Process for the preparation of uroporphyrin i derivatives and use thereof
By synthesizing a variety of uroporphyrin I derivatives in vitro, the problems of difficult synthesis and unsatisfactory yield in the existing technology have been solved, and the efficient preparation of a variety of uroporphyrin I derivatives has been achieved, demonstrating their application potential in pigments, anticancer drugs and plant growth regulators.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- INST OF MICROBIOLOGY CHINESE ACAD OF SCI
- Filing Date
- 2026-04-14
- Publication Date
- 2026-07-17
AI Technical Summary
Existing methods for synthesizing uroporphyrin I derivatives are unsystematic, with difficult chemical synthesis and low yields, while microbial synthesis suffers from unsatisfactory yields and poor metal selectivity, making it difficult to achieve the co-production of multiple metalloporphyrin compounds.
A variety of uroporphyrin I derivatives were prepared by in vitro synthesis, by controlling the chelation reaction of different metal salts with uroporphyrin I under specific pH and temperature conditions, and esterified uroporphyrin I was prepared by esterification reaction.
The efficient preparation of various uroporphyrin I derivatives was achieved, demonstrating their potential applications in pigments, anticancer drugs, and plant growth regulators. In particular, Cu-UP I showed superior effects in anticancer activity and UPI in promoting plant growth.
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