is installed on the top of a U-shaped frame (101). The output end of the lifting electric actuator (201) is fixedly connected to a sealing frame (202), and the interior of the sealing frame (202) is provided with multiple upper spray pipes (203) that communicate with the upper liquid inlet pipe (102). The clamping assembly (003) includes a support frame (301), a clamping frame (304) is fixedly connected to the bottom of the support frame (301), and a plurality of bases (302) are fixedly connected inside the support frame (301). The bases (302) have water inlet holes (303) that cooperate with the upper spray pipe (203) inside. An internal cleaning assembly (005) includes a fixed frame (501) and a partition plate below the fixed frame (501). Multiple adjusting blocks (504) are fixedly connected inside the fixed frame (501). A rotating seat (507) is rotatably connected inside each adjusting block (504). An outer tube (508) is fixedly connected to the top of the rotating seat (507). An inner tube (506) is rotatably connected inside the outer tube (508). A lower diversion pipe (505) is rotatably connected to the bottom of the inner tube (506). An inclined rod (510) is fixedly connected to the top of the inner tube (506). The inclined rod (510) is drively connected to the outer tube (508).

2. The high-throughput pharmacokinetic experimental sample residue removal machine according to claim 1, characterized in that: The C-shaped frame (101) is configured in the shape of a C-shape. A cleaning tank (105) is fixedly connected inside the C-shaped frame (101). The partition is fixedly connected to the inside of the cleaning tank (105). The lower liquid inlet pipe (103) is connected to the cleaning tank (105) at the position above the partition. The liquid outlet pipe (104) is connected to the cleaning tank (105) at the position below the partition.

3. The high-throughput pharmacokinetic experimental sample residue removal machine according to claim 1, characterized in that: An upper buffer block (204) is fixedly connected below the sealing frame (202). Multiple upper spray pipes (203) are provided, and multiple upper spray pipes (203) are connected to the upper liquid inlet pipe (102).

4. The high-throughput pharmacokinetic experimental sample residue removal device according to claim 1, characterized in that: The clamping frame (304) has multiple placement frames (305) fixedly connected inside. Each placement frame (305) has a fixed limiting block (306) fixedly connected to its front and rear sides, and each placement frame (305) has a movable clamping block (307) movably connected to its left and right sides.

5. A high-throughput pharmacokinetic experiment sample residue removal machine according to claim 4, characterized in that: The back of the movable clamping block (307) is fixedly connected to a limiting rod (309), the end face of the limiting rod (309) is inclined, the end of the clamping frame (304) is rotatably connected to a knob (310), the knob (310) is internally threaded to a lead screw (311), the end of the lead screw (311) is fixedly connected to a push rod (312), the push rod (312) slides inside the clamping frame (304), the side of the push rod (312) is fixedly connected to a push block (313), and the push block (313) cooperates with the limiting rod (309).

6. A high-throughput pharmacokinetic experiment sample residue removal machine according to claim 5, characterized in that: The movable clamping block (307) has an internal movable groove (314), and an arc-shaped movable block (308) is slidably connected inside the movable groove (314). The outer side of the arc-shaped movable block (308) is recessed.

7. A high-throughput pharmacokinetic experiment sample residue removal machine according to claim 1, characterized in that: It also includes a lifting assembly (004), which includes four fixing blocks (401). The four fixing blocks (401) are respectively fixed at the four corners of the inner wall of the cleaning tank (105). An elastic telescopic rod (402) is fixedly connected to the top of the fixing block (401). A lifting frame (403) is fixedly connected to the top of the elastic telescopic rod (402). A guide block (404) is fixedly connected to the inner side of the lifting frame (403). The guide block (404) cooperates with the upper buffer block (204).

8. The high-throughput pharmacokinetic experimental sample residue removal machine according to claim 1, characterized in that: The fixed frame (501) is fixedly connected to the cleaning tank (105). A motor (502) is installed on the outside of the cleaning tank (105). A protective groove (106) covers the outside of the motor (502). A rotating rod (503) is fixedly connected to the end of the motor (502) through a coupling. The rotating rod (503) passes through the inside of the fixed frame (501) and is rotatably connected to the fixed frame (501). A vortex rod is also fixedly connected to the outside of the rotating rod (503). A vortex rod is fixedly connected to the outside of the inner tube (506). The turbine (514) is connected to the worm gear, and a gear (515) is fixedly connected to the outside of the inner tube (506). A driven gear (516) is rotatably connected inside the adjusting block (504). The gear (515) meshes with the driven gear (516). An internal gear ring (517) is fixedly connected to the inside of the rotating seat (507). The internal gear ring (517) meshes with the driven gear (516). A bearing (518) is provided between the inner tube (506) and the rotating seat (507).

9. A high-throughput pharmacokinetic experiment sample residue removal machine according to claim 8, characterized in that: An inclined bevel tooth (511) is fixedly connected to the outside of the inclined rod (510), and an upper bevel tooth (509) is fixedly connected to the top of the outer tube (508). The inclined bevel tooth (511) and the upper bevel tooth (509) are meshed together. The top of the inclined rod (510) is connected to a lower spray pipe (512). Brushes (513) are fixedly connected to both the inclined bevel tooth (511) and the outside of the outer tube (508).

Images