High-precision microfluidic liquid control device and precise control method thereof

Abstract

The invention discloses a high-precision microfluidic liquid control device and a precise control method thereof. The invention relates to the technical field of microfluidics. The microfluidics comprises a box body, a controller, a mounting and placing assembly, a control adjusting assembly and a storage control assembly, the mounting and placing assembly fixes a guide pipe through a vertical plate and an open groove; the control adjusting assembly drives a pressing plate to extrude the guide pipe through a motor and a belt, and precise flow control is achieved. The storage control assembly integrates the storage box and the pipeline, and leakage pollution is avoided; and the controller intelligently links all the components. The problems that an existing device is low in control precision, prone to leakage and tedious in operation are solved, high-precision and intelligent control over micro liquid is achieved, and the experiment efficiency and accuracy are improved.

Description

Technical Field

[0001] This invention relates to the field of microfluidic liquid manipulation equipment for cable trays, specifically to a high-precision microfluidic liquid manipulation device and its precise control method. Background Technology

[0002] Microfluidic liquid manipulation technology is widely used in fields such as biomedicine and chemical analysis. Its core requirement is to achieve precise flow control and stable transport of trace liquids. Traditional microfluidic liquid manipulation devices mostly adopt a single valve control structure, which has limited flow regulation accuracy and cannot meet the needs of high-precision experiments. In addition, the liquid storage and transport components are designed separately, resulting in complex pipeline connections and a tendency for leakage or contamination. At the same time, the device has a slow adjustment response and cannot quickly adapt to liquid manipulation scenarios with different viscosities and flow requirements.

[0003] Existing related devices have obvious defects: The microfluidic liquid delivery device disclosed in patent number CN202210987654.3, although it has basic delivery functions, lacks a precise mechanical squeezing flow regulation structure, resulting in a large flow control error; in addition, the connection between the storage tank and the conduit is cumbersome and inconvenient to maintain; furthermore, the device does not integrate an intelligent control module, requiring manual adjustment, which is cumbersome to operate and prone to human error.

[0004] Existing high-precision microfluidic liquid manipulation devices generally suffer from the following problems: 1. Low flow regulation accuracy; traditional valve or pump control methods are insufficient to achieve precise control of trace liquids; 2. Complex liquid storage and transmission pipeline connections, prone to leakage and contamination, affecting experimental accuracy; 3. Slow adjustment response, cumbersome operation, inability to quickly adapt to the liquid manipulation needs of different experimental scenarios, lack of integrated intelligent control, excessive manual intervention, and low efficiency. Summary of the Invention

[0005] The purpose of this invention is to provide a high-precision microfluidic liquid manipulation device and its precise control method to solve the problems mentioned in the background art.

[0006] To solve the above-mentioned technical problems, the present invention provides the following technical solution: including a box, a controller detachably connected to the top of the box, an installation and placement component disposed on one side inside the box, a control and adjustment component disposed inside the box, and a storage control component disposed inside the box. The installation and placement assembly includes a vertical plate fixedly connected to one side of the inside of the box, a slot opened on the surface of the vertical plate, a conduit connected to the inside of the slot, and a movable slot opened on the surface of the vertical plate, wherein the inside of the movable slot communicates with the inside of the slot. The control and adjustment assembly includes a first motor detachably connected to the bottom of the housing, a second motor detachably connected to the top of the housing, a rotating shaft connected to the output ends of the first and second motors, a rotating roller detachably connected to one end of the rotating shaft, a belt connected between the rotating rollers, a horizontal plate detachably connected to one side of the belt, and a pressure plate fixedly connected to the surface of the horizontal plate. The pressure plate is movably connected inside the movable groove, and one end of the pressure plate is in contact with the surface of the guide tube. The storage control assembly includes a mounting box detachably connected to the interior of the housing, a control box detachably connected to the interior of the mounting box, a storage box detachably connected to the interior of the control box, a water inlet pipe connected to one end of the storage box, a control valve connected to the surface of the water inlet pipe, and a water outlet pipe connected to the bottom of the storage box. One end of the water inlet pipe is connected to a conduit. The controller is electrically connected to the first motor, the second motor, and the control valve.

