Gas-phase-containing reaction system

Abstract

The invention discloses a gas-phase-containing reaction system which comprises a reactor unit, a liquid-phase feeding and discharging unit, a gas-phase feeding unit, a controller unit and an input unit, the liquid-phase feeding and discharging unit comprises a solvent feeding end and a feeding and discharging end, the feeding and discharging end is provided with a plurality of groups of subunits, and each subunit accommodates a plurality of groups of matched reaction bottles and product bottles; the reaction bottle is communicated with a feed port of the reactor unit, the solvent supply end is communicated with the feed port of the reactor unit, and a discharge port of the reactor unit is communicated with a product bottle matched with the reaction bottle; the subunits where the reaction bottles and the product bottles required by the current reaction are located are in a locked state so as to prevent the reaction bottles and / or the product bottles from being put in or taken out, and the other subunits are in a state that the reaction bottles and / or the product bottles can be put in or taken out. The gas-phase-containing reaction system can simplify a reaction material and a product collection pipeline, reduce the control difficulty, and can realize addition or reduction of reactions in the reaction process.

Description

Technical Field

[0001] This invention relates to the field of flow chemistry, and in particular to a reaction system containing a gas phase. Background Technology

[0002] Gas-phase reactions are an important class of reactions in flow chemistry, such as hydrogenation reactions. Prior patent CN12000130A discloses a gas reaction control system in which multiple reactants and products are supplied through different pipelines. This control system is complex, has too many parameter settings, is prone to errors, and, because multiple reactants are placed in a specific configuration, no additional reactions can be added during the reaction process, resulting in low system utilization. Summary of the Invention

[0003] The technical problem to be solved by the present invention is to provide a reaction system containing a gas phase, which can simplify the collection pipelines of reactants and products, reduce the difficulty of control, and enable the addition or reduction of reactions during the reaction process.

[0004] To solve the above-mentioned technical problems, the present invention provides a gas-phase reaction system, comprising: A reactor unit includes at least one reactor; The liquid phase loading and unloading unit includes a solvent supply end and a loading and unloading end. The loading and unloading end has multiple sub-units, and each sub-unit contains multiple sets of matched reaction flasks and product flasks. The reaction flasks are connected to the feed inlet of the reactor unit, the solvent supply end is connected to the feed inlet of the reactor unit, and the discharge outlet of the reactor unit is connected to the product flasks matched with the reaction flasks. A gas-phase feeding unit is connected to the feed inlet of the reactor unit; The controller unit is signal-connected to the reactor unit, liquid phase loading / unloading unit, and gas phase feeding unit to control the reaction process. The input unit is connected to the controller unit via signals and is used to input response parameters to the controller unit. During the reaction, the sub-unit containing the reaction flask and product flask required for the current reaction is locked to prevent the insertion or removal of the reaction flask and / or product flask, while the other sub-units are in a state where the reaction flask and / or product flask can be inserted or removed.

[0005] Preferably, the reactor unit further includes: A heating device used to heat the reactor; A reactor upstream control valve is located upstream of the reactor and is used to switch reactors. A downstream control valve is located downstream of the reactor to work in conjunction with a front control valve to switch the reactor. The back pressure valve, located downstream of the control valve after the reactor, is used to regulate the pressure required for the reaction.

[0006] Preferably, a first filter is connected in series between the reactor and the downstream control valve; A first pressure transmitter is connected in series between the back pressure valve and the control valve after the reactor to monitor the pressure of the reaction system. Downstream of the back pressure valve is a first three-way valve connected in series. The back pressure valve is connected to the inlet of the first three-way valve, the first outlet of the first three-way valve is connected to the product bottle, and the second outlet of the first three-way valve is connected to the waste liquid bottle. A first bubble detector is installed between the back pressure valve and the first three-way valve.

[0007] Preferably, the reactor unit also includes an empty tube, which is connected in parallel with the reactor.

