Pressurized flushing device for hyperthermic intraperitoneal perfusion chemotherapy

Abstract

The invention discloses a pressurizing flushing device for hyperthermic intraperitoneal perfusion chemotherapy, and relates to the technical field of medical instruments. Comprising a puncture catheter and a multidirectional flow guide nozzle, the puncture catheter comprises a catheter body, multiple sets of supporting cavities are formed in the catheter body in the length direction, the supporting cavities are communicated through second air inlet channels, and the supporting cavities are of an arc-shaped structure; the end part of the guide pipe body is connected with a multidirectional flow guide nozzle; one end of the nozzle main body is connected with a drainage guide pipe; the drainage catheter is used for connecting a chemotherapy pump machine; the nozzle body comprises a sprayer and a connecting pipe. The other end of the connecting pipe is connected with the drainage catheter; a plurality of through holes are formed in the spray head; and a rotor is rotationally arranged in the connecting pipe. The catheter is prevented from being bent and collapsed under the action of external force such as extrusion of visceral organs in the abdominal cavity and body position change, and it is ensured that a liquid medicine conveying channel is smooth; in addition, the contact uniformity of the liquid medicine and the abdominal cavity wall, especially the peritoneal micro transfer focus, is obviously improved.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to a pressurized irrigation device for intraperitoneal hyperthermic chemotherapy. Background Technology

[0002] Hyperthermic intraperitoneal chemotherapy (HIPEC) is an important clinical treatment for peritoneal malignancies and a method for preventing postoperative peritoneal metastasis. It involves circulating a constant-temperature chemotherapy solution into the peritoneal cavity, utilizing the synergistic effect of hyperthermia and chemotherapy to kill tumor cells. The puncture catheter, as a key interventional device in HIPEC, is primarily used to establish a drug delivery channel between the peritoneal cavity and external perfusion equipment.

[0003] Due to the complex anatomical structure inside the abdominal cavity, existing puncture catheters are generally prone to bending and collapse during insertion and perfusion, which can obstruct the perfusion channel and affect the normal circulation and delivery of chemotherapy drugs.

[0004] To ensure catheter patency, current techniques often increase strength by thickening the catheter wall or using rigid materials, but this reduces catheter flexibility and increases the risk of insertion injury. Conversely, more flexible catheters, due to insufficient self-support, are prone to bending and flattening under intra-abdominal pressure, leading to obstructed access. Furthermore, catheter displacement and slippage are common during infusion, causing chemotherapy drugs to leak outside the abdominal cavity, affecting the effectiveness of infusion therapy, and increasing patient discomfort and the risk of complications.

[0005] Furthermore, existing technologies are insufficient for flushing out micrometastases, which are often hidden in peritoneal folds. Traditional low-pressure soaking methods lack dynamic mechanical flushing force, making it difficult to increase the drug concentration in these deposited tumor cells or drug "dead zones," thus affecting the radical cure effect.

[0006] Therefore, it is necessary to provide a device for pressurized irrigation of the peritoneal cavity for hyperthermic chemotherapy. Summary of the Invention

[0007] The main objective of this invention is to provide a pressurized irrigation device for intraperitoneal hyperthermic perfusion chemotherapy to solve the problems existing in the prior art.

[0008] To solve the above-mentioned technical problems, the present invention adopts the following technical solution: A hyperthermic peritoneal chemotherapy pressurized irrigation device includes interconnected puncture catheters and multi-directional flow nozzles; The puncture catheter includes a catheter body, in which multiple sets of support cavities are sequentially arranged along the length direction. The support cavities are sequentially connected through a second air inlet channel, and the support cavities have an arc-shaped structure. Multiple flow guide nozzles are connected to the ends of the catheter body. The multi-directional flow nozzle includes a nozzle body, one end of which is connected to a drainage conduit; the drainage conduit is used to connect to a chemotherapy pump; the nozzle body includes a nozzle head and a connecting pipe; one end of the connecting pipe is fixedly connected to the nozzle head, and the other end is connected to the drainage conduit; multiple through holes are evenly arranged on the nozzle head; a rotor is rotatably arranged inside the connecting pipe.