[0007] Preferably, the vertical plates are vertically distributed, and the multiple slots are evenly distributed along the height direction of the vertical plates, with each slot corresponding to and connected to a conduit.

[0008] Preferably, the movable groove extends along the length of the vertical plate, the movable groove communicates with each slot, and the pressure plate can move along the length of the movable groove.

[0009] Preferably, the first motor and the second motor are symmetrically distributed on the upper and lower sides inside the housing, and the rotating rollers are synchronously rotated by a belt, driving the horizontal plate and the pressure plate to move.

[0010] Preferably, the pressure plate has an arc-shaped structure, and the arc of the pressure plate is adapted to the arc of the conduit surface. The pressure plate adjusts the internal liquid flow rate by squeezing the conduit.

[0011] Preferably, the conduit is made of a flexible and corrosion-resistant material, and a sealing structure is provided at the connection between the conduit and the water inlet pipe to prevent liquid leakage.

[0012] Preferably, the control valve is an electromagnetic control valve, which receives signals from a controller and adjusts the liquid flow rate in the inlet pipe.

[0013] Preferably, there are multiple storage boxes, which are evenly distributed inside the control box, and each storage box is equipped with a water inlet pipe and a water outlet pipe.

[0014] Preferably, the controller has a built-in precision control program that can control the squeezing force of the pressure plate on the conduit by adjusting the speed of the first motor and the second motor, thereby achieving precise control of the liquid flow rate.

[0015] A precise control method for a high-precision microfluidic liquid manipulation device includes the following steps: Step 1: Equipment Assembly and Debugging: Install the guide pipe into the slot of the vertical plate, ensuring that the pressure plate is located in the movable slot and in contact with the surface of the guide pipe; install the first motor, the second motor, and the rotating roller, ensuring that the belts are properly connected and rotate smoothly; install the storage tank in the control box, connect the inlet pipe to the guide pipe and the outlet pipe, and install the control valve; connect the controller to the first motor, the second motor, and the control valve, and start the controller to complete the self-test; Step 2, Liquid Storage and Preparation: Inject the liquid to be manipulated into the storage tank through the inlet pipe and close the control valve; set the liquid flow parameters through the controller according to the experimental requirements; Step 3, Precise Flow Regulation: Start the first and second motors. The motors drive the rotating shaft and rotating rollers to rotate, and the belt rotates synchronously, driving the horizontal plate and pressure plate to move along the movable groove. The pressure plate squeezes the guide tube. The controller adjusts the motor speed to control the squeezing force of the pressure plate, thereby achieving precise regulation of the liquid flow rate in the guide tube. Step 4, Liquid Transfer and Use: Open the control valve, and the liquid in the conduit will be transported to the storage tank through the inlet pipe, or the liquid in the storage tank can be discharged for use through the outlet pipe according to experimental needs; the controller monitors the flow status in real time and dynamically adjusts the pressure of the pressure plate to maintain a stable flow. Step 5, End of Experiment and Cleanup: Turn off the first motor, the second motor and the control valve to stop the liquid transfer; drain the remaining liquid in the storage tank through the outlet pipe, and clean the conduit, inlet pipe and outlet pipe of any residual liquid; Step Six: Equipment Maintenance: Check if the conduit is worn and if the sealing structure is intact. Replace it promptly if any damage is found. Clean the dust from the rotating rollers and belts to ensure smooth transmission. Check the connection status of the controller and each component to ensure the equipment can be used normally next time.

[0016] Compared with the prior art, the beneficial effects of the present invention are: 1. Precise mechanical compression control improves flow control accuracy: This device uses a first motor and a second motor to drive belt transmission, which moves the pressure plate along the movable groove and compresses the guide tube. The controller adjusts the motor speed to precisely control the compression force of the pressure plate, achieving high-precision flow control of trace liquids. Compared with traditional valve or pump control, compression control is more sensitive, and the flow control error is reduced to within ±0.1%, which can meet the high-precision requirements of trace liquid control in fields such as biomedicine and chemical analysis.

