A multi-effect herbal composite soothing repair composition and a method of making the same

Abstract

The present application relates to a kind of multi-effect herbaceous plant composite soothing repair composition and its preparation method, belong to the cosmetic technical field.The present application is by mixing glacial low deuterium water and superoxide dismutase to obtain A component, add D component (specific proportion nicotinamide mononucleotide (NMN) and modified hyaluronic acid microsphere) by the special interaction of the two with low deuterium water, form "triple synergistic carrier system", significantly improve the penetration and stability of active substance;B component is to mix hydroxyl asiaticoside and humectant.Meanwhile, the composite extract prepared by mixing the extract of radix stephaniae tetrandrae, the extract of gentiana and the extract of piper methysticum is C component, after mixing with A, B, D each component, low deuterium water can well carry the active ingredient in plant extract, hydroxyl asiaticoside and humectant in B component are mixed, can give full play to the moisturizing effect.The composition obtained after mixing A, B, C, D component has excellent soothing repair effect.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology and relates to a multi-effect herbal compound soothing and repairing composition and its preparation method. Background Technology

[0002] Sensitive skin is primarily characterized by a compromised skin barrier function, making it susceptible to external stimuli and triggering inflammatory reactions. Symptoms include redness, swelling, pain, and burning, which continuously damage skin cells and the skin barrier. In response, numerous cosmetic products claiming to repair sensitive skin have emerged on the market. These products aim to repair sensitive skin by moisturizing and soothing it, regulating immune balance, enhancing skin immunity, and suppressing inflammation.

[0003] However, existing cosmetics on the market offer only one function: hydration, repair, or anti-inflammation. The added chemical ingredients can easily irritate the skin, and large molecules can clog skin channels, causing secondary damage. Furthermore, plant extracts, SOD, and other bioactive ingredients generally suffer from poor stability, low transdermal absorption, and poor compatibility between components. Therefore, there is an urgent need to invent a purely natural composition that, through perfect synergy, achieves a three-in-one effect of hydration, repair, and anti-inflammation, while simultaneously protecting the skin from secondary physical and chemical damage. Summary of the Invention

[0004] The purpose of this invention is to provide a multi-effect herbal compound soothing and repairing composition and its preparation method. The prepared composition has excellent soothing and repairing functions.

[0005] The objective of this invention can be achieved through the following technical solutions: A multi-effect herbal compound soothing and repairing composition comprising the following raw materials in parts by weight: Component A: 85-95 parts deuterated water, 2-4 parts superoxide dismutase; Component B: 1-2 parts asiaticoside, 4-8 parts moisturizer; Component C: 1-2 parts gentian extract, 1-2 parts Stephania tetrandra extract, 1-2 parts kava extract; Component D: 0.5-1.5 parts nicotinamide mononucleotide (NMN), 1-3 parts modified hyaluronic acid microspheres.

[0006] As a preferred embodiment of the present invention, the preparation process of the moisturizer is as follows: (1) Low-deuterium water, sodium polyglutamate, and acetylglucosamine are stirred at 35-40°C to form a hydrophilic core mixture A; (2) Mix isosorbide dimethyl ether with hydrogenated lecithin with a phase change temperature of 32~34℃ at a mass ratio of 1: (0.2~0.5); (3) Under high pressure microfluidic homogeneous conditions, the shell material of step (2) is wrapped around the core of step (1) to form microcapsules with a particle size of 50~200 nm.

[0007] As a preferred embodiment of the present invention, the acetyl glucosamine solution is an aqueous solution of acetyl glucosamine with a mass fraction of 10-15%.

[0008] As a preferred embodiment of the present invention, the hydrogenated lecithin and isosorbide dimethyl ether are mixed at a speed of 300 r / min for 20-25 min.

[0009] As a preferred technical solution of the present invention, the mass ratio of mixture A to the isosorbide dimethyl ether mixture obtained in step (2) is 1:(3~5).

[0010] As a preferred embodiment of the present invention, the deuterium-rich water is natural glacial deuterium-rich water. Before use, this natural glacial deuterium-rich water undergoes a UV-ozone synergistic activation treatment for 10-20 minutes to reduce its oxidation-reduction potential (ORP) to below -200 mV. Furthermore, the deuterium content is less than 140 ppm.

[0011] As a preferred embodiment of the present invention, the deuterium content of the natural glacial low-deuterium water is 15~50ppm.

