Nursing pad for old people and preparation method thereof

Abstract

The invention belongs to the field of nursing pad preparation, and particularly relates to a nursing pad for old people and a preparation method thereof. The nursing pad for old people comprises an upper-layer pad, a middle-layer pad and a lower-layer pad, the middle-layer pad is composed of a smell absorbent and the like, the smell absorbent is composed of a polypeptide substance and the like, the amino acid sequence of the polypeptide substance is AHKSKLHQHVWRY, and the polypeptide substance can highly absorb peculiar smell representative trans-2-nonenal and diacetyl. The upper-layer pad has certain absorption capacity and can restrain growth of microorganisms, the middle-layer pad can provide certain supporting force and keep relatively dry and comfortable contact body feeling, the lower-layer pad achieves the final anti-seepage effect, and the situation that the nursing pad is not attractive after being used for a long time is avoided. The prepared nursing pad for the old people can relieve the body odor of the old people, and is friendly to the old people and good in nursing effect.

Description

Technical Field

[0001] This invention belongs to the field of nursing pad preparation, specifically relating to a nursing pad for the elderly and its preparation method. Background Technology

[0002] Elderly people require professional care due to declining physical function and chronic diseases. However, limited by economic constraints and lifestyle habits, many elderly people find it difficult to obtain comfortable care. Elderly care presents several challenges: the elderly often face decreased muscle strength and balance, increasing the risk of fractures from falls, thus requiring constant supervision; disabled or cognitively impaired elderly individuals typically require assistance with bathing and dressing, placing physical demands on caregivers; and the psychological well-being of the elderly needs to be considered, with a shortage of qualified caregivers. Therefore, given these limitations, the use of appropriate care facilities and equipment in elderly care can help alleviate these difficulties.

[0003] Nursing pads are a type of mattress material with basic absorbency. They can be used for bed care of disabled elderly people and can also be used by other people in need. However, existing nursing pads often have problems such as poor absorbency, poor permeability, and inability to effectively remove odors, which limits their application in elderly care. Summary of the Invention

[0004] Based on the above problems, the present invention provides a nursing pad for the elderly, comprising an upper pad, a middle pad, and a lower pad, wherein the middle pad is composed of an odor absorber, etc., and the odor absorber is composed of polypeptide substances, etc., the amino acid sequence of the polypeptide substances is AHKSKLHQHVWRY, which can achieve high absorption of odor representatives trans-2-nonenal and diacetyl.

[0005] An elderly care pad includes an upper pad, a middle pad, and a lower pad. The upper and middle pads are body contact layers. The middle pad is rectangular or rounded rectangle. The front of the middle pad contacts the upper pad, and the back of the middle pad contacts the lower pad. The upper pad consists of a pad cover and a filling material. The pad cover is preferably made of pure cotton, and the filling material consists of the following components by weight: 20-30 parts microcrystalline cellulose, 10-15 parts antibacterial agent, and 50-70 parts cotton. The antibacterial agent is a natural plant extract, preferably one or more of the following: dandelion, *Clematis chinensis*, Sichuan pepper, and *Thalictrum euryana* extracts, which can achieve an antibacterial rate of 80-90% against Staphylococcus aureus (ATCC 6538), *Escherichia coli* (8099), and *Candida albicans* (ATCC10231). The method for preparing the upper pad is as follows: H1. Microcrystalline cellulose and antibacterial agent are thoroughly mixed and dried by spray drying to obtain dried material. The inlet air temperature is 60-80℃, the rotation speed is 2000-2400rpm, and the injection volume is 80-100mL / h. H2. After mixing the cotton and dried material from both sides, fill the pad with the mixture and sew it into individual compartments to obtain the upper pad.

[0006] Preferably, the individual compartments are rhomboid in shape.

[0007] The middle layer pad is composed of the following raw materials in parts by weight: 50-80 parts odor absorber, 30-40 parts sisal, 40-50 parts polyvinylpyrrolidone, 10-15 parts multi-walled carbon nanotubes, and 100-140 parts diphenylmethane diisocyanate. The odor absorber is composed of the following materials in parts by weight: 30-50 parts polypeptide substance, 10-15 parts dodecyl pentasiloxane, 80-90 parts hydrogen-containing polymethylsiloxane, and 120-140 parts polyvinyl alcohol resin. The amino acid sequence of the polypeptide is AHKSKLHQHVWRY, namely alanine-histidine-lysine-serine-lysine-leucine-histidine-glutamine-histidine-valine-tryptophan-arginine-tyrosine. It is specifically prepared and synthesized using NPC monomers of each amino acid. The general structural formula of each NPC monomer is as follows: Figure 1 As shown.

[0008] The preparation method of the polypeptide substance is as follows: S1. According to the amino acid sequence of the polypeptide, obtain the corresponding NPC monomers and tyrosine of each amino acid, that is, the molar ratio of alanine NPC monomer: histidine NPC monomer: lysine NPC monomer: serine NPC monomer: leucine NPC monomer: glutamine NPC monomer: valine NPC monomer: tryptophan NPC monomer: arginine NPC monomer: tyrosine is 1:3:2:1:1:1:1:1:1:1:1; S2. Dissolve arginine NPC monomer in dimethylacetamide, then add tert-butyl 3-aminopropionate and mix. Stir the mixture at 60-80℃ and 200-250 rpm for 2-4 hours to obtain mixture A. S3. Add tyrosine, dicyclohexylcarbodiimide, and N-hydroxysuccinimide to the mixture A obtained in step S2 and continue stirring for 10-12 hours. Then place it in ice water and let it stand for 1-2 hours. Then filter it through a filter membrane, wash the precipitate with water 3-5 times, and freeze dry it under vacuum to obtain substance B. S4. Repeat step S2 with tryptophan NPC monomer to obtain mixture C. Then add substance B obtained in step S3, dicyclohexylcarbodiimide, and N-hydroxysuccinimide ester. Continue stirring for 10-12 hours, then place in ice water and let stand for 1-2 hours. Then filter through a filter membrane, wash the precipitate with water 3-5 times, and freeze dry under vacuum to obtain substance D. S5. Repeat step S4 sequentially with valine NPC monomer, histidine NPC monomer, glutamine NPC monomer, histidine NPC monomer, leucine NPC monomer, lysine NPC monomer, serine NPC monomer, lysine NPC monomer, histidine NPC monomer, and alanine NPC monomer until substance N is obtained. S6. Dissolve substance N obtained in step S5 in methyl tert-butyl ether, let stand for 1-2 hours, centrifuge at 800-1000g for 20-30 minutes, discard the supernatant, wash the precipitate with water 3-5 times, centrifuge again, and purify by silica gel chromatography to obtain the polypeptide substance.