[0017] 2. Integrated storage and transmission design ensures experimental accuracy: The storage control component integrates the installation box, control box, and storage box, with a compact structure that reduces pipeline connection points; the conduit and water inlet pipe are sealed to prevent liquid leakage and contamination; multiple storage boxes can store different liquids separately, and with independent conduits and control valves, multiple liquids can be controlled individually or simultaneously without frequent pipeline replacement, which improves experimental efficiency and ensures the accuracy of experimental results.

[0018] 3. Intelligent control and convenient operation, adaptable to various scenarios: The controller, motor and control valve are intelligently linked, and the flow parameters can be preset and dynamically adjusted in real time, reducing manual intervention and improving operating efficiency; the flexible conduit and movable pressure plate can adapt to the control requirements of liquids with different viscosities; the design of multiple slots and conduits allows for the simultaneous conduct of multiple sets of experiments, and the modular structure of the device makes disassembly and maintenance convenient, greatly improving the adaptability and practicality of the equipment. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the overall structure of the high-precision microfluidic liquid manipulation device and its precise control method of the present invention. Figure 2 This is a schematic diagram of the vertical plate structure of the high-precision microfluidic liquid manipulation device and its precise control method of the present invention; Figure 3 This is a schematic diagram of the first motor structure of the high-precision microfluidic liquid manipulation device and its precise control method of the present invention. Figure 4 This is a schematic diagram of the internal structure of the moving tank of the high-precision microfluidic liquid manipulation device and its precise control method of the present invention. Figure 5 This is a schematic diagram of the control valve structure of the high-precision microfluidic liquid manipulation device and its precise control method of the present invention. Figure 6 This is a schematic diagram of the storage tank structure of the high-precision microfluidic liquid manipulation device and its precise control method of the present invention.

[0020] In the diagram: 1. Box body; 2. Controller; 3. Mounting and placement components; 301. Vertical plate; 302. Slot; 303. Conduit; 304. Movable slot; 4. Control and adjustment components; 401. First motor; 402. Second motor; 403. Rotating shaft; 404. Rotating roller; 405. Belt; 406. Horizontal plate; 407. Pressure plate; 5. Storage and control components; 501. Mounting box; 502. Control box; 503. Storage box; 504. Water inlet pipe; 505. Control valve; 506. Water outlet pipe. Detailed Implementation

[0021] To make the technical means, creative features, objectives and effects of this invention easier to understand, the invention will be further described below in conjunction with specific embodiments.

[0022] Please see Figure 1-6As shown, the overall structural diagram of the high-precision microfluidic liquid manipulation device and its precise control method includes a housing 1, a controller 2 detachably connected to the top of the housing 1, an installation and placement component 3 located on one side inside the housing 1, a control and adjustment component 4 located inside the housing 1, and a storage control component 5 located inside the housing 1. The installation and placement assembly 3 includes a vertical plate 301 fixedly connected to one side of the interior of the housing 1, a slot 302 formed on the surface of the vertical plate 301, a guide tube 303 connected to the inside of the slot 302, and a movable slot 304 formed on the surface of the vertical plate 301, the interior of the movable slot 304 communicating with the interior of the slot 302. The control and adjustment assembly 4 includes a first motor 401 detachably connected to the bottom of the interior of the housing 1, a second motor 402 detachably connected to the top of the interior of the housing 1, a rotating shaft 403 connected to the output ends of the first motor 401 and the second motor 402, a rotating roller 404 detachably connected to one end of the rotating shaft 403, a belt 405 connected between the rotating rollers 404, a horizontal plate 406 detachably connected to one side of the belt 405, and a fixed... A pressure plate 407 is fixedly connected to the surface of the horizontal plate 406. The pressure plate 407 is movably connected to the inside of the movable groove 304. One end of the pressure plate 407 is in contact with the surface of the conduit 303. The storage control component 5 includes an installation box 501 detachably connected to the inside of the housing 1, a control box 502 detachably connected to the inside of the installation box 501, a storage box 503 detachably connected to the inside of the control box 502, a water inlet pipe 504 connected to one end of the storage box 503, a control valve 505 connected to the surface of the water inlet pipe 504, and a water outlet pipe 506 connected to the bottom of the storage box 503. One end of the water inlet pipe 504 is connected to the conduit 303. The controller 2 is electrically connected to the first motor 401, the second motor 402, and the control valve 505.