[0012] A method for preparing a multi-effect herbal compound soothing and repairing composition includes the following steps: S1. Mix the activated deuterium-rich water with SOD and stir at 60~65℃ to obtain component A; S2. Prepare a thermosensitive moisturizer by adding asiaticoside to obtain component B; S3. The three plant extracts of component C and half the amount of modified hyaluronic acid microspheres of component D were pre-ball-milled and co-treated for 2 hours, and then passed through a 300-mesh sieve to obtain the pre-composite component C'. S4. Cool component A to 40~45℃, add NMN and the remaining modified hyaluronic acid microspheres from component D, and stir at 350r / min for 20min. S5. Add component B to the system in S4 and stir for 1-2 hours; S6. Finally, add the pre-composite component C' and continue stirring at 35~45℃ for 35~50min to obtain the multi-effect herbal compound soothing and repairing composition.

[0013] In this invention, the diameter of low-deuterium water molecules is similar to that of hydrophilic channels on the cell membrane, resulting in stronger permeability. It more easily passes through cell membrane water channels and binds with water in skin cells, forming a stable hydration layer that effectively locks in moisture and achieves better moisturizing effects. This is the basis for its soothing and repairing effects. Simultaneously, low-deuterium water can scavenge free radicals, inhibit oxidative stress reactions, and alleviate skin aging and dullness.

[0014] Superoxide dismutase (SOD) can catalyze the conversion of superoxide anion free radicals into hydrogen peroxide and oxygen, effectively reducing oxidative stress, thereby protecting skin cells from free radical damage, accelerating skin metabolism, repairing the sebum film, maintaining skin moisture, forming a protective film on the skin surface, enhancing the skin barrier function, improving cell activity, promoting the skin cell regeneration and self-repair capabilities, and helping to improve skin inflammation and soothe the skin.

[0015] The modified hyaluronic acid microspheres of component D in this invention are porous microspheres formed by electrostatic self-assembly of succinylated hyaluronic acid and silk fibroin. The average particle size is 80±20 nm, the zeta potential is -25~-35 mV, and the encapsulation efficiency of hydroxyasiaticoside can reach more than 92%.

[0016] Acetyl glucosamine is hydrophilic and can adsorb and retain water molecules, increasing the skin's water content and improving its moisturizing ability. Mixing acetyl glucosamine solution with sodium polyglutamate can improve the hydrophilicity of sodium polyglutamate. Then, mixing it with isosorbide dimethyl ether yields a moisturizer.

[0017] Sodium polyglutamate (SPG) molecules contain numerous hydroxyl, carboxyl, and other polar groups. These polar groups can form hydrogen bonds both within and between molecules, thereby binding and locking in a large amount of moisture. It can form a protective film on the skin surface, effectively preventing moisture loss. Acetyl glucosamine is a molecular precursor of hyaluronic acid, which can promote the synthesis of hyaluronic acid, thus exerting moisturizing and hydrating effects. Isosorbide dimethyl ether has strong water solubility and can penetrate into the skin to replenish the skin's required moisture and regulate the skin's moisture content. The combination of these three ingredients can form a complementary moisturizing system, providing the skin with comprehensive and deep hydration.

[0018] Both sodium polyglutamate and acetylglucosamine have the ability to repair damaged skin barriers, maintaining excellent moisturizing properties while possessing a certain degree of repair ability.

[0019] asiaticoside effectively inhibits neutrophils in the skin and reduces the production of inflammatory factors, thereby calming the skin and relieving sensitivity. asiaticoside primarily acts on the skin's connective tissue, helping to accelerate the repair process of damaged tissue and repair the skin barrier. Furthermore, asiaticoside promotes collagen expression in the dermis, enhancing skin elasticity and firmness, while accelerating the skin's self-repair process.

[0020] This invention uses gentian extract, Stephania tetrandra extract, and kava extract as component C. As plant extracts, the active ingredients in gentian extract have a strong inhibitory effect on inflammatory factors, reducing inflammatory responses in tissues such as redness, swelling, and pain, thereby soothing the skin. Furthermore, gentian extract can promote skin barrier repair, enhance the skin's defense capabilities, and prevent damage from harmful external substances. The flavonoids and polyphenols in gentian extract can scavenge free radicals, reduce free radical damage to the skin, and protect skin cells from oxidative stress.

[0021] Stephania tetrandra extract can inhibit inflammatory factors and exert its anti-inflammatory effect by blocking NF-κB activation. Furthermore, Stephania tetrandra extract can inhibit the release of histamine, an itch-inducing factor, from mast cells, effectively relieving skin itching and soothing sensitive skin. Simultaneously, Stephania tetrandra extract can directly bind to peptidoglycan (PGN) and lipopolysaccharide (LPS), exhibiting antibacterial activity, particularly against Staphylococcus aureus.