[0009] Furthermore, a threaded sleeve is fixedly connected to the outer wall of the catheter body, and a fixing sleeve is threadedly connected to the threaded sleeve. The fixing sleeve is provided with a fixing outer edge, and an adhesive layer is provided on the end face of the fixing outer edge. The adhesive layer is used to adhere to the surface of the affected area.

[0010] Furthermore, the second air intake channel is a narrow-diameter channel opened inside the duct body, the end of the second air intake channel extends outward, and a plurality of the supporting cavities are equidistantly arranged along the length direction of the duct body, the curvature of the supporting cavity being 250-300°.

[0011] Furthermore, the conduit body is also provided with a first air intake channel, and an air-blocking bladder is connected to the end of the first air intake channel. The air-blocking bladder is located near the end of the conduit body. An anti-slip layer is provided on the inner wall of the conduit body, and the anti-slip layer is located near the end of the conduit body. The anti-slip layer is used to support the air-blocking bladder.

[0012] Furthermore, the end of the first air intake channel extends outward, and the first air intake channel is a narrow-diameter channel opened in the duct body. The distance between the first air intake channel and the two ends of the support cavity is equal.

[0013] Furthermore, the nozzle is spherical at the end facing the patient's abdominal cavity.

[0014] Furthermore, the axis of the through hole is at a certain angle to the straight line from the through hole to the center of the ball.

[0015] Furthermore, the connecting tube includes a Venturi tube section and a connecting section; one end of the connecting section has a narrowed diameter for connecting to the drainage conduit; the rotor is disposed within the throat of the Venturi tube section; a variable diameter channel is provided at the center of the rotor, and the diameter of the variable diameter channel gradually increases from the inlet section of the Venturi tube section to the diffuser section.

[0016] Furthermore, a fixed support rod is provided at the center of the variable diameter channel; a fixed plate is provided at one end of the variable diameter channel near the inlet section, the outer side of the fixed plate is fixedly connected to the side wall of the variable diameter channel, and the center is fixedly connected to the fixed support rod; multiple guide vanes are evenly arranged above the fixed plate along the circumference of the fixed support rod, the inner side of the guide vanes is engaged with the fixed support rod, and multiple water passage grooves are provided on the fixed plate along the circumference of the fixed support rod; the gap between two adjacent sets of guide vanes corresponds one-to-one with the water passage grooves, and the water passage grooves and gaps form a water outlet slit.

[0017] Furthermore, the guide vane is angled relative to the plane containing the radial line of the rotor, so that the water flow direction of the outlet slit forms a certain angle with the water flow direction of the drainage pipe.

[0018] Compared with the prior art, the present invention has the following beneficial effects: The catheter body features multiple sets of arc-shaped support cavities along its length, connected by a second air inlet channel. Gas can be injected into the second air inlet channel to fill the arc-shaped support cavities. Utilizing the bending resistance of the arc structure and the supporting force after gas filling, the structural strength and compression resistance of the catheter body are effectively enhanced. This prevents the catheter from bending or collapsing under external forces such as compression from abdominal organs or changes in body position, ensuring unobstructed drug delivery and facilitating the smooth execution of intraperitoneal hyperthermic chemotherapy. At the same time, it eliminates the need to increase the catheter wall thickness or use rigid materials, maintaining catheter flexibility and reducing the risk of damage to abdominal organs and blood vessels during catheter insertion, thus improving safety.

[0019] To address the issues of uneven drug distribution and insufficient flushing force in existing intraperitoneal hyperthermic perfusion chemotherapy (IPC) methods, a multi-directional flow nozzle is installed at the end of the drainage catheter. A rotor is installed inside each nozzle; the water flow causes the rotor to rotate, inducing a vortex field in the peritoneal fluid through guide plates. Through-holes at the nozzle tip enable multi-angle pressurized flushing, creating dynamic circulation under pressure. This significantly improves the uniformity of contact between the drug and the peritoneal wall, especially micrometastases in the peritoneum. The reaction force of the water flow drives the nozzle to rotate or create vortices, transforming the traditional "static pressurization" into "dynamic agitation," greatly enhancing the therapeutic effect of IPC. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the internal structure of the puncture catheter in this invention.

