Suction and filtration injector

Abstract

A suction and filtration injector is provided with an outer cylinder, an inner cylinder, a filter and a plunger. The outer cylinder is provided with a first inner cavity with a first diameter and a backflow port located in the first inner cavity. The inner barrel is provided with a second inner cavity with a second diameter, the second diameter is smaller than the first diameter, the inner barrel is fixed in the first inner cavity, the inner barrel is provided with a plurality of through holes and a suction port located in the second inner cavity, and the through holes allow fluid communication between the inner barrel and the outer barrel; the filter is arranged between the first inner cavity and the second inner cavity and covers the plurality of through holes; the plunger is arranged in the second inner cavity.

Description

[0001] Cross-reference to related applications This disclosure claims priority to U.S. Provisional Patent Application No. 63 / 530,398, filed August 2, 2023, entitled “Aspiration Filtering Injector,” the entire contents of which are incorporated herein by reference. Background Technology

[0002] When aspirating bodily fluids and any solids they carry (such as emboli in the blood), an aspiration catheter is used. This catheter aspirates not only the solids but also a large amount of accompanying fluid. Significant loss of certain bodily fluids (such as blood) can have serious negative effects on an organism, so it is desirable to return as much of the fluid as possible to the organism after removing the solids. Summary of the Invention

[0003] This disclosure generally relates to an aspiration and filtering syringe that allows a user to return bodily fluids to the organism after solids have been aspirated along with these fluids. The syringe includes several features to allow for rapid reusability during procedures without the need for device replacement and without causing excessive loss of bodily fluids. The syringe also maintains compatibility with existing devices and accessories, such as catheters, stopcocks, pumps, etc., and helps operators reduce the time required for clinical procedures.

[0004] One embodiment of this disclosure is an apparatus comprising: an outer cylinder having a first inner cavity with a first diameter and a reflux port located in the first inner cavity; an inner cylinder having a second inner cavity with a second diameter smaller than the first diameter, fixed within the first inner cavity, having a plurality of through holes allowing fluid communication between the inner and outer cylinders, and an intake port located in the second inner cavity; a filter disposed between the first and second inner cavities and covering the plurality of through holes; and a plunger disposed in the second inner cavity.

[0005] One embodiment of this disclosure is an apparatus comprising: an outer cylinder having a first inner cavity with a first diameter and including a reflux port defined in a first wall of the first inner cavity; an inner cylinder having a second inner cavity with a second diameter smaller than the first diameter, fixed within the first inner cavity and including a filter device defined in a second wall of the second inner cavity; and a plunger disposed in the second inner cavity.

[0006] One embodiment of this disclosure is an apparatus comprising: an outer cylinder having a first inner cavity with a first diameter, and including: a first opening at a first end of the first inner cavity; a second opening on a second side of the first inner cavity; and a reflux port defined in a first wall of the first inner cavity and located between the first opening and the second opening; and an inner cylinder having a second inner cavity with a second diameter smaller than the first diameter, fixed within the first inner cavity, and including: a first port extending through the first opening; a second port extending through the second opening; and a porous filter defined in a second wall of the second inner cavity and located between the first port and the second port; and a pressure applying device connected to the second port.

[0007] One embodiment of this disclosure is a method comprising: establishing fluid communication between a living organism and an inhalation port and a return port of a filtration and aspiration device; applying negative pressure to a first cavity of the filtration and aspiration device, the first cavity being in fluid communication with a second cavity via a filter, to aspirate bodily fluids from the living organism through the inhalation port; collecting the bodily fluids in the first cavity, wherein the bodily fluids contain obstructions aspirated from the living organism; separating the obstructions from the bodily fluids through the filter to retain the obstructions in the first cavity and allow the bodily fluids to enter a second cavity containing the first cavity; and returning the bodily fluids that entered the second cavity to the living organism through the return port. Attached Figure Description

[0008] The accompanying drawings illustrate various elements of one or more embodiments of this disclosure and are not intended to limit the scope of protection of this disclosure.

[0009] In the accompanying drawings, some elements may not be drawn to scale with other elements in order to show details more clearly. Furthermore, where possible, the same reference numerals are used to denote the same elements in multiple drawings.

[0010] It is conceivable that elements and features of one embodiment may be advantageously incorporated into other embodiments without further description or illustration. For example, since the drawings may show alternative views and states at different times, various elements shown in the first drawing may be omitted from the illustrations in the second drawing, and this does not imply that these elements are excluded from being included in the embodiments shown or discussed in association with the second drawing.

[0011] Figure 1A provides a view of an assembled device according to an embodiment of the present disclosure.

[0012] Figure 1B provides an exploded view of the components of an apparatus according to an embodiment of the present disclosure.

[0013] Figures 2A-2C provide views of filters according to embodiments of the present disclosure.

[0014] Figures 3A and 3B provide views of an example plunger according to an embodiment of the present disclosure.

[0015] Figures 4A-4C provide views of the outer cylinder according to embodiments of the present disclosure.

[0016] Figures 5A-5D provide views of the inner cylinder according to embodiments of the present disclosure.

[0017] Figure 6 provides a schematic diagram of the flow of bodily fluids through a device according to an embodiment of the present disclosure.

[0018] Figure 7 is a flowchart describing user operations of a device according to an embodiment of the present disclosure. Detailed Implementation

[0019] This disclosure generally relates to an improved filtration aspiration device that allows bodily fluids (e.g., blood, lymph, cerebrospinal fluid) aspirated from a living organism to be returned to the subject's body after filtration to remove any aspirated solids. Among other benefits, the aspiration device described herein allows for the avoidance of excessive blood loss during aspiration, avoidance of the need for blood transfusions after or during aspiration, and enables the filtration of more bodily fluids because the subject does not lose any fluids.