[0009] Preferably, in step S2, the molar ratio of arginine NPC monomer: dimethylacetamide: tert-butyl 3-aminopropionate is 8-10: 3-5: 2-4. Preferably, in step S3, the molar ratio of tyrosine: dicyclohexylcarbodiimide: N-hydroxysuccinimide ester is 6-8:0.4-0.8:0.3-0.5, the stirring conditions in step S3 are the same as in step S2, and filtration is performed using a 0.45μm PES microporous membrane. Preferably, in step S6, the mass-to-volume ratio of substance N to methyl tert-butyl ether is 20-30:100-140.

[0010] The odor absorber is prepared as follows: V1. Weigh dodecylpentasiloxane and hydrogen-containing polymethylsiloxane, place them in 1,4-dioxane, heat to 50-60℃ and stir at 250-280 rpm for 30-45 minutes to obtain mixture E; V2. Place polyvinyl alcohol resin and polypeptide in water, stir thoroughly until uniform, and then add to mixture E obtained in step V1. Homogenize using a high-speed homogenizer at 3000-4000 rpm for 30-40 seconds, and then spray to form plastic particles with a diameter of 300-400 μm, which are odor absorbers.

[0011] Preferably, in step V1, the amount of 1,4-dioxane used is 2-3 times the mass of dodecylpentasiloxane; Preferably, the amount of water used in step V2 is 3-4 times the mass of the polyvinyl alcohol resin.

[0012] The preparation method of the middle layer pad is as follows: T1. Wash the sisal with water at 80-100℃ for 1-2 hours, let it air dry, then wash it again until the water stops dripping. Soak it in a 1-2% sodium hydroxide solution for 24-36 hours. After taking it out, wash it thoroughly with plenty of water, then let it air dry and cut it into small square pieces of 0.5-0.8 cm. T2. Dissolve polyvinylpyrrolidone in water, then add multi-walled carbon nanotubes, and sonicate at 100-120W for 3-4 hours to obtain liquid G; T3. Mix the small pieces of sisal obtained in step T1, the liquid G obtained in step T2, the odor absorber, and diphenylmethane diisocyanate. Stir until evenly dispersed, then heat to 60-80°C. Pour into a molding apparatus and maintain at 100-120°C for 6-8 hours to obtain the middle layer pad.

[0013] Preferably, in step T2, the mass-volume ratio of polyvinylpyrrolidone to water is 5-8:100-120. Preferably, in step T3, the shaping device is a finished product specification controller for the intermediate pad, used to control the length, width and thickness of the intermediate pad, and to select a material that does not deform, melt or react with the raw materials of the intermediate pad at a temperature of 100-120℃.

[0014] The lower pad is made of HPDE material or TPO material; The method for preparing the elderly care pad is as follows: An elderly care pad can be obtained by using adhesive to bond the back of the middle layer pad to the lower layer pad, and then directly covering the front of the middle layer pad with the upper layer pad, or by using fixing aids to fix it to the front of the middle layer pad. Preferably, the lower pad should be fully bonded to the back of the middle pad and cover the four sides of the middle pad in relation to its thickness; Preferably, the length and width parameters of the middle pad are related to the height and width of the elderly person, with the length of the middle pad exceeding the height of the elderly person by 1.1-1.2 times and the width of the middle pad exceeding the width of the elderly person by 1.05-1.1 times. Preferably, the upper pad does not need to be the same length as the middle pad, but the width must be the same. The length of the upper pad is selected according to the needs of the elderly for intensive care, and the thickness of the upper pad should be 1-2 mm. Ideally, the adhesive is not limited to any particular product, as long as it is safe and harmless, and can be used to fix auxiliary items such as Velcro products.

[0015] The beneficial effects of this invention are as follows: This invention prepares a polypeptide substance using NPC monomers of various amino acids. The initial amino acid structure of this polypeptide has been shown in relevant literature to have a certain absorption capacity for body odor in the elderly. Considering the stability, solubility, and ease of synthesis during polypeptide synthesis, this invention modifies the initial amino acid sequence of the polypeptide, ultimately obtaining the amino acid sequence of the polypeptide substance provided by this invention. A method for preparing this polypeptide substance is also provided. The obtained polypeptide substance exhibits high absorption of odor representatives trans-2-nonenal and diacetyl. The polypeptide substance is encapsulated in an odor absorber, allowing the polypeptide substance and odor absorber to better exist in the middle layer pad while slightly sacrificing high odor absorption. The middle layer pad provides support, suitable for comfortable sleep, and provides space for the polypeptide substance and odor absorber to exert their effects, while maintaining a relatively dry feel. The upper layer pad mixes antibacterial agents, microcrystalline cellulose, and cotton, which, while possessing a certain absorption capacity, inhibits microbial growth. The upper layer pad is also appropriately sized, making it flexible and easy to replace. The lower layer pad provides the final leak-proof effect, preventing the pad from becoming unsightly after long-term use. Attached Figure Description

[0016] The accompanying drawings, which form part of this specification, are used to provide a further understanding of the invention. The illustrative embodiments of the invention and their descriptions are used to explain the invention and do not constitute an undue limitation of the invention. In the drawings: Figure 1 Here is the general structural formula for each amino acid NPC monomer, where R is the R group of the amino acid; Figure 2 The hydrogen nuclear magnetic resonance spectrum of the polypeptide prepared in Example 5; Figure 3 The carbon NMR spectrum of the polypeptide prepared in Example 5; Figure 4 This is a line graph showing the change in trans-2-nonenal concentration over time. Figure 5 This is a line graph showing the change in diacetyl concentration over time. Detailed Implementation

[0017] Example 1: This example provides a method for preparing an upper pad, the specific steps of which are as follows: The upper pad in this embodiment consists of a pad cover and a filling material. The pad cover is preferably made of pure cotton. The filling material consists of the following components in parts by weight: 20 parts microcrystalline cellulose, 10 parts antibacterial agent, and 50 parts cotton. The antibacterial agent is dandelion extract, specifically obtained by steam extraction, with a purity of 93%, and an antibacterial rate of 88% against Staphylococcus aureus (ATCC 6538), Escherichia coli (8099), and Candida albicans (ATCC 10231). H1. Microcrystalline cellulose and antibacterial agent were thoroughly mixed and dried by spray drying to obtain dried material. The inlet air temperature was 60℃, the rotation speed was 2000rpm, and the injection volume was 80mL / h. H2. After mixing the cotton and dried material from both sides, fill the pad with the mixture and sew it into a diamond-shaped grid to obtain the upper pad.

