Continuous drying and crushing integrated machine for heparin sodium crude product production

Abstract

The application is suitable for the field of heparin sodium crude product production, and provides a continuous drying and smashing integrated machine for heparin sodium crude product production, which comprises a secondary drying and smashing box, a drying and smashing cylinder assembly is arranged in the secondary drying and smashing box, the drying and smashing cylinder assembly is used for receiving heparin sodium wet solid introduced by a primary drying and smashing box; the drying and smashing cylinder assembly comprises a feeding pipe, a power shaft and a drying and smashing cylinder structure; the drying and smashing cylinder structure comprises a drying and smashing outer cylinder and at least two drying and smashing inner cylinders which are sequentially sleeved; the feeding pipe is communicated to the innermost drying and smashing inner cylinder of the at least two drying and smashing inner cylinders through a hose; the power shaft is used for synchronously driving the drying and smashing outer cylinder and the drying and smashing inner cylinders to rotate; the heparin sodium wet solid can be fully guaranteed to be in full contact with the heating body of the cylinder mesh in the sequentially graded smashing process, which is beneficial to linkage and cooperation of the two processes of drying and smashing, and reduces equipment investment cost and maintenance cost.

Description

Technical Field

[0001] This invention relates to the field of crude heparin sodium production, and more particularly to a continuous drying and pulverizing integrated machine for crude heparin sodium production. Background Technology

[0002] Heparin sodium is a sodium salt of sulfated aminoglucan extracted from the intestinal mucosa of animals such as pigs or cattle. It belongs to the mucopolysaccharide class and is a widely used, potent anticoagulant in clinical practice. Its mechanism of action mainly involves binding to antithrombin III, enhancing the latter's inhibitory effect on coagulation factors, thereby exerting its anticoagulant effect. The general process for producing crude heparin sodium is as follows: using porcine small intestinal mucosa as raw material, crude heparin sodium is obtained through enzymatic hydrolysis, ion exchange adsorption, elution, ethanol precipitation, dehydration, and drying. Drying and pulverization are the final steps in crude product production and are crucial for obtaining a physically stable product that is easy to store and subsequently refined. Heparin sodium is hygroscopic, and vacuum drying is mostly used to avoid degradation and inactivation at high temperatures.

[0003] Currently, the drying and pulverizing processes in the production of crude heparin sodium are typically completed using separate equipment. In the drying stage, existing technologies often employ vacuum drying ovens or low-temperature vacuum drying ovens to heat and dry the wet solid heparin sodium. However, during the drying process, heparin sodium is prone to clumping due to the upward movement of moisture, affecting the uniformity of drying. To solve this problem, existing drying devices usually require the addition of a turning mechanism to agitate the wet solid heparin sodium to achieve uniform heating. For example, Chinese Patent Application No. 202222513343.0 discloses a heparin sodium drying device, which, during the drying process, drives a second motor to move a sliding rod, causing a triangular cone-shaped baffle at the end of the lever to abut against the bottom of the tray. As the tray rotates, the baffle flips the heparin sodium within the tray, improving drying efficiency and uniformity. However, this type of turning mechanism only serves the uniform heating requirement of the drying stage and cannot be applied to the subsequent pulverizing process.

[0004] In existing equipment configurations for producing crude heparin sodium, drying and pulverization are typically completed by two independent sets of equipment. The dried material needs to be transferred to a separate pulverizing unit for further processing, leading to poor process integration and low production efficiency. More importantly, the turning mechanism added during the drying process to address the clumping problem of heparin sodium cannot be reused in the pulverizing mechanism due to structural and functional limitations, preventing the drying and pulverizing processes from working in tandem. The drying and pulverizing equipment operate independently, each requiring its own drive system and transmission mechanism, resulting in bulky equipment, large footprint, and significantly increased equipment investment and maintenance costs. Chinese Patent Application No. 201922121899.3 discloses a raw material processing equipment for heparin sodium production. This equipment integrates the drying and feeding mechanism with the pulverizing mechanism within the same housing. The drying and feeding mechanism uses a material cylinder with internal spiral blades and external heating coils to achieve heating and drying during material transport. However, the drying and pulverizing processes in this equipment remain two independent execution units. The spiral blades used to turn the material during drying cannot function during the pulverizing stage, and the two mechanisms operate independently, with the drive system unable to coordinate. Chinese patent application number 202020640415.6 discloses a multi-stage pulverizer for heparin sodium processing, which features an independent pulverizing chamber for multi-stage pulverization after drying. None of the aforementioned devices have solved the problems of integrated drying and pulverizing functions and the reuse of the turning mechanism. The overall structure of the equipment remains bulky, hindering cost reduction and production process simplification. Therefore, developing a crude heparin sodium production equipment that can organically integrate drying and pulverizing functions, achieve coordinated control, and simplify the equipment structure is of significant practical importance. Summary of the Invention

[0005] The purpose of this invention is to provide a continuous drying and pulverizing integrated machine for the production of crude heparin sodium. It aims to solve the problems in the prior art where drying and pulverizing are separate processes, and an additional mechanism is needed to turn the wet solid heparin sodium to ensure uniform heating during the drying process. However, this additional turning mechanism cannot be applied to the pulverizing mechanism, resulting in the inability to link drying and pulverizing together. Furthermore, the separate addition of mechanisms would lead to bloated equipment and increased cost.

[0006] Specifically: A continuous drying and pulverizing integrated machine for the production of crude heparin sodium includes a primary drying and pulverizing chamber and a secondary drying and pulverizing chamber. The primary drying and pulverizing chamber is mounted above the secondary drying and pulverizing chamber, and the two chambers are interconnected. The secondary drying and pulverizing chamber contains two symmetrically distributed drying and pulverizing cylinder assemblies. These assemblies receive wet heparin sodium solids introduced from the primary drying and pulverizing chamber and are used for continuous rotational drying and pulverizing of the wet heparin sodium solids. Each drying and pulverizing cylinder assembly includes a feed pipe, a drive shaft, and a drying and pulverizing cylinder structure. The drying and pulverizing cylinder structure is used for synchronous drying and pulverizing of the wet heparin sodium solids. The drying and pulverizing cylinder structure includes an outer drying and pulverizing cylinder and at least two inner drying and pulverizing cylinders arranged in sequence. The inner drying and pulverizing cylinders are located inside the outer drying and pulverizing cylinder and on the columnar centerline of the outer drying and pulverizing cylinder. A feed pipe is ball-hinged at one end of the drying and pulverizing cylinder structure and connected to the innermost inner drying and pulverizing cylinder among the at least two inner drying and pulverizing cylinders via a flexible hose. A power shaft is assembled at the other end of the drying and pulverizing cylinder structure. The power shaft is used to transmit power to the drying and pulverizing cylinder structure, synchronously driving the outer drying and pulverizing cylinder and the inner drying and pulverizing cylinder to rotate. The mesh size of the multiple inner drying and pulverizing cylinders decreases sequentially from the inside to the outside and then to the outer drying and pulverizing cylinder.

[0007] In a further embodiment: the drying and pulverizing cylinder assembly further includes a sealing disc, a hinged ball, and a connecting seat. The sealing disc is assembled at one end of the drying and pulverizing cylinder structure and is used to position and fix the outer drying and pulverizing cylinder and at least two inner drying and pulverizing cylinders. The connecting seat is fixed on the columnar centerline of the sealing disc. The hinged ball is hinged to the connecting seat. One end of the feed pipe passes through the hinged ball and is connected to the innermost inner drying and pulverizing cylinder among the at least two inner drying and pulverizing cylinders via a flexible hose. The other end of the feed pipe is connected to the converging vertical pipe and is fixed together with the converging vertical pipe. The converging vertical pipe is located at the center of the secondary drying and pulverizing box and is connected to the primary drying and pulverizing box. A conveying auger is installed inside the feed pipe.

