A natural nano-selenium optimized combination method for inhibiting proliferation of cancer cells, inducing apoptosis of cancer cells and repairing damaged body tissue cells
By optimizing the combination of multi-source organic selenium and antioxidant vitamins, stable natural nano-selenium capsules were prepared, which solved the problems of low bioavailability and insufficient safety of traditional selenium preparations, and achieved synergistic effects of inhibiting cancer cell proliferation, inducing apoptosis and repairing tissues.
Patent Information
- Application Number
- CN202610254539.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-03-03
- Publication Date
- 2026-05-26
AI Technical Summary
In existing technologies, traditional selenium preparations suffer from single form, low bioavailability, insufficient safety, and poor targeting, making it difficult to simultaneously achieve the triple effects of cancer inhibition, apoptosis promotion, and tissue repair. Furthermore, there is a lack of synergistic formulation systems for natural nano-selenium.
An optimized combination of multi-source organic selenium (L-seleno-methylselenocysteine, selenium-enriched yeast) and antioxidant vitamins (L-sodium ascorbate, D-biotin) is used to form stable natural nano-selenium through in-situ reduction. This nano-selenium is then combined with excipients (edible corn starch, maltodextrin, magnesium stearate, hydroxypropyl starch empty capsules) to prepare a capsule dosage form, achieving a synergistic effect.
It achieves high bioavailability in inhibiting cancer cell proliferation, inducing cancer cell apoptosis, and repairing damaged body tissues and cells. The dosage form is stable, with low toxicity and side effects, making it suitable for long-term dietary supplementation.
Abstract
Description
Technical Field
[0001] This invention relates to the field of natural nano-selenium composition technology, specifically to an optimized combination method of natural nano-selenium that inhibits cancer cell proliferation, induces cancer cell apoptosis, and repairs damaged body tissue cells, as well as its preparation and application. Background Technology
[0002] Selenium is an essential trace element for the human body, participating in key physiological processes such as antioxidation, immune regulation, and anti-tumor activity. Traditional selenium preparations suffer from problems such as limited form, low bioavailability, insufficient safety, and poor targeting; a single selenium source cannot simultaneously achieve the triple effects of cancer inhibition, apoptosis promotion, and tissue repair.
[0003] In existing technologies, nano-selenium has high activity and low toxicity, but it is mostly chemically synthesized, lacking natural sources and synergistic formulation systems; there are no reports on the synergistic effect of vitamin C, biotin and organic selenium, or optimized combination methods for in-situ stable nano-sizing.
[0004] To address the aforementioned deficiencies, this invention provides an optimized combination of natural nano-selenium, consisting of multi-source organic selenium, antioxidant vitamins, and biotin, achieving synergistic effects in inhibiting cancer, promoting apoptosis, and repairing tissues. Summary of the Invention
[0005] Purpose To overcome the shortcomings of existing technologies, a natural, safe, and highly bioavailable nano-selenium optimized composition is provided, which can inhibit cancer cell proliferation, induce cancer cell apoptosis, and repair damaged body tissue cells.
[0006] Technical solution A natural nano-selenium optimized composition that inhibits cancer cell proliferation, induces cancer cell apoptosis, and repairs damaged body tissue cells, composed of main raw materials and excipients: - Main ingredients: Sodium L-ascorbate, selenium-enriched yeast, L-ascorbic acid, D-biotin, L-seleno-methylselenocysteine; - Excipients: Edible corn starch, maltodextrin, magnesium stearate, hydroxypropyl starch empty capsules; - Active ingredients and content: Each capsule contains 100μg selenium, 100μg D-biotin, and 100mg vitamin C.
[0007] Key principles: - L-seleno-methylselenocysteine and selenium-enriched yeast provide dual organic selenium sources, which are metabolized to generate active intermediates such as methylselenool, which target and inhibit cancer cell proliferation and initiate apoptosis pathways. - L-ascorbic acid / sodium L-ascorbate provides a reducing environment to generate stable natural nano-selenium in situ, improving dispersibility and absorption efficiency; - D-Biotin participates in energy metabolism and DNA repair, and works synergistically with selenium and vitamin C to protect normal cells and repair damaged tissues; - The excipients ensure formability, flowability and stability, making them suitable for oral capsule formulations.
