一种湿态组织粘附胶及其制备方法和应用
Carbon dioxide bubbles and nano-calcium polyphosphate are generated by the metathesis reaction of calcium-based powder with polyphosphate organic acids. This disrupts the interfacial water layer and achieves nano-crosslinking, solving the problem of weak adhesion on the surface of moist tissue, improving wound healing quality and hemostasis, and reducing costs.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- AFFILIATED HOSPITAL OF GUANGDONG MEDICAL UNIV
- Filing Date
- 2026-04-15
- Publication Date
- 2026-07-17
AI Technical Summary
The interfacial water layer on the surface of moist tissue affects the adhesion ability of bioadhesives, resulting in poor wound closure and insufficient physical protection. Existing methods have limited effectiveness in removing interfacial water and may damage the network structure of adhesive hydrogels.
Through the metathesis reaction of calcium-based powder with polyphosphate organic acid, carbon dioxide bubbles and nano-calcium polyphosphate are generated in situ, which disrupts the interfacial hydration layer and achieves nano-crosslinking, thereby enhancing the adhesion performance. The water-repellent properties of carbon dioxide bubbles and the crosslinking of nano-calcium polyphosphate enhance the adhesion of the hydrogel.
It achieves efficient tissue adhesion in a moist environment, improves wound healing quality, rapidly controls traumatic bleeding, reduces the risk of hemorrhagic shock, and lowers the cost of clinical application.
Smart Images
Figure CN122005900B_ABST