A heparin coating and a preparation method, a vascular heparin-coated stent and a preparation method

By using substrate pretreatment and ultraviolet light curing technology, covalent bonding between the heparin coating and the substrate is achieved, which solves the problems of easy thrombosis and easy coating peeling of vascular covered stents, and improves the anticoagulation effect and service life of the stent.

CN122141028APending Publication Date: 2026-06-05HEBEI KANGYU MEDICAL INSTR CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HEBEI KANGYU MEDICAL INSTR CO LTD
Filing Date
2026-01-14
Publication Date
2026-06-05

AI Technical Summary

Technical Problem

Traditional vascular stent grafts are prone to thrombosis after implantation in lower limb vessels. The heparin coating is prone to detachment or is toxic. Existing preparation methods have weak bonding strength or are subject to harsh conditions, affecting the safety and lifespan of use.

Method used

By introducing hydroxyl and carboxyl active groups through substrate pretreatment, modifying heparin to carry photoreactive groups, and combining ultraviolet light curing, covalent bonding between heparin and the substrate is achieved, thus preparing an anticoagulant coating.

Benefits of technology

The heparin coating bonds firmly to the substrate, exhibits significant anticoagulation effects, and has good biocompatibility, avoiding the shortcomings of traditional methods and extending the lifespan and safety of the stent.

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Abstract

The present application relates to the technical field of medical stents, and discloses a heparin coating and a preparation method, a vascular heparin covered stent and a preparation method, the heparin coating is prepared by introducing a photo-reactive group on a heparin molecule through substrate pretreatment, heparin modification, ultraviolet light curing and other modes, and the process does not use toxic reagents; the vascular covered stent comprises a wavy spiral, a flexible and stretchable stent body, an inner stent cylinder film and an outer silk stent covered film, a coating is coated on the inner surface of the cylinder film and the outer surface of the covered film, the vascular environment of long-distance and repeated bending of lower limbs can be met, the heparin coating is firmly combined, has long-lasting anticoagulation, effectively inhibits thrombosis, and greatly improves the safety and service life of the stent.
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