[0008] In a further embodiment: the drying and pulverizing cylinder assembly also includes:

[0009] A housing is installed at the other end of the drying and pulverizing cylinder structure away from the sealing disc, and is used to position and fix the outer drying and pulverizing cylinder and at least two inner drying and pulverizing cylinders; a power shaft is inserted and fixed on the housing, and is used to transmit power to the drying and pulverizing cylinder structure through the housing, so as to synchronously drive the outer drying and pulverizing cylinder and the inner drying and pulverizing cylinder to rotate.

[0010] The positioning ring is rotated and fitted onto the drive shaft via a bearing ring.

[0011] Electric telescopic rod A, one end of which is rotatably mounted on the positioning ring, and the other end is fixed inside the secondary drying and pulverizing chamber;

[0012] The motor is mounted at the end of the secondary drying and pulverizing chamber; a telescopic shaft is connected to the output shaft of the motor via a coupling; the telescopic shaft is mounted on the power shaft via a universal joint.

[0013] In a further embodiment: the storage shell has an annular groove inside, and multiple sealing airbags are installed in the annular groove, with the multiple sealing airbags being nested in sequence; the multiple sealing airbags correspond one-to-one with the drying and pulverizing outer cylinder and at least two drying and pulverizing inner cylinders.

[0014] In a further embodiment: the sealing airbag component includes:

[0015] The base ring is fixed to the bottom of the annular groove;

[0016] The inner liner ring is integrally fixed at one end to the base ring, and the other end is fixed to the end of the drying and pulverizing outer cylinder or the drying and pulverizing inner cylinder; the column center line of the inner liner ring and the column center line of the base ring are on the same straight line; the inner diameter of the inner liner ring is the same as the inner diameter of the base ring, and the outer diameter of the inner liner ring is smaller than the outer diameter of the base ring, so that an annular outer groove is formed from the outside of the inner liner ring to the side of the base ring.

[0017] In a further embodiment: the sealing airbag component also includes:

[0018] A sealing airbag is movably fitted onto the inner liner ring; one end of the sealing airbag is connected to the base ring, and the other end faces the drying and pulverizing cylinder structure; the sealing airbag is connected to the exhaust fan through a connecting pipe, and the exhaust fan is installed inside the housing; a solenoid valve A is installed on the connecting pipe;

[0019] Multiple electric telescopic rods B are arranged in a ring array around the sealed airbag; the sidewalls of the electric telescopic rods B are connected to the sealed airbag, one end of the electric telescopic rod B is fixed to the base ring, and the other end faces the drying and pulverizing cylinder structure.

[0020] In a further embodiment: the sealing airbag further includes an air heater connected to an exhaust fan; the exhaust fan is connected to the sealing airbag via the air heater and a connecting pipe; multiple air guide holes are provided on the inner liner ring, and the multiple air guide holes are distributed in a ring array along the inner liner ring; one end of the air guide hole is connected to the drying and pulverizing outer cylinder or the drying and pulverizing inner cylinder, and the other end is connected to the collection chamber; the collection chamber is located in the inner liner ring, and a solenoid valve B is installed on the collection chamber; the collection chamber is connected to the air heater, and a solenoid valve C is installed at the connection between the air heater and the collection chamber.

[0021] In a further embodiment: the drying and pulverizing outer cylinder and the drying and pulverizing inner cylinder adopt the same structure, and the drying and pulverizing outer cylinder includes:

[0022] Multiple drying columns are arranged in a ring array along the inner liner ring and correspond one-to-one with multiple air guide holes; the drying columns are inserted and fixed in the air guide holes;

[0023] Multiple drying rings are distributed along the drying column array and are all fixed on the drying column; the multiple drying rings and multiple drying columns are woven to form multiple cylindrical mesh openings;

[0024] The drying ring and drying column have the same structure. The drying column includes an inlet pipe and an outlet pipe. The outlet pipe is inserted inside the inlet pipe, and one end of the outlet pipe extends out of the inlet pipe and into the air guide hole, where it is connected to the solenoid valve B. The solenoid valve B is connected to the outside of the drying and pulverizing cylinder assembly. The end of the inlet pipe is fixed to the air guide hole and communicates with it. A drying sleeve is fitted over the inlet pipe. The drying sleeve is made of a corrosion-resistant elastic material. Multiple air inlets are provided on the inlet pipe, and the array of air inlets is distributed on the inlet pipe. The air inlets are used to connect the inside of the inlet pipe to the inside of the drying sleeve.

[0025] Compared with existing technologies, the continuous drying and pulverizing integrated machine for the production of crude heparin sodium of the present invention can achieve the following:

[0026] 1. After the wet solid heparin sodium enters the drying and pulverizing cylinder structure through the feed pipe, it first enters the innermost drying and pulverizing inner cylinder. The power shaft is then activated, synchronously transmitting power to the drying and pulverizing outer and inner cylinders, causing them to rotate synchronously. During this process, the wet solid heparin sodium is sequentially spread evenly on the inner walls of multiple drying and pulverizing inner cylinders, and is pulverized using the inner walls of the inner cylinders while being heated and dried. Because the mesh size of the multiple drying and pulverizing inner cylinders decreases sequentially from the inside out to the outer cylinder, the wet solid heparin sodium is ensured to fully contact the heating element in the cylinder mesh during the sequential pulverization process. This facilitates the coordinated operation of the drying and pulverizing processes, reducing equipment investment and maintenance costs.

[0027] 2. Start the motor. The motor transmits power to the power shaft through the telescopic shaft and universal joint. The power shaft transmits power synchronously to the outer and inner drying and pulverizing cylinders of the drying and pulverizing cylinder structure, causing the outer and inner drying and pulverizing cylinders to rotate synchronously. During this process, the electric telescopic rod A is periodically activated to extend and retract, so that the wet solid heparin sodium inside the outer and inner drying and pulverizing cylinders is shaken when they rotate synchronously. This further improves the dispersion of the wet solid heparin sodium and the contact surface with the inner wall of the inner drying and pulverizing cylinder. This allows the inner wall of the inner drying and pulverizing cylinder to heat and dry the wet solid heparin sodium while the mesh of the inner drying and pulverizing cylinder is used to pulverize the wet solid heparin sodium.

[0028] 3. During the synchronous rotation of the outer and inner drying and pulverizing cylinders, multiple electric telescopic rods B are first activated. These rods extend to seal the air bladders outside the outer or inner drying and pulverizing cylinder. With the air bladders extended on both sides of the outer or inner cylinder, the wet heparin sodium solids are evenly and smoothly locked inside and outside the cylinder. The exhaust fan supplies air to one side of the outer or inner cylinder for expansion, while solenoid valve A releases air and contracts on the other side, resulting in a reduction in space on one side and an expansion on the other. This completes the adjustment of the wet heparin sodium solids... The process involves heating and drying the inner wall of the drying and pulverizing inner cylinder while simultaneously using the inner cylinder's mesh for uniform pulverization. With solenoid valve A closed, an exhaust fan is used to inflate the sealed airbag on the side of the drying and pulverizing outer or inner cylinder that has already been vented using solenoid valve A. Then, solenoid valve A is used again to vent and contract the sealed airbag on the other side of the drying and pulverizing outer or inner cylinder that has already been inflated using the exhaust fan. This achieves secondary adjustment of the space on both sides of the drying and pulverizing outer or inner cylinder. By periodically starting the exhaust fan and solenoid valve A, the wet heparin sodium can be periodically and precisely passed through the inner wall of the drying and pulverizing inner cylinder for heating and drying while simultaneously using the inner cylinder's mesh for uniform pulverization.

