Lesion finding and positioning and targeted drug guiding system and method based on acousto-optic coupling functional film layer

Abstract

The invention relates to the technical field of noninvasive medical imaging, acousto-optic coupling and targeted drug delivery, and discloses a lesion finding and positioning and targeted drug guiding system and method based on an acousto-optic coupling functional film layer. Based on intelligent processing equipment with acoustics, optics and signal processing capacity, non-invasive discovery and accurate fault positioning of human tissue / body fluid lesions and directional guidance and local enrichment of targeted drugs are achieved in a time-sharing mode through the same physical area of the same acousto-optic coupling integrated functional film layer. The membrane layer multiplies the frequency of a low-frequency signal of 20Hz-20kHz into medical ultrasound of 2MHz-10MHz to complete imaging positioning, and meanwhile, targeted drug guidance such as optical / acoustic power, magnetic targeting and ultrasonic transdermal infiltration promotion is realized through the special optical / energy conducting layer, so that the drug focus enrichment rate is increased, and the side effects of the whole body are reduced. Equipment hardware does not need to be transformed, the film layer is flexible in form and wide in adaptability, medical diagnosis and treatment functions are integrated into consumer electronic equipment for the first time, low-cost popularization is achieved, and the system is suitable for targeted drug treatment guidance of various lesions such as solid tumors, virus infection lesions and chronic inflammation lesions, can be applied to multiple scenes such as families, primary medical treatment and hospitals and has wide application prospects. And the method has the remarkable advantages of high precision, noninvasive safety and the like.

Description

Technical Field

[0001] This invention relates to the fields of non-invasive medical imaging, acoustic-optical coupling, and targeted drug delivery technology. Specifically, it refers to an integrated system and method that relies on intelligent processing equipment (including consumer-grade electronic devices and medical devices) to achieve non-invasive detection and precise tomographic localization of lesions in human tissues / body fluids through an integrated acoustic-optical coupling functional membrane layer, as well as the directional guidance and local enrichment of targeted drugs to lesions. It is applicable to the guidance of targeted drug treatment for various lesions such as solid tumors, hematological malignancies, viral infections, chronic inflammatory lesions, and fibrotic lesions. Background Technology

[0002] Current targeted drug therapies suffer from low lesion enrichment rates and significant systemic side effects. Furthermore, lesion detection and localization, along with targeted drug delivery, are separate processes requiring various high-cost, bulky medical devices. Some of these devices are contraindicated due to ionizing radiation or strong magnetic fields, hindering their widespread adoption in primary care and home settings. While conventional consumer-grade smart devices (smartphones, tablets, etc.) have extremely high penetration rates, they lack medical ultrasound imaging capabilities and have not been developed for targeted drug guidance. Existing acousto-optic coupling functional membranes are only used for imaging or treatment, without publicly demonstrating the integration of "acoustic-optic transmission imaging localization" and "precise targeted drug guidance" through the same membrane and physical region. Moreover, they lack seamless compatibility with consumer electronic devices, resulting in a lack of low-cost, widely applicable integrated solutions.

[0003] Clinical studies have shown that precise focusing of energy / fields such as light, sound, magnetism, and electricity can improve the lesion enrichment rate of targeted drugs, while gentle energy guidance causes no tissue damage. Currently, there is an urgent need for a technical solution that integrates lesion detection and localization with targeted drug guidance, is compatible with consumer-grade smart devices, requires no hardware modification, and is low-cost and easily accessible. This solution would address the pain point of the current separation between targeted drug treatment and diagnostic equipment, while also overcoming the problems of unclear functional membrane structure and ambiguous coupling of guidance mechanisms in existing technologies. Summary of the Invention

[0004] (I) System Composition The system of this invention consists of at least one intelligent processing carrier, an integrated acoustic-optical coupling functional membrane, a scanning mechanism, a targeted drug guidance module, and a processing and positioning module. It requires no modification to the carrier hardware and achieves an integrated closed loop of "lesion detection - precise positioning - targeted drug guidance." Its core innovation lies in the first-ever integration of medical-grade ultrasound imaging and targeted drug guidance functions into a consumer-grade electronic device. Intelligent processing carriers include consumer electronic devices (mobile phones, tablets) and medical devices (medical all-in-one machines, dedicated diagnostic hosts), all of which have the ability to transmit audio at 20Hz-20kHz, collect echoes, and process signals. The optical signal unit is not a necessary configuration and can be directly adapted to this system without hardware modification, giving full play to the advantages of the widespread use of consumer devices and reducing the cost of use.

