Noon tea tablet and preparation method thereof

Abstract

The invention provides noon tea tablets and a preparation method thereof. The noon tea tablets are successfully prepared by using a wet granulation process, the problem that the original noon tea preparations (granules and hard capsules) are inconvenient to use is solved, and the noon tea tablets better meet the market requirements. The preparation method of the tablet composition is simple in process, reduces the cost of a medicinal preparation, is economical, and is suitable for large-scale industrial production.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical preparation technology, specifically to a noon tea tablet and its preparation method. Background Technology

[0002] The Wu Shi Cha formula originates from Tian Zhong Cha in the Qing Dynasty's *Ba Cui Liang Fang* (Exquisite Prescriptions), and is modified from it. It is a tea bag preparation, and the formula consists of: Atractylodes lancea, Bupleurum chinense, Notopterygium incisum, Saposhnikovia divaricata, Angelica dahurica, Ligusticum chuanxiong, Pogostemon cablin, Peucedanum praeruptorum, Forsythia suspensa, Citrus reticulata peel, Crataegus pinnatifida, Citrus aurantium, Malt (fried), Glycyrrhiza uralensis, Massa fermentata (fried), Platycodon grandiflorus, Perilla frutescens, Magnolia officinalis, and black tea. The formula has a sweet and bitter taste, with a tea aroma, and functions to dispel wind and cold, clear the exterior and promote digestion, and resolve turbidity and harmonize the stomach. It is mainly used to treat exogenous wind-cold, headache and cough, body aches, chills or mild fever, internal food stagnation, dampness and food obstruction, abdominal distension, loss of appetite, or accompanied by chills, nausea and diarrhea, fatigue, seasickness, motion sickness, and acclimatization problems. In modern clinical practice, morning tea is often used to treat symptoms such as vomiting and diarrhea, chills and fever caused by exogenous wind-cold combined with spleen and stomach dysfunction, or loss of appetite and abdominal discomfort caused by water and soil incompatibility.

[0003] Many families are accustomed to using Wu Shi Cha (a traditional Chinese herbal tea) when they have a cold or diarrhea. However, the Wu Shi Cha granules and hard capsules available on the market still cannot fully meet the market demands of modern society. Granules are more expensive, prone to deliquescence, have slightly poorer palatability, and are not convenient to use. Hard capsules are slower to take effect and are more expensive.

[0004] Therefore, we hope to explore the preparation of noon tea tablets to solve the problems of inconvenience in using noon tea and its high cost. Summary of the Invention

[0006] In view of this, the present invention proposes a midday tea tablet and a preparation method to solve the above problems.

[0007] The technology of the present invention is implemented as follows: a midday tea tablet, said tablet being made from the following raw and excipient materials: midday tea extract, microcrystalline cellulose, sodium carboxymethyl starch, and magnesium stearate.

[0008] A further embodiment is that the tablets are made from the following raw and excipient materials in weight percentage: internal addition: 35%-38% of tea extract (after drying); 53%-60% of microcrystalline cellulose; external addition: 5%-7% of sodium carboxymethyl starch; 0.8%-1.2% of magnesium stearate.

[0009] A further embodiment is that the tablet comprises the following components: internal addition: 5g of midday tea extract (dried weight); 7.5g of microcrystalline cellulose; external addition: 0.8g of sodium carboxymethyl starch; 0.13g of magnesium stearate.

[0010] A further option is that the noon tea extract is prepared from the following medicinal materials: Atractylodes lancea, Bupleurum chinense, Notopterygium incisum, Saposhnikovia divaricata, Angelica dahurica, Ligusticum chuanxiong, Pogostemon cablin, Peucedanum praeruptorum, Forsythia suspensa, Citrus reticulata peel, Crataegus pinnatifida, Citrus aurantium, Hordeum vulgare (fried), Glycyrrhiza uralensis, Massa fermentata (fried), Platycodon grandiflorus, Perilla frutescens leaf, and Magnolia officinalis.

[0011] A further method is to prepare the noon tea extract by the following method: soak each medicinal material in distilled water at room temperature for 64 minutes, and decoct twice, each time for 1 hour. Filter with gauze, mix the filtrates, evaporate to a thick paste, and cool at room temperature.

[0012] The method for preparing afternoon tea tablets of the present invention includes the following steps: The extract was mixed with microcrystalline cellulose to prepare a suitable soft material. After adding a small amount of anhydrous ethanol, granulate quickly through a 10-mesh sieve. Dry the granules and sieve them through a 16-mesh and an 80-mesh sieve to obtain granules. Add magnesium stearate and sodium carboxymethyl starch, then compress into tablets.