[0018] In this embodiment, the upper pad is 40 cm long, 90 cm wide, and 1 mm thick.

[0019] Example 2: This example provides a method for preparing an upper pad, the specific steps of which are as follows: The upper pad in this embodiment consists of a pad cover and a filling material. The pad cover is preferably made of pure cotton. The filling material consists of the following components in parts by weight: 25 parts microcrystalline cellulose, 12 parts antibacterial agent, and 60 parts cotton. The antibacterial agent is Thalictrum euryana extract, specifically obtained by steam extraction, with a purity of 95%, and an antibacterial rate of 92% against Staphylococcus aureus (ATCC 6538), Escherichia coli (8099), and Candida albicans (ATCC 10231). H1. Microcrystalline cellulose and antibacterial agent were thoroughly mixed and spray-dried to obtain dried material. The inlet air temperature was 70℃, the rotation speed was 2200rpm, and the injection volume was 90mL / h. H2. After mixing the cotton and dried material from both sides, fill the pad with the mixture and sew it into a diamond-shaped grid to obtain the upper pad.

[0020] In this embodiment, the upper pad is 40 cm long, 85 cm wide, and 1.5 mm thick.

[0021] Example 3: This example provides a method for preparing an upper pad, the specific steps of which are as follows: The upper pad in this embodiment consists of a pad cover and a filling material. The pad cover is preferably made of pure cotton. The filling material consists of the following components in parts by weight: 30 parts microcrystalline cellulose, 15 parts antibacterial agent, and 70 parts cotton. The antibacterial agent is an extract of Clematis chinensis, specifically obtained by extraction with 95% ethanol, with a purity of 92%. It has an antibacterial rate of 89% against Staphylococcus aureus (ATCC 6538), Escherichia coli (8099), and Candida albicans (ATCC 10231). H1. Microcrystalline cellulose and antibacterial agent were thoroughly mixed and spray-dried to obtain dried material. The inlet air temperature was 80℃, the rotation speed was 2400rpm, and the injection volume was 100mL / h. H2. After mixing the cotton and dried material from both sides, fill the pad with the mixture and sew it into a diamond-shaped grid to obtain the upper pad.

[0022] In this embodiment, the upper pad is 40 cm long, 82 cm wide, and 2 mm thick.

[0023] Example 4: This example provides a method for preparing a polypeptide substance, the specific steps of which are as follows: S1. According to the amino acid sequence of the polypeptide, obtain the corresponding NPC monomers and tyrosine of each amino acid, that is, the molar ratio of alanine NPC monomer: histidine NPC monomer: lysine NPC monomer: serine NPC monomer: leucine NPC monomer: glutamine NPC monomer: valine NPC monomer: tryptophan NPC monomer: arginine NPC monomer: tyrosine is 1:3:2:1:1:1:1:1:1:1:1; S2. Arginine NPC monomer, dimethylacetamide, and tert-butyl 3-aminopropionate were obtained in a molar ratio of 8:3:2. The arginine NPC monomer was dissolved in dimethylacetamide, and then tert-butyl 3-aminopropionate was added and mixed. The mixture was stirred continuously at 200 rpm for 2 hours at 60°C to obtain mixture A. S3. Tyrosine, dicyclohexylcarbodiimide, and N-hydroxysuccinimide ester were obtained in a molar ratio of 6:0.4:0.3. Tyrosine, dicyclohexylcarbodiimide, and N-hydroxysuccinimide ester were added to the mixture A obtained in step S2. The mixture was stirred at 200 rpm at 60°C for 10 hours. Then it was placed in ice water and allowed to stand for 1 hour. The mixture was then filtered using a 0.45 μm PES microporous membrane. The precipitate was washed with water three times and then freeze-dried under vacuum to obtain substance B. S4. Repeat step S2 with tryptophan NPC monomer to obtain mixture C. Then add substance B obtained in step S3, dicyclohexylcarbodiimide, and N-hydroxysuccinimide ester. Continue stirring for 10 hours, then place in ice water and let stand for 1 hour. Then filter using a 0.45μm PES microporous membrane. Wash the precipitate with water 3 times and freeze dry under vacuum to obtain substance D. S5. Repeat step S4 sequentially with valine NPC monomer, histidine NPC monomer, glutamine NPC monomer, histidine NPC monomer, leucine NPC monomer, lysine NPC monomer, serine NPC monomer, lysine NPC monomer, histidine NPC monomer, and alanine NPC monomer until substance N is obtained. S6. Weigh the substance N obtained in step S5 and methyl tert-butyl ether according to the mass-volume ratio of 20g:100mL. Dissolve substance N in methyl tert-butyl ether, let stand for 1 hour, centrifuge at 800g for 20 minutes, discard the supernatant, wash the precipitate with water 3 times, centrifuge again, and purify by silica gel chromatography to obtain the polypeptide substance.

