Ultrasonic bubble removing instrument for microbubbles of injector
By using an ultrasonic defoamer to break down microbubbles in the syringe by vibrating water molecules at high frequencies, the problem of removing microbubbles from drug syringes is solved, thereby improving drug utilization and safety.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- THE SECOND AFFILIATED HOSPITAL TO NANCHANG UNIV
- Filing Date
- 2024-02-01
- Publication Date
- 2026-05-12
AI Technical Summary
Existing technologies are insufficient to effectively remove microbubbles invisible to the naked eye from drug injectors, resulting in low drug absorption rates, waste, and safety hazards.
An ultrasonic defoamer is used, which generates high-frequency vibrations in a water tank using an ultrasonic device. Water molecules collide with the microbubbles inside the agent, releasing air and causing it to escape.
It effectively removes microbubbles from the syringe, improves drug absorption, reduces waste, and ensures patient safety.
Smart Images

Figure CN122006294A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of medical auxiliary devices, and more particularly to a syringe microbubble ultrasonic defoamer. Background Technology
[0002] In the pharmaceutical field, improving drug absorption rates and reducing adverse drug reactions are critical issues that require continuous attention during drug development. Drug preparation processes inevitably generate bubbles of varying sizes, especially microbubbles with diameters below 50µm. These microbubbles rise slowly due to their own contraction and increase in negative charge, making them difficult to effectively remove from the solution. Patients preparing injectable medications at home, such as home-administered anticancer drugs or recombinant human growth hormone powder, often experience incomplete drug dissolution due to insufficient mixing of the powder and water for injection or incorrect preparation methods. This results in numerous bubbles of varying sizes, which cannot be effectively removed even after standing for several minutes. These microbubbles, injected into the patient's body, can lead to a series of consequences: drug adheres to the bubble walls, resulting in low absorption and utilization rates; unnecessary drug waste, leading to direct and indirect economic losses; and the bubbles themselves and their walls carrying incompletely dissolved drug into the body, potentially even threatening the patient's life.
[0003] There are currently no effective methods or corresponding technologies for removing air bubbles, especially tiny air bubbles that are invisible to the naked eye, from the inside of a syringe after dispensing medication. Therefore, this invention patent proposes an ultrasonic defoamer for removing air bubbles from syringes. Summary of the Invention
[0004] Based on the above problems, the purpose of this invention is to provide a syringe microbubble ultrasonic defoaming device. The invention adopts the following technical solution:
[0005] This invention provides a syringe microbubble ultrasonic defoamer, comprising:
[0006] A water tank, wherein the top of the water tank is an open structure and the bottom is provided with a base;
[0007] An ultrasonic device is disposed on the side wall of the water tank;
[0008] Two piston retainers are provided, both located at the bottom of the water tank. The two piston retainers work together to secure and clamp the syringe.
[0009] Preferably, the water tank is provided with an outer shell made of environmentally friendly plastic material.
[0010] Preferably, the number of ultrasonic devices is two, and they are symmetrically arranged on the side wall of the water tank;
[0011] The ultrasonic device includes an ultrasonic transducer, which is fixed to the wall of the water tank, and the radiating surface of the ultrasonic transducer is connected to a vibration diffuser disposed in the water tank.
[0012] Preferably, the radiating surface of the ultrasonic transducer is provided with two of the aforementioned diffractors, which form a semi-circular shape.
[0013] Preferably, the piston retainer includes two rotating shafts that are poweredly connected to the drive device. The rotating shafts are rotatably and sealed to the base, and the outer wall of the rotating shafts is provided with arc-shaped blades.
[0014] Preferably, the outer wall of the rotating shaft is provided with two arc-shaped blades arranged vertically at intervals; the lower arc-shaped blade is spiral-shaped.
[0015] Preferably, the water tank is made of stainless steel.
[0016] Preferably, a support ring is provided above the piston retainer, and the support ring is fixed to the inner wall of the water tank.
[0017] Compared with the prior art, the beneficial technical effects of the present invention are as follows:
[0018] This invention utilizes ultrasonic waves to generate high-frequency vibrations, causing water molecules to collide violently with the inner and outer walls of the syringe. This causes the air bubbles inside the medication to burst under vacuum, releasing air that overflows upwards, thus achieving the purpose of removing microbubbles inside the medication. Attached Figure Description
[0019] The present invention will be further described below with reference to the accompanying drawings.
[0020] Figure 1 This is a schematic diagram of the structure of the syringe microbubble ultrasonic defoamer in an embodiment of the present invention;
[0021] Figure 2 This is a front view schematic diagram of the two piston retainers clamping and fixing the syringe in an embodiment of the present invention;
[0022] Figure 3 This is a top view schematic diagram of the structure of the syringe clamped and fixed by two piston retainers in an embodiment of the present invention.
[0023] Explanation of reference numerals in the attached drawings: 1. Water tank; 2. Base; 3. Ultrasonic device; 301. Ultrasonic transducer; 302. Vibration diffuser; 4. Piston retainer; 401. Rotating shaft; 402. Arc-shaped blade; 5. Outer shell; 6. Syringe; 601. Syringe piston; 602. Piston handle; 7. Support ring. Detailed Implementation
[0024] To make the technical problems, technical solutions, and beneficial effects of the present invention clearer, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments.