[0022] Kava pepper extract acts on nerve endings, where its capsaicin and other components occupy skin receptors and inhibit the release of inflammatory mediators, blocking neuronal signal transmission and suppressing sensitivity transmission, thus achieving an immediate calming effect. Furthermore, kava pepper extract has a significant effect in relieving micro-inflammation of the skin, reducing inflammatory reactions caused by exposure to large amounts of compounds and ultraviolet radiation. Simultaneously, kava pepper extract improves skin hydration, reduces redness and erythema, effectively soothes skin, relieves redness, heat, stinging, and itching, stabilizes and strengthens the skin's microbial barrier, and enhances the skin's resistance.

[0023] Component C of this invention is a compound extract prepared by mixing Stephania tetrandra extract, Gentiana scabra extract, and Kava extract. Both Stephania tetrandra extract and Gentiana scabra extract have significant anti-inflammatory effects; their combination further enhances the anti-inflammatory effect, effectively relieving skin inflammation and redness. Both Gentiana scabra extract and Kava extract have calming and soothing effects on the skin; their combination can quickly relieve skin discomfort and soothe the skin. Both Stephania tetrandra extract and Kava extract have certain antioxidant capabilities; their combination can resist free radical damage and delay the skin aging process. Therefore, this compound plant extract has significant benefits and synergistic effects, improving skin condition, strengthening the skin barrier, and providing effective soothing and repairing effects.

[0024] The beneficial effects of this invention are: This invention solves a long-standing technical problem: in existing technologies, bioactive ingredients such as plant extracts and SOD generally suffer from poor stability, low transdermal absorption, and poor compatibility among components. This invention introduces a specific ratio of nicotinamide mononucleotide (NMN) and modified hyaluronic acid microspheres. Through the special interaction between these two and deuterium-free water, a "triple-effect carrier system" is formed, significantly improving the permeability and stability of the active ingredient. Specifically, the deuterium-free water in component A, NMN in component D, and the modified hyaluronic acid microspheres together constitute the "triple-effect carrier system," with the following mass ratio: deuterium-free water : NMN : modified hyaluronic acid microspheres = (85~95) : (0.5~1.5) : (1~3). Furthermore, when the mass ratio of the three plant extracts in component C is 1:1:1, a synergistic peak in the inhibition rate of inflammatory factors TNF-α and IL-6 occurs when used in combination with component D.

[0025] A non-obvious synergistic effect was produced: Experimental data fully demonstrates that when components A, C, and D of the present invention are combined in a specific ratio, a synergistic peak is observed in the inhibition rate of key inflammatory factors. This effect is not a simple summation of the effects of each component, but rather stems from the multiple positive cyclical interactions between low-deuterium water activating SOD, NMN enhancing cellular energy metabolism, modified microspheres promoting penetration, and plant extracts targeting multiple points of inflammation. This synergistic relationship cannot be directly derived from the prior art by those skilled in the art.

[0026] The moisturizer is designed with a core-shell microcapsule structure that exhibits temperature-sensitive response, enabling intelligent controlled release. The moisturizer rapidly releases its contents at skin temperatures (>32°C), with the release rate decreasing by more than 80% below 28°C. This technology ensures that the moisturizer rapidly releases its active ingredients at body temperature while also allowing for proper storage of the active components at room temperature.

[0027] Process innovation plays a crucial role in determining product performance: This invention is not a simple mixing process, but rather guides the entire system to form a thermodynamically stable self-assembled nanostructure through precise temperature control, feeding sequence, and pretreatment steps (such as ball milling pre-composite and UV-ozone activation). Comparative experiments (Comparative Example 3) clearly show that, even when using the same raw materials, failure to follow this specific process results in a significant decrease in the stability and transdermal absorption rate of the final product, proving that this preparation method is an indispensable technical key to achieving excellent results. Detailed Implementation

[0028] To further illustrate the technical means and effects of the present invention in achieving its intended purpose, the following detailed description of the specific implementation methods, structures, features, and effects of the present invention, in conjunction with embodiments, is provided below.

[0029] In the following examples and comparative examples: The deuterium-free water is natural glacial deuterium-free water. Before use, the natural glacial deuterium-free water needs to undergo ultraviolet-ozone synergistic activation treatment for 10-20 minutes to reduce its oxidation-reduction potential (ORP) to below -200 mV.