[0024] Example 5: This example provides a method for preparing a polypeptide substance, the specific steps of which are as follows: S1. According to the amino acid sequence of the polypeptide, obtain the corresponding NPC monomers and tyrosine of each amino acid, that is, the molar ratio of alanine NPC monomer: histidine NPC monomer: lysine NPC monomer: serine NPC monomer: leucine NPC monomer: glutamine NPC monomer: valine NPC monomer: tryptophan NPC monomer: arginine NPC monomer: tyrosine is 1:3:2:1:1:1:1:1:1:1:1; S2. Arginine NPC monomer, dimethylacetamide, and tert-butyl 3-aminopropionate were obtained in a molar ratio of 9:4:3. The arginine NPC monomer was dissolved in dimethylacetamide, and then tert-butyl 3-aminopropionate was added and mixed. The mixture was stirred continuously at 220 rpm for 3 hours at 70°C to obtain mixture A. S3. Tyrosine, dicyclohexylcarbodiimide, and N-hydroxysuccinimide ester were obtained in a molar ratio of 7:0.6:0.4. Tyrosine, dicyclohexylcarbodiimide, and N-hydroxysuccinimide ester were added to the mixture A obtained in step S2. The mixture was stirred at 220 rpm at 70°C for 11 hours. Then it was placed in ice water and allowed to stand for 1.5 hours. The mixture was then filtered using a 0.45 μm PES microporous membrane. The precipitate was washed with water four times and then freeze-dried under vacuum to obtain substance B. S4. Repeat step S2 with tryptophan NPC monomer to obtain mixture C. Then add substance B obtained in step S3, dicyclohexylcarbodiimide, and N-hydroxysuccinimide ester. Continue stirring for 11 hours, then place in ice water and let stand for 1.5 hours. Then filter using a 0.45μm PES microporous membrane. Wash the precipitate with water 4 times and freeze dry under vacuum to obtain substance D. S5. Repeat step S4 sequentially with valine NPC monomer, histidine NPC monomer, glutamine NPC monomer, histidine NPC monomer, leucine NPC monomer, lysine NPC monomer, serine NPC monomer, lysine NPC monomer, histidine NPC monomer, and alanine NPC monomer until substance N is obtained. S6. Weigh the substance N obtained in step S5 and methyl tert-butyl ether according to the mass-volume ratio of 24g:120mL. Dissolve substance N in methyl tert-butyl ether, let stand for 1.5 hours, centrifuge at 900g for 24 minutes, discard the supernatant, wash the precipitate with water 4 times, centrifuge again, and purify by silica gel chromatography to obtain the polypeptide substance.

[0025] Example 6: This example provides a method for preparing a polypeptide substance, the specific steps of which are as follows: S1. According to the amino acid sequence of the polypeptide, obtain the corresponding NPC monomers and tyrosine of each amino acid, that is, the molar ratio of alanine NPC monomer: histidine NPC monomer: lysine NPC monomer: serine NPC monomer: leucine NPC monomer: glutamine NPC monomer: valine NPC monomer: tryptophan NPC monomer: arginine NPC monomer: tyrosine is 1:3:2:1:1:1:1:1:1:1:1; S2. Arginine NPC monomer, dimethylacetamide, and tert-butyl 3-aminopropionate were obtained in a molar ratio of 10:5:4. The arginine NPC monomer was dissolved in dimethylacetamide, and then tert-butyl 3-aminopropionate was added and mixed. The mixture was stirred continuously at 250 rpm for 4 hours at 80°C to obtain mixture A. S3. Tyrosine, dicyclohexylcarbodiimide, and N-hydroxysuccinimide ester were obtained in a molar ratio of 8:0.8:0.5. Tyrosine, dicyclohexylcarbodiimide, and N-hydroxysuccinimide ester were added to the mixture A obtained in step S2. The mixture was stirred at 250 rpm at 80°C for 12 hours. Then it was placed in ice water and allowed to stand for 2 hours. The mixture was then filtered using a 0.45 μm PES microporous membrane. The precipitate was washed with water 5 times and then freeze-dried under vacuum to obtain substance B. S4. Repeat step S2 with tryptophan NPC monomer to obtain mixture C. Then add substance B obtained in step S3, dicyclohexylcarbodiimide, and N-hydroxysuccinimide ester. Continue stirring for 12 hours, then place in ice water and let stand for 2 hours. Then filter using a 0.45μm PES microporous membrane. Wash the precipitate with water 5 times and freeze dry under vacuum to obtain substance D. S5. Repeat step S4 sequentially with valine NPC monomer, histidine NPC monomer, glutamine NPC monomer, histidine NPC monomer, leucine NPC monomer, lysine NPC monomer, serine NPC monomer, lysine NPC monomer, histidine NPC monomer, and alanine NPC monomer until substance N is obtained. S6. Weigh the substance N obtained in step S5 and methyl tert-butyl ether according to the mass-volume ratio of 30g:140mL. Dissolve substance N in methyl tert-butyl ether, let stand for 2 hours, centrifuge at 1000g for 30 minutes, discard the supernatant, wash the precipitate with water 5 times, centrifuge again, and purify by silica gel chromatography to obtain the polypeptide substance.

[0026] Example 7: This example provides a method for preparing an odor absorbent, the specific steps of which are as follows: The odor absorber of this embodiment is composed of the following parts by weight: 30 parts of polypeptide substance prepared in Example 4, 10 parts of dodecylpentasiloxane, 80 parts of hydrogen-containing polymethylsiloxane, and 120 parts of polyvinyl alcohol resin. V1. Weigh 1,4-dioxane in twice the mass of dodecylpentasiloxane, place dodecylpentasiloxane and hydrogen-containing polymethylsiloxane in 1,4-dioxane, heat to 50°C and stir at 250 rpm for 30 minutes to obtain mixture E; V2. Weigh three times the mass of water to the polyvinyl alcohol resin, place the polyvinyl alcohol resin and polypeptide in the water, stir thoroughly until evenly mixed, and then add it to the mixture E obtained in step V1. Homogenize using a high-speed homogenizer at 3000 rpm for 30 seconds, and then spray to form plastic particles with a diameter of 300 μm, which are the odor absorbers.

[0027] Example 8: This example provides a method for preparing an odor absorbent, the specific steps of which are as follows: The odor absorber of this embodiment is composed of the following parts by weight: 40 parts of polypeptide substance prepared in Example 5, 12 parts of dodecylpentasiloxane, 85 parts of hydrogen-containing polymethylsiloxane, and 130 parts of polyvinyl alcohol resin. V1. Weigh 1,4-dioxane in 2.5 times the mass of dodecylpentasiloxane, place dodecylpentasiloxane and hydrogen-containing polymethylsiloxane in 1,4-dioxane, heat to 55°C and stir at 260 rpm for 38 minutes to obtain mixture E; V2. Weigh 3.5 times the mass of water to the polyvinyl alcohol resin, place the polyvinyl alcohol resin and polypeptide in the water, stir thoroughly until evenly mixed, and then add it to the mixture E obtained in step V1. Homogenize using a high-speed homogenizer at 3500 rpm for 35 seconds, and then spray to form plastic particles with a diameter of 350 μm, which are the odor absorbers.