[0008] Preferably, the loading and unloading ends also include: A sample injection needle is used to draw material from a reaction flask; The sample dispensing needle is used to deliver the product into a product vial that is compatible with the reaction flask. The second three-way valve has its first inlet connected to the injection needle, and a second bubble detector and a second filter are installed between it and the reaction flask. A plunger pump, connected in series downstream of the discharge port of the second three-way valve; The third three-way valve has its inlet connected to the outlet of the plunger pump and its first outlet connected to the waste liquid bottle. The first check valve is connected in series downstream of the second discharge port of the third three-way valve. The three-way valve has its first inlet connected to the outlet of the first one-way valve, and its outlet connected to the inlet of the control valve before the reactor.

[0009] Preferably, the solvent supply side also includes: Solvent bottles are used to hold solvents; The solvent control valve is connected to the solvent bottle and the second inlet of the second three-way valve; The syringe controls the input and output of solvent via a solvent control valve.

[0010] Preferably, the gas phase feeding unit includes: The reaction gas supply end is used to supply the gases required for the reaction into the reactor; A pressure reducing valve, connected in series downstream of the reactant gas supply end, is used to regulate the pressure of the reactant gas. The fourth three-way valve has its first air inlet connected to the air outlet of the pressure reducing valve, and its air outlet connected to the second feed inlet of the three-way valve.

[0011] Preferably, a first ball valve is connected in series between the reactant gas supply end and the pressure reducing valve; A second pressure transmitter and a gas mass flow controller are connected in series between the pressure reducing valve and the fourth three-way valve. A gas storage tank and a second check valve are connected in series between the fourth three-way valve and the second inlet of the three-way valve.

[0012] Preferably, the gas phase feeding unit also includes: The inert gas supply end is connected to the second inlet of the fourth three-way valve, and a second ball valve is installed between it and the second inlet of the fourth three-way valve.

[0013] Preferably, the sub-unit is provided with a cleaning station, which has a liquid outlet connected to a solvent control valve (214).

[0014] This invention improves the liquid phase loading and unloading unit by matching the reaction flask and product flask in the sub-unit, which helps to simplify the reaction pipeline. At the same time, by providing multiple sub-units, each sub-unit is independent of the others. During the reaction, the sub-unit used is locked, but other sub-units can be used to increase the reaction, thereby improving the utilization rate of the equipment. Attached Figure Description

[0015] To more clearly illustrate the technical solution of the present invention, the accompanying drawings used in the present invention will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0016] Figure 1 This is a schematic diagram of the gas-phase reaction system of the present invention; Figure 2 This is an assembly drawing of the gas-phase reaction system of the present invention; Figure 3 This is a schematic diagram of the robotic arm of the gas-phase reaction system of the present invention; Figure 4 This is a schematic diagram of a reaction flask and product flask in a gas-phase reaction system; Wherein, 101-reactor; 102-heating device; 103-reactor front control valve; 104-reactor rear control valve; 105-back pressure valve; 106-first pressure transmitter; 107-first three-way valve; 108-first bubble detector; 109-empty tube; 110-first filter; 200A-loading / unloading end; 200B-solvent supply end; 201-subunit; 202-reaction flask; 203-product bottle; 204-injection needle; 205-sampling needle; 206-second three-way valve; 207-second bubble detector; 208-second... Filter; 209-Plunger pump; 210-Third three-way valve; 211-First check valve; 212-Three-way valve; 213-Solvent bottle; 214-Solvent control valve; 215-Injector; 301-Reaction gas supply end; 302-Pressure reducing valve; 303-Fourth three-way valve; 304-First ball valve; 305-Second pressure transmitter; 306-Gas mass flow controller; 307-Gas storage tank; 308-Second check valve; 309-Inert gas supply end; 310-Second ball valve; 400-Waste liquid bottle; 500-Robotic arm; 600-Reagent rack. Detailed Implementation