[0030] Sodium polyglutamate: purchased from Zhengzhou Rongyuan Chemical Products Co., Ltd.; Acetyl glucosamine: purchased from Hongrui Biotechnology Co., Ltd., product number: 448; Isosorbide dimethyl ether: purchased from Jinan Shanhai Chemical Technology Co., Ltd.; Superoxide dismutase: purchased from Shandong Pingju Biotechnology Co., Ltd.; Hydroxyacinthin: Purchased from Hubei Qifei Pharmaceutical & Chemical Co., Ltd.; Gentian extract: purchased from Shaanxi Jianhe Biotechnology Co., Ltd.; Stephania tetrandra extract: purchased from Shaanxi Sinote Biotechnology Co., Ltd.; Kava pepper extract: purchased from Shaanxi Sinote Biotechnology Co., Ltd.

[0031] Nicotinamide mononucleotide: Shenzhen Xijia Biotechnology Co., Ltd. Modified hyaluronic acid microspheres: Taiyuan Fufushengtong Biotechnology Co., Ltd. The preparation process of the moisturizer is as follows: First, deuterium-free water and sodium polyglutamate were mixed and stirred at 300 rpm for 10 min at 35°C. Then, while maintaining the temperature and stirring speed, a 10% (w / w) aqueous solution of acetylglucosamine was added and stirred for another 10 min to obtain mixture A, in which the mass ratio of deuterium-free water, sodium polyglutamate, and acetylglucosamine aqueous solution was 15:2:3. Isosorbide dimethyl ether at a mass ratio of 1:0.3 was mixed with hydrogenated lecithin at a temperature variation of 32–34°C. Under high-pressure microfluidic homogenization conditions, the shell material was encapsulated within the core to form microcapsules with a particle size of 50–200 nm. Preparation of a multi-effect herbal compound soothing and repairing composition: S1. Mix the activated deuterium-rich water with SOD and stir at 60~65℃ to obtain component A; S2. Prepare a temperature-sensitive moisturizer to obtain component B; S3. The three plant extracts of component C (weight ratio 1:1:1) and half of the modified hyaluronic acid microspheres of component D were pre-ball-milled and co-treated for 2 hours, and then passed through a 300-mesh sieve to obtain the pre-composite component C'. S4. Key steps: Cool component A to 40~45℃, add NMN and the remaining modified hyaluronic acid microspheres from component D, stir at 350r / min for 20min to induce the formation of a nano micelle network composed of deuterium water, NMN and hyaluronic acid microspheres. S5. Add component B to the system in S4 and stir for 1-2 hours; S6. Finally, add the pre-composite C' component and continue stirring at 35~45℃ for 35~50min to form the final self-assembled nano-encapsulation system.

[0032] Example 2 The difference between Example 2 and Example 1 is that the weight ratio of the three plant extracts in component C of step S3 is 1.5:1.5:1.5, while the rest of the operations are the same.

[0033] Example 3 The difference between Example 3 and Example 1 is that the weight ratio of the three plant extracts in component C of step S3 is 2:2:2, and the mass fraction of the acetyl glucosamine aqueous solution is 15% in the preparation of the humectant. All other operations are the same.

[0034] Comparative Example 1 The difference between Comparative Example 1 and Example 1 is that Comparative Example 1 does not contain component D, but all other operations are the same.

[0035] Comparative Example 2 The difference between Comparative Example 2 and Example 1 is that the modified hyaluronic acid microspheres in component D were replaced with an equal amount of ordinary sodium hyaluronate, while the rest of the operations were the same.

[0036] Comparative Example 3 The difference between Comparative Example 3 and Example 1 is that all components A, B, C, and D are mixed at once during the preparation process, and the order of S3-S6 is not followed. All other operations are the same.

[0037] Comparative Example 4 The difference between Comparative Example 4 and Example 1 is that the deuterium water used in the preparation process was completely replaced with ordinary deionized water, while the rest of the operations were the same.

[0038] Test method: The composition prepared by this invention can be used directly as a spray. Test site: face.

[0039] By having test subjects complete consumer questionnaires, the researchers can evaluate whether the products have soothing, moisturizing, sensitive skin-friendly, and gentle, non-irritating effects.

[0040] After the selected participants signed informed consent forms, they underwent testing. A total of 140 participants were selected, with 140 valid participants, including 60 males and 80 females, with an average age of 27.8 ± 11.2 years.

[0041] Test method: Subjects cleansed their faces with facial cleansing products and dried their skin with lint-free absorbent paper towels. They then sat quietly for 30 minutes in an environment of 20-22°C and 40%-60%RH.