[0005] Acousto-optic coupling integrated functional membrane: The core integrated functional structure (continuous and complete, with indivisible functions) enables time-division imaging and targeted drug guidance within the same region, with flexible forms (film / integration / coating, etc.). The four core layers work together: Coupling matching layer: Biocompatible material, eliminating air loss and achieving acoustic / optical / energy impedance matching; Acoustic processing layer: Multi-level resonant microcavity array, which completes the frequency doubling conversion of low-frequency signals to medical ultrasound to ensure imaging accuracy; Optical / Energy Conduction Layer: Define the materials (optical resin, light-transmitting polymer, fiber array, conductive film) and thickness (0.01-0.1mm) to achieve imaging light signal transmission and optical / acoustic / electric guided energy focusing and delivery, while magnetic guided energy can directly penetrate; Acousto-optic isolation layer: an anti-interference material to prevent crosstalk between imaging and guidance signals.

[0006] Scanning mechanism: It can complete the screening of lesions in the whole human body through various relative scanning methods, with no imaging blind spots, and can be operated manually or by simple devices.

[0007] Targeted drug guidance module: Clearly defines the coupling method with the membrane layer (integrated into the carrier, external interface, independent bonding), provides multiple types of guidance energy / field, adapts to multiple types of targeted drugs, and has adjustable output intensity.

[0008] Processing and Positioning Module: The system control center, which clarifies the implementation of the time-sharing isolation mechanism (shutting down the acoustic emission unit and shielding the echo acquisition channel), realizes imaging reconstruction, three-dimensional positioning of lesions, time-sharing control, energy regulation, safety monitoring and data recording, and works in conjunction with the carrier processor.

[0009] (II) Working Methods This invention achieves imaging localization and targeted drug guidance in the same physical region of the same membrane layer in a time-division manner. The operation process is simple, and the core steps are as follows: Membrane configuration (closely fits the human body) → Full-domain scanning imaging (detects lesions) → 3D localization of lesions (calibrates coordinates) → Time-segmented isolation (closes acoustic channels) → Targeted drug guidance (precise energy / field focusing to achieve drug enrichment in lesions) → Effect verification and data recording (restart imaging verification, quantify enrichment rate, record full-process data) → Collaborative guidance for deep / multiple lesions (multi-device energy / field overlay, distributed zonal guidance).

[0010] The drug enrichment rate is quantified by high performance liquid chromatography or near-infrared fluorescence imaging. Compared with conventional administration methods, the improvement rate is ≥60%, ensuring that the technical effect can be verified.

[0011] (III) Beneficial Effects Its core innovation is outstanding: it enables the detection and localization of lesions and the guidance of targeted drugs in the same physical area of ​​the same membrane layer at different times, and it is the first to be compatible with consumer electronic devices (mobile phones, tablets), achieving medical-grade functions without the need to modify the hardware, breaking through the limitations of existing technologies and realizing low-cost popularization.

[0012] Clear structure and well-defined coupling: The material, structure and function of the optical / energy conduction layer are clearly defined, the coupling mode between the targeted drug guiding module and the membrane layer is clarified, and the problems of unclear structure and unclear coupling in the existing technology are solved. The technical solution is reproducible.

[0013] Precise guidance and low side effects: Ultrasound provides precise three-dimensional localization of lesions, guiding energy / fields to focus precisely, increasing drug accumulation rate in lesions by ≥60% compared to conventional drug administration, reducing systemic distribution, and significantly reducing the side effects of targeted drugs.

[0014] Multi-drug and multi-mode compatibility: It can be matched with various targeted drugs such as photodynamic therapy, sonodynamic therapy, and magnetic nanoparticle drug delivery, and supports multiple guidance methods such as light, sound, magnetism, and electricity, making it suitable for various lesions.

[0015] Non-invasive, safe, and without contraindications: The entire process uses non-invasive ultrasound imaging combined with gentle energy / field guidance, eliminating contraindications to ionizing radiation and strong magnetic fields; the membrane is made of biocompatible materials, and the guiding energy intensity is adjustable, causing no tissue damage.