[0029] 4. The exhaust fan sends air into the air heater, which heats the air before it enters the collection chamber. The air then flows through the air guide holes into the inlet pipe and is dispersed through multiple inlet holes into the space between the inlet pipe and the drying jacket. This allows the drying jacket to use the hot air inside to dry wet heparin sodium solids. During the expansion of the drying jacket, the size of the mesh openings can be adjusted to compress and dry the wet heparin sodium solids. The air, after heat conduction, collects at the end of the outlet pipe and flows along the outlet pipe into solenoid valve B, finally exiting outside the drying and pulverizing cylinder assembly. Because the hot air enters steadily through the inlet pipe, the periodic expansion of the drying jacket can be achieved by periodically opening and closing solenoid valve B.

[0030] 5. When the outer drying and pulverizing cylinder and multiple inner drying and pulverizing cylinders rotate synchronously under the drive of a motor, and the mesh size of the inner drying and pulverizing cylinders decreases sequentially from the inside to the outside, while the electric telescopic rod A is periodically activated to extend and retract during rotation, causing the outer and inner drying and pulverizing cylinders to shake during synchronous rotation, the above features work together to achieve particle size classification of heparin sodium wet solids during the sequential pulverization process. This is achieved not only through the gradual reduction of mesh size, but also through shaking, resulting in a more uniform distribution of the heparin sodium wet solids on the inner wall of the cylinder, preventing particle size loss due to separation. Material accumulation or localized excessive thickness caused by centrifugal force or gravity significantly increases the contact area and frequency between wet heparin sodium and the mesh heating element of the cylinder, enabling the drying and pulverizing processes to work together in the same rotating and shaking motion. By directly integrating the shaking function into the rotation process of the drying and pulverizing cylinder structure, there is no need to add an additional independent turning mechanism or material conveying mechanism. This allows for all-round dynamic heating of wet heparin sodium while pulverizing, which improves drying efficiency and avoids the problems of equipment bulkiness and increased costs caused by the separation of drying and pulverizing and the inability to reuse the turning mechanism in traditional equipment.

[0031] 6. When the sealing airbag extends and seals to the outside of the drying and pulverizing outer cylinder or inner cylinder via the extension of the electric telescopic rod B, while the sealing airbag on one side of the cylinder is expanded by the exhaust fan and the sealing airbag on the other side is deflated and contracted by the solenoid valve A, and the opening and closing states of the exhaust fan and solenoid valve A are periodically switched, the above features, in conjunction with the synchronous rotation of the drying and pulverizing outer cylinder and inner cylinder, enable the wet solid heparin sodium to be evenly and smoothly locked inside and outside the cylinder. Furthermore, by periodically changing the size of the space on both sides of the cylinder, the wet solid heparin sodium is repeatedly and precisely locked. The material passes precisely through the mesh of the outer or inner drying and pulverizing cylinder, thus achieving uniform pulverization while being heated and dried. By utilizing an expandable and contractible sealed airbag and periodic inflation and deflation control, the problem of uniform sieving of wet heparin sodium solids due to poor flowability during pulverization is not only solved, but also the active control of the material passing through the mesh is achieved. This transforms the drying and pulverization process from passive mechanical extrusion to a controllable pneumatic pushing process, significantly improving the uniformity of pulverization and sieving efficiency. At the same time, it avoids dependence on traditional pulverizing blades or grinding parts, further simplifying the equipment structure.

[0032] 7. After the exhaust fan heats the air in the air heater, it is introduced into the collection chamber, then enters the air inlet pipe through the air guide hole, and dispersed into the space between the air inlet pipe and the drying jacket through multiple air inlets. This allows the drying jacket to use the internal hot air to heat and dry the wet solid heparin sodium. Simultaneously, the expansion and contraction of the drying jacket are controlled by periodically opening and closing the solenoid valve B. During the expansion process, the size of the mesh of the outer or inner drying and pulverizing cylinder is adjusted, and the wet solid heparin sodium is squeezed. These features, combined with the mesh structure and rotation of the outer or inner drying and pulverizing cylinder, enable the hot air to act as both a drying medium and a means of mesh adjustment and compression pulverization. The power source integrates heating, mesh size adjustment, and extrusion crushing into a single drying jacket structure. The periodic expansion of the drying jacket, caused by the introduction of hot air, not only achieves uniform heating of wet heparin sodium but also dynamically changes the mesh size, generating active extrusion force on the material. This allows for auxiliary crushing of wet heparin sodium without the need for additional mechanical extrusion devices. Simultaneously, the hot air circulates within the drying jacket and is discharged through the exhaust pipe, ensuring full utilization of thermal energy. This avoids the energy waste and structural redundancy caused by separating the heating and crushing systems in traditional equipment, achieving synergistic effects of integrated drying, crushing, and heat recovery. Attached Figure Description

[0033] Figure 1 This is a schematic diagram of the continuous drying and pulverizing integrated machine for the production of crude heparin sodium according to the present invention;

[0034] Figure 2 for Figure 1 Schematic diagram of the structure of the intermediate-stage drying and pulverizing component;

[0035] Figure 3 for Figure 2 Schematic diagram of the structure of the intermediate drying pulverizing roller;

[0036] Figure 4 for Figure 1 Schematic diagram of the structure of the intermediate-stage drying and pulverizing chamber;

[0037] Figure 5 This is a schematic diagram of the drying and pulverizing cylinder assembly in this invention;

[0038] Figure 6 for Figure 5 A schematic diagram of the structure of the intermediate drying and pulverizing cylinder assembly after it has been flipped over;

[0039] Figure 7 for Figure 5 A demonstration image of the medium-drying pulverizing cylinder assembly after being sealed with a sealing airbag component;

[0040] Figure 8 for Figure 5A schematic diagram of the structure of the intermediate drying and pulverizing cylinder assembly after the sealing disc has been removed;

[0041] Figure 9 for Figure 8 A schematic diagram of the assembly structure of the outer cylinder for intermediate drying and pulverizing and the sealing airbag component;

[0042] Figure 10 for Figure 8 A schematic diagram of the structure in which multiple sealing airbag components are assembled inside the storage shell;

[0043] Figure 11 for Figure 9 Schematic diagram of the structure of the central sealing airbag component;

[0044] Figure 12 for Figure 9 Schematic diagram of the structure of the outer cylinder for drying and pulverizing;

[0045] Figure 13 for Figure 12 Schematic diagram of the structure of the drying column;

[0046] Figure 14 for Figure 13 A schematic cross-sectional view of the drying column;

[0047] Figure 15 This is a demonstration diagram of how the sealed airbag and the drying and pulverizing outer cylinder work together to dry and pulverize wet heparin sodium solids in this invention.

[0048] In the picture:

[0049] 100 units for primary drying and pulverizing chamber, 200 units for secondary drying and pulverizing chamber, 300 units for drying and pulverizing cylinder assembly, and 400 units for wet solid heparin sodium.