[0028] Example 9: This example provides a method for preparing an odor absorbent, the specific steps of which are as follows: The odor absorber of this embodiment is composed of the following parts by weight: 50 parts of polypeptide substance prepared in Example 6, 15 parts of dodecyl pentasiloxane, 90 parts of hydrogen-containing polymethylsiloxane, and 140 parts of polyvinyl alcohol resin. V1. Weigh 1,4-dioxane in 3 times the mass of dodecylpentasiloxane, place dodecylpentasiloxane and hydrogen-containing polymethylsiloxane in 1,4-dioxane, heat to 60°C and stir at 280 rpm for 45 minutes to obtain mixture E; V2. Weigh 4 times the mass of water to the polyvinyl alcohol resin, place the polyvinyl alcohol resin and polypeptide in the water, stir thoroughly until evenly mixed, and then add it to the mixture E obtained in step V1. Homogenize using a high-speed homogenizer at 4000 rpm for 40 seconds, and then spray to form plastic particles with a diameter of 400 μm, which are the odor absorbers.

[0029] Example 10: This example provides a method for preparing a middle layer pad, the specific steps of which are as follows: The middle layer of this embodiment is composed of the following parts by weight of raw materials: 50 parts of the odor absorber prepared in Example 7, 30 parts of sisal, 40 parts of polyvinylpyrrolidone, 10 parts of multi-walled carbon nanotubes, and 100 parts of diphenylmethane diisocyanate. T1. Wash the sisal with water at 80℃ for 2 hours, let it air dry, then wash it again until the water stops dripping. Soak it in a 1% sodium hydroxide solution for 36 hours. After taking it out, wash it thoroughly with plenty of water, then let it air dry and cut it into 0.5 cm square pieces. T2. Weigh polyvinylpyrrolidone and water according to a mass-volume ratio of 5g:100mL, dissolve polyvinylpyrrolidone in water, then add multi-walled carbon nanotubes, and sonicate at 100W for 3 hours to obtain liquid G. T3. Mix the small pieces of sisal obtained in step T1, the liquid G obtained in step T2, the odor absorber, and diphenylmethane diisocyanate. Stir until evenly dispersed, then heat to 60°C, pour into a molding apparatus, and maintain at 100°C for 8 hours to obtain the middle layer pad. The molding tool used in this embodiment is made of wood, is a cuboid, and has an inner length of 180 cm, a width of 90 cm, and a thickness of 0.35 cm.

[0030] Example 11: This example provides a method for preparing an intermediate pad, the specific steps of which are as follows: The middle layer of this embodiment is composed of the following parts by weight of raw materials: 60 parts of the odor absorber prepared in Example 8, 35 parts of sisal, 45 parts of polyvinylpyrrolidone, 12 parts of multi-walled carbon nanotubes, and 120 parts of diphenylmethane diisocyanate. T1. Wash the sisal with 90℃ water for 1.5 hours, let it air dry, then wash it again until the water stops dripping. Soak it in a 1.5% sodium hydroxide solution for 30 hours. After taking it out, wash it thoroughly with plenty of water, then let it air dry and cut it into 0.6 cm square pieces. T2. Weigh polyvinylpyrrolidone and water according to a mass-volume ratio of 7g:110mL, dissolve polyvinylpyrrolidone in water, then add multi-walled carbon nanotubes, and sonicate at 110W for 3.5 hours to obtain liquid G. T3. Mix the small pieces of sisal obtained in step T1, the liquid G obtained in step T2, the odor absorber, and diphenylmethane diisocyanate. Stir until evenly dispersed, then heat to 70°C, pour into a molding apparatus, and maintain at 110°C for 7 hours to obtain the middle layer pad.

[0031] The molding tool used in this embodiment is made of wood, is a cuboid, and has an inner length of 178 cm, a width of 85 cm, and a thickness of 0.3 cm.

[0032] Example 12: This example provides a method for preparing an intermediate pad, the specific steps of which are as follows: The middle layer of this embodiment is composed of the following parts by weight of raw materials: 80 parts of the odor absorber prepared in Example 9, 40 parts of sisal, 50 parts of polyvinylpyrrolidone, 15 parts of multi-walled carbon nanotubes, and 140 parts of diphenylmethane diisocyanate. T1. Wash the sisal with 100℃ water for 1 hour, let it air dry, then wash it again until the water stops dripping. Soak it in a 2% sodium hydroxide solution for 24 hours. After taking it out, wash it thoroughly with plenty of water, then let it air dry and cut it into 0.8 cm square pieces. T2. Weigh polyvinylpyrrolidone and water according to a mass-volume ratio of 8g:120mL, dissolve polyvinylpyrrolidone in water, then add multi-walled carbon nanotubes, and sonicate at 120W for 4 hours to obtain liquid G. T3. Mix the small pieces of sisal obtained in step T1, the liquid G obtained in step T2, the odor absorber, and diphenylmethane diisocyanate. Stir until evenly dispersed, then heat to 80°C, pour into a molding apparatus, and maintain at 120°C for 6 hours to obtain the middle layer pad.

[0033] The molding tool used in this embodiment is made of wood, is a cuboid, and has an inner length of 175 cm, a width of 82 cm, and a thickness of 0.2 cm.

[0034] Example 13: This example provides a method for preparing a nursing pad for the elderly. The specific steps are as follows: In this embodiment of the elderly care pad, the upper pad is prepared according to Example 1, the middle pad is prepared according to Example 10, and the lower pad is made of HPDE material; The back of the middle layer pad is bonded to the lower layer pad using water-based polyurethane adhesive produced by Anhui Huatai New Materials Co., Ltd., covering the four sides of the middle layer pad that are related to its thickness. The upper layer pad is then placed directly on the front of the middle layer pad to obtain the elderly care pad.