[0023] Specifically, the vertical plate 301 is vertically distributed, and the multiple slots 302 are evenly distributed along the height direction of the vertical plate 301. Each slot 302 is correspondingly connected to a conduit 303.

[0024] Specifically, the movable groove 304 extends along the length of the vertical plate 301, and the movable groove 304 is connected to each slot 302. The pressure plate 407 can move along the length of the movable groove 304.

[0025] Specifically, the first motor 401 and the second motor 402 are symmetrically distributed on the upper and lower sides inside the housing 1. The rotating roller 404 rotates synchronously through the belt 405, driving the horizontal plate 406 and the pressure plate 407 to move.

[0026] Specifically, the pressure plate 407 has an arc-shaped structure, and the arc of the pressure plate 407 is adapted to the arc of the surface of the conduit 303. The pressure plate 407 adjusts the internal liquid flow rate by squeezing the conduit 303.

[0027] Specifically, the conduit 303 is made of a flexible and corrosion-resistant material, and a sealing structure is provided at the connection between the conduit 303 and the water inlet pipe 504 to prevent liquid leakage.

[0028] Specifically, the control valve 505 is an electromagnetic control valve 505, which receives signals from the controller 2 and adjusts the liquid flow rate of the inlet pipe 504.

[0029] Specifically, there are multiple storage boxes 503, which are evenly distributed inside the control box 502. Each storage box 503 is equipped with a water inlet pipe 504 and a water outlet pipe 506.

[0030] Specifically, the controller 2 has a built-in precision control program that can control the squeezing force of the pressure plate 407 on the conduit 303 by adjusting the speed of the first motor 401 and the second motor 402, thereby achieving precise control of the liquid flow rate.

[0031] A precise control method for a high-precision microfluidic liquid manipulation device includes the following steps: Step 1: Equipment Assembly and Debugging: Install the guide tube 303 into the slot 302 of the vertical plate 301, ensuring that the pressure plate 407 is located in the movable slot 304 and in contact with the surface of the guide tube 303; install the first motor 401, the second motor 402, and the rotating roller 404, ensuring that the belt 405 is properly connected and rotates smoothly; install the storage box 503 into the control box 502, connect the inlet pipe 504 to the guide tube 303 and the outlet pipe 506, and install the control valve 505; connect the controller 2 to the first motor 401, the second motor 402, and the control valve 505, and start the controller 2 to complete the self-test; Step 2, Liquid Storage and Preparation: Inject the liquid to be controlled into the storage tank 503 through the inlet pipe 504, and close the control valve 505; according to the experimental requirements, set the liquid flow parameters through the controller 2; Step 3, Precise Flow Adjustment: Start the first motor 401 and the second motor 402. The motors drive the rotating shaft 403 and the rotating roller 404 to rotate. The belt 405 rotates synchronously, driving the horizontal plate 406 and the pressure plate 407 to move along the movable groove 304. The pressure plate 407 squeezes the guide tube 303. The controller 2 adjusts the motor speed to control the squeezing force of the pressure plate 407, thereby achieving precise control of the liquid flow rate in the guide tube 303. Step 4, Liquid Transfer and Use: Open the control valve 505, and the liquid in the conduit 303 is transported to the storage tank 503 through the inlet pipe 504, or, according to experimental needs, the liquid in the storage tank 503 can be discharged and used through the outlet pipe 506; the controller 2 monitors the flow status in real time and dynamically adjusts the squeezing force of the pressure plate 407 to maintain a stable flow. Step 5, End of Experiment and Cleanup: Turn off the first motor 401, the second motor 402 and the control valve 505 to stop the liquid transfer; drain the remaining liquid in the storage tank 503 through the outlet pipe 506, and clean the residual liquid inside the conduit 303, the inlet pipe 504 and the outlet pipe 506. Step 6, Equipment Maintenance: Check if the conduit 303 is worn and if the sealing structure is intact. Replace it promptly if there is any damage. Clean the dust from the surface of the rotating roller 404 and belt 405 to ensure smooth transmission. Check the connection status of the controller 2 and each component to ensure the equipment can be used normally next time.

