Preparation method of targeted temperature-sensitive drug-loaded composite microspheres based on attapulgite

By preparing targeted thermosensitive drug-loaded composite microspheres based on attapulgite, and combining attapulgite, gypenosides, inulin and folic acid with lauric acid coating, a multifunctional synergistic drug delivery system was constructed. This system solved the problems of poor targeting and inaccurate release of chemotherapy drugs, and achieved efficient and low-toxicity tumor treatment.

CN122097572APending Publication Date: 2026-05-29CHONGQING UNIV
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Patent Information

Application Number
CN202610138909.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-01-31
Publication Date
2026-05-29

AI Technical Summary

Technical Problem

Existing chemotherapy drugs suffer from poor targeting, wide systemic distribution, and significant toxic side effects, making it difficult to achieve precise control of drug release and selectivity for tumor tissues. Furthermore, existing systems have limited functionality, making it difficult to achieve precise controlled release through colon-specific delivery, active tumor targeting, and near-infrared light triggering.

Method used

A method for preparing targeted thermosensitive drug-loaded composite microspheres based on attapulgite was adopted. By purifying a mixture of attapulgite, gypenosides, inulin and folic acid, and combining spray drying technology and melt impregnation method, lauric acid was coated on the surface of the primary drug-loaded composite microspheres to construct a multifunctional synergistic drug delivery system with colon-targeting, active targeting and near-infrared photothermal triggering.

Benefits of technology

It achieves intelligent controlled release of drugs, improves treatment efficacy, reduces systemic toxic side effects of chemotherapy, and realizes highly efficient and low-toxicity synergistic treatment. It also has precise controlled release functions such as colon-targeted, active-targeted, and near-infrared photothermal triggering.

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Abstract

The embodiment of the invention discloses a preparation method of targeted temperature-sensitive drug-loaded composite microspheres based on attapulgite. The preparation method comprises the following steps: purifying original attapulgite based on an aqueous solution of inorganic strong acid to obtain purified attapulgite; mixing the purified attapulgite, gypenoside, inulin and folic acid to obtain a mixed material, and mixing the mixed material and deionized water to obtain a composite microsphere suspension; conveying the composite microsphere suspension into a spray dryer for granulation to obtain primary drug-loaded composite microspheres; lauric acid is coated on the surface and in pores of the primary drug-loaded composite microsphere by adopting a melt impregnation method, and the primary drug-loaded composite microsphere coated with lauric acid is cooled to room temperature to obtain the targeted temperature-sensitive drug-loaded composite microsphere. According to the invention, the on-off type controlled release of the medicine based on temperature change can be realized, the targeting property and the treatment accuracy of the medicine are obviously improved, the toxic and side effects of the whole body of chemotherapy can be reduced from the source, and the efficient and low-toxicity synergistic treatment is realized.
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