[0050] 110 primary drying and pulverizing component, 120 chain box, 130 drive unit, 140 support bar, 150 drying and pulverizing roller, 151 rotating column, 152 drying and pulverizing disc;

[0051] Feed inlet 210, secondary drying and pulverizing chamber 220, motor 230, sealing flip cover 240, support leg 250;

[0052] Sealing disc 310, hinge ball 320, feed pipe 330, connecting seat 340, power shaft 350, positioning ring 351, electric telescopic rod A 352, storage shell 360, sealing airbag component 370, sealing airbag 371, electric telescopic rod B 372, base ring 373, inner liner ring 374, air guide hole 375, drying and pulverizing cylinder structure 380, drying and pulverizing outer cylinder 381, drying and pulverizing inner cylinder 382; drying ring 3811, drying column 3812, drying sleeve 3813, air inlet pipe 3814, air outlet pipe 3815, air inlet hole 3816. Detailed Implementation

[0053] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention.

[0054] The specific implementation of the present invention will be described in detail below with reference to specific embodiments.

[0055] Example 1

[0056] like Figure 1 As shown, this embodiment provides a continuous drying and pulverizing integrated machine for the production of crude heparin sodium. It mainly addresses the problems in existing technologies where drying and pulverizing are separate processes. Furthermore, during the drying process, an additional mechanism is needed to agitate the wet heparin sodium solids for uniform heating. However, this agitation mechanism cannot be applied to the pulverizing mechanism, resulting in a lack of coordination between drying and pulverizing. Additionally, the separate addition of mechanisms leads to bloated equipment and increased costs. This integrated machine mainly includes a primary drying and pulverizing chamber 100 and a secondary drying and pulverizing chamber 200. The primary drying and pulverizing chamber 100 is mounted above the secondary drying and pulverizing chamber 200, and the primary and secondary drying and pulverizing chambers 100 are interconnected.

[0057] After the wet solid heparin sodium 400 is placed into the primary drying and pulverizing chamber 100 for preliminary synchronous drying and pulverizing, it is then introduced into the secondary drying and pulverizing chamber 200 for secondary synchronous drying and pulverizing.

[0058] Please continue reading. Figure 4 , Figure 5 and Figure 8 The secondary drying and pulverizing chamber 200 is internally equipped with two symmetrically distributed drying and pulverizing cylinder assemblies 300. The drying and pulverizing cylinder assembly 300 receives the heparin sodium wet solid 400 introduced from the primary drying and pulverizing chamber 100 and is used for continuous rotary drying and pulverizing of the heparin sodium wet solid 400. The drying and pulverizing cylinder assembly 300 includes:

[0059] The drying and pulverizing cylinder structure 380 is used for simultaneously drying and pulverizing wet solid heparin sodium 400; the drying and pulverizing cylinder structure 380 includes a drying and pulverizing outer cylinder 381 and at least two drying and pulverizing inner cylinders 382 arranged in sequence, the drying and pulverizing inner cylinders 382 are located inside the drying and pulverizing outer cylinder 381 and are located on the columnar center line of the drying and pulverizing outer cylinder 381.

[0060] The feed pipe 330 is ball-hinged to one end of the drying and pulverizing cylinder structure 380 and is connected to the innermost drying and pulverizing inner cylinder 382 of at least two drying and pulverizing inner cylinders 382 via a hose.

[0061] A power shaft 350 is mounted on the other end of the drying and pulverizing cylinder structure 380; the power shaft 350 is used to transmit power to the drying and pulverizing cylinder structure 380, and synchronously drive the drying and pulverizing outer cylinder 381 and the drying and pulverizing inner cylinder 382 to rotate.

[0062] Among them, the mesh size of the multiple drying and pulverizing inner cylinders 382 decreases sequentially from the inside to the outside, and then to the drying and pulverizing outer cylinder 381.

[0063] Therefore, after the wet solid heparin sodium 400 enters the drying and pulverizing cylinder structure 380 through the feed pipe 330, it will first enter the innermost drying and pulverizing inner cylinder 382. The power shaft 350 is then activated, synchronously transmitting power to the drying and pulverizing outer cylinder 381 and the drying and pulverizing inner cylinder 382 of the drying and pulverizing cylinder structure 380, causing them to rotate synchronously. During this process, the wet solid heparin sodium 400 will be successively spread evenly on the inner walls of multiple drying and pulverizing inner cylinders 382, ​​and simultaneously dried by heating the inner walls of the inner cylinders 382 while being pulverized using the mesh of the inner cylinders 382. Since the mesh size of the multiple drying and pulverizing inner cylinders 382 decreases sequentially from the inside out to the drying and pulverizing outer cylinder 381, the wet solid heparin sodium 400 can be fully contacted with the heating element of the cylinder mesh during the sequential pulverization process. This facilitates the coordinated operation of the drying and pulverizing processes, reducing equipment investment and maintenance costs.

[0064] Example 2

[0065] This embodiment is based on Embodiment 1, and the drying and pulverizing cylinder assembly 300 is further specified.

[0066] Please see Figure 5 and Figure 6 The drying and pulverizing cylinder assembly 300 further includes:

[0067] The sealing disc 310 is assembled at one end of the drying and pulverizing cylinder structure 380 and is used to position and fix the drying and pulverizing outer cylinder 381 and at least two drying and pulverizing inner cylinders 382.

[0068] The connecting seat 340 is fixed on the columnar centerline of the sealing disc 310;

[0069] A hinged ball 320 is hinged to the connecting seat 340; one end of the feed pipe 330 passes through the hinged ball 320 and is connected to the innermost drying and pulverizing inner cylinder 382 of at least two drying and pulverizing inner cylinders 382 via a hose; the other end of the feed pipe 330 is connected to the converging vertical pipe and is fixed together with the converging vertical pipe; the converging vertical pipe is located at the center of the secondary drying and pulverizing box 200 and is connected to the primary drying and pulverizing box 100; a material conveying auger is installed inside the feed pipe 330.

[0070] It should be further explained that the material conveying auger is existing technology. Of course, as is well known to those skilled in the art, the material conveying auger also needs to be provided with a power device to enable it to work normally. And as is well known to those skilled in the art, the provision of such power is commonplace and is a conventional means or common knowledge. It will not be elaborated here. Those skilled in the art can make any selection or configuration according to their needs or convenience.

[0071] After the wet solid heparin sodium 400 is placed into the primary drying and pulverizing chamber 100 for preliminary synchronous drying and pulverizing, it will be introduced into the collection vertical pipe of the secondary drying and pulverizing chamber 200. The conveying auger is started, and the conveying auger transports the wet solid heparin sodium 400 in the collection vertical pipe through the feed pipe 330 and the hose to the innermost drying and pulverizing inner cylinder 382. The power shaft 350 is started, and the power shaft 350 synchronously transmits power to the drying and pulverizing outer cylinder 381 and the drying and pulverizing inner cylinder 382 of the drying and pulverizing cylinder structure 380, causing the drying and pulverizing outer cylinder 381 and the drying and pulverizing inner cylinder 382 to rotate synchronously. During this process, the wet solid heparin sodium 400 will be spread flat on the inner wall of multiple drying and pulverizing inner cylinders 382 in sequence, and is pulverized by the heat drying of the inner wall of the drying and pulverizing inner cylinder 382 and the mesh of the drying and pulverizing inner cylinder 382.

[0072] Further: Please see Figures 4-6 The drying and pulverizing cylinder assembly 300 further includes:

[0073] A housing 360 is installed on the other end of the drying and pulverizing cylinder structure 380 away from the sealing disc 310, and is used to position and fix the drying and pulverizing outer cylinder 381 and at least two drying and pulverizing inner cylinders 382; a power shaft 350 is inserted and fixed on the housing 360, and is used to transmit power to the drying and pulverizing cylinder structure 380 through the housing 360, so as to synchronously drive the drying and pulverizing outer cylinder 381 and the drying and pulverizing inner cylinder 382 to rotate.