[0016] Widely compatible and flexible in various scenarios: It supports both consumer and medical devices, and the membrane layer is flexible, enabling applications in multiple scenarios such as home self-examination guidance, primary healthcare screening guidance, and hospital clinical treatment guidance. Detailed Implementation

[0017] The technical solution of the present invention is described below with reference to the embodiments. Any modifications that do not deviate from the core principle of the present invention, namely, "realizing lesion detection and localization and targeted drug guidance in the same physical area of ​​the same membrane layer at different times, and adapting to consumer electronic devices without modification," are all within the scope of protection.

[0018] General testing conditions: ambient temperature 25℃, humidity 50%; ultrasound echo signal-to-noise ratio test using ATS 539 standard ultrasound phantom, repeated 10 times; drug enrichment rate test: with the same drug dose and the same time point, compared with the conventional administration method, quantitative analysis was performed using high performance liquid chromatography.

[0019] Example 1: Smartphone + Flexible Film + Photodynamic Guidance (Superficial Tumors / Photodynamic Targeted Drugs) The intelligent processing carrier is a regular smartphone (without hardware modifications). The integrated acoustic-optical coupling functional membrane is a flexible film attached to the corresponding areas of the phone's speaker, microphone, and camera, with a total membrane thickness of 0.1mm. The acoustic processing layer is a three-level resonant microcavity array (1μm thin film + 2μm air gap). The optical / energy conduction layer is made of optical resin with a thickness of 0.02mm, and the tested echo signal-to-noise ratio is 16.5±1.2dB. The scanning method involves manually holding the phone and swinging it in an arc to achieve relative scanning between the membrane and the human body. The targeted drug guidance module is a near-infrared light emitting unit integrated into the phone's camera (integrated into the carrier). During operation, the membrane is first attached to the corresponding area of ​​the mobile phone, ensuring close contact between the coupling matching layer and the superficial tumor site. The mobile phone then emits a low-frequency signal, which is doubled by the membrane to 2MHz for ultrasound scanning and imaging. The processing and positioning module reconstructs the tomographic image and calibrates the tumor's three-dimensional coordinates. After shutting down the acoustic emission unit and microphone acquisition channel, the photodynamic targeted drug is applied to the lesion surface. The near-infrared light emission unit is then activated, and the near-infrared light is precisely focused on the tumor coordinate area through the optical / energy conduction layer, guiding the drug to penetrate and accumulate within the tumor tissue. After guidance is complete, the acoustic channel is restarted to verify the drug accumulation effect. High-performance liquid chromatography (HPLC) detection shows that the drug accumulation concentration at the lesion is 80% higher than with conventional application, with no significant systemic distribution. This method is suitable for home / primary care screening guidance, and the mobile phone can achieve medical-grade functionality without hardware modifications.

[0020] Example 2: Integrated medical device + integrated membrane + magnetic targeted focusing guidance (deep solid tumors / magnetic nanoparticles for drug delivery) The intelligent processing carrier is a medical integrated machine. The integrated acoustic-optical coupling functional membrane is an integrated membrane located at the probe head of the integrated machine, with a total membrane thickness of 0.8mm. The acoustic processing layer is a three-level resonant microcavity array (3μm thin film + 5μm air gap). The optical / energy conduction layer is made of light-transmitting polymer material with a thickness of 0.05mm. The echo signal-to-noise ratio is 16.2±1.3dB at a working frequency of 2MHz. The scanning method involves three integrated machines arranged in a triangular array, achieving collaborative scanning of deep lesions through 360° rotation and horizontal translation of the probe head. The targeted drug guidance module is an external magnetic targeting generation unit connected to the integrated machine interface. During operation, the membrane adheres closely to the deep abdominal / thoracic tumor (>3cm). Three integrated machines scan collaboratively, emitting low-frequency signals that are frequency-doubled to 5MHz by the membrane to complete deep tomographic imaging and pinpoint the tumor's precise three-dimensional coordinates. After shutting down the acoustic emission unit and sound acquisition channel, magnetic nanoparticles are injected intravenously, activating the magnetic targeting unit. The magnetically guided energy penetrates the membrane and is precisely focused on the tumor area, guiding the magnetic nanoparticles in the blood to move directionally and accumulate locally in the tumor tissue. After guidance is completed, the acoustic channel is restarted to verify the accumulation. Near-infrared fluorescence imaging shows that the drug concentration at the lesion is 60% higher than that of conventional intravenous injection, and the systemic toxic side effects of chemotherapy drugs are significantly reduced, making it suitable for clinical treatment in hospitals.