[0020] The system includes a syringe having an inner barrel, an outer barrel, a filter (see Figures 2A-2C), a pressure application device (e.g., a pump or plunger, see Figures 3A and 3B), an intake port, and a return port. Through-holes in the inner barrel wall allow bodily fluids drawn through the intake port to pass through a filter located between the inner and outer barrels. Blood clots, stones, plaques, and other solids are trapped by this filter, while the bodily fluids pass through. In this way, solids are separated from bodily fluids. After passing through the filter, the bodily fluids can be returned to the organism through the return port located on the outer barrel wall.

[0021] Figures 1A and 1B provide an assembled state view and an exploded state view of the apparatus 100 according to an embodiment of the present disclosure, respectively.

[0022] Figure 1A provides a view of an assembled device 100 according to an embodiment of the present disclosure. In Figure 1A, an inner cylinder 150 is secured within the inner cavity of an outer cylinder 140. In various embodiments, a filter 120 is disposed in contact with the outer wall of the inner cylinder 150 to form a filter segment within the inner cavity of the outer cylinder 140 and can be held in place by friction, tabs, adhesives, compression between the two cavities, or similar means. In some embodiments, a filter 120 is disposed in contact with the inner wall of the inner cylinder 150 to form a filter segment and can be held in place by friction, tabs, adhesives, or similar means. In this embodiment, depending on the size and material used, gaskets 160 (one or more of gaskets 160a and 160b) may typically scrape along the filter 120 or filter segment during use, potentially causing the filter 120 and gaskets 160 to rub against or become stuck together. To reduce the likelihood or extent of undesirable scraping / sticking, the filter 120 may include a cartridge filter (not shown). The transversely defined through-holes on the outer wall of the inner cylinder 150 and the pores in the filter 120 provide a filtration device to allow bodily fluids to flow from the inner cavity of the inner cylinder 150 to the inner cavity of the outer cylinder 140, while trapping various solids that cannot pass through the filtration device within the inner cylinder 150. In various embodiments, depending on the size of the solids to be trapped relative to the through-holes defined in the inner cylinder 150, the filter 120 may be omitted from the filtration device, so that the filtration section may be defined at least by the through-holes and optionally by the filter 120 disposed in the flow path between the respective cavities of the inner cylinder 150 and the outer cylinder 140 (e.g., above or below the through-holes). In another embodiment, the through-holes on the inner cylinder 150 may include “micropores” serving as the filtration section, thus eliminating the need for a separate filter 120 element. In this embodiment, if one or more through-holes of the inner cylinder 150 become clogged during use, the inner cylinder 150 may be removed and / or replaced.

[0023] The plunger 130 is located within the inner cavity of the inner cylinder 150 and serves as a negative pressure source, although in some embodiments, the plunger 130 may be omitted and replaced with another negative pressure source (e.g., a pump). A stop 110 is fixed through the wall of the inner cylinder 150 and, when the plunger 130 is pulled out to its intended maximum extent, the stop 110 prevents the plunger 130 from being completely pulled out of the inner cavity of the inner cylinder 150 by physical contact with the plunger 130.

[0024] During use, the user draws bodily fluid into the inner cavity of the inner cylinder 150 through the suction port 152 by pulling the plunger 130 outward from the inner cavity (or applying another negative pressure source). The bodily fluid then enters through holes in the wall of the inner cylinder 150 and flows into the filter 120. The filter 120 traps any blood clots, stones, plaques, and other solids, while allowing liquids and smaller solids (such as blood cells) to pass through. The filtered bodily fluid can then be returned to the organism through the return port 142. More detailed views of an embodiment of the filter 120 are shown in Figures 2A-2C. An embodiment of the plunger 130 is shown in Figures 3A and 3C. Figure 3B The figures are shown in more detail below. More detailed views of an embodiment of the outer cylinder 140 are shown in Figures 4A-4C. Further details of an embodiment of the inner cylinder 150 are shown in Figures 5A-5D.

[0025] exist Figure 1B In this embodiment of the present disclosure, device 100 is shown in an exploded view. Device 100 includes a first gasket 160a (generally referred to as gasket 160), which, when assembled, is circumferentially disposed around a suction port 152 located at an end face of an interlocking thread on the outer side of the inner cylinder 150 and the inner side of the outer cylinder 140. The first gasket 160a prevents bodily fluids from entering the interlocking thread through the suction port 152 and facilitates the formation of a seal after assembly to apply negative pressure to a living organism via device 100.

[0026] A second gasket 160b is circumferentially disposed within the inner cylinder 150. After assembly, the second gasket 160b contacts the inner wall of the outer cylinder 140 and the outer wall of the inner cylinder 150 on a first side of the filter 120. In some embodiments, the second gasket 160b also contacts the longitudinally opposite side of the interlocking thread to the first gasket 160a. The second gasket 160b prevents bodily fluids that have penetrated the wall of the inner cylinder 150 from entering the interlocking thread and facilitates the formation of a seal after assembly to apply negative pressure to the organism through the device 100.

[0027] A third gasket 160c is circumferentially disposed within the inner cylinder 150. After assembly, the third gasket 160c contacts the inner wall of the outer cylinder 140 and the outer wall of the inner cylinder 150 on a second side of the filter 120, which longitudinally opposes the side of the filter 120 that, in some embodiments, contacts the second gasket 160b. The third gasket 160c prevents bodily fluids that have passed through the wall of the inner cylinder 150 from flowing out of the device through the interface between the inner cylinder 150 and the outer cylinder 140, which is longitudinally opposite to the interlocking threads, and facilitates the formation of a seal after assembly to apply negative pressure to the organism through the device 100.

[0028] A fourth gasket 160d is circumferentially disposed on the plunger 130. After the device 100 is assembled, the fourth gasket 160d contacts the inner wall of the inner cylinder 150 and the outer surface of the plunger 130. The fourth gasket 160d is a head gasket that serves as a seal between the plunger 130 and the inner cylinder 150, preventing air from flowing in from the plunger port (580, see Figure 5A) and allowing the plunger 130 to apply fluid pressure within the inner cavity of the inner cylinder 150.