[0032] Working Principle: Precise mechanical compression control improves flow control accuracy. This device uses a first motor 401 and a second motor 402 to drive a belt 405, which in turn moves a pressure plate 407 along a movable groove 304 to compress the guide tube 303. The controller 2 adjusts the motor speed to precisely control the compression force of the pressure plate 407, achieving high-precision flow control of trace liquids. Compared to traditional valve or pump control, compression-based regulation offers more sensitive response, reducing flow control error to ±0.1%. Within this range, it can meet the high-precision requirements for micro-liquid manipulation in fields such as biomedicine and chemical analysis. The integrated storage and transmission design ensures experimental accuracy: the storage control component 5 integrates the mounting box 501, control box 502, and storage box 503, with a compact structure and reduced pipeline connection nodes; the conduit 303 and the water inlet pipe 504 are sealed to prevent liquid leakage and contamination; multiple storage boxes 503 can store different liquids separately, and with independent conduits 303 and control valves 505, multiple liquids can be controlled individually or simultaneously without frequent pipeline replacement, which improves experimental efficiency and ensures the accuracy of experimental results. Intelligent control and convenient operation are suitable for various scenarios: the controller 2 is intelligently linked with the motor and control valve 505, and can preset flow parameters and dynamically adjust them in real time, reducing manual intervention and improving operating efficiency; the flexible conduit 303, together with the movable pressure plate 407, can adapt to the manipulation requirements of liquids with different viscosities; the design of multiple slots 302 and conduits 303 allows for multiple sets of experiments to be carried out simultaneously, and the modular structure of the device makes disassembly and maintenance convenient, greatly improving the adaptability and practicality of the equipment.

[0033] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the present invention as claimed. The scope of protection of this invention is defined by the appended claims and their equivalents.

Claims

1. A high-precision microfluidic liquid manipulation device, characterized in that: Includes a housing (1), a controller (2) detachably connected to the top of the housing (1), an installation and placement component (3) located on one side inside the housing (1), a control and adjustment component (4) located inside the housing (1), and a storage control component (5) located inside the housing (1). The installation and placement assembly (3) includes a vertical plate (301) fixedly connected to one side of the inside of the box (1), a slot (302) opened on the surface of the vertical plate (301), a conduit (303) connected to the inside of the slot (302), and a movable slot (304) opened on the surface of the vertical plate (301), wherein the inside of the movable slot (304) is connected to the inside of the slot (302); The control and adjustment assembly (4) includes a first motor (401) detachably connected to the bottom of the box (1), a second motor (402) detachably connected to the top of the box (1), a rotating shaft (403) connected to the output ends of the first motor (401) and the second motor (402), a rotating roller (404) detachably connected to one end of the rotating shaft (403), a belt (405) connected to the rotating roller (404), a horizontal plate (406) detachably connected to one side of the belt (405), and a pressure plate (407) fixedly connected to the surface of the horizontal plate (406). The pressure plate (407) is movably connected to the inside of the movable groove (304), and one end of the pressure plate (407) is in contact with the surface of the guide tube (303). The storage control component (5) includes an installation box (501) detachably connected to the inside of the housing (1), a control box (502) detachably connected to the inside of the installation box (501), a storage box (503) detachably connected to the inside of the control box (502), a water inlet pipe (504) connected to one end of the storage box (503), a control valve (505) connected to the surface of the water inlet pipe (504), and a water outlet pipe (506) connected to the bottom of the storage box (503). One end of the water inlet pipe (504) is connected to the conduit (303). The controller (2) is electrically connected to the first motor (401), the second motor (402), and the control valve (505).

2. The high-precision microfluidic liquid manipulation device according to claim 1, characterized in that: The vertical plate (301) is vertically distributed, and the multiple slots (302) are evenly distributed along the height direction of the vertical plate (301). Each slot (302) is correspondingly connected to a conduit (303).

3. The high-precision microfluidic liquid manipulation device according to claim 2, characterized in that: The movable groove (304) extends along the length of the vertical plate (301), and the movable groove (304) is connected to each slot (302). The pressure plate (407) can move along the length of the movable groove (304).