[0074] The positioning ring 351 is rotatably mounted on the drive shaft 350 via a bearing ring.

[0075] The electric telescopic rod A352 has one end rotatably mounted on the positioning ring 351, and the other end is fixed inside the secondary drying and pulverizing box 200;

[0076] Motor 230 is mounted at the end of the secondary drying and pulverizing chamber 200. A telescopic shaft is connected to the output shaft of motor 230 via a coupling. (The telescopic shaft includes a receiving tube, an inserting rod, and a pneumatic telescopic rod. The inserting rod is movably inserted inside the receiving tube. A limiting groove is provided on the inner wall of the receiving tube, distributed along the main body of the receiving tube and parallel to its cylindrical centerline. A limiting flange is provided on the outer wall of the inserting rod to match the limiting groove, and the limiting flange slides within the limiting groove. The pneumatic telescopic rod is fixed inside the receiving tube and used to control the degree of insertion of the inserting rod inside the receiving tube, thereby adjusting the length of the telescopic shaft.) The telescopic shaft is mounted on the power shaft 350 via a universal joint.

[0077] The motor 230 is started, and the motor 230 transmits power to the power shaft 350 through the telescopic rotating shaft and the universal joint. The power shaft 350 transmits power synchronously to the drying and pulverizing outer cylinder 381 and the drying and pulverizing inner cylinder 382 of the drying and pulverizing cylinder structure 380, driving the drying and pulverizing outer cylinder 381 and the drying and pulverizing inner cylinder 382 to rotate synchronously. During this process, the electric telescopic rod A352 is periodically activated to extend and retract, so that the heparin sodium wet solid 400 inside the drying and pulverizing outer cylinder 381 and the drying and pulverizing inner cylinder 382 are shaken when they rotate synchronously, which further improves the dispersion of the heparin sodium wet solid 400 and the contact surface with the inner wall of the drying and pulverizing inner cylinder 382. This allows the inner wall of the drying and pulverizing inner cylinder 382 to heat and dry the heparin sodium wet solid 400 from all directions, while the mesh of the drying and pulverizing inner cylinder 382 is used to pulverize the heparin sodium wet solid 400.

[0078] Please see Figure 5 The storage shell 360 has an annular groove inside, and multiple sealing airbags 370 are installed in the annular groove. The multiple sealing airbags 370 are arranged in a sequential nested manner. The multiple sealing airbags 370 correspond one-to-one with the drying and pulverizing outer cylinder 381 and at least two drying and pulverizing inner cylinders 382.

[0079] Please see Figures 5-11 The sealing airbag component 370 includes:

[0080] The base ring 373 is fixed to the bottom of the annular groove;

[0081] The inner lining ring 374 is integrally fixed at one end to the base ring 373, and the other end is fixed to the end of the drying and pulverizing outer cylinder 381 or the drying and pulverizing inner cylinder 382. The columnar center line of the inner lining ring 374 and the columnar center line of the base ring 373 are on the same straight line. The inner diameter of the inner lining ring 374 is the same as the inner diameter of the base ring 373, and the outer diameter of the inner lining ring 374 is less than the outer diameter of the base ring 373. Thus, an annular outer groove is formed from the outside of the inner lining ring 374 to the side of the base ring 373.

[0082] Please see Figures 5-11 The sealing airbag component 370 further includes:

[0083] A sealing airbag 371 is movably sleeved on an inner liner ring 374; one end of the sealing airbag 371 is connected to a base ring 373, and the other end faces the drying and pulverizing cylinder structure 380; the sealing airbag 371 is connected to an exhaust fan through a connecting pipe, and the exhaust fan is installed inside the storage shell 360; a solenoid valve A is installed on the connecting pipe.

[0084] Multiple electric telescopic rods B372 are arranged in a ring array around the sealing airbag 371; the side walls of the electric telescopic rods B372 are connected to the sealing airbag 371, one end of the electric telescopic rods B372 is fixed to the base ring 373, and the other end faces the drying and pulverizing cylinder structure 380.

[0085] Therefore, during the synchronous rotation of the outer drying and pulverizing cylinder 381 and the inner drying and pulverizing cylinder 382, ​​multiple electric telescopic rods B372 are first activated. The electric telescopic rods B372 extend to seal the sealing airbags 371 to the outside of the outer drying and pulverizing cylinder 381 or the inner drying and pulverizing cylinder 382. After the sealing airbags 371 on both the inner and outer sides of the outer drying and pulverizing cylinder 381 or the inner drying and pulverizing cylinder 382 are extended, the wet heparin sodium 400 can be evenly and smoothly locked inside and outside the cylinders of the outer drying and pulverizing cylinder 381 or the inner drying and pulverizing cylinder 382 (see details for reference). Figure 15 When the exhaust fan supplies air to one side of the drying and pulverizing outer cylinder 381 or the drying and pulverizing inner cylinder 382 for expansion, solenoid valve A releases air and contracts on the other side of the drying and pulverizing outer cylinder 381 or the drying and pulverizing inner cylinder 382, ​​thus reducing the space on one side of the drying and pulverizing outer cylinder 381 or the drying and pulverizing inner cylinder 382 and expanding the space on the other side; this completes the precise heating and drying of heparin sodium wet solid 400 through the inner wall of the drying and pulverizing inner cylinder 382, ​​while simultaneously using the mesh of the drying and pulverizing inner cylinder 382 for uniform pulverization; after closing solenoid valve A, the exhaust fan supplies air to the drying and pulverizing outer cylinder 381 or the drying and pulverizing inner cylinder 382 that has already been vented by solenoid valve A. The sealing airbag 371 on this side of the inner cylinder 382 is expanded by air supply, and the sealing airbag 371 on the other side of the outer cylinder 381 or inner cylinder 382, ​​which has been inflated by the exhaust fan, is deflated and contracted by the solenoid valve A, thereby achieving secondary adjustment of the space on both sides of the outer cylinder 381 or inner cylinder 382. After periodically starting the exhaust fan and solenoid valve A, it is possible to periodically adjust the heparin sodium wet solid 400 to repeatedly and accurately pass through the inner wall of the inner cylinder 382 for heating and drying, while using the mesh of the inner cylinder 382 for uniform pulverization.

[0086] Please see Figures 5-11The sealing airbag component 370 also includes an air heater connected to an exhaust fan; the exhaust fan is connected to the sealing airbag 371 via the air heater and a connecting pipe; the inner liner ring 374 has multiple air guide holes 375, which are distributed in a ring array along the inner liner ring 374; one end of the air guide hole 375 is connected to the drying and pulverizing outer cylinder 381 or the drying and pulverizing inner cylinder 382, ​​and the other end is connected to the collection chamber; the collection chamber is located in the inner liner ring 374, and a solenoid valve B is installed on the collection chamber; the collection chamber is connected to the air heater, and a solenoid valve C is installed at the connection between the air heater and the collection chamber.

[0087] It should be noted that the exhaust fan and air heater are existing technologies, and their detailed structures can be found in existing literature and journals. They can also be purchased directly on the market, or components can be purchased on the market and assembled, etc. They are not the subject of this invention and will not be described in detail here.