[0029] In various embodiments, gasket 160 is configured to maintain an airtight seal or engagement when applied pressures of ±20 psi, ±40 psi, or similar. In some embodiments, the interlocking thread and the second gasket 160b are located longitudinally opposite the suction port 152. In some embodiments, depending on the different arrangement of components or the use of a permanent seal between the inner cylinder 150 and the outer cylinder 140, one or more of the interlocking thread and gaskets 160a-c may be omitted.

[0030] Figures 2A-2C provide views of a filter 120 according to an embodiment of the present disclosure.

[0031] Figure 2A is a view of an example filter 120 with an arcuate distance of 360 degrees according to an embodiment of the present disclosure. As shown, the filter 120 is a cylinder made of filter material 210, having an inner wall 220 and an outer wall 230. Although the end faces of the cylinder are shown as regular circular edges, in some embodiments, the end faces may include cuts or other irregular structures to define clearance spaces that interact with protrusions on the outer wall of the inner cylinder 150, acting as foolproof elements to ensure the desired orientation of the filter 120 in the installed state. In some embodiments, the length of the filter 120 is two-thirds or less of the inner cavity length of the inner cylinder 150, and the dimensions are determined according to the porous portion of the inner cylinder 150.

[0032] Figure 2B is a view of a filter 120 with an arcuate distance between 180 and 360 degrees according to an embodiment of the present disclosure. As shown, the filter 120 is a partially cylindrical body made of filter material 210, having an inner wall 220, an outer wall 230, and a gap or groove 240 extending along the length of the cylinder. In some embodiments, the gap or groove 240 is positioned within the device 100 to align with a non-perforated region (512) of the inner cylinder 150, which is discussed in more detail in Figure 5D. Although the gap or groove 240 shown covers an arcuate distance of approximately 60 degrees and has a rectangular edge profile, in some embodiments, the gap or groove 240 may cover an arcuate distance greater than or less than 60 degrees, or have an edge profile with a different shape, serving as a foolproof element to ensure the desired orientation of the filter 120 in the installed state.

[0033] Figure 2C is a view of a filter 120 with an arcuate distance of less than 180 degrees according to an embodiment of the present disclosure. As shown, the filter 120 is a curved sheet made of filter material 210, having an inner wall 220 and an outer wall 230. Although the illustrated curved sheet of filter material 210 covers an arcuate distance of approximately 120 degrees and has a rectangular edge profile, in some embodiments, the filter material 210 may cover an arcuate distance greater than or less than 120 degrees, or have an edge profile with a different shape, serving as a foolproof element to ensure the desired orientation of the filter 120 in the installed state.

[0034] In various embodiments of filter 120, bodily fluids enter filter material 210 through inner wall 220 and exit through outer wall 230. In some embodiments, filter material 210 is positioned within device 100 to align with the perforated portion of inner cylinder 150. Larger solids suspended in the bodily fluids are trapped by the curved plates of filter material 210, and in some embodiments, its pore size is designed to be non-hemolytic (e.g., allowing red blood cells to pass through without rupturing). For example, the pore area can be 40-160 square micrometers (μm). 2 This allows red blood cells to pass through pores without damage (e.g., hemolysis). Therefore, the non-hemolytic filter 120 can return body fluid containing intact (e.g., usable by the organism) red blood cells to the organism while removing larger solids (e.g., thrombi, plaques, foreign bodies, necrotic tissue, etc.) from the body fluid. The device 100 is designed so that the filter 120 can be quickly and easily removed, replaced, or cleaned during device 100 operation (e.g., in the event of clogging).

[0035] The thickness of filter 120 can vary in different embodiments and can be based in part on the gap distance between the outer diameter of inner cylinder 150 and the inner diameter of outer cylinder 140. In various embodiments, the difference between the outer and inner diameters is between 2 and 4 mm (approximately 0.08 to 0.15 inches), which defines a fluid recirculation gap between the first and second inner cavities, a gap that filter 120 at least partially occupies (see Figure 6 for more details). Although filter 120 can be of various thicknesses, in this example, a filter 120 with a thickness of approximately 1.4 mm, or 35-70% of the 2-4 mm example fluid recirculation gap, would reduce the free space in the fluid recirculation gap to approximately 0.6-2.6 mm.

[0036] Figures 3A and 3B provide views of an example plunger 130 according to an embodiment of the present disclosure.

[0037] Figure 3A is a view of an example plunger 130 according to an embodiment of the present disclosure. The plunger 130 includes a head 310, a handle 330, and a body 320 connecting the head 310 and the handle 330. The head 310 generates suction pressure when sealing against the inner wall of the inner cylinder 150, and the handle 330 is provided for an operator to hold when pulling or pushing the plunger 130. When the operator pulls the handle 330 outward from the assembled device 100, the rest of the plunger 130 moves outward, and the head 310 changes the volume of the sealed portion of the inner cavity of the inner cylinder 150, thereby applying negative pressure to the suction port 152.

[0038] Figure 3B is a view of an example plunger 130 according to an embodiment of the present disclosure. The plunger 130 includes a first head 310 for generating suction pressure when sealing against the inner wall of the inner cylinder 150; a second head 340 for generating suction pressure when sealing against the inner wall of the inner cylinder 150; a handle 330 for an operator to grip when pulling or pushing the plunger 130; and a body 320 connecting the first head 310 and the second head 340 to the handle 330. When the operator pulls the handle 330 outward from the assembled device 100, the remaining portion of the plunger 130 moves outward, and the head 310 changes the volume of the sealing portion of the inner cavity of the inner cylinder 150, thereby applying fluid pressure to the suction port 152. Furthermore, since there is a through hole on the inner cylinder 150, pulling the plunger 130 may cause a loss of fluid pressure. Therefore, when the first head 310 reaches the filter section 510 (see, for example, Figures 5A-5D), the second head 340 maintains fluid pressure by sealing with a different part of the inner wall of the inner cylinder 150 that is not through-hole.