[0017] The technical solutions of the present invention will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0018] refer to Figure 1-4 This invention illustrates a gas-phase reaction system comprising: The reactor unit includes at least one reactor 101; The liquid phase loading and unloading unit includes a solvent supply end 200B and a loading and unloading end 200A. The loading and unloading end 200A has multiple sub-units 201, and each sub-unit 201 contains multiple sets of matched reaction flasks 202 and product flasks 203. The reaction flasks 202 are connected to the feed inlet of the reactor unit, the solvent supply end 200B is connected to the feed inlet of the reactor unit, and the discharge outlet of the reactor unit is connected to the product flasks 203 matched with the reaction flasks 202. A gas-phase feeding unit is connected to the feed inlet of the reactor unit; The controller unit is signal-connected to the reactor unit, liquid phase loading / unloading unit, and gas phase feeding unit to control the reaction process. The input unit is connected to the controller unit via signals and is used to input response parameters to the controller unit. During the reaction, the subunit 201 containing the reaction flask 202 and product flask 203 required for the current reaction is locked to prevent the insertion or removal of the reaction flask 202 and / or product flask 203, while the other subunits 201 are in a state where the reaction flask 202 and / or product flask 203 can be inserted or removed.

[0019] In this invention, the liquid phase loading and unloading unit has been improved by matching reaction flasks 202 and product flasks 203. For example, through a reagent rack 600, the reaction flasks 202 and product flasks 203 used in a set of reactions are placed in the same reagent rack 600. Multiple reagent racks 600 are placed in the same sub-unit 201. At the same time, multiple sub-units 201 are provided. When a set of reaction flasks 202 and product flasks 203 in a sub-unit 201 are used in a reaction, the sub-unit 201 is in a locked state, that is, the sub-unit 201 cannot be opened and the reaction flasks 202 and / or product flasks 203 cannot be put in or taken out. However, other sub-units 201 are in a state where they can be opened. When it is necessary to add one or more sets of reactions, they can be placed on the reagent racks 600 of other sub-units 201, thereby improving the equipment utilization rate. If reagent rack 600, reaction flask 202, and product flask 203 are all set to the same size, it facilitates the control of sample injection and effusion. For example, injection needle 204 and effusion needle 205 can be fixed on robotic arm 400. During reaction changes, robotic arm 400 moves along the X and Y axes, but when moving to the corresponding reaction flask 202 and product flask 203, only Z-axis movement is required (e.g., ...). Figure 3 As shown in the diagram, this setup simplifies the injection and effluent pipelines, requiring only one pipeline each for injection and effluent, thus reducing control complexity. It should be noted that a cleaning station is provided within subunit 201 for cleaning the injection needle 204 and effluent needle 205. Preferably, the cleaning station has a liquid outlet connected to a solvent control valve 214, which supplies the necessary solvent to the cleaning station. The cleaning station can be located within each subunit 201 for timely cleaning before and after the reaction; alternatively, it can be located within a single subunit 201, with the priority of reactant release and cleaning signal reception used to lock and unlock the subunit 201 with the cleaning station. Of course, if this limitation is not desired, it can also be a station not located within subunit 201 but arranged parallel to it, as long as it can effectively clean the injection needle 204 and effluent needle 205.

[0020] Additionally, it should be noted that the controller unit of this invention is used to control the reaction process according to the set reaction parameters. For example, it controls the temperature of the reaction unit, the heating time, the selection of reactor 101, etc., and controls the amount and speed of material supply in the liquid phase feeding unit and the gas phase feeding unit. At the same time, it issues an alarm or stops the reaction when the detected parameters are no longer within the range of the input parameters. The controller unit can be, for example, an MCU, a PC, etc., and the control process is implemented by computer programming means (e.g., PLC, etc.). Since this can be implemented by existing technology, it will not be described in detail. The input unit in this invention can be, for example, an existing input device such as a touch screen, hardware interface, keyboard and mouse. By inputting reaction-related parameters to the controller unit through the input unit, the controller unit controls the reaction process according to the reaction parameters. In one specific embodiment, the reactor unit further includes: Heating device 102 is used to heat reactor 101; A reactor upstream control valve 103 is located upstream of reactor 101 for switching reactor 101; The downstream control valve 104 is located downstream of the reactor 101 to cooperate with the upstream control valve 103 to switch the reactor 101. Back pressure valve 105 is located downstream of control valve 104 after the reactor and is used to regulate the pressure required for the reaction.