[0021] Example 3: Dedicated diagnostic and treatment host + coated membrane + ultrasound-guided transdermal penetration enhancement (chronic inflammation / topical targeted drugs) The intelligent processing carrier is a dedicated diagnostic and treatment host. The integrated acoustic-optical coupling functional membrane is a coated membrane, fabricated as a continuous integral structure on the host's detection surface, with a total membrane thickness of 0.5 mm. The acoustic processing layer is a three-level resonant microcavity array (2 μm thin film + 3 μm air gap). The optical / energy conduction layer uses fiber optic array material with a thickness of 0.03 mm and an echo signal-to-noise ratio ≥15 dB. The scanning method involves 6 hosts arranged in a ring array to achieve full-area scanning of the inflammatory lesion. The targeted drug guidance module is a low-intensity ultrasound generator integrated into the host. During operation, the membrane coupling matching layer adheres closely to the site of chronic inflammation in the human body. Six main units work together to scan and complete imaging, calibrating the three-dimensional coordinates of the inflammatory lesion. After shutting down the acoustic emission unit and the sound acquisition channel, the topical anti-inflammatory targeted drug is applied to the surface of the inflammatory lesion. The low-intensity ultrasound generation unit is then activated, and the ultrasound is precisely focused on the coordinate area of ​​the inflammatory lesion through the optical / energy conduction layer. The ultrasound cavitation effect promotes the transdermal penetration of the targeted drug. After the guidance is completed, the acoustic channel is restarted to verify the drug penetration effect. The temperature of the guided area is monitored throughout the process. Detection by high-performance liquid chromatography shows that the drug concentration in the inflamed tissue is increased by 70% compared to conventional application, and the onset time is shortened by 50%, making it suitable for specialist outpatient treatment.

[0022] Example 4: Multi-device hybrid array + acoustic dynamic guidance (HIV infection focus / acoustic targeted drug) The intelligent processing carrier is a hybrid array consisting of mobile phones, tablets, and medical all-in-one machines, with no hardware modifications required for any of the devices. The integrated acoustic-optical coupling functional membrane layer is configured with flexible films (mobile phones / tablets) or integrated films (medical all-in-one machines) depending on the device type. The optical / energy conduction layers are made of optical resin or light-transmitting polymer materials, both meeting the core imaging and guidance function requirements, with an echo signal-to-noise ratio of ≥15dB. The scanning method involves multiple devices arranged around the human body, combined with limb movements to complete a full-body scan without blind spots. The targeted drug guidance module is a low-intensity ultrasound generator integrated into each device. During the procedure, all devices are equipped with corresponding membranes and fit tightly against various parts of the body. Multiple devices work together to scan and complete whole-body tomographic imaging, identifying and calibrating the three-dimensional coordinates of HIV infection foci. After shutting down the acoustic channels of each device, the patient is given an oral sonodynamic targeted drug. The multiple devices are activated in stages according to the coordinates of the infection foci. The ultrasound is precisely focused on each infection foci area through the membrane, activating the sonodynamic targeted drug and guiding the drug to accumulate in the cells of the infection foci. After the guidance is completed, the imaging channel is restarted to verify each infection foci one by one. Through near-infrared fluorescence imaging, the drug concentration at the infection foci is increased by 90% compared to conventional oral administration, avoiding systemic side effects such as liver and kidney damage and bone marrow suppression, making it suitable for infectious disease specialist diagnosis and treatment.

[0023] Example 5: Embedded host + embedded membrane + electroporation-guided permeation (fibrotic lesions / targeted repair drugs) The intelligent processing carrier is an embedded diagnostic host. The integrated acoustic-optical coupling functional membrane is an embedded diaphragm located at the host's probe end, with a total membrane thickness of 0.2 mm. The acoustic processing layer is a three-level resonant microcavity array (1.5 μm thin film + 3 μm air gap). The optical / energy conduction layer is an embedded conductive polymer film with a thickness of 0.01 mm and an echo signal-to-noise ratio of 15.8 ± 1.0 dB. The scanning method involves the arc-shaped oscillation of the host's probe end to achieve precise local scanning of the liver area. The targeted drug guidance module is a microcurrent electroporation unit integrated into the host. During operation, the membrane adheres closely to the liver. The main unit emits a low-frequency signal, which is frequency-doubled to 3MHz by the membrane to scan and image the liver fibrosis lesions, calibrating their three-dimensional coordinates. After closing the acoustic channel, the targeted repair drug is injected into the tissue surrounding the lesion. The electroporation unit is then activated, and a microcurrent is precisely focused onto the fibrotic lesion area through a conductive polymer film. The electroporation effect opens the tissue cell membrane channels, promoting the penetration of the targeted repair drug into the lesion cells. After the procedure is completed, the acoustic channel is restarted to verify the drug enrichment effect. The microcurrent intensity is monitored throughout the process, and high-performance liquid chromatography (HPLC) is used to detect that the drug enrichment concentration in the lesion is 75% higher than that of conventional local injection, accelerating the reversal of fibrotic tissue. This method is suitable for gastroenterology / hepatology treatment.