[0039] Figures 4A-4C provide views of an example outer cylinder 140 according to an embodiment of the present disclosure.

[0040] Figure 4A is a view of an example outer cylinder 140 according to an embodiment of the present disclosure, which has threads at one end of the suction port 152. As shown, the outer cylinder 140 includes a generally cylindrical body 460 made of a rigid material, such as nylon, plastic, metal, or glass. The body 460 includes a return port 142 defined on a sidewall, a first opening 410 defined at one end of the body 460, a second opening 420 defined at the longitudinal end of the body 460 opposite to the first opening 410, and a threaded portion 450 defined on the inner wall of the body, adjacent to the first opening 410 relative to the second opening 420. When the device 100 is assembled, the first opening 410 allows the suction port 152 to protrude outward from the inner cylinder 150, the second opening 420 allows the inner cylinder 150 to be inserted into the outer cylinder 140, and the return port 142 allows filtered fluid to flow out of the inner cavity of the outer cylinder 140 during operation of the device 100. In some embodiments, the reflux port 142 includes an adapter for connecting the reflux port 142 to tubing and tubing accessories that are connected to a living organism and control the flow of bodily fluids. In various embodiments, the threaded portion 450 secures the outer cylinder 140 to the inner cylinder 150 via a corresponding threaded portion 550 in the inner cylinder 150 (see FIG. 5A); however, other designs may include different securing methods.

[0041] For example, Figure 4B This is a view of an example outer cylinder 140 according to an embodiment of the present disclosure, which has threads at one end opposite to the suction port 152. When the threaded portion 450 of the outer cylinder 140 is positioned close to the second opening 420 relative to the first opening 410, the corresponding threaded portion 550 in the inner cylinder 150 is also in a similar position (see FIG. 5B).

[0042] In another example, FIG4C is a view of a threadless outer cylinder 140 according to an embodiment of the present disclosure. When the body 460 is threadless, in various embodiments, the outer cylinder 140 can be fixed to the inner cylinder 150 by thermal welding, epoxy resin, adhesive, or other connection methods. In some embodiments, the outer cylinder 140 and the inner cylinder 150 are constructed as a single component, for example, by an additive manufacturing process.

[0043] Although not shown in Figures 4A-4C, the body 460 may include or connect a plurality of gaskets 160 to help maintain a seal when the device 100 is in use. In some embodiments, a first gasket 160a is connected to the inner surface of the outer cylinder 140 surrounding the first opening 410 (see Figures 4A-4C). In some embodiments, a second gasket 160b is connected to the inner surface of the body 460 relative to the second opening 420 near the threaded portion 450 (see Figure 4A). In some embodiments, a third gasket 160c is connected to the inner surface of the body 460 relative to the threaded portion 450 near the second opening 420 (see Figure 4A) or relative to the first opening 410 near the threaded portion 450 (see Figure 4B). These gasket connection locations may supplement, combine with, or replace connection locations on the outer surface of the inner cylinder 150.

[0044] Figures 5A-5D provide views of an example inner cylinder 150 according to an embodiment of the present disclosure.

[0045] Figure 5A This is a view of an example inner cylinder 150 according to an embodiment of the present disclosure, which has a threaded portion 550 at one end of the suction port 152. The inner cylinder 150 includes a porous filter portion 510 having a plurality of through holes 570 defined through the wall of the filter portion 510. The plurality of through holes 570 allow fluid communication between the inner cavity of the inner cylinder 150 and a fluid reflux gap defined by a portion of the inner cavity of the outer cylinder 140 not occupied by the inner cylinder 150 or the filter 120. The fluid communication allowed by the through holes includes allowing bodily fluids to pass through the filter 120 in contact with the filter portion 510.

[0046] A first non-porous portion 520 is located at one end of the filter portion 510 of the inner cylinder 150, and a second non-porous portion 530 is located at the other end. Both the first and second non-porous portions 520 and 530 include a plurality of seats 560a-c (generally or collectively referred to as seats 560) for securing the gasket 160 to the inner cylinder 150. In FIG. 5A, the first non-porous portion 520 includes a threaded portion 550 and a second seat 560b. After assembly of the device 100, the threaded portion 550 secures the inner cylinder 150 to the outer cylinder 140 via a corresponding threaded portion 450 in the outer cylinder 140 (see FIG. 4A). After assembly of the device 100, the second seat 560b holds the second gasket 160b in place (see FIG. 1B).

[0047] The second non-porous portion 530 of the inner cylinder 150 is connected to the end of the filter portion 510 that is longitudinally opposite to the first non-porous portion 520 of the cylinder. The second non-porous portion 530 includes a third seat 560c and a mounting point 532. After the device 100 is assembled, the third seat 560c holds the third gasket 160c in place, and the mounting point 532 secures the stop 110 in place. The plunger port 580 is located at the end of the second non-porous portion 530 that is longitudinally opposite to the first non-porous portion 520. The plunger port 580 allows the plunger 130 to enter and exit the inner cavity of the inner cylinder 150, with the pull-out distance controlled by the stop 110 (see Figure 1B).

[0048] In various embodiments, the non-porous portions on opposite longitudinal sides of the filter portion 510 each occupy at least 15% of the length of the inner cylinder 150, with the remaining length occupied by the filter portion 510. In various embodiments, the length of the non-porous portions allows the plunger 130 to form a tighter seal than the filter portion 510 (e.g., due to the presence of through-holes and pores designed for the passage of bodily fluids). Therefore, the distance between the non-porous portions and the distance between the first and second heads of the dual-headed plunger 130 (see, for example, FIG. 2B) are configured such that at least one plunger head remains sealed to the non-porous portion at any time when the device 100 is assembled and used.