[0025] like Figures 1 to 3 As shown, this embodiment discloses a syringe microbubble ultrasonic defoamer, including a water tank 1, an ultrasonic device 3, and a piston retainer 4. The top of the water tank 1 is open, and a base 2 is fixed to the bottom. The ultrasonic device 3 is disposed on the side wall of the water tank 1. The water tank 1 is made of stainless steel, and the outside of the water tank 1 is covered by an environmentally friendly plastic shell 5, which shields and covers the exposed ultrasonic device 3. There are two piston retainers 4, both of which are disposed at the bottom of the water tank 1. The two piston retainers 4 cooperate to fix and clamp the syringe 6.
[0026] As a method for achieving ultrasonic vibration, in this embodiment, the ultrasonic device 3 includes an ultrasonic transducer 301, which is fixed to the wall of the water tank 1. The radiating surface of the ultrasonic transducer 301 is connected to a vibration diffuser 302 disposed in the water tank 1. The ultrasonic transducer 301 is electrically connected to an ultrasonic generator via a signal line.
[0027] In this embodiment, there are two ultrasonic devices 3, which are symmetrically arranged on the side wall of the water tank 1; the radiation surface of the ultrasonic transducer 301 is provided with two vibration diffusers 302, and the two vibration diffusers 302 form a semi-arc.
[0028] As a structure capable of fixing and clamping the syringe 6, in this embodiment, the piston retainer 4 includes two rotating shafts 401 that are poweredly connected to the driving device. The rotating shafts 401 are rotatably and sealed on the base 2. The driving device can be disposed inside the base 2. Arc-shaped blades 402 are provided on the outer wall of the rotating shafts 401. The arc-shaped blades 402 are used to squeeze and clamp the syringe 6.
[0029] In this embodiment, two arc-shaped blades 402 arranged vertically at intervals are provided on the outer wall of the rotating shaft 401; the lower arc-shaped blade 402 is spiral-shaped. Except for this embodiment, the two arc-shaped blades 402 on the rotating shaft 401 can be designed as spirals.
[0030] In this embodiment, a support ring 7 is provided above the piston retainer 4, and the support ring 7 is fixed on the inner wall of the water tank 1.
[0031] The invention is used as follows:
[0032] First, water is poured into the water tank 1. The syringe 6 is then placed upside down in the water tank 1. Under the action of the driving device, one of the two piston retainers 4 at the bottom of the water tank 1 rotates clockwise, and the other rotates counterclockwise. As the two piston retainers 4 rotate in opposite directions, the two upper arc-shaped blades 402 cooperate to tightly clamp and fix the syringe piston 601. Since the lower arc-shaped blades 402 are spiral-shaped, while the two lower arc-shaped blades 402 are tightly clamping and fixing the syringe piston 601, they also press down on the piston handle 602. The two piston retainers 4 form an axial and radial clamping and fixing of the syringe 6.
[0033] During the process of clamping and fixing the syringe 6 with the two piston retainers 4, the upper support ring 7, because it is sleeved on the syringe 6, will provide initial support and positioning for the syringe 6.
[0034] After the syringe 6 is clamped and fixed, the two ultrasonic devices 3 generate high-frequency sound wave vibrations. The tank wall of the water tank 1 and the amplifying plate 302 in the water tank 1 transmit the high-frequency vibration waves to the water. The water molecules in the water tank 1 collide strongly with the syringe 6, causing the air bubbles inside the medicine to rupture under vacuum and release air to overflow upwards, thereby achieving the purpose of removing the microbubbles inside the medicine in the syringe.
[0035] The embodiments described above are merely preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Various modifications and improvements made by those skilled in the art to the technical solutions of the present invention without departing from the spirit of the present invention should fall within the protection scope defined by the claims of the present invention.
Claims
1. A syringe microbubble ultrasonic defoamer, characterized in that, include: Water tank (1), the top of the water tank (1) is an open structure and the bottom is provided with a base (2); An ultrasonic device (3) is provided on the side wall of the water tank (1); Piston retainer (4), there are two piston retainers (4), and both are set at the bottom of the water tank (1). The two piston retainers (4) are used to fix and clamp the syringe (6).
2. The syringe microbubble ultrasonic defoamer according to claim 1, characterized in that: The water tank (1) is equipped with an outer shell (5) made of environmentally friendly plastic material.
3. The syringe microbubble ultrasonic defoamer according to claim 1, characterized in that: The number of ultrasonic devices (3) is two, and they are symmetrically arranged on the side wall of the water tank (1); The ultrasonic device (3) includes an ultrasonic transducer (301), which is fixed on the wall of the water tank (1). The radiation surface of the ultrasonic transducer (301) is connected to a vibration diffuser (302) disposed in the water tank (1).
4. The syringe microbubble ultrasonic defoamer according to claim 3, characterized in that: The ultrasonic transducer (301) has two amplifying plates (302) on its radiating surface, and the two amplifying plates (302) form a semi-circular shape.
5. The syringe microbubble ultrasonic defoamer according to claim 1, characterized in that: The piston retainer (4) includes two rotating shafts (401) that are powered by the drive device. The rotating shafts (401) are rotatably and sealed on the base (2). The outer wall of the rotating shafts (401) is provided with arc-shaped blades (402).
6. The syringe microbubble ultrasonic defoamer according to claim 5, characterized in that: Two arc-shaped blades (402) are arranged vertically on the outer wall of the rotating shaft (401); the lower arc-shaped blade (402) is spiral-shaped.
7. The syringe microbubble ultrasonic defoamer according to claim 1, characterized in that: The water tank (1) is made of stainless steel.
8. The syringe microbubble ultrasonic defoamer according to claim 1, characterized in that: A support ring (7) is provided above the piston holder (4), and the support ring (7) is fixed on the inner wall of the water tank (1).