[0008] Beneficial effects 1. Synergistic anti-cancer effect: The combination of multiple selenium forms, vitamin C, and biotin works synergistically to selectively inhibit cancer cell proliferation and induce apoptosis, while remaining safe for normal cells; 2. Natural nano-sizing: In-situ reduction to form nano-selenium, with uniform particle size, high bioavailability, and low toxicity; 3. Repairing the body: Antioxidant + DNA repair + metabolic support promotes the repair of damaged tissue cells; 4. Stable dosage form: Capsules, with precise content, convenient to take, and suitable for long-term dietary supplementation. Detailed Implementation Example
[0010] - Main ingredients: Sodium L-ascorbate (appropriate amount), selenium-enriched yeast (appropriate amount), L-ascorbic acid 100mg / capsule, D-biotin 100μg / capsule, L-seleno-methylselenocysteine (appropriate amount, equivalent to 100μg selenium / capsule). - Excipients: Edible corn starch, maltodextrin, magnesium stearate, and hydroxypropyl starch empty capsules in appropriate amounts; - Preparation: 1. Pass the raw materials through a 100-mesh sieve and mix them according to the specified ratio; 2. Add maltodextrin and corn starch, mix and granulate; 3. Dry, then add magnesium stearate and mix thoroughly; 4. Capsule filling, quality inspection, and packaging.
[0011] Effect verification - Cell experiments: It has significant inhibitory effects on the proliferation of various cancer cell lines and induces apoptosis, but has no significant effect on the survival rate of normal cells; - Animal experiments: It can reduce tumor weight in tumor models, increase antioxidant enzyme levels, and promote the repair of damaged tissues; - Stability: Accelerated stability test, content uniformity and related substances meet the requirements.
[0012] Industrial applicability The raw materials of this invention are readily available, the process is mild and suitable for industrial production, and it can be made into capsules, tablets, powders, etc., for use in functional foods and dietary supplements such as tumor adjuvant conditioning, body damage repair, and antioxidant health care.
Claims
1. A natural nano-selenium optimized combination method for inhibiting the proliferation of cancer cells, inducing apoptosis of cancer cells and repairing damaged cells of body tissues, characterized in that, The composition is composed of the following raw materials: sodium L-ascorbate, selenium-rich yeast, L-ascorbic acid, D-biotin, L-selenium-methyl selenocysteine as main raw materials; auxiliary materials are edible corn starch, malt dextrin, magnesium stearate, hydroxypropyl starch hollow capsule; each finished product contains: selenium 100 μg, D-biotin 100 μg, vitamin C 100 mg.
2. The natural nano-selenium optimized composition as claimed in claim 1, wherein, The L-selenium-methyl selenocysteine is compounded with selenium-rich yeast to provide an organic selenium source, and the L-ascorbic acid and sodium L-ascorbate are synergistically reduced and stabilized to form natural nano-selenium in situ.
3. The natural nano-selenium optimized composition as claimed in claim 1, wherein, The composition is a capsule, and the content is a uniform powder with uniform particle size, good stability and high oral bioavailability.
4. The natural nano-selenium optimized composition as claimed in claim 1, wherein, The composition selectively inhibits cancer cell proliferation, induces cancer cell apoptosis, has no toxicity to normal tissue cells, and promotes the repair of damaged body tissue cells.
5. A method for preparing the optimized natural nano-selenium composition according to any one of claims 1-4, characterized in that, The method comprises the following steps: (1) according to the proportion, sodium L-ascorbate, selenium-rich yeast, L-ascorbic acid, D-biotin, L-selenium-methyl selenocysteine are weighed and mixed uniformly; (2) add edible corn starch, malt dextrin, wet or dry mixing granulation; (3) after drying, add magnesium stearate total mixture, fill into hydroxypropyl starch hollow capsule, and obtain.
6. Use of the natural nano-selenium optimized composition according to any one of claims 1-4 in the preparation of functional food or dietary supplement for inhibiting cancer cell proliferation, inducing cancer cell apoptosis, and repairing damaged body tissue cells.