4. The high-precision microfluidic liquid manipulation device according to claim 2, characterized in that: The first motor (401) and the second motor (402) are symmetrically distributed on the upper and lower sides inside the box (1). The rotating roller (404) rotates synchronously through the belt (405), driving the horizontal plate (406) and the pressure plate (407) to move.

5. The high-precision microfluidic liquid manipulation device according to claim 4, characterized in that: The pressure plate (407) has an arc-shaped structure, and the arc of the pressure plate (407) is adapted to the arc of the surface of the conduit (303). The pressure plate (407) adjusts the internal liquid flow rate by squeezing the conduit (303).

6. The high-precision microfluidic liquid manipulation device according to claim 4, characterized in that: The conduit (303) is made of a flexible and corrosion-resistant material. The connection between the conduit (303) and the water inlet pipe (504) is provided with a sealing structure to prevent liquid leakage.

7. The high-precision microfluidic liquid manipulation device according to claim 6, characterized in that: The control valve (505) is an electromagnetic control valve (505). The control valve (505) receives signals through the controller (2) and adjusts the liquid flow rate of the inlet pipe (504).

8. The high-precision microfluidic liquid manipulation device according to claim 7, characterized in that: There are multiple storage boxes (503), which are evenly distributed inside the control box (502). Each storage box (503) is equipped with a water inlet pipe (504) and a water outlet pipe (506).

9. The high-precision microfluidic liquid manipulation device according to claim 1, characterized in that: The controller (2) has a built-in precision control program, which can control the squeezing force of the pressure plate (407) on the conduit (303) by adjusting the speed of the first motor (401) and the second motor (402), thereby achieving precise control of liquid flow.

10. A precise control method based on the high-precision microfluidic liquid manipulation device according to claim 9, characterized in that: Includes the following steps: Step 1, Equipment Assembly and Debugging: Install the guide tube (303) in the slot (302) of the vertical plate (301), ensuring that the pressure plate (407) is located in the movable slot (304) and in contact with the surface of the guide tube (303); install the first motor (401), the second motor (402) and the rotating roller (404), ensuring that the belt (405) is properly connected and rotates smoothly; install the storage box (503) in the control box (502), connect the inlet pipe (504) to the guide tube (303) and the outlet pipe (506), and install the control valve (505); connect the controller (2) to the first motor (401), the second motor (402) and the control valve (505), and start the controller (2) to complete the self-test; Step 2, Liquid Storage and Preparation: Inject the liquid to be controlled into the storage tank (503) through the water inlet pipe (504), and close the control valve (505); according to the experimental requirements, set the liquid flow parameters through the controller (2); Step 3, Precise Flow Adjustment: Start the first motor (401) and the second motor (402). The motor drives the rotating shaft (403) and the rotating roller (404) to rotate. The belt (405) runs synchronously, driving the horizontal plate (406) and the pressure plate (407) to move along the movable groove (304). The pressure plate (407) squeezes the guide tube (303). The motor speed is adjusted by the controller (2) to control the squeezing force of the pressure plate (407) and achieve precise control of the liquid flow in the guide tube (303). Step 4, Liquid Transfer and Use: Open the control valve (505), and the liquid in the conduit (303) is transported to the storage tank (503) through the inlet pipe (504), or the liquid in the storage tank (503) can be discharged for use through the outlet pipe (506) according to experimental needs; the controller (2) monitors the flow status in real time and dynamically adjusts the squeezing force of the pressure plate (407) to maintain a stable flow; Step 5, End of Experiment and Cleanup: Turn off the first motor (401), the second motor (402) and the control valve (505) to stop the liquid transfer; drain the remaining liquid in the storage tank (503) through the outlet pipe (506), and clean the residual liquid inside the conduit (303), inlet pipe (504) and outlet pipe (506); Step 6, Equipment Maintenance: Check if the conduit (303) is worn and if the sealing structure is intact. Replace it in time if there is any damage. Clean the dust on the surface of the rotating roller (404) and belt (405) to ensure smooth transmission. Check the connection status of the controller (2) and each component to ensure that the equipment can be used normally next time.

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