[0049] End wall 540 closes the longitudinal end of the first non-porous portion 520 opposite to the plunger port 580. Suction port 152 is located at end wall 540 and allows fluid to flow into the inner cavity of inner cylinder 150 through opening 542. First seat 560a is located around suction port 152 and close to end wall 540; when device 100 is assembled, first seat 560a holds first gasket 160a in place (see FIG. 1B). In some embodiments, suction port 152 includes an adapter for connecting suction port 152 to tubing and tubing accessories connected to a living organism and controlling the flow of bodily fluids.

[0050] The outer diameter of the inner cylinder 150 (at least the filter portion 510) is smaller than the inner diameter of the filter 120 (in some embodiments, the inner curved surface diameter of the sheet filter material 210). The outer diameters of the inner cylinder 150 and the filter 120 (or the outer curved surface diameter of the filter material 210) are, in turn, smaller than the inner diameter of the outer cylinder 140. In some embodiments, the relative diameters of the inner cylinder 150, the filter 120, and the outer cylinder 140 are selected such that the inner cavity of the outer cylinder 140 has an empty portion outside the filter 120. In some embodiments, the filter 120 is sized such that its inner surface contacts the outer surface of the inner cylinder 150.

[0051] Figure 5B This is a view of an example inner cylinder 150 according to an embodiment of the present disclosure, which has a threaded portion 550 at one end opposite to the suction port 152. Similar to the inner cylinder 150 shown in FIG. 5A, the inner cylinder 150 shown in FIG. 5B includes a filter portion 510 with multiple through holes 570, a first non-perforated portion 520, a second non-perforated portion 530 having a mounting point 532 and a third seat portion 560c, an end wall 540, a suction port 152 having an opening 542 and a first seat portion 560a, and a plunger port 580. In the illustrated embodiment, the threaded portion 550 is provided on the second non-perforated portion 530. After the device 100 is assembled, the threaded portion 550 secures the inner cylinder 150 to the outer cylinder 140 via a corresponding threaded portion 450 in the outer cylinder 140 (see FIG. 4B). In embodiments where the threaded portion 550 is located in the second non-perforated portion 530, the second seat portion 560b can be omitted because the threaded portion 550 can be sealed and isolated from the inner cavity of the outer cylinder 140 by the third gasket 160c.

[0052] Figure 5C is a view of an example threadless inner cylinder 150 according to an embodiment of the present disclosure. Similar to the inner cylinder 150 shown in Figure 5A, the inner cylinder 150 shown in Figure 5C includes a filter portion 510 with a plurality of through holes 570, a first non-perforated portion 520, a second non-perforated portion 530 with a mounting point 532, an end wall 540, a suction port 152 with an opening 542, and a plunger port 580. In the illustrated embodiment, the threaded portion 550 is omitted, and the inner cylinder 150 can be fixed to the outer cylinder 140 by a variety of permanent connection methods (e.g., heat welding, epoxy resin, adhesive, etc.). When a permanent connection is used, the seat portion 560 of the outer cylinder 140 can be omitted, and the gasket 160 of the device 100 can be omitted, because the permanent connection forms a sealed joint or eliminates the interface between components that require the gasket 160 for auxiliary sealing.

[0053] Figure 5D is a view of an example inner cylinder 150 including a region without through holes, according to an embodiment of the present disclosure.

[0054] Similar to the inner cylinder 150 shown in FIG. 5A, the inner cylinder 150 shown in FIG. 5D includes a filter portion 510 having multiple through holes 570, a first non-porous portion 520 having a threaded portion 550 and a second seat portion 560b, a second non-porous portion 530 having a mounting point 532 and a third seat portion 560c, an end wall 540, an intake port 152 having an opening 542 and a first seat portion 560a, and a plunger port 580. In the illustrated embodiment, a non-porous region 512 exists on the wall of the filter portion 510. In various embodiments, the region 512 corresponds to a gap or groove 240 in the filter 120 and protrudes from the outer surface of the inner cylinder 150 to prevent the filter 120 from rotating within the inner cavity of the outer cylinder 140 after the device 100 is assembled.

[0055] Figure 6 The illustration shows a bodily fluid flowing through device 100 to trap solids 630 according to an embodiment of the present disclosure. When plunger 130 is pulled outward, or when negative pressure is applied to the organism through device 100, the bodily fluid enters a first inner cavity 610 of inner cylinder 150. This bodily fluid may contain solids 630 drawn from the organism. The bodily fluid flows from the first inner cavity 610 into through-holes in the wall of inner cylinder 150 and pores in filter 120, and then into a second inner cavity 620 of outer cylinder 140. The bodily fluid flows from the second inner cavity 620 to return port 142, and exits from opening 430 of return port 142, thus potentially being returned to the organism.

[0056] Figure 7 is a flowchart of an example method 700 according to an embodiment of the present disclosure.

[0057] In step 710, the operator establishes fluid communication with the organism. In various embodiments, the operator establishes fluid communication between the organism and the suction port 152, and between the return port 142 and the organism. Thus, the device 100 can draw bodily fluids into the inner cavity 610, retain any solids in the inner cavity 610, and allow solid-free bodily fluids in the outer cavity 620 to be returned to the organism. In various embodiments, one or more valves or stopcocks are provided between the device 100 and the organism, connected via various tubing, conduits, or interfaces / puncture points on the organism, allowing the operator to selectively connect and disconnect the fluid communication between the organism and the device 100.

[0058] In step 720, the operator applies negative pressure to the bodily fluid. Applying negative pressure can be achieved by pulling the plunger 130 outward relative to the assembled device 100, activating a pump, or other means. The negative pressure draws the bodily fluid into the device 100 through the suction port 152. Additionally, the operator can apply negative pressure to the return port 142 to facilitate the extraction of bodily fluid collected in the outer cavity 620 from the device 100. In various embodiments, the operator may apply these negative pressures simultaneously or at different times.