Claims

1. A lesion detection, localization, and targeted drug guidance system based on an acousto-optic coupling functional membrane, characterized in that, It includes at least one intelligent processing carrier, an integrated acoustic-optical coupling functional membrane, a scanning mechanism, a targeted drug guidance module, and a processing and positioning module; The intelligent processing carrier is an electronic device equipped with an acoustic emission unit, a sound pickup unit, an optical unit, and a processor. It can generate audio / vibration signals of at least 20Hz-20kHz, collect echo signals, and perform signal processing and control. It can be adapted without modifying the hardware and includes, but is not limited to, mobile phones, tablets, computers, medical all-in-one machines, embedded terminals, and dedicated diagnostic and treatment hosts. The integrated acoustic-optical coupling functional membrane is an integrated functional structure (continuous and complete, with indivisible functions). It is configured on a carrier in any form, such as a flexible film, rigid membrane, built-in layer, coating, film, or embedded component in the outer shell. It achieves the following time-division multiplexing from the same physical region: ① frequency conversion, focusing, and transmission-type tomographic imaging of human tissue / fluid to complete lesion detection and precise localization; ② targeted drug delivery guided by energy / field coupling to achieve drug enrichment in lesions; the total membrane thickness is 0.05mm–5mm, and includes at least: Coupling matching layer: Biocompatible materials (medical hydrophilic gel, optical resin) to achieve acoustic / optical / energy impedance matching and eliminate air loss; Acoustic processing layer: A multi-level resonant microcavity array composed of a micron-level thin film (preferably 0.5-5μm) + an air gap (preferably 1-10μm), with a single-level frequency doubling coefficient of 10-20, and three levels connected in series to achieve a frequency doubling of 1000-8000 times, doubling the 20Hz–20kHz low-frequency signal to the 2MHz–10MHz medical ultrasound frequency band, with an echo signal-to-noise ratio ≥15dB; Optical / Energy Conduction Layer: Materials include optical resin, light-transmitting polymer, fiber array or conductive film (adapted for electroporation guidance), with a thickness of 0.01-0.1 mm. Imaging light signals are transmitted through this layer, and energy / fields (light, sound, electricity) are focused and delivered through this layer. Magnetic energy can penetrate this layer and act directly on the lesion. Acousto-optic isolation layer: anti-signal interference materials (porous acoustic foam, metal shielding film) to avoid crosstalk between imaging and guidance signals; The scanning mechanism realizes relative scanning between the carrier / membrane layer and the human body / body fluid. The scanning methods include at least one of rotation, translation, arc swing, multi-device fixed array, human body / partial limb movement, and movement of the support device supporting the human body. The targeted drug guiding module can generate one or more guiding energies / fields among photodynamic, acoustic, magnetic targeting, ultrasound transdermal permeation, and electroporation permeation. The module can be integrated inside the intelligent processing carrier, externally connected to the carrier interface, or attached to the membrane as an independent unit. The photodynamic / acoustic / electric guiding energy is precisely focused on the lesion area through the optical / energy conduction layer of the membrane, while the magnetic guiding energy penetrates the membrane and acts directly. The processing and positioning module enables echo signal acquisition, noise reduction, tomographic image reconstruction, precise three-dimensional localization of lesions, time-division isolation control of imaging and guidance, and adjustment of guidance energy / field output. It can be equipped with a micro-sensor integrated into the membrane layer to monitor physiological parameters of the guidance area in real time.

2. The system according to claim 1, characterized in that, The materials, morphology, molding process, and assembly method of the acoustic-optical coupling integrated functional membrane layer, as long as they achieve the functions of acoustic frequency conversion focusing, lesion imaging and positioning, and targeted drug guidance energy / field coupling focusing and delivery, are all within the scope of protection of this invention; membrane layers in the form of coatings, platings, etc., are continuous integrated structures with complete functions, and the assembly timing is not limited by factory-installed / user-terminal attachment.