[0021] Figure 2 This is a partial structural diagram of the puncture catheter in this invention.

[0022] Figure 3 This is a schematic diagram of the structure of the multi-directional flow nozzle in this invention.

[0023] Figure 4This is a schematic diagram of the internal structure of the multi-directional flow nozzle in this invention.

[0024] Figure 5 This is a cross-sectional view of the rotor in this invention.

[0025] Figure 6 This is a top view of the rotor in this invention.

[0026] The components are as follows: 1. Threaded sleeve; 2. Fixed sleeve; 3. First air intake channel; 4. Support cavity; 5. Conduit body; 6. Anti-slip layer; 7. Sealing airbag; 8. Second air intake channel; 9. Nozzle body; 10. Drainage conduit; 11. Nozzle; 111. Through hole; 12. Connecting pipe; 121. Venturi tube section; 122. Connecting section; 13. Silicone layer; 14. Rotor; 141. Variable diameter channel; 142. Fixed support rod; 143. Fixed plate; 144. Guide vane; 145. Water channel; 15. Bearing. Detailed Implementation

[0027] The technical solution of the present invention will be further described below with reference to the accompanying drawings and embodiments.

[0028] Example 1

[0029] Combination Figures 1-6 The present invention provides a pressure irrigation device for intraperitoneal hyperthermic perfusion chemotherapy, comprising a puncture catheter and a multi-directional flow nozzle connected to each other. In this embodiment, the puncture catheter and the multi-directional flow nozzle are connected by threads.

[0030] The puncture catheter includes a catheter body 5, and multiple sets of support cavities 4 are arranged sequentially along the length direction inside the catheter body 5. The support cavities 4 are connected sequentially through a second air inlet channel 8, and the support cavities 4 have an arc-shaped structure. The catheter body 5 is also provided with a first air inlet channel 3, and the end of the first air inlet channel 3 is connected to a blocking airbag 7, which is located near the end of the catheter body 5.

[0031] Multiple sets of arc-shaped support cavities 4 are arranged along the length of the catheter body 5. In conjunction with the second air inlet channel 8 connecting each set of support cavities 4, gas can be injected into the second air inlet channel 8 to fill each set of arc-shaped support cavities 4. Utilizing the bending resistance of the arc structure and the supporting force after the gas is filled, the structural strength and compression resistance of the catheter body 5 are effectively enhanced. This prevents the catheter from bending or collapsing under external forces such as compression of abdominal organs or changes in body position, ensuring unobstructed drug delivery channels and smooth intraperitoneal hyperthermic perfusion chemotherapy. At the same time, there is no need to increase the catheter wall thickness or use rigid materials, which takes into account the flexibility of the catheter, reduces the risk of damage to abdominal organs and blood vessels during catheter insertion, and improves the safety of use.

[0032] The first air inlet channel 3 on the catheter body 5 and the occlusion balloon 7 near the end of the catheter body 5 can be inflated through the first air inlet channel 3 to make the occlusion balloon 7 fit tightly against the patient's abdominal puncture site after expansion, thereby effectively sealing the puncture site and preventing chemotherapy drugs from leaking out of the abdominal cavity from the puncture gap. This avoids drug waste and complications such as skin irritation and abdominal infection caused by leakage, and further improves the safety and reliability of treatment.

[0033] In other preferred embodiments, a threaded sleeve 1 is fixedly connected to the outer wall of the catheter body 5, and a fixed sleeve 2 is threadedly connected to the threaded sleeve 1. The fixed sleeve 2 is provided with a fixed outer edge, and an adhesive layer is provided on the end face of the fixed outer edge. The adhesive layer is used to attach to the surface of the affected area.