[0021] More specifically, a first filter 110 is connected in series between reactor 101 and reactor downstream control valve 104; a first pressure transmitter 106 is connected in series between back pressure valve 105 and reactor downstream control valve 104 to monitor the pressure of the reaction system. Downstream of the back pressure valve 105 is a first three-way valve 107 connected in series. The back pressure valve 105 is connected to the inlet of the first three-way valve 107, the first outlet of the first three-way valve 107 is connected to the product bottle 203, and the second outlet of the first three-way valve 107 is connected to the waste liquid bottle 400. A first bubble detector 108 is provided between the back pressure valve 105 and the first three-way valve 107.

[0022] More specifically, the reactor unit also includes an empty tube 109, which is connected in parallel with the reactor 101.

[0023] In this specific embodiment, the heating device 102 is, for example, an oil bath or other device capable of heating the reactor 101. Preferably, when there are multiple reactors 101, a pre-reactor control valve 103 is installed upstream of the reactor 101, and a post-reactor control valve 104 is installed downstream of the reactor 101 to control different reactions entering different reactors 101, so that multiple reactions can proceed sequentially. The number of passages of the pre-reactor control valve 103 and the post-reactor control valve 104 can be determined according to the number of reactors 101. For example, when there are five reactors 101 and one empty pipe 109, the pre-reactor control valve 103 and the post-reactor control valve 104 can be selected as six-position seven-way valves. The back pressure valve 105 and the pressure reducing valve 302 in the gas phase feeding unit both serve to control the pressure of the reaction system. It should be noted that the first three-way valve 107 is used to switch the material input to the product bottle 203 or to the waste liquid bottle 400; the first bubble detector 108 is used to monitor whether there are bubbles in the material discharged from the reactor 101; it should also be noted that the reactor 101 is preferably a tubular reactor, and when there are multiple reactors, they are set in parallel, and one or more empty pipes 109 are connected in parallel for cleaning the common pipeline. In one specific embodiment, the loading / unloading end 200A further includes: The injection needle 204 is used to draw material from the reaction flask 202; The sample dispensing needle 205 is used to deliver the product into the product bottle 203, which is matched with the reaction bottle 202; The second three-way valve 206 has its first inlet connected to the injection needle 204, and a second bubble detector 207 and a second filter 208 are provided between it and the reaction flask 202. A plunger pump 209 is connected in series downstream of the discharge port of the second three-way valve 206; The third three-way valve 210 has its inlet connected to the outlet of the plunger pump 209 and its first outlet connected to the waste liquid bottle 400. The first one-way valve 211 is connected in series downstream of the second discharge port of the third three-way valve 210. The three-way valve 212 has its first inlet connected to the outlet of the first one-way valve 211, and its outlet connected to the inlet of the control valve 103 before the reactor.

[0024] More specifically, the solvent supply side 200B also includes: Solvent bottle 213 is used to contain solvents; Solvent control valve 214 is connected to solvent bottle 213 and the second inlet of second three-way valve 206; The syringe 215 controls the input and output of solvent via the solvent control valve 214.