3. The system according to claim 1, characterized in that, The system employs a time-division isolation mechanism for imaging and targeted drug guidance, which is implemented by the processing and positioning module through timing scheduling: before guidance, the acoustic emission unit of the intelligent processing carrier is shut down and the echo acquisition channel of the pickup unit is shielded, completely blocking the transmission of acoustic signals; during guidance, any acoustic signal emission and acquisition are prohibited to avoid interference with the guidance energy / field; after guidance is completed, the acoustic emission unit and echo acquisition channel are restarted through the processing and positioning module to restore the imaging function.

4. The system according to claim 1, characterized in that, The targeted drug includes at least one of photodynamic targeted drugs, acoustic targeted drugs, magnetic nanoparticles, liposome targeted drugs, and antibody-drug conjugate targeted drugs. The targeted drug guidance module matches the corresponding guidance method according to the type of targeted drug. In the case of electroporation-assisted permeation guidance, a conductive thin film (material is a conductive polymer or metal thin film) is embedded in the optical / energy conduction layer to realize microcurrent conduction.

5. The system according to claim 1, characterized in that, It can be used to work in collaboration with one or more carriers of any type, and achieve targeted drug guidance for deep lesions (>3cm), hematologic lesions, and multiple lesions throughout the body by superimposing energy / fields from multiple devices and angles. The methods include multi-device collaborative focusing, single-device multi-output head guidance, and multi-device time-sharing irradiation guidance.

6. A method for lesion detection, localization, and targeted drug guidance based on an acousto-optic coupling functional membrane, characterized in that, Includes the following steps: Step 1: Membrane configuration. The integrated acoustic-optical coupling functional membrane layer is configured in any way (film application, built-in, integrated, coating, plating, embedding) in the corresponding area of ​​the acoustic and optical units of the intelligent processing carrier, so that the coupling matching layer is tightly attached to the human body / body fluid to be detected and air gaps are eliminated. Step 2: Full-area scanning and lesion detection. The scanning mechanism completes a full-area scan of human tissues / fluids. The low-frequency signal output by the carrier is frequency-doubled to 2MHz–10MHz by the membrane layer and focused ultrasound is transmitted through the human body. After the echo is frequency-reduced and collected, the processing and positioning module reduces noise, analyzes and reconstructs the tomographic image to detect abnormal lesion areas. Step 3: Precise lesion localization. The processing and localization module identifies the lesion boundary and extent based on tomographic images and calibrates its precise three-dimensional coordinates. Step 4: Time-sharing isolation and targeted drug guidance. After the acoustic emission unit and echo acquisition channel are shut down by the processing and positioning module, the targeted drug is applied to the human body. The guiding energy / field of the targeted drug guidance module is precisely focused on the three-dimensional coordinate area of ​​the lesion through the same physical area of ​​the membrane. The light / sound / electric guiding energy is delivered through the optical / energy conduction layer, and the magnetic guiding energy penetrates the membrane to achieve directional movement, local enrichment or transdermal / tissue penetration guidance of the drug. Step 5: Guidance effect verification and data recording. The acoustic emission unit and echo acquisition channel are restarted through the processing and positioning module to verify the drug enrichment of lesions. The drug enrichment concentration is quantitatively analyzed by high performance liquid chromatography or near-infrared fluorescence imaging and compared with the drug concentration of the lesion at the same time point under the same dosage and conventional administration method (oral / intravenous injection / topical application). The enrichment improvement rate is ≥60%. The entire process records diagnostic and treatment data such as tomographic images, lesion coordinates, and guidance parameters. Step 6: Treatment of deep / multiple lesions. Deep lesions (>3cm) are treated by multi-device, multi-angle collaborative energy / field superposition to achieve deep focusing. Multiple lesions throughout the body are treated by multi-device array distributed partitioning and phased guidance.

7. The method according to claim 6, characterized in that, In step 6, the lesions include at least one of solid tumors, hematologic tumors, viral infections, chronic inflammation, and fibrotic lesions. When the intelligent processing carrier is a consumer-grade electronic device (mobile phone, tablet), medical-grade imaging positioning and targeted drug guidance functions can be achieved without modifying the hardware, significantly reducing the cost of diagnostic and treatment equipment.