[0013] The noon tea tablets prepared by this invention exhibit good disintegration and the process is simple, which helps to solve the problem of inconvenience in using other dosage forms of noon tea. Attached Figure Description

[0014] Figure 1 : Prepare soft materials from raw materials.

[0015] Figure 2 : Prepare tablets from soft materials and test them. Detailed Implementation To better understand the technical content of this invention, specific embodiments are provided below to further illustrate the invention.

[0016] Unless otherwise specified, the experimental methods used in the embodiments of this invention are all conventional methods.

[0017] Unless otherwise specified, all materials and reagents used in the embodiments of this invention are commercially available.

[0018] The prescription for the Noon Tea tablets includes: 5g of Noon Tea extract (dried weight); 7.5g of microcrystalline cellulose; plus: 0.8g of sodium carboxymethyl starch; and 0.13g of magnesium stearate.

[0019] The preparation method of the above-mentioned midday tea tablets includes the following steps: Soak each raw material in distilled water at room temperature for 60 minutes, ensuring the water level is above the medicinal materials. Boil the above-mentioned soaked medicinal materials with distilled water twice, each time for 1 hour, filter with gauze, and mix the filtrates; Evaporate the filtrate to a thick paste and cool to room temperature; Take 20g of extract and add 15g of microcrystalline cellulose to prepare a suitable soft material. After adding a small amount of anhydrous ethanol, granulate quickly through a 10-mesh sieve. After drying, the particles were granulated using a 16-mesh sieve and an 80-mesh sieve, yielding 13g of granules. Magnesium stearate 0.13g (1%) and sodium carboxymethyl starch 0.80g (6%) were added to the granules, and the mixture was compressed into tablets to obtain Wu Shi Cha tablets.

[0020] The disintegration time test results of the formulation of this invention are as follows: 1# 22 min; 2# 28 min; 3# 31 min; 4# 32 min; 5# 32 min; 6# 34 min.

[0021] As can be seen from the results in the table above, the Wu Shi Cha tablets prepared by the present invention disintegrate well, which is beneficial to improving the administration method of Wu Shi Cha.

[0022] The above description of specific embodiments of the present invention does not limit the present invention. Those skilled in the art can make various changes or modifications based on the present invention, and as long as they do not depart from the spirit of the present invention, they should all fall within the scope of protection of the claims of the present invention.

Claims

1. A midday tea tablet, characterized in that, The tablets are made from the following raw and excipient materials: noon tea extract, microcrystalline cellulose, sodium carboxymethyl starch, and magnesium stearate.

2. The midday tea tablets according to claim 1, characterized in that, The tablets comprise the following ingredients by weight percentage: Added ingredients: 35%-38% midday tea extract (after drying); 53%-60% microcrystalline cellulose; Additional ingredients: sodium carboxymethyl starch 5%-7%; magnesium stearate 0.8%-1.2%.

3. The midday tea tablet according to claim 1, characterized in that, The midday tea extract is prepared from the following medicinal materials: Atractylodes lancea, Bupleurum chinense, Notopterygium incisum, Saposhnikovia divaricata, Angelica dahurica, Ligusticum chuanxiong, Pogostemon cablin, Peucedanum praeruptorum, Forsythia suspensa, Citrus reticulata peel, Crataegus pinnatifida, Citrus aurantium, Hordeum vulgare (fried), Glycyrrhiza uralensis, Massa fermentata (fried), Platycodon grandiflorus, Perilla frutescens leaf, and Magnolia officinalis.

4. The midday tea tablet according to claim 1, characterized in that, The noon tea extract is prepared by the following method: each medicinal material is soaked in distilled water at room temperature for 64 minutes, and then decocted twice at about 60°C for 1 hour each time. The extract is filtered with gauze, the filtrates are mixed, evaporated to a thick paste, and cooled to room temperature.

5. The midday tea tablet according to claim 1, characterized in that, The tablet preparation method is as follows: Take the extract and add microcrystalline cellulose to prepare a suitable soft mass. Add a small amount of anhydrous ethanol and quickly granulate using a 10-mesh sieve. Dry the mass and then granulate using a 16-mesh and an 80-mesh sieve to obtain granules. Add magnesium stearate and sodium carboxymethyl starch, and compress into tablets.

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