[0059] In step 730, the device 100 collects bodily fluids, which may contain solids 630, in the inner cavity of the inner cylinder 150. The collected bodily fluids flow into a through-hole 570 on the wall of the filter section 510 of the inner cylinder 150 (see Figures 5A-5D and Figure 6).

[0060] In step 740, device 100 separates solid 630 from bodily fluid. Bodily fluid flows from through-hole 570 in the wall of inner cylinder 150 into the pores of filter 120. Filter 120 traps larger solids 630 or otherwise prevents larger solids 630 from leaving the inner cavity, while allowing bodily fluid and smaller solids (e.g., blood cells) to enter the outer cavity 620 of outer cylinder 140 (see Figures 5A-5D and Figure 6).

[0061] In step 750, device 100 returns the bodily fluid to the organism. In some embodiments, the bodily fluid exits device 100 through return port 142 and is directly returned to the organism. In various embodiments, an operator may apply positive pressure (e.g., push the plunger 130 inward, reverse pump) to the bodily fluid collected in the inner cavity 610 to push the fluid outward from the inner cavity 610 to the outer cavity 620 and out through return port 142. In embodiments where the operator applies positive pressure, the operator may close the fluid communication between the suction port 152 and the organism before applying positive pressure. Alternatively, the operator may apply negative pressure to return port 142 to draw the bodily fluid from the inner cavity 610 to the outer cavity 620 and out of device 100 into a collection container, and then (indirectly) return it to the organism.

[0062] In step 760, the operator determines whether a blockage has occurred or whether the plunger 130 has reached its end of travel (e.g., the stop 110 prevents the plunger 130 from being pulled out further). If neither of these conditions occurs, and the operator wishes to continue aspiration, method 700 returns to step 720 to continue applying negative pressure to aspirate more bodily fluids, thereby aspirating more solids 630. When a blockage is detected or the plunger 130 reaches its end of travel, method 700 proceeds to step 770.

[0063] In step 770, the operator shuts off the fluid communication with the organism, thereby preventing additional bodily fluid from entering device 100 through suction port 152 or leaving device 100 through return port 142. In some embodiments, method 700 proceeds to steps 780, 790, or terminates at step 770 when the user determines that a threshold amount of bodily fluid has been collected, the blockage has been adequately aspirated, or similar circumstances. In some embodiments, method 700 may proceed directly to step 790.

[0064] In step 780, the operator removes and replaces filter 120 to clear any blockages in filter 120. In some embodiments, the operator cleans filter 120 to remove blockages or collect material trapped in filter 120 and reinstalls filter 120 into device 100; while in some embodiments, the user discards filter 120 and replaces the original filter 120 with a new filter 120 before proceeding to step 790 or returning to step 710.

[0065] In step 790, the operator resets the plunger 130 to its initial suction position within the device 100. In various embodiments, the operator resets the plunger 130 by pushing it inward into the assembled device 100. In some embodiments (e.g., when a pump is used to apply negative pressure), step 790 may be omitted.

[0066] After clearing the blockage (according to step 780) or resetting the plunger 130 (according to step 790), method 700 returns to step 710, where the operator re-establishes fluid communication between the organism and device 100 to resume suction.

[0067] The descriptions and illustrations of one or more embodiments provided in this disclosure are intended to fully and completely disclose the scope of the claimed subject matter to those skilled in the art, and are not intended to limit or constrain the scope of the claimed subject matter in any way. The aspects, examples, and details provided in this disclosure are considered sufficient to demonstrate the inventor's full mastery of the invention and to enable those skilled in the art to implement the claimed subject matter in the best possible manner. Descriptions of structures, resources, operations, and actions well-known to those skilled in the art may be abbreviated or omitted to avoid obscuring lesser-known or unique aspects of the subject matter of this disclosure. Unless expressly stated herein, the claimed subject matter should not be construed as limited to any embodiments, aspects, examples, or details provided in this disclosure. Whether features (including structural and methodological features) are shown or described collectively or separately herein, these features are intended to be selectively included or omitted to produce embodiments with a particular set of features. Furthermore, any or all of the functions and actions shown or described herein may be performed in any order or simultaneously.

[0068] Upon reading the description and illustrations of this disclosure, those skilled in the art will conceive of variations, modifications, and alternative embodiments that fall within the broad spirit of the overall inventive concept provided in this disclosure and do not depart from the wider scope of this disclosure.

[0069] As used in this disclosure, the phrase “at least one of the following” refers to any set of such items, including sets containing only a single element and all possible combinations thereof. For example, when referring to “at least one of the following: A, B, or C” or “at least one of the following: A, B, and C”, the phrase is intended to cover the set A, B, C, AB, BC, and ABC, wherein the set may include one or more instances of a given member (e.g., AA, AAA, AAB, AABBCCC, etc.) and any order thereof.

[0070] As used in this disclosure, the term “determine” encompasses a variety of actions, including calculation, operation, processing, derivation, investigation, search (e.g., through a table, database or other data structure), identification, receiving (e.g., receiving information), access (e.g., accessing data in memory), retrieval, parsing, selection, choosing, building, and similar actions.

[0071] As used in this disclosure, the terms “substantially,” “approximately,” “about,” and other relative terms cover values ​​within ±5% of the stated quantity, percentage, or range, unless a different approximate range is explicitly stated for the stated quantity, percentage, or range, or the context of the value indicates that a different approximate range is more appropriate. For example, a value identified as about X% should be understood to include values ​​between 0.95*X% and 1.05*X% or between (… Values ​​between (0.05X)% and (X+0.05X)%, but in various contexts this value may stop at zero or 100%. In another example, a feature described as substantially parallel or perpendicular to another feature should be understood as having a deviation from the parallel or perpendicular direction within ±9 degrees. Any value stated in relative terms should be understood to include the stated value as well as any range or subrange between the specified or implied endpoint values.