[0025] In this specific embodiment, for example, there is one injection needle 204 and one extraction needle 205, which are fixed to a robotic arm 400. The robotic arm 400 moves in the X and Y axes to switch between different sets of reaction flasks 202 and product flasks 203 in different sub-units 201. The robotic arm 400 moves in the Z axis to allow the injection needle 204 to enter / exit the reaction flask 202 and the extraction needle 205 to enter / exit the product flask 203. The matching settings of the reaction flask 202 and the product flask 203 will not be incorrect. The second three-way valve 206 is used to transport the solvent and the material in the reaction bottle 202; the second bubble detector 207 is used to detect whether the material in the reaction bottle 202 has been evacuated; the second filter 208 is used to filter the reaction material; the plunger pump 209 is used to extract the material required for the reaction (including the material in the reaction bottle 202 and the solvent in the solvent bottle 213); the third three-way valve 210 is used to switch the material to the reactor unit or to the waste liquid bottle 400; the first one-way valve 211 can prevent backflow of the material; the gaseous material and the liquid material are combined at the three-way valve 212 and then transported to the reactor unit. Solvent control valve 214 is used to deliver solvent to the outlet of the cleaning station to clean the outer wall of injection needle 204 and the outer wall of dispensing needle 205, or to deliver it to the second three-way valve 206 (used for reaction, purging of plunger pump 209 or cleaning of injection needle 204, etc.); syringe 215 is used for purging plunger pump 209, cleaning injection needle 204 and dispensing needle 205, cleaning pipeline, etc. In one specific implementation, the gas phase feeding unit includes: The reaction gas supply end 301 is used to supply the reaction gas into the reactor 101; Pressure reducing valve 302 is connected in series downstream of the reaction gas supply end 301 and is used to regulate the pressure of the reaction gas; The fourth three-way valve 303 has its first air inlet connected to the air outlet of the pressure reducing valve 302, and its air outlet connected to the second feed inlet of the three-way valve 212.

[0026] More specifically, a first ball valve 304 is connected in series between the reaction gas supply end 301 and the pressure reducing valve 302; A second pressure transmitter 305 and a gas mass flow controller 306 are connected in series between the pressure reducing valve 302 and the fourth three-way valve 303. A gas storage tank 307 and a second one-way valve 308 are connected in series between the second inlet of the fourth three-way valve 303 and the three-way valve 212.

[0027] More specifically, the gas phase feeding unit also includes: An inert gas supply end 309 is connected to the second air inlet of the fourth three-way valve 303, and a second ball valve 310 is installed between the inert gas supply end 309 and the second air inlet of the fourth three-way valve 303.

[0028] In this specific embodiment, the reaction gas supply end 301 is used to provide the gas required for the reaction, such as hydrogen, and can be a gas generator or a gas supply interface at the factory end; the pressure reducing valve 302 is used to regulate the pressure of the reaction gas, and together with the back pressure valve 105, it plays the role of regulating the pressure of the reaction system; the fourth three-way valve 303 controls the input of reaction gas and / or inert gas; the first ball valve 304 opens or closes the reaction gas; the second pressure transmitter 305 monitors the pressure of the reaction gas; the gas mass flow controller 306 regulates the flow rate of the reaction gas; the gas storage tank 307 prevents liquid backflow into the hydrogen flow meter and damage to it; the second check valve 308 prevents material backflow; the inert gas supply end 309 is used to provide inert gases such as nitrogen, and can be a gas generator or a gas supply interface at the factory end; the second ball valve 310 opens or closes the inert gas.

[0029] The gas-phase reaction system provided by this invention includes the following operating modes: I. Cleaning of the inlet and outlet needles for the reaction: 1. Cleaning of the inner wall of the injection needle before reaction: The robotic arm controls the injection needle 204 and the discharge needle 205 to be placed in the cleaning station. The solvent multi-way valve 214 connects the syringe 215 and the solvent bottle 213. After the syringe 215 draws out the solvent, the solvent multi-way valve 214 connects the syringe 215 and the second three-way valve 206. The second three-way valve 206 connects the second filter 208 and the solvent control valve 214. The syringe 215 pushes the solvent directly out of the injection needle 204, completing the cleaning of the inner wall of the injection needle.

[0030] 2. Cleaning of the outer walls of the inlet and outlet needles: At the cleaning station, the solvent multi-way valve 214 connects the syringe 215 and the solvent bottle 213. After the syringe 215 draws out the solvent, the solvent multi-way valve 214 connects the syringe 215 and the loading / unloading end 200A. The syringe 215 pushes the solvent out of the outlet of the cleaning station to the outer walls of the inlet needle 204 and the outlet needle 205, thus completing the cleaning of the outer walls of the inlet and outlet needles.