[0088] Please see Figure 8 , Figures 12-14 The drying and pulverizing outer cylinder 381 and the drying and pulverizing inner cylinder 382 adopt the same structure. The drying and pulverizing outer cylinder 381 includes:

[0089] Multiple drying columns 3812 are arranged in a ring array along the inner liner ring 374 and correspond one-to-one with multiple air guide holes 375; the drying columns 3812 are inserted and fixed in the air guide holes 375.

[0090] Multiple drying rings 3811 are arranged in an array along the drying column 3812 and are all fixed on the drying column 3812; the multiple drying rings 3811 and the multiple drying columns 3812 are woven to form multiple cylindrical meshes;

[0091] The drying ring 3811 and the drying column 3812 have the same structure (it should be noted that the drying ring 3811 and the drying column 3812 are identical except that one is straight and the other is circular); the drying column 3812 includes an inlet pipe 3814 and an outlet pipe 3815. The outlet pipe 3815 is inserted inside the inlet pipe 3814, and one end of the outlet pipe 3815 extends out of the inlet pipe 3814 and into the air guide hole 375, where it connects to the solenoid valve B; The solenoid valve B is connected to the outside of the drying and pulverizing cylinder assembly 300; the end of the air inlet pipe 3814 is fixed on the air guide hole 375 and communicates with the air guide hole 375; a drying sleeve 3813 is fitted on the outside of the air inlet pipe 3814, and the drying sleeve 3813 is made of corrosion-resistant elastic material; multiple air inlets 3816 are opened on the air inlet pipe 3814, and the multiple air inlets 3816 are arrayed on the air inlet pipe 3814, and the air inlets 3816 are used to connect the inside of the air inlet pipe 3814 to the inside of the drying sleeve 3813.

[0092] It should be noted that the drying sleeve 3813 made of corrosion-resistant elastic material is existing technology. Its detailed structure can be found in existing literature and journals, and it can also be purchased directly on the market, or its components can be purchased on the market and assembled, etc. It is not what this invention is meant to protect, and will not be described in detail here.

[0093] Therefore, the exhaust fan sends air into the air heater, heats it, and then guides it into the collection chamber. The air then enters the air inlet pipe 3814 through the air guide hole 375 and is dispersed into the space between the air inlet pipe 3814 and the drying sleeve 3813 through multiple air inlets 3816. This allows the drying sleeve 3813 to dry the wet solid heparin sodium 400 using the hot air inside. During the expansion of the drying sleeve 3813, the size of the mesh openings can be adjusted to compress and dry the wet solid heparin sodium 400. The air, after heat conduction, gathers at the end of the air outlet pipe 3815 and is discharged into the solenoid valve B along the air outlet pipe 3815, finally exiting to the outside of the drying and pulverizing cylinder assembly 300. Because the hot air in the air inlet pipe 3814 enters stably, the periodic expansion of the drying sleeve 3813 can be achieved by periodically opening and closing the solenoid valve B.

[0094] It should also be noted that there can be multiple exhaust fans, which are respectively matched with the drying column 3812 and the sealing airbag 371; this is prior art, and its detailed structure can be found in existing literature and journals, and can also be purchased directly on the market, or the components can be purchased on the market to assemble it, etc.; it is not what this invention is meant to protect, and will not be described in detail here.

[0095] Example 3

[0096] This embodiment, based on embodiment 1 or 2, specifies the primary drying and pulverizing chamber 100 and the secondary drying and pulverizing chamber 200.

[0097] Please see Figure 4 The secondary drying and pulverizing chamber 200 includes:

[0098] The secondary drying and pulverizing chamber 220 is installed at the bottom of the primary drying and pulverizing chamber 100;

[0099] The feed inlet 210 is located at the top of the secondary drying and pulverizing chamber 220; the feed inlet 210 is used to connect the secondary drying and pulverizing chamber 220 to the primary drying and pulverizing chamber 100 (the specific connecting vertical pipe is set at the bottom of the feed inlet 210 and connected to the feed inlet 210).

[0100] Multiple support legs 250 are arrayed and distributed on both sides of the secondary drying and pulverizing chamber 220;

[0101] The sealing flip cover 240 is rotatably mounted on the bottom of the secondary drying and pulverizing chamber 220 and is used to open or seal the secondary drying and pulverizing chamber 220.

[0102] Please see Figures 1-3 The primary drying and pulverizing chamber 100 includes a primary drying and pulverizing chamber body and a primary drying and pulverizing component 110 installed inside the primary drying and pulverizing chamber body. The primary drying and pulverizing component 110 includes:

[0103] Support bar 140 is assembled inside the primary drying and pulverizing chamber;

[0104] Multiple drying and pulverizing rollers 150 are rotatably mounted on the support bar 140;

[0105] A chain box 120, which is equipped with a chain and multiple sprockets, is installed inside the primary drying and pulverizing chamber. The chain box 120 is used for the rotational assembly of multiple drying and pulverizing rollers 150. The multiple drying and pulverizing rollers 150 are in one-to-one correspondence with multiple sprockets. The sprockets are fixed at the ends of the drying and pulverizing rollers 150, and the drying and pulverizing rollers 150 are connected to the chain by the power transmission of the sprockets.

[0106] A drive unit 130, which includes a geared motor and a servo motor, is mounted in a chain box 120 and connected to the chain power transmission.

[0107] The drying and pulverizing roller 150 includes a rotating column 151 and multiple drying and pulverizing discs 152 mounted on the rotating column 151; a hydraulic telescopic rod is fixed at each end of the rotating column 151, and the hydraulic telescopic rod is used to drive the rotating column 151 to move periodically along its column direction.

[0108] It should also be noted that the drying and pulverizing disc 152 is existing technology. For example, the drying and pulverizing disc 152 is equipped with a heating wire, and its detailed structure can be found in existing literature and journals. It can also be purchased directly on the market, or components can be purchased on the market to assemble it, etc. It is not what this invention is meant to protect, and will not be described in detail here.

[0109] Therefore, the drive unit 130 transmits power to multiple drying and pulverizing rollers 150 through chains and multiple sprockets. During the rotation of the multiple drying and pulverizing rollers 150, the hydraulic telescopic rod is activated to extend and retract, driving the rotating column 151 to move periodically along its column direction, so that the multiple drying and pulverizing rollers 150 pulverize the heparin sodium wet solid 400 during the process of heating and drying the heparin sodium wet solid 400 using the drying and pulverizing disc 152.

[0110] In summary: When the drying and pulverizing outer cylinder 381 and multiple drying and pulverizing inner cylinders 382 rotate synchronously under the drive of motor 230, and the mesh size of the multiple drying and pulverizing inner cylinders 382 decreases sequentially from the inside to the outside, and the electric telescopic rod A352 is periodically activated to extend and retract during rotation, causing the drying and pulverizing outer cylinder 381 and drying and pulverizing inner cylinders 382 to shake during synchronous rotation, the above features work together to achieve particle size classification of heparin sodium wet solids 400 during the sequential pulverization process, not only through the gradual reduction of mesh size, but also through shaking, causing the heparin sodium wet solids 400 to separate on the inner wall of the cylinder. The cloth is more evenly distributed, avoiding material accumulation or excessive local thickness caused by centrifugal force or gravity, thus significantly increasing the contact area and contact frequency between the heparin sodium wet solids 400 and the cylinder mesh heating element. This allows the drying and pulverizing processes to work together in the same rotating and shaking motion. By directly integrating the shaking function into the rotation process of the drying and pulverizing cylinder structure 380, there is no need to add an additional independent turning mechanism or material conveying mechanism. This allows for all-round dynamic heating of the heparin sodium wet solids 400 while pulverizing, which not only improves drying efficiency but also avoids the problems of equipment bulkiness and increased costs caused by the separation of drying and pulverizing in traditional equipment and the inability to reuse the turning mechanism.