[0072] As used in this disclosure, all numerical values ​​given in the examples herein (whether or not specified as approximations) essentially include values ​​within a precision range and rounding error. For example, the value 4.5 should be understood to include values ​​from 4.45 to 4.54, and the value 4.50 should be understood to include values ​​from 4.495 to 4.504. Furthermore, any numerical value or range that explicitly or contextually refers to an integer number (e.g., approximately X users, approximately between Y and Z states) should be understood to be rounded down or up to the nearest integer value (e.g., X ± 1 users, ...). (1 and Z+1 states).

[0073] The following claims are not intended to limit themselves to the embodiments shown herein, but should enjoy the full scope consistent with the language used in the claims. In the claims, a singular reference to an element does not mean “one and only one” unless expressly stated otherwise, but should be understood as “one or more” or “at least one”. Unless expressly stated otherwise, the term “some” refers to one or more. No element of any claim shall be construed under 35 USC § 112(f) unless the element is expressly referred to using the phrase “means for…” or “steps for…”. All structural and functional equivalents of elements of the various aspects described in this disclosure—whether now known to those skilled in the art or hereafter known—are expressly incorporated herein by reference and are intended to be covered by the claims. Furthermore, regardless of whether such disclosure is expressly stated in the claims, nothing disclosed in this disclosure is intended as a donation to the public.

Claims

1. An apparatus (100) comprising: An outer cylinder (140) having a first inner cavity (610) of a first diameter and a return port (142) located in the first inner cavity; Inner cylinder (150) having a second inner cavity (620) of a second diameter smaller than the first diameter, the inner cylinder being fixed within the first inner cavity, the inner cylinder having a plurality of through holes (570) and a suction port (152) located in the second inner cavity, the plurality of through holes allowing fluid communication between the inner cylinder and the outer cylinder; A filter section, the filter section being defined by the plurality of through holes; as well as A plunger (130) is disposed in the second inner cavity.

2. The device according to claim 1, wherein the inner cylinder is fixed to the outer cylinder by threads on the inner cylinder and the outer cylinder, and the device further includes a plurality of gaskets (160) disposed between the inner cylinder and the outer cylinder to maintain a seal.

3. The apparatus of claim 2, wherein the plurality of gaskets comprises: A first gasket (160a) is circumferentially disposed at the suction port, the suction port being located at the end face of the inner cylinder on the first side of the thread; The second gasket (160b) is circumferentially disposed in the inner cylinder and contacts the first inner cavity on the first side of the filter section and the second side of the thread, wherein the second side of the thread is longitudinally opposite to the first side of the thread; as well as The third gasket (160c) is circumferentially disposed in the inner cylinder and contacts the first inner cavity on the second side of the filter section, wherein the second side of the filter section is longitudinally opposite to the first side of the filter section.

4. The apparatus of claim 2, wherein the plurality of gaskets comprises: A first gasket (160a) is circumferentially disposed at the suction port, the suction port being located at the end face of the inner cylinder on the first side of the filter section; as well as A second gasket (160c) is circumferentially disposed on the inner cylinder and contacts the first inner cavity on the second side of the filter section. The second side of the filter section is longitudinally opposite to the first side of the filter section, and the second gasket is located longitudinally between the filter section and the thread.

5. The apparatus of claim 1, wherein the inner cylinder is fixed to the outer cylinder by at least one of the following methods: The inner cylinder is welded to the outer cylinder; A sealed joint is formed by the adhesive between the inner cylinder and the outer cylinder; and The outer cylinder and the inner cylinder are formed as a single piece by additive manufacturing.

6. The apparatus of claim 1, wherein the filter section is disposed around the periphery of the second inner cavity at a given arcuate distance of less than 360 degrees.

7. The apparatus of claim 1, wherein the filter section comprises a plurality of pores, wherein each of the plurality of pores defines a surface area of ​​40-160 square micrometers (μm). 2 The area of ​​).

8. The apparatus of claim 1, wherein the plunger includes a head gasket (160d) having a third diameter at least as large as the second diameter, and the plunger is configured to draw negative pressure onto the intake port defined in an end face of the inner cylinder and to prevent air from flowing in from the plunger port (580), the plunger port being defined at a longitudinally opposite end of the inner cylinder to the intake port.

9. The apparatus of claim 1, wherein the difference between the first diameter and the second diameter is between 2 mm and 4 mm to define a fluid reflux gap between the first cavity and the second cavity.

10. The apparatus of claim 1, wherein the second inner cavity comprises a first non-porous portion and a second non-porous portion, the first non-porous portion being longitudinally disposed between the end face of the inner cylinder and the filter section, the second non-porous portion being longitudinally disposed between plunger ports, the plunger ports being defined at one end of the inner cylinder opposite the end face in the longitudinal direction, wherein, The first non-perforated portion occupies at least 15 percent of the length of the inner cylinder, and the second non-perforated portion occupies at least 15 percent of the length of the inner cylinder.

11. The apparatus of claim 1, wherein the filtering section further comprises a filter (120) disposed between the first inner cavity and the second inner cavity, in a flow path spanning the plurality of through holes.

12. An apparatus (100) comprising: The outer cylinder (140) has a first inner cavity of a first diameter and includes a return port (142) defined in a first wall of the first inner cavity; Inner cylinder (150), the inner cylinder having a second inner cavity with a second diameter smaller than the first diameter, the inner cylinder being fixed within the first inner cavity, and the inner cylinder including a filter device defined in a second wall of the second inner cavity; as well as A plunger (130) is disposed in the second inner cavity.