[0031] II. During the reaction: The robotic arm controls the injection needle and the dispensing needle to move to the required positions of the reaction flask and product flask, and sends the injection needle into the reaction flask and the dispensing needle into the product flask. First, the plunger pump is emptied: the solvent multi-way valve 214 connects the syringe 215 and the solvent bottle 213. After the syringe 215 draws out the solvent, the solvent multi-way valve 214 connects the syringe 215 and the second three-way valve 206. The second three-way valve 206 connects the solvent multi-way valve 214 and the plunger pump 209. At the same time, the solvent is pushed to the plunger pump 209 through the second three-way valve 206 and the emptying operation is completed. After the plunger pump is emptied, the solvent multi-way valve 214 and the second three-way valve 206 work together to open the plunger pump 209, solvent bottle 213, and reaction bottle 202, so that the solvent and the material in the reaction bottle can be transported to the reaction pipeline after the plunger pump 209 is opened; at the same time, the corresponding valve of the gas phase feeding unit is also opened to facilitate the supply of the gas required for the reaction to the reactor unit, and the corresponding valve downstream of the reactor unit is also in the open state to facilitate the timely discharge of the material after the reaction is completed.

[0032] III. When the reaction is complete: When the second bubble detector 207 detects continuous bubbles, it indicates that the material in the reaction flask has been used up. First, the plunger pump is emptied, and then the infeed and outlet needles are cleaned. The solvent multi-way valve 214 connects the syringe 215 and the solvent bottle 213. After the syringe 215 draws out the solvent, the solvent multi-way valve 214 connects the syringe 215 and the second three-way valve 206. The second three-way valve 206 connects the second filter 208 and the solvent control valve 214. The syringe 215 pushes the solvent from the injection needle 204 to the reaction flask 202. The second three-way valve 206 connects the second filter 208 and the plunger pump 209. The plunger pump 209 is turned on to deliver the solvent in the reaction flask 202 for pipeline cleaning.

[0033] IV. Cleaning of the injection and dispensing needles after the reaction is complete: Same as cleaning of the injection and dispensing needles before the reaction. To further illustrate the present invention, reference is made to... Figure 2-4 This illustrates a specific structure of the invention, comprising two adjacent frames, as shown in the reference diagram. Figure 2 The robotic arm is preferably housed within a frame, which provides a degree of protection. Meanwhile, the components of the liquid phase loading / unloading unit and the gas phase feeding unit are distributed within this frame according to actual space requirements. The reactor unit, control unit, and input unit are distributed within another frame, also according to actual space requirements. (Reference) Figure 3 The injection and extraction needles are fixed to a robotic arm, which can move along three axes: X, Y, and Z. (Reference) Figure 4 The diagram shows a reaction flask and product flask assembly placed within a reagent rack for easy placement within a sub-unit. The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A reaction system containing a gas phase, characterized in that, include: A reactor unit, including at least one reactor (101). The liquid phase loading and unloading unit includes a solvent supply end (200B) and a loading and unloading end (200A). The loading and unloading end (200A) has multiple sub-units (201), each sub-unit (201) containing multiple sets of matched reaction flasks (202) and product flasks (203). The reaction flasks (202) are connected to the feed inlet of the reactor unit, the solvent supply end (200B) is connected to the feed inlet of the reactor unit, and the discharge outlet of the reactor unit is connected to the product flasks (203) matched with the reaction flasks (202). A gas-phase feeding unit is connected to the feed inlet of the reactor unit; The controller unit is signal-connected to the reactor unit, liquid phase loading / unloading unit, and gas phase feeding unit to control the reaction process. The input unit is connected to the controller unit via signals and is used to input response parameters to the controller unit. During the reaction, the sub-unit (201) containing the reaction flask (202) and product flask (203) required for the current reaction is locked to prevent the insertion or removal of the reaction flask (202) and / or product flask (203), while the other sub-units (201) are in a state where the reaction flask (202) and / or product flask (203) can be inserted or removed.