[0042] 1. In vitro anti-inflammatory synergistic effect test: Using an LPS-induced macrophage (RAW 264.7) inflammation model, the inhibition rates of the inflammatory factors TNF-α and IL-6 in each embodiment and comparative example were measured. The average test results are shown in Table 1. Table 1 Results analysis: The anti-inflammatory effects of Examples 1, 2, and 3 (including component D and specific processes) were significantly better than those of other groups, and exceeded those of commercially available benchmark products by about 38%, proving that a non-obvious synergistic effect of 1+1>2 was generated between component D and components ABC.

[0043] Comparison of composition stability and transdermal absorption: Table 2 Results analysis: The specific components of this invention (low-deuterium water, modified hyaluronic acid microspheres) work together with the stepwise self-assembly process to greatly improve the stability of active ingredients (especially SOD, which is sensitive to heat and shear force), and the transdermal efficiency is increased by nearly 4 times by utilizing the formed nanomicelle network.

[0044] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent embodiments without departing from the scope of the present invention. Any simple modifications, equivalent changes and alterations made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.

Claims

1. A multi-effect herbal compound soothing and repairing composition, characterized in that, The ingredients include the following parts by weight: Component A: 85-95 parts deuterium-free water, 2-4 parts superoxide dismutase; Component B: 1-2 parts asiaticoside, 4-8 parts thermosensitive moisturizer; Component C: 1-2 parts gentian extract, 1-2 parts Stephania tetrandra extract, 1-2 parts kava extract; Component D: 0.5-1.5 parts nicotinamide mononucleotide (NMN), 1-3 parts modified hyaluronic acid microspheres.

2. The multi-effect herbal compound soothing and repairing composition according to claim 1, characterized in that, The temperature-sensitive moisturizer is a microcapsule with a core-shell structure, and its preparation process is as follows: (1) Low-deuterium water, sodium polyglutamate, and acetylglucosamine are stirred at 35-40°C to form a hydrophilic core mixture A; (2) Mix isosorbide dimethyl ether with hydrogenated lecithin with a phase change temperature of 32~34℃; (3) Under high pressure microfluidic homogeneous conditions, the shell material of step (2) is wrapped around the core of step (1) to form microcapsules with a particle size of 50~200 nm.

3. The multi-effect herbal compound soothing and repairing composition according to claim 2, characterized in that, The acetyl glucosamine solution is an aqueous solution of acetyl glucosamine with a mass fraction of 10-15%.

4. The multi-effect herbal compound soothing and repairing composition according to claim 2, characterized in that, The mass ratio of the mixture A to the isosorbide dimethyl ether mixture obtained in step (2) is 1:(3~5).

5. The multi-effect herbal compound soothing and repairing composition according to claim 2, characterized in that, The hydrogenated lecithin and isosorbide dimethyl ether were mixed at a speed of 300 r / min for 20-25 min.

6. The multi-effect herbal compound soothing and repairing composition according to claim 1, characterized in that, The modified hyaluronic acid microspheres are porous microspheres formed by electrostatic self-assembly of succinylated hyaluronic acid and silk fibroin, with an average particle size of 80±20 nm and a zeta potential of -25 to -35 mV.

7. The multi-effect herbal compound soothing and repairing composition according to any one of claims 1-2, characterized in that, The deuterium-rich water is natural glacial deuterium-rich water, which needs to be treated with ultraviolet-ozone synergistic activation for 10-20 minutes before use to reduce its oxidation-reduction potential (ORP) to below -200 mV.

8. The multi-effect herbal compound soothing and repairing composition according to claim 7, characterized in that, The deuterium content of the natural glacial low-deuterium water is less than 140 ppm.

9. The multi-effect herbal compound soothing and repairing composition according to claim 8, characterized in that, The deuterium content of the natural glacial low-deuterium water is 15~50 ppm.

10. A method for preparing a multi-effect herbal compound soothing and repairing composition as described in any one of claims 1-9, characterized in that, Includes the following steps: S1. Mix the activated deuterium-rich water with SOD and stir at 60~65℃ to obtain component A; S2. Prepare a thermosensitive moisturizer by adding asiaticoside to obtain component B; S3. The three plant extracts of component C and half the amount of modified hyaluronic acid microspheres of component D were pre-ball-milled and co-treated for 2 hours, and then passed through a 300-mesh sieve to obtain the pre-composite component C'. S4. Cool component A to 40~45℃, add NMN and the remaining modified hyaluronic acid microspheres from component D, and stir at 350r / min for 20min. S5. Add component B to the system in S4 and stir for 1-2 hours; S6. Finally, add the pre-composite component C' and continue stirring at 35~45℃ for 35~50min to obtain the multi-effect herbal compound soothing and repairing composition.

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