[0034] The threaded cannula 1 and the fixed cannula 2 are connected by threads. With the fixed outer edge and adhesive layer, the puncture catheter can be stably fixed on the surface of the affected area. The adhesive layer is attached to the surface of the affected area to form a basic fixation. The threaded connection structure can flexibly adjust the height of the fixed cannula 2 to adapt to the skin flatness and catheter insertion depth of different patients' puncture sites, ensuring that the catheter body 5 will not shift or slip off due to the movement of abdominal organs or changes in the patient's position after fixation.

[0035] In other preferred embodiments, the second air intake channel 8 is a narrow-diameter channel opened in the duct body 5, the end of the second air intake channel 8 extends outward, and a plurality of support cavities 4 are equidistantly arranged along the length direction of the duct body 5, the curvature of the support cavity 4 being 250-300°.

[0036] The second air inlet channel 8 is designed as a narrow-diameter channel, which allows for precise control of the gas inlet rate and volume. Simultaneously, the narrow-diameter structure saves space in the support cavity 4 of the catheter body 5, avoiding encroachment on the effective space of the drug delivery channel. Multiple support cavities 4 are equidistantly arranged along the length of the catheter body 5, ensuring even distribution of support force across all sections of the catheter body 5 after gas filling. This prevents bending and collapse caused by insufficient local support. The equidistant arrangement also ensures balanced stress on the catheter body 5, reducing localized stress concentration. The support cavities 4 are set with an arc of 250-300°. This arc range maximizes the bending resistance of the support cavities 4, avoiding both insufficient support and easy bending due to excessive arc, and excessive space occupation and compromised catheter flexibility due to excessive arc.

[0037] In other preferred embodiments, the end of the first air intake channel 3 extends outward. The first air intake channel 3 is a narrow-diameter channel formed within the conduit body 5, and the distance between the first air intake channel 3 and both ends of the support cavity 4 is equal. The equal distance between the first air intake channel 3 and both ends of the support cavity 4 makes the gas delivery path of the first air intake channel 3 more uniform.

[0038] In other preferred embodiments, the catheter body 5 is provided with an anti-torsion structure, which includes a plurality of protrusions evenly distributed on the inner wall of the catheter body 5. The evenly distributed protrusions on the inner wall of the catheter body 5 form a stable anti-torsion structure, which can effectively enhance the torsional resistance of the catheter body 5 and prevent the catheter from twisting during insertion, use, and changes in patient position. The evenly distributed protrusions ensure balanced stress on the inner wall of the catheter body 5, enhancing torsional resistance without compromising the structural integrity of the catheter body 5 or affecting its flexibility.

[0039] In other preferred embodiments, the first air intake channel 3 and the second air intake channel 8 are respectively connected to a medical air pump through an air delivery pipe.

[0040] In other preferred embodiments, an anti-slip layer 6 is provided on the inner wall of the catheter body 5, adjacent to the end of the catheter body 5, and is used to support the occlusion balloon 7. The anti-slip layer 6, located near the end of the catheter body 5 and conforming to the inner wall, provides precise and stable support for the occlusion balloon 7, preventing displacement or shifting of the occlusion balloon 7 after inflation due to lack of support. This ensures that the occlusion balloon 7 always conforms to the corresponding position at the end of the catheter body 5, precisely aligning with the puncture site, guaranteeing a tight seal, and effectively preventing leakage of chemotherapy drugs from the puncture gap.

[0041] In other preferred embodiments, the catheter body 5 is made of thermoplastic polyurethane material, and the occlusion balloon 7 is made of thermoplastic elastomer medical film material.

[0042] The multi-directional flow nozzle includes a nozzle body 9, one end of which is connected to a drainage conduit 10; the drainage conduit 10 is used to connect to a chemotherapy pump.