2. The reaction system as described in claim 1, characterized in that, The reactor unit also includes: Heating device (102) is used to heat reactor (101). A reactor upstream control valve (103) is provided upstream of the reactor (101) for switching reactors (101). A downstream control valve (104) is located downstream of the reactor (101) to cooperate with the upstream control valve (103) to switch the reactor (101). A back pressure valve (105) is located downstream of the control valve (104) after the reactor and is used to regulate the pressure required for the reaction.

3. The reaction system as described in claim 2, characterized in that, A first filter (110) is connected in series between the reactor (101) and the downstream control valve (104). A first pressure transmitter (106) is connected in series between the back pressure valve (105) and the reactor downstream control valve (104) to monitor the pressure of the reaction system; Downstream of the back pressure valve (105) is a first three-way valve (107), the back pressure valve (105) is connected to the inlet of the first three-way valve (107), the first outlet of the first three-way valve (107) is connected to the product bottle (203), and the second outlet of the first three-way valve (107) is connected to the waste liquid bottle (400). A first bubble detector (108) is provided between the back pressure valve (105) and the first three-way valve (107).

4. The reaction system as described in claim 1, characterized in that, The reactor unit also includes an empty tube (109), which is connected in parallel with the reactor (101).

5. The reaction system as described in claim 1, characterized in that, The loading and unloading end (200A) also includes: The injection needle (204) is used to draw material from the reaction flask (202); A sample dispensing needle (205) is used to deliver the product into a product vial (203) that is matched with the reaction flask (202); The second three-way valve (206) has its first inlet connected to the injection needle (204), and a second bubble detector (207) and a second filter (208) are installed between it and the reaction flask (202). A plunger pump (209) is connected in series downstream of the discharge port of the second three-way valve (206); The third three-way valve (210) has its inlet connected to the outlet of the plunger pump (209) and its first outlet connected to the waste liquid bottle (400). The first check valve (211) is connected in series downstream of the second discharge port of the third three-way valve (210). The three-way valve (212) has its first inlet connected to the outlet of the first check valve (211), and its outlet connected to the inlet of the control valve (103) before the reactor.

6. The reaction system as described in claim 5, characterized in that, The solvent supply side (200B) also includes: Solvent bottle (213), which is used to hold solvent; The solvent control valve (214) is connected to the solvent bottle (213) and the second inlet of the second three-way valve (206); The syringe (215) controls the input and output of solvent via a solvent control valve (214).

7. The reaction system as described in claim 5, characterized in that, The gas phase feeding unit includes: The reaction gas supply end (301) is used to supply the reaction gas into the reactor (101); A pressure reducing valve (302), which is connected in series downstream of the reaction gas supply end (301), is used to regulate the pressure of the reaction gas; The fourth three-way valve (303) has its first air inlet connected to the air outlet of the pressure reducing valve (302), and its air outlet connected to the second feed inlet of the three-way valve (212).

8. The reaction system as described in claim 7, characterized in that, A first ball valve (304) is connected in series between the reaction gas supply end (301) and the pressure reducing valve (302). A second pressure transmitter (305) and a gas mass flow controller (306) are connected in series between the pressure reducing valve (302) and the fourth three-way valve (303). A gas storage tank (307) and a second check valve (308) are connected in series between the fourth three-way valve (303) and the second inlet of the three-way valve.

9. The reaction system as described in claim 7, characterized in that, The gas phase feeding unit also includes: An inert gas supply end (309) is connected to the second inlet of the fourth three-way valve (303), and a second ball valve (310) is installed between the inert gas supply end (309) and the second inlet of the fourth three-way valve (303).

10. The reaction system as described in claim 6, characterized in that, The subunit (201) is equipped with a cleaning station, which has a liquid outlet connected to the solvent control valve (214).

Images