[0035] Example 14: This example provides a method for preparing a nursing pad for the elderly. The specific steps are as follows: In this embodiment of the elderly care pad, the upper layer pad is prepared in Example 2, the middle layer pad is prepared in Example 11, and the lower layer pad is made of TPO material; The back of the middle layer pad is bonded to the lower layer pad using water-based polyurethane adhesive produced by Anhui Huatai New Materials Co., Ltd., covering the four sides of the middle layer pad that are related to its thickness. The back of the upper layer pad is then fixed to the front of the middle layer pad using Velcro. This process yields an elderly care pad.

[0036] Example 15: This example provides a method for preparing a nursing pad for the elderly. The specific steps are as follows: In this embodiment of the elderly care pad, the upper pad is prepared as in Example 3, the middle pad is prepared as in Example 12, and the lower pad is made of HPDE material. The back of the middle layer pad is bonded to the lower layer pad using water-based polyurethane adhesive produced by Anhui Huatai New Materials Co., Ltd., thus covering the four sides of the middle layer pad related to its thickness. The sides of the upper layer pad are then fixed to the front of the middle layer pad with clips, thus obtaining the elderly care pad.

[0037] Experimental test: I. Structural Analysis of Polypeptides The polypeptide prepared in Example 5 was analyzed by proton and carbon NMR spectra. The proton NMR spectrum is shown below. Figure 2 As shown, the carbon NMR spectrum is as follows: Figure 3 As shown, the following results can also be seen: 1H NMR: δ 0.83–0.96 (12H, 0.89 (d, J = 6.8 Hz), 0.89 (d, J = 6.8 Hz),0.91 (d, J = 6.7 Hz), 0.91 (d, J = 6.7, Hz)), H 1.81 (1.19–16) =7.3, 7.0 Hz), 1.35 (tt, J = 7.3, 7.0 Hz), 1.37 (d, J = 6.7 Hz), 1.39 (tt, J =7.4, 6.9 Hz), 1.39 (tt, J = 7.4, 6.7 = 70 Hz), 1.3 1.44(tt, J = 7.3, 7.0 Hz), 1.51 (tt, J = 7.4, 7.3 Hz), 1.51 (tt, J = 7.4, 7.3Hz), 1.56 (tsept, J = 6.8, 6.6 Hz), 1.67 = 1.7 (dt (dt, J =7.4, 7.0 Hz), 1.74 (dd, J = 7.5, 6.8 Hz), 1.74 (dd, J = 7.5, 6.8 Hz)), 1.88–2.02 (2H, 1.95 (dt, J = 7.5 Hz), J.3, 6.9. 6.9 Hz)), 2.02-2.22(5H, 2.09 (dsept, J = 7.2, 6.8 Hz), 2.13 (q, J = 7.3 Hz), 2.13 (q, J = 7.3Hz), 2.17 (d, J = 7.1 = 7), 2.29–2.41 (2H, 2.35 (t, J =7.4 Hz), 2.35 (t, J = 7.4 Hz)), 2.56–2.71 (10H, 2.62 (t, J = 7.0 Hz), 2.62(t, J = 3.6 = 3), 2.63 (d, J = 6.4 Hz), 2.63 (t, J = 7.3Hz), 2.63 (t, J = 7.3 Hz), 2.65 (d, J = 6.6 Hz), 2.65 (d, J = 6.6 Hz), 2.65(d, J = 6).65 (d, J = 6.6 Hz)), 2.76-2.85 (2H, 2.81 (s), 2.81 (s)),3.07-3.17 (2H, 3.12 (s), 3.12 (s)), 3.19-3.31 (2H, 3.25 (d, J = 6.8 Hz), 3.25(d, J = 6.8 Hz)), 3.36-3.48 (3H, 3.42 (d, J = 7.0 Hz), 3.42 (d, J = 7.0 Hz),3.42 (d, J = 7.0 Hz)), 3.62-3.85 (6H, 3.68 (d, J = 7.0 Hz), 3.68 (d, J = 7.0Hz), 3.77 (d, J = 7.0 Hz), 3.78 (d, J = 7.0 Hz), 3.78 (d, J = 7.0 Hz), 3.79(q, J = 6.7 Hz)), 4.18-4.88 (18H, 4.24 (d, J = 7.2 Hz), 4.35 (t, J = 7.3 Hz),4.37 (t, J = 7.5 Hz), 4.41 (t, J = 7.3 Hz), 4.41 (t, J = 7.3 Hz), 4.54 (d, J= 15.9 Hz), 4.54 (d, J = 15.9 Hz), 4.54 (t, J = 7.0 Hz), 4.60 (d, J = 15.9Hz), 4.63 (t, J = 6.8 Hz), 4.63 (s), 4.75 (t, J = 6.6 Hz), 4.75 (t, J = 6.6Hz), 4.76 (dd, J = 6.4, 6.3 Hz), 4.80 (d, J = 15.9 Hz), 4.81 (d, J = 15.9Hz), 4.81 (d, J = 15.9 Hz), 4.82 (t, J = 7.4 Hz)), 6.52 (1H, dt, J = 1.7, 0.5Hz), 6.91 (2H, s), 7.00-7.17 (4H, 7.06 (tdd, J = 7.9, 1.1, 0.5 Hz), 7.08(ddd, J = 8.0, 7.8, 1.8 Hz), 7.12 (s)), 7.34 (1H, ddt, J = 8.0, 1.1, 0.5 Hz),7.62 (1H, dddd, J = 7.9, 1.8, 1.7, 0.5 Hz). 13C NMR: δ 17.6 (1C, s), 18.6-18.8 (2C, 18.6 (s), 18.7 (s)), 22.5-22.7(4C, 22.6 (s), 22.6 (s), 22.6 (s), 22.6 (s)), 24.4 (1C, s), 27.1 (1C, s),27.3-27.4 (2C, 27.4 (s), 27.4 (s)), 29.0 (1C, s), 30.2 (1C, s), 30.9 (1C, s),31.1-31.3 (2C, 31.2 (s), 31.2 (s)), 32.2 (1C, s), 38.2 (1C, s), 40.5 (1C, s),40.8-40.8 (2C, 40.8 (s), 40.8 (s)), 41.6 (1C, s), 42.5-42.5 (3C, 42.5 (s),42.5 (s), 42.5 (s)), 50.7 (1C, s), 51.7 (1C, s), 52.0-52.1 (4C, 52.0 (s),52.0 (s), 52.0 (s), 52.1 (s)), 53.3-53.3 (4C, 53.3 (s), 53.3 (s), 53.3 (s),53.3 (s)), 54.9 (1C, s), 57.3 (1C, s), 58.0-58.0 (3C, 58.0 (s), 58.0 (s),58.0 (s)), 58.8 (1C, s), 61.5 (1C, s), 66.5-66.5 (3C, 66.5 (s), 66.5 (s),66.5 (s)), 102.3 (1C, s), 111.3 (1C, s), 115.7 (2C, s), 120.6 (1C, s), 128.1-128.3 (2C, 128.2 (s), 128.2 (s)), 128.4 (1C, s), 130.0 (2C, s), 133.7 (1C,s), 135.4 (1C, s), 136.3 (1C, s), 151.6-151.8 (3C, 151.7 (s), 151.7 (s),151.7 (s)), 156.5 (1C, s), 157.4 (1C, s), 170.3 (1C, s), 171.1 (1C, s),171.8-172.0 (9C, 171.9 (s), 171.9 (s), 171.9 (s), 171.9 (s), 171.9 (s), 171.9(s), 171.9 (s), 171.9 (s), 171.9 (s)), 172.5 (1C, s), 174.0 (1C, s), 174.4(1C, s). II. Odor Absorption Effect Test Trans-2-nonenal and diacetyl were used as the main sources of odor in the experiments. Taking trans-2-nonenal as an example, the polypeptide prepared in Example 5 was incubated with magnetic beads in PBS buffer (pH 7.4) for 12 hours. After drying, it was added to a 50 ppm trans-2-nonenal solution and treated for 30, 60, 120, 240, 480, and 960 minutes, respectively. The concentration of trans-2-nonenal was then measured. The experimental procedure for diacetyl was the same as above, except that the trans-2-nonenal solution was replaced with a diacetyl solution. The detection conditions for trans-2-nonenal were as described in relevant literature: high-performance liquid chromatography (HPLC), C18, 5 µm, 12.5 × 4.6 mm column, mobile phase: methanol-water (75:25 v / v), ammonium formate: 1 mM, flow rate: 1.0 mL / min, injection volume: 10 µL. The determination method for diacetyl was based on the following literature: Ye Haipeng, Shao Ji, Tan Siwei, et al. Pre-column derivatization-high performance liquid chromatography method for diacetyl in workplace air [J]. Environmental and Occupational Medicine, 2023, 40(09): 1079-1084. This literature describes the high performance liquid chromatography detection method for diacetyl. In addition, parallel experimental groups were set up in the experimental process to ensure the reliability of the data.