[0043] The nozzle body 9 includes a nozzle 11 and a connecting tube 12; the nozzle 11 is spherical with a hollow interior, located at one end facing the patient's abdominal cavity; one end of the connecting tube 12 is fixedly connected to the nozzle 11, and the other end is connected to the drainage conduit 10.

[0044] The outer surfaces of the nozzle 11 and the connecting tube 12 are both covered with a layer of silicone 13, which is soft and has smooth, rounded edges to prevent scratching of the peritoneum and intestinal serosa when moving or coming into contact with the abdominal cavity.

[0045] The nozzle 11 has a plurality of through holes 111 evenly arranged within the top hemisphere. The axis of the through hole 111 is at a certain angle to the straight line from the through hole 111 to the center of the sphere.

[0046] The connecting tube 12 includes a venturi tube section 121 and a connecting section 122; one end of the connecting section 122 has a narrowed diameter for connecting to the drainage conduit 10; a rotor 14 is rotatably provided at the throat of the venturi tube section 121, and the rotation of the rotor 14 due to the impact of the liquid can increase the pressure of the liquid and form a vortex.

[0047] The rotor 14 is rotatably mounted in the center of the throat of the Venturi tube section 121 via a bearing 15; a variable diameter channel 141 is provided in the center of the rotor 14, and the diameter of the variable diameter channel 141 gradually increases from the inlet section to the diffuser section of the Venturi tube section 121.

[0048] A fixed support rod 142 is provided at the center of the variable diameter channel 141; a fixed plate 143 is provided at one end of the variable diameter channel 141 near the inlet section, the outer side of the fixed plate 143 is fixedly connected to the side wall of the variable diameter channel 141, and the center is fixedly connected to the fixed support rod 142.

[0049] Multiple water passage grooves 145 are arranged on the fixed plate 143 along the circumference of the fixed support rod 142; multiple guide vanes 144 are evenly arranged on the upper part of the fixed plate 143 along the circumference of the fixed support rod 142, and the inner side of the guide vanes 144 is engaged with the fixed support rod 142. The gap between two adjacent sets of guide vanes 144 corresponds one-to-one with the water passage grooves 145, and the water passage grooves 145 and the gaps form a water outlet slit, allowing the liquid medicine to enter the nozzle 11 through the water outlet slit.

[0050] The guide vane 144 is set at an angle relative to the radial line of the rotor 14, so that the water flow direction of the outlet slit forms a certain angle with the water flow direction of the drainage pipe 10.

[0051] The drug solution impacts the rotor 14 and is ejected tangentially through the water outlet slit. The combined action of multiple tangentially ejected liquid streams induces a slowly rotating vortex field around the nozzle and even throughout the peritoneal cavity. This vortex drives the overall flow of the drug solution within the peritoneal cavity, ensuring continuous and uniform contact between the chemotherapy drug and the peritoneal wall. This allows the drug solution to reach the dead zones of the peritoneal cavity, effectively flushing and covering micrometastases in the peritoneum.

[0052] The above description is merely a preferred embodiment of the present invention and does not constitute any limitation on the technical scope of the present invention. Therefore, any minor modifications, equivalent changes and alterations made to the above embodiments based on the technical essence of the present invention shall still fall within the scope of the technical solution of the present invention.

Claims

1. A pressurized irrigation device for intraperitoneal hyperthermic perfusion chemotherapy, characterized in that, Includes interconnected puncture catheters and multi-directional flow nozzles; The puncture catheter includes a catheter body (5), and multiple sets of support cavities (4) are arranged sequentially along the length direction inside the catheter body (5). The support cavities (4) are connected sequentially through a second air inlet channel (8). The support cavities (4) have an arc-shaped structure. Multiple flow guide nozzles are connected to the end of the catheter body (5). The multi-directional flow nozzle includes a nozzle body (9), one end of which is connected to a drainage conduit (10); the drainage conduit (10) is used to connect to a chemotherapy pump; the nozzle body (9) includes a nozzle (11) and a connecting pipe (12); one end of the connecting pipe (12) is fixedly connected to the nozzle (11), and the other end is connected to the drainage conduit (10); a plurality of through holes (111) are uniformly arranged on the nozzle (11); a rotor (14) is rotatably arranged inside the connecting pipe (12).

