Drug-loaded contact lenses based on interface confinement and step-by-step assembly and preparation method and application thereof

By constructing a functional layer on the surface of the contact lens through interface-confined hierarchical assembly technology, the problem of balancing functional load and lens performance in existing technologies is solved. This enables efficient drug release at the lesion site and maintenance of lens performance, making it suitable for treatment in multiple scenarios.

CN122398709APending Publication Date: 2026-07-17ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV
Filing Date
2026-05-11
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing drug-eluting contact lenses struggle to balance functional load and body performance, the effective sites on the lens surface and lesion interface are not fully utilized, and the response release capability is insufficient.

Method used

Using soft contact lenses containing tertiary amine sites as the reaction substrate, a dynamic functional layer confined at the interface is constructed by assembling phenylboronic acid, polyphenol structures, and metal ion functional layers in a stepwise manner. By utilizing the interaction between phenylboronic acid and polyphenols and the responsiveness of the metal-polyphenol network, the dynamic release of drugs in acidic and reactive oxygen species environments can be achieved.

Benefits of technology

It improves the interface functional density, enhances the responsiveness of the lens surface functional layer, ensures efficient drug release at the lesion site, maintains the lens's transparency, water content, and mechanical properties, and is suitable for multiple treatment scenarios such as anti-infection, anti-inflammation, and repair promotion.

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Abstract

本发明公开一种基于界面限域逐级组装的载药隐形眼镜及其制备方法和应用，方法包括步骤：将含叔胺位点的隐形眼镜在水性介质中溶胀平衡后，依次浸入含苯硼酸衍生物的溶液、含多酚组分的溶液、含金属离子的溶液中反应，得到所述载药隐形眼镜。本发明以含有叔胺位点隐形眼镜为基底，逐层组装苯硼酸‑多酚‑金属动态功能层，由于镜片网络中叔胺位点与外界反应物集中于表面及近表层区域，能够在避免大量功能组分进入体相内部的前提下，提高界面功能密度，所构筑的界面功能层能够在弱酸感染微环境中优先释放金属离子，并在活性氧升高时发生部分或整体解组装，从而实现病理微环境响应性递药。
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Citation Information

Patent Citations

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  • Drug-loaded contact lens with nano-pores as well as preparation method and application of drug-loaded contact lens

    CN118519286A