[0038] Simultaneously, the odor absorbents prepared in Examples 7, 8, and 9 were used in the experiments. Taking trans-2-nonenal as an example, the odor absorbent was added to a 50 ppm trans-2-nonenal solution and treated for 30, 60, 120, 240, 480, and 960 minutes, respectively. The concentration of trans-2-nonenal was then measured after treatment. The experimental procedure for diacetyl was the same as described above, except that the trans-2-nonenal solution was replaced with a diacetyl solution.

[0039] The absorption of trans-2-nonenal by polypeptides and odor absorbers is as follows: Figure 4 As shown, by Figure 4 It can be seen that the polypeptide has a better absorption effect on trans-2-nonenal, reducing the concentration of trans-2-nonenal to 45% of the initial concentration after 960 minutes. In contrast, the odor absorber absorbs trans-2-nonenal more slowly. The odor absorber prepared in Example 9 reduced the concentration of trans-2-nonenal to 58% of the initial concentration after 960 minutes.

[0040] The absorption of diacetyl by polypeptides and odor absorbers is as follows: Figure 5As shown, by Figure 5 It was found that both the peptide and the odor absorber exhibited rapid absorption of diacetyl, achieving 50% absorption after 960 minutes. However, the peptide still showed better absorption than the odor absorber. Although the peptide can perform well under suitable conditions, considering its final presence in the pad, it is necessary to add it to the odor absorber to maximize its effectiveness.

[0041] Furthermore, the odor absorption simulation in solution form cannot fully reflect the presence of odors in the air, but it does not affect the odor absorber's ability to absorb odors effectively. Considering the specific usage scenario of the pad, the odor absorber can absorb odors when in contact with the human body.

[0042] III. Evaluation of the Actual Performance of Nursing Pads The nursing pads prepared in Examples 14, 15, and 16 were provided free of charge to nursing homes. Professional nursing staff scored the pads on their ability to absorb waste, odor, and dryness of the body contact layer, with a maximum score of 5 points for each item. The pads were laid out before going to bed at night and scored and evaluated promptly after waking up in the morning for 14 consecutive days, during which time professional nursing staff changed shifts 1-2 times.

[0043] The scoring and evaluation forms were collected, and those with missing or incomplete records were removed, resulting in a total of 186 scoring and evaluation forms. Professional caregivers were generally satisfied with the dryness of the body contact layer of the nursing pads, followed by the absorption of waste and odor. Considering that professional caregivers are in the same environment for a long time and their sense of smell is no longer sensitive to odors, the scoring of odor absorption has a certain degree of subjectivity.

[0044] The above embodiments are not intended to limit the present invention, nor is the present invention limited to the above embodiments. Any changes, modifications, additions, or substitutions made by those skilled in the art within the scope of the present invention should also fall within the protection scope of the present invention.

Claims

1. A nursing pad for the elderly, characterized in that, It includes an upper pad, a middle pad, and a lower pad. The upper and middle pads are body contact layers. The middle pad is rectangular or rounded rectangle. The front of the middle pad contacts the upper pad, and the back of the middle pad contacts the lower pad. The upper pad consists of a pad cover and a filling material. The pad cover is made of pure cotton, and the filling material consists of the following components by weight: 20-30 parts microcrystalline cellulose, 10-15 parts antibacterial agent, and 50-70 parts cotton. The middle layer pad is composed of the following raw materials in parts by weight: 50-80 parts odor absorber, 30-40 parts sisal, 40-50 parts polyvinylpyrrolidone, 10-15 parts multi-walled carbon nanotubes, and 100-140 parts diphenylmethane diisocyanate. The odor absorber is composed of the following materials in parts by weight: 30-50 parts polypeptide substance, 10-15 parts dodecyl pentasiloxane, 80-90 parts hydrogen-containing polymethylsiloxane, and 120-140 parts polyvinyl alcohol resin. The lower pad is made of HPDE material or TPO material.