2. The intraperitoneal hyperthermic perfusion chemotherapy pressurized irrigation device as described in claim 1, characterized in that, A threaded sleeve (1) is fixedly connected to the outer wall of the catheter body (5). A fixed sleeve (2) is threadedly connected to the threaded sleeve (1). The fixed sleeve (2) is provided with a fixed outer edge. An adhesive layer is provided on the end face of the fixed outer edge. The adhesive layer is used to adhere to the surface of the affected area.

3. The intraperitoneal hyperthermic perfusion chemotherapy pressurized irrigation device as described in claim 1, characterized in that, The second air intake channel (8) is a narrow channel opened in the duct body (5). The end of the second air intake channel (8) extends outward. Multiple support cavities (4) are equidistantly arranged along the length direction of the duct body (5). The arc of the support cavity (4) is 250-300°.

4. The intraperitoneal hyperthermic perfusion chemotherapy pressurized irrigation device as described in claim 1, characterized in that, The catheter body (5) is also provided with a first air intake channel (3), and the end of the first air intake channel (3) is connected to a blocking airbag (7). The blocking airbag (7) is located near the end of the catheter body (5). The inner wall of the catheter body (5) is provided with an anti-slip layer (6). The anti-slip layer (6) is located near the end of the catheter body (5). The anti-slip layer (6) is used to support the blocking airbag (7).

5. The intraperitoneal hyperthermic perfusion chemotherapy pressurized irrigation device as described in claim 4, characterized in that, The end of the first air intake channel (3) extends outward. The first air intake channel (3) is a narrow channel opened in the duct body (5). The distance between the first air intake channel (3) and the two ends of the support cavity (4) is equal.

6. The intraperitoneal hyperthermic perfusion chemotherapy pressurized irrigation device as described in claim 1, characterized in that, The nozzle (11) is spherical at the end facing the patient's abdominal cavity.

7. The intraperitoneal hyperthermic perfusion chemotherapy pressurized irrigation device as described in claim 1, characterized in that, The axis of the through hole (111) is at a certain angle to the straight line from the through hole (111) to the center of the ball.

8. The intraperitoneal hyperthermic perfusion chemotherapy pressurized irrigation device as described in claim 1, characterized in that, The connecting tube (12) includes a Venturi tube section (121) and a connecting section (122); the connecting section (122) has a narrowed diameter at one end for connecting to the drainage conduit (10); the rotor (14) is located in the throat of the Venturi tube section (121); the rotor (14) has a variable diameter channel (141) at its center, and the diameter of the variable diameter channel (141) gradually increases from the inlet section to the diffuser section of the Venturi tube section (121).

9. The intraperitoneal hyperthermic perfusion chemotherapy pressurized irrigation device as described in claim 8, characterized in that, A fixed support rod (142) is provided at the center of the variable diameter channel (141); a fixed plate (143) is provided at one end of the variable diameter channel (141) near the inlet section, the outer side of the fixed plate (143) is fixedly connected to the side wall of the variable diameter channel (141), and the center is fixedly connected to the fixed support rod (142); a plurality of guide vanes (144) are evenly arranged above the fixed plate (143) along the circumference of the fixed support rod (142), the inner side of the guide vanes (144) is snapped with the fixed support rod (142), and a plurality of water passage grooves (145) are arranged on the fixed plate (143) along the circumference of the fixed support rod (142); the gap between two adjacent sets of guide vanes (144) corresponds one-to-one with the water passage grooves (145), and the water passage grooves (145) and the gaps form a water outlet slit.

10. The intraperitoneal hyperthermic perfusion chemotherapy pressurized irrigation device as described in claim 9, characterized in that, The guide vane (144) is set at an angle relative to the radial line of the rotor (14), so that the water flow direction of the outlet slit forms a certain angle with the water flow direction of the drainage pipe (10).

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