[0111] When the sealing airbag 371 extends and seals to the outside of the drying and pulverizing outer cylinder 381 or the drying and pulverizing inner cylinder 382 via the extension of the electric telescopic rod B372, and simultaneously the sealing airbag 371 on one side of the cylinder is expanded by the exhaust fan and the sealing airbag 371 on the other side is deflated and contracted by the solenoid valve A, and the opening and closing states of the exhaust fan and the solenoid valve A are periodically switched, the above features, in conjunction with the synchronous rotation of the drying and pulverizing outer cylinder 381 and the drying and pulverizing inner cylinder 382, ​​can achieve the smooth and uniform locking of the heparin sodium wet solid 400 on both the inner and outer sides of the cylinder, and by periodically changing the size of the space on both sides of the cylinder, the heparin sodium wet solid... The material 400 repeatedly and precisely passes through the mesh of the drying and pulverizing outer cylinder 381 or the drying and pulverizing inner cylinder 382, ​​thereby achieving uniform pulverization while heating and drying. By utilizing the expandable and contractible sealed airbag 371 and periodic inflation and deflation control, not only is the problem of poor flowability of heparin sodium wet solid 400 during the pulverization process difficult to sieve evenly, but it also realizes the active control of the material passing through the mesh, transforming the drying and pulverization process from passive mechanical extrusion to a controllable pneumatic pushing process. This significantly improves the uniformity of pulverization and sieving efficiency, while avoiding reliance on traditional pulverizing blades or grinding parts, further simplifying the equipment structure.

[0112] When the exhaust fan sends air into the air heater for heating, it is then introduced into the collection chamber, and then enters the air inlet pipe 3814 through the air guide hole 375. The air is then dispersed into the space between the air inlet pipe 3814 and the drying jacket 3813 through multiple air inlet holes 3816, allowing the drying jacket 3813 to use the internal hot air to heat and dry the heparin sodium wet solid 400. Simultaneously, the expansion and contraction of the drying jacket 3813 are controlled by periodically opening and closing the solenoid valve B. During the expansion process, the size of the mesh of the drying and pulverizing outer cylinder 381 or the drying and pulverizing inner cylinder 382 is adjusted, and the heparin sodium wet solid 400 is compressed. These features, combined with the mesh structure and rotation of the drying and pulverizing outer cylinder 381 or the drying and pulverizing inner cylinder 382, ​​enable the hot air to act as both a drying medium and a drying agent. As the power source for mesh adjustment and extrusion crushing, the drying jacket 3813 integrates heating, mesh adjustment, and extrusion crushing functions into the same structure. By filling the jacket with hot air, the drying jacket 3813 expands periodically, which not only achieves uniform heating of heparin sodium wet solid 400, but also dynamically changes the mesh size to generate active extrusion force on the material. Thus, it completes the auxiliary crushing of heparin sodium wet solid 400 without the need for an additional mechanical extrusion device. At the same time, the hot air circulates within the drying jacket 3813 and is discharged through the air outlet 3815, realizing full utilization of thermal energy. This avoids the energy waste and structural redundancy caused by the separation of the heating system and crushing system in traditional equipment, achieving synergistic efficiency of drying, crushing, and heat recovery integration.

[0113] In the description of this invention, unless otherwise stated, "a plurality of" means two or more. It should be noted that, unless otherwise explicitly specified and limited, the terms "installed," "connected," and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art will understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0114] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of the present invention.

Claims

1. A continuous drying and pulverizing integrated machine for the production of crude heparin sodium, comprising a primary drying and pulverizing chamber (100) and a secondary drying and pulverizing chamber (200), wherein the primary drying and pulverizing chamber (100) is mounted above the secondary drying and pulverizing chamber (200), and the primary drying and pulverizing chamber (100) and the secondary drying and pulverizing chamber (200) are interconnected; characterized in that, The secondary drying and pulverizing chamber (200) is internally equipped with two symmetrically distributed drying and pulverizing cylinder assemblies (300). The drying and pulverizing cylinder assembly (300) is used for continuous rotary drying and pulverizing of the heparin sodium wet solid (400) after receiving it from the primary drying and pulverizing chamber (100). The drying and pulverizing cylinder assembly (300) includes: A drying and pulverizing cylinder structure (380) is used for simultaneously drying and pulverizing wet solid heparin sodium (400); the drying and pulverizing cylinder structure (380) includes a drying and pulverizing outer cylinder (381) and at least two drying and pulverizing inner cylinders (382) arranged in sequence, the drying and pulverizing inner cylinders (382) being located inside the drying and pulverizing outer cylinder (381) and on the columnar centerline of the drying and pulverizing outer cylinder (381); The feed pipe (330) is ball-hinged to one end of the drying and pulverizing cylinder structure (380) and connected to the innermost drying and pulverizing inner cylinder (382) of at least two drying and pulverizing inner cylinders (382) via a hose; A power shaft (350) is mounted on the other end of the drying and pulverizing cylinder structure (380); the power shaft (350) is used to transmit power to the drying and pulverizing cylinder structure (380) and synchronously drive the drying and pulverizing outer cylinder (381) and the drying and pulverizing inner cylinder (382) to rotate. Among them, the mesh size of the multiple drying and pulverizing inner cylinders (382) decreases sequentially from the inside to the outside, and then to the drying and pulverizing outer cylinder (381).

2. The continuous drying and pulverizing integrated machine for crude heparin sodium production according to claim 1, characterized in that, The drying and pulverizing cylinder assembly (300) also includes: A sealing disc (310) is assembled at one end of the drying and pulverizing cylinder structure (380) and is used to position and fix the drying and pulverizing outer cylinder (381) and at least two drying and pulverizing inner cylinders (382); The connecting seat (340) is fixed on the columnar centerline of the sealing disc (310); A hinged ball (320) is hinged to the connecting seat (340); one end of the feed pipe (330) passes through the hinged ball (320) and is connected to the innermost drying and pulverizing inner cylinder (382) of at least two drying and pulverizing inner cylinders (382) via a hose; the other end of the feed pipe (330) is connected to the converging vertical pipe and is fixed together with the converging vertical pipe; the converging vertical pipe is located at the center of the secondary drying and pulverizing box (200) and is connected to the primary drying and pulverizing box (100); a material conveying auger is installed inside the feed pipe (330).

3. The continuous drying and pulverizing integrated machine for crude heparin sodium production according to claim 2, characterized in that, The drying and pulverizing cylinder assembly (300) also includes: A housing (360) is installed on the other end of the drying and pulverizing cylinder structure (380) away from the sealing disc (310) and is used to position and fix the drying and pulverizing outer cylinder (381) and at least two drying and pulverizing inner cylinders (382); a power shaft (350) is inserted and fixed on the housing (360) and is used to transmit power to the drying and pulverizing cylinder structure (380) through the housing (360) to synchronously drive the drying and pulverizing outer cylinder (381) and the drying and pulverizing inner cylinder (382) to rotate. The positioning ring (351) is rotatably mounted on the power shaft (350) via the bearing ring; The electric telescopic rod A (352) is rotatably mounted on the positioning ring (351) at one end and fixed inside the secondary drying and pulverizing box (200) at the other end; The motor (230) is mounted at the end of the secondary drying and pulverizing box (200); the output shaft of the motor (230) is connected to a telescopic shaft via a coupling; the telescopic shaft is mounted on the power shaft (350) via a universal joint.