13. The apparatus of claim 12, wherein the filtering device is disposed around the periphery of the second inner cavity at a given arcuate distance of less than 360 degrees.

14. The apparatus of claim 12, wherein the filtering device is disposed along the length of the second inner cavity, and the length of the filtering device is less than two-thirds of the length of the second inner cavity.

15. The apparatus of claim 12, wherein the plunger includes a head gasket (160d) having a third diameter at least as large as the second diameter, and the plunger is configured to draw negative pressure onto an intake port (152) defined in an end face of the inner cylinder and to prevent air from flowing in from a plunger port (580) defined on an end of the inner cylinder opposite the intake port in the longitudinal direction.

16. An apparatus (100) comprising: An outer cylinder (140) having a first inner cavity of a first diameter, and the outer cylinder comprising: The first opening (410) at the first end of the first inner cavity; The second opening (420) on the second side of the first inner cavity; and A return port (142), the return port being defined in a first wall of the first cavity and located between the first opening and the second opening; and An inner cylinder (150) having a second inner cavity with a second diameter smaller than a first diameter, the inner cylinder being fixed within the first inner cavity, and the inner cylinder comprising: The first port (152) extends through the first opening; The second port (580) extends through the second opening; and A porous filter (510) defined in the second wall of the second inner cavity and located between the first port and the second port; and A pressure application device, which is connected to the second port.

17. The apparatus of claim 16, wherein the pressure applying device comprises at least one of the following: Pump; Negative pressure source; as well as A plunger (130) is disposed in the second inner cavity, the plunger including a head gasket (160d) that abuts against the second wall to form an airtight seal.

18. The apparatus of claim 16, wherein the porous filter is a non-hemolytic filter, and the pore area of ​​the non-hemolytic filter is approximately 40-160 square micrometers (μm). 2 ).

19. The apparatus of claim 16, wherein the inner cylinder is fixed to the outer cylinder by threads defined on the inner cylinder and the outer cylinder, the apparatus further comprising a plurality of gaskets disposed between the inner cylinder and the outer cylinder to maintain an airtight seal.

20. The apparatus of claim 16, wherein the inner cylinder is secured to the outer cylinder by at least one of the following means: The inner cylinder is welded to the outer cylinder; An airtight joint is formed between the inner cylinder and the outer cylinder using an adhesive; and The outer cylinder and the inner cylinder are formed as a single piece by additive manufacturing.

21. The apparatus of claim 16, wherein both the first port and the return port include an adapter for connecting conduits and conduit fittings.

22. A method (700) comprising: Open (710) the fluid communication between the organism and the suction port (152) and the return port (142) of the filter suction device (100); A negative pressure (720) is applied to the first inner cavity (610) of the filter suction device, the first inner cavity being in fluid communication with the second inner cavity (620) through filters (510, 120) to extract bodily fluids from the organism through the suction port; Collect (730) the body fluid in the first cavity, wherein the body fluid contains obstructions aspirated from the organism; The filter separates the blockage from the body fluid (740) to retain the blockage in the first cavity and allow the body fluid to flow into the second cavity, the first cavity being included in the second cavity; as well as The body fluid that has flowed into the second inner cavity is returned (750) to the organism through the return port.

23. The method of claim 22, wherein the bodily fluid comprises blood, and the obstruction is at least one of the following: thrombus; plaque; Necrotic tissue; and foreign body.

24. The method of claim 22, wherein the negative pressure is applied by pulling the plunger (130) disposed in the first inner cavity outward from the filtering suction device, the method further comprising, in response to the plunger reaching the suction stop position (760): (770) Close (770) the fluid communication between the organism and the suction port and the return port of the filter suction device; Return the plunger (790) to the initial suction position in the first cavity; Reopen (710) the fluid communication between the organism and the suction port and the return port of the filter suction device; as well as The negative pressure is reapplied (720) to the first inner cavity of the filter suction device to restore the extraction of bodily fluids from the organism through the suction port.

25. The method of claim 22, further comprising, in response to identifying (760) that the filter of the filter suction device is clogged: (770) Close the fluid communication between the organism and the suction port and the return port of the filter suction device; Remove the first cavity from the second cavity (780); Remove and replace the filter (780) from the first cavity; The first inner cavity is reinstalled (780) into the second inner cavity; Return the plunger (790) to the initial suction position in the first cavity; Reopen the fluid communication between the organism and the suction port and the return port of the filter suction device (710); as well as The negative pressure is reapplied (720) to the first inner cavity of the filter suction device to restore the extraction of bodily fluids from the organism through the suction port.

26. The method of claim 25, wherein removing and replacing the filter from the first cavity comprises: Remove the filter from the first inner cavity; as well as Perform one of the following steps: Remove any blockages from the filter and reinstall the filter into the first inner cavity; or A new filter, which will serve as the filter, is installed into the first cavity.

27. An apparatus (100) comprising: Outer cylinder (140), the outer cylinder having a first inner cavity of a first diameter and a return port (142) located in the first inner cavity; Inner cylinder (150), the inner cylinder having a suction port (152) and a second inner cavity with a second diameter smaller than the first diameter, the inner cylinder being fixed inside the first inner cavity; as well as A plunger (130) is disposed in the second inner cavity. The first inner cavity of the outer cylinder and the second inner cavity of the inner cylinder are in fluid communication at the filter section (510).

28. The apparatus of claim 27, wherein the filtering portion includes a plurality of through holes (570) between the first inner cavity and the second inner cavity.

29. The apparatus of claim 28, wherein the filtering portion further comprises a filter (120) at the plurality of through-holes.

30. The apparatus of claim 29, wherein the filter is disposed between the first inner cavity and the second inner cavity, and is located above or below the plurality of through holes.

31. The apparatus of claim 28, wherein the plurality of through holes are micropores.

32. The apparatus of claim 31, wherein the micropores are located on the inner cylinder.

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