A cationically modified pdrn delivery system, and methods of making and using the same
By combining cationic-modified lipid-based vesicle materials with PDRN, the problems of low transdermal absorption efficiency, poor stability, and cellular uptake barriers of PDRN in the cosmetic field have been solved, achieving efficient and stable PDRN delivery, which is suitable for skin repair and anti-aging cosmetics.
CN122140544APending Publication Date: 2026-06-05HANGZHOU MODA FRONTIER BIOTECHNOLOGY CO LTD
Patent Information
- Authority / Receiving Office
- CN Β· China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HANGZHOU MODA FRONTIER BIOTECHNOLOGY CO LTD
- Filing Date
- 2026-03-13
- Publication Date
- 2026-06-05
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Figure CN122140544A_ABST
Abstract
The application provides a cation-modified PDRN delivery system and a preparation method and application thereof, and comprises cationic lipid-based vesicles and PDRN adsorbed on the surface of the cationic lipid-based vesicles, wherein the cationic lipid-based vesicles are lipid-based vesicles modified with cations on the surface, and are selected from any one of cationic liposomes or cation-modified natural plant vesicles, aiming to realize high encapsulation efficiency, excellent long-term stability, excellent skin permeability and cell uptake efficiency of PDRN, and the process is simple, reproducible, and no toxic organic solvents such as diethyl ether are needed in the whole process, in line with the principle of green chemistry, and easy to carry out large-scale production, and can be widely applied to the preparation of skin repair preparations and anti-aging cosmetics.
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