4. The continuous drying and pulverizing integrated machine for crude heparin sodium production according to claim 3, characterized in that, The storage shell (360) has an annular groove inside, and multiple sealing airbags (370) are installed in the annular groove. The multiple sealing airbags (370) are arranged in sequence. The multiple sealing airbags (370) correspond one-to-one with the drying and pulverizing outer cylinder (381) and at least two drying and pulverizing inner cylinders (382).

5. The continuous drying and pulverizing integrated machine for crude heparin sodium production according to claim 4, characterized in that, The sealing airbag component (370) includes: The base ring (373) is fixed to the bottom of the annular groove; The inner lining ring (374) is integrally fixed at one end to the base ring (373), and the other end is fixed at the end of the drying and pulverizing outer cylinder (381) or the drying and pulverizing inner cylinder (382). The column center line of the inner lining ring (374) and the column center line of the base ring (373) are on the same straight line. The inner diameter of the inner lining ring (374) is the same as the inner diameter of the base ring (373), and the outer diameter of the inner lining ring (374) is smaller than the outer diameter of the base ring (373). Thus, an annular outer groove is formed from the outside of the inner lining ring (374) to the side of the base ring (373).

6. The continuous drying and pulverizing integrated machine for crude heparin sodium production according to claim 5, characterized in that, The sealing airbag component (370) further includes: A sealing airbag (371) is movably fitted onto an inner liner ring (374); one end of the sealing airbag (371) is connected to a base ring (373), and the other end faces the drying and pulverizing cylinder structure (380); the sealing airbag (371) is connected to an exhaust fan via a connecting pipe, and the exhaust fan is installed inside a housing (360); a solenoid valve A is installed on the connecting pipe; Multiple electric telescopic rods B (372) are arranged in a ring array around the sealing airbag (371); the sidewalls of the electric telescopic rods B (372) are connected to the sealing airbag (371), one end of the electric telescopic rods B (372) is fixed to the base ring (373), and the other end faces the drying and pulverizing cylinder structure (380).

7. The continuous drying and pulverizing integrated machine for crude heparin sodium production according to claim 6, characterized in that, The sealing airbag component (370) also includes an air heater connected to an exhaust fan; the exhaust fan is connected to the sealing airbag (371) via the air heater and a connecting pipe; multiple air guide holes (375) are provided on the inner liner ring (374), and the multiple air guide holes (375) are distributed in a ring array along the inner liner ring (374); one end of the air guide hole (375) is connected to the drying and pulverizing outer cylinder (381) or the drying and pulverizing inner cylinder (382), and the other end is connected to the collection chamber; the collection chamber is opened in the inner liner ring (374), and a solenoid valve B is installed on the collection chamber; the collection chamber is connected to the air heater, and a solenoid valve C is installed at the connection between the air heater and the collection chamber.

8. The continuous drying and pulverizing integrated machine for crude heparin sodium production according to claim 7, characterized in that, The drying and pulverizing outer cylinder (381) and the drying and pulverizing inner cylinder (382) adopt the same structure. The drying and pulverizing outer cylinder (381) includes: Multiple drying columns (3812) are arranged in a ring array along the inner liner ring (374) and correspond one-to-one with multiple air guide holes (375); the drying columns (3812) are inserted and fixed in the air guide holes (375); Multiple drying rings (3811) are arranged in an array along the drying column (3812) and are all fixed on the drying column (3812); the multiple drying rings (3811) and the multiple drying columns (3812) are woven to form multiple cylindrical meshes; The drying ring (3811) and the drying column (3812) have the same structure; the drying column (3812) includes an inlet pipe (3814) and an outlet pipe (3815), the outlet pipe (3815) is inserted inside the inlet pipe (3814), and one end of the outlet pipe (3815) extends out of the inlet pipe (3814) and into the air guide hole (3815), and is connected to the solenoid valve B; the solenoid valve B is connected to the outside of the drying and pulverizing cylinder assembly (300); the inlet pipe (3811) and the drying column (3812) have the same structure; the drying column (3812) includes an inlet pipe (3814) and an outlet pipe (3815), the outlet pipe (3815) is inserted inside the inlet pipe (3814), and the outlet pipe (3815) extends into the air guide hole (375), and is connected to the solenoid valve B; the solenoid valve B is connected to the outside of the drying and pulverizing cylinder assembly (300); the inlet pipe (3811) and the drying column (3812) have the same structure; the drying column (3811) includes an inlet pipe (3814) and an outlet pipe (3815), the outlet pipe (3815) is inserted inside the inlet pipe (3814), the outlet pipe (3815) extends into the air guide hole (375), and is connected to the solenoid valve B; the solenoid valve B is connected to the outside of the drying and pulverizing cylinder assembly (300); the drying column (3811) and the drying column (3812) have the same structure; the drying column (3811) includes an inlet pipe (3814) and an outlet pipe (3815), the outlet pipe (3815) extends into the air guide hole (3815), the outlet pipe (3815) extends into the air guide hole ( 14) The end is fixed on the air guide hole (375) and connected to the air guide hole (375); the air inlet pipe (3814) is covered with a drying sleeve (3813), which is made of corrosion-resistant elastic material; multiple air inlets (3816) are opened on the air inlet pipe (3814), and the multiple air inlets (3816) are arrayed on the air inlet pipe (3814). The air inlets (3816) are used to connect the inside of the air inlet pipe (3814) to the inside of the drying sleeve (3813).

9. The continuous drying and pulverizing integrated machine for the production of crude heparin sodium according to claim 1, characterized in that, The secondary drying and pulverizing chamber (200) includes: The secondary drying and pulverizing chamber (220) is installed at the bottom of the primary drying and pulverizing chamber (100); The feed inlet (210) is located at the top of the secondary drying and pulverizing chamber (220); the feed inlet (210) is used to connect the secondary drying and pulverizing chamber (220) to the primary drying and pulverizing chamber (100). Multiple support legs (250) are arrayed on both sides of the secondary drying and pulverizing chamber (220); A sealing flip cover (240) is rotatably mounted on the bottom of the secondary drying and pulverizing chamber (220) and is used to open or seal the secondary drying and pulverizing chamber (220).

10. The continuous drying and pulverizing integrated machine for crude heparin sodium production according to claim 1, characterized in that, The primary drying and pulverizing chamber (100) includes a primary drying and pulverizing chamber body and a primary drying and pulverizing component (110) installed inside the primary drying and pulverizing chamber body. The primary drying and pulverizing component (110) includes: Support bar (140) is assembled inside the primary drying and pulverizing chamber; Multiple drying and pulverizing rollers (150) are rotatably mounted on the support bar (140); A chain box (120) with a chain and multiple sprockets inside is assembled inside the primary drying and pulverizing chamber; the chain box (120) is used for the rotational assembly of multiple drying and pulverizing rollers (150); the multiple drying and pulverizing rollers (150) correspond one-to-one with the multiple sprockets, the sprockets are fixed at the ends of the drying and pulverizing rollers (150), and the drying and pulverizing rollers (150) are connected to the chain by the sprocket power transmission; A drive unit (130) containing a geared motor and a servo motor is mounted in a chain box (120) and connected to the chain power transmission. The drying and pulverizing roller (150) includes a rotating column (151) and multiple drying and pulverizing discs (152) mounted on the rotating column (151); a hydraulic telescopic rod is fixed at each end of the rotating column (151), and the hydraulic telescopic rod is used to drive the rotating column (151) to move periodically along its column direction.

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