2. The elderly care pad according to claim 1, characterized in that, The antibacterial agent is a natural plant extract, one or more of the following: dandelion, Clematis armandii, Sichuan pepper, and Thalictrum euryana extract, which can achieve an antibacterial rate of 80-90% against Staphylococcus aureus, Escherichia coli, and Candida albicans.

3. The elderly care pad according to claim 2, characterized in that, The method for preparing the upper pad is as follows: H1. Microcrystalline cellulose and antibacterial agent are thoroughly mixed and dried by spray drying to obtain dried material. The inlet air temperature is 60-80℃, the rotation speed is 2000-2400rpm, and the injection volume is 80-100mL / h. H2. After mixing the cotton and dried material from both sides, fill the pad with the mixture and sew it into individual compartments to obtain the upper pad.

4. A nursing pad for the elderly according to claim 3, characterized in that, The amino acid sequence of the polypeptide is AHKSKLHQHVWRY, namely alanine-histidine-lysine-serine-lysine-leucine-histidine-glutamine-histidine-valine-tryptophan-arginine-tyrosine. It is synthesized using NPC monomers of each amino acid, and the specific preparation method is as follows: S1. According to the amino acid sequence of the polypeptide, obtain the corresponding NPC monomers and tyrosine of each amino acid, that is, the molar ratio of alanine NPC monomer: histidine NPC monomer: lysine NPC monomer: serine NPC monomer: leucine NPC monomer: glutamine NPC monomer: valine NPC monomer: tryptophan NPC monomer: arginine NPC monomer: tyrosine is 1:3:2:1:1:1:1:1:1:1:1; S2. Dissolve arginine NPC monomer in dimethylacetamide, then add tert-butyl 3-aminopropionate and mix. Stir the mixture at 60-80℃ and 200-250 rpm for 2-4 hours to obtain mixture A. S3. Add tyrosine, dicyclohexylcarbodiimide, and N-hydroxysuccinimide to the mixture A obtained in step S2 and continue stirring for 10-12 hours. Then place it in ice water and let it stand for 1-2 hours. Then filter it through a filter membrane, wash the precipitate with water 3-5 times, and freeze dry it under vacuum to obtain substance B. S4. Repeat step S2 with tryptophan NPC monomer to obtain mixture C. Then add substance B obtained in step S3, dicyclohexylcarbodiimide, and N-hydroxysuccinimide ester. Continue stirring for 10-12 hours, then place in ice water and let stand for 1-2 hours. Then filter through a filter membrane, wash the precipitate with water 3-5 times, and freeze dry under vacuum to obtain substance D. S5. Repeat step S4 sequentially with valine NPC monomer, histidine NPC monomer, glutamine NPC monomer, histidine NPC monomer, leucine NPC monomer, lysine NPC monomer, serine NPC monomer, lysine NPC monomer, histidine NPC monomer, and alanine NPC monomer until substance N is obtained. S6. Dissolve the substance N obtained in step S5 in methyl tert-butyl ether, let it stand for 1-2 hours, centrifuge at 800-1000g for 20-30 minutes, discard the supernatant, wash the precipitate with water 3-5 times, centrifuge again, and purify by silica gel chromatography to obtain the polypeptide substance. In step S2, the molar ratio of arginine NPC monomer: dimethylacetamide: tert-butyl 3-aminopropionate is 8-10: 3-5: 2-4. In step S3, the molar ratio of tyrosine: dicyclohexylcarbodiimide: N-hydroxysuccinimide ester is 6-8:0.4-0.8:0.3-0.

5. The stirring conditions in step S3 are the same as in step S2, and filtration is performed using a 0.45μm PES microporous membrane. In step S6, the mass-to-volume ratio of substance N to methyl tert-butyl ether is 20-30:100-140.

5. A nursing pad for the elderly according to claim 4, characterized in that, The odor absorber is prepared as follows: V1. Weigh dodecylpentasiloxane and hydrogen-containing polymethylsiloxane, place them in 1,4-dioxane, heat to 50-60℃ and stir at 250-280 rpm for 30-45 minutes to obtain mixture E; V2. Place polyvinyl alcohol resin and polypeptide in water, stir thoroughly until evenly mixed, and then add to the mixture E obtained in step V1. Homogenize using a high-speed homogenizer at 3000-4000 rpm for 30-40 seconds, and then spray to form plastic particles with a diameter of 300-400 μm, which are odor absorbers. In step V1, the amount of 1,4-dioxane used is 2-3 times the mass of dodecylpentasiloxane; In step V2, the amount of water used is 3-4 times the mass of the polyvinyl alcohol resin.

6. A nursing pad for the elderly according to claim 5, characterized in that, The preparation method of the middle layer pad is as follows: T1. Wash the sisal with water at 80-100℃ for 1-2 hours, let it air dry, then wash it again until the water stops dripping. Soak it in a 1-2% sodium hydroxide solution for 24-36 hours. After taking it out, wash it thoroughly with plenty of water, then let it air dry and cut it into small square pieces of 0.5-0.8 cm. T2. Dissolve polyvinylpyrrolidone in water, then add multi-walled carbon nanotubes, and sonicate at 100-120W for 3-4 hours to obtain liquid G; T3. Mix the small pieces of sisal obtained in step T1, the liquid G obtained in step T2, the odor absorber, and diphenylmethane diisocyanate. Stir until evenly dispersed, then heat to 60-80°C. Pour into a molding apparatus and maintain at 100-120°C for 6-8 hours to obtain the middle layer pad. In step T2, the mass-volume ratio of polyvinylpyrrolidone to water is 5-8:100-120.

7. A method for preparing an elderly care pad according to any one of claims 1-6, characterized in that, The method for preparing the elderly care pad is as follows: An elderly care pad can be obtained by using adhesive to bond the back of the middle layer pad to the lower layer pad, and then directly covering the front of the middle layer pad with the upper layer pad, or by using fixing aids to fix it to the front of the middle layer pad. The lower pad should be fully bonded to the back of the middle pad and cover all four sides of the middle pad, which are related to its thickness.

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