A sers platform composite substrate and a preparation method and application thereof

By leveraging the layered structure of the OCC@TiO2@AgNPs composite substrate and the photocatalytic properties of TiO2, the problems of low detection efficiency and high cost of antibiotics have been solved, achieving highly sensitive, broad-spectrum, and sustainable detection results, which are suitable for aquaculture and food safety monitoring.

CN122409501APending Publication Date: 2026-07-17JIANGNAN UNIV

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGNAN UNIV
Filing Date
2026-04-22
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing technologies for antibiotic detection suffer from low efficiency and low accuracy. Traditional SERS substrates are difficult to identify and recycle, resulting in high detection costs and a heavy environmental burden.

Method used

The OCC@TiO2@AgNPs composite substrate with a layered structure achieves broad-spectrum and high-sensitivity detection through the semiconductor-plasmotropic synergistic enhancement effect, and utilizes the photocatalytic properties of TiO2 to achieve efficient regeneration and recycling of the substrate.

Benefits of technology

It enables the detection of multiple antibiotics at the pM level, covering a detection range from 10 pM to 107 pM. It has high detection accuracy, low cost, and is environmentally friendly, making it suitable for aquaculture and food safety monitoring.

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Abstract

本发明涉及生物检测技术领域,尤其是指一种SERS平台复合基底及其制备方法和应用。本发明通过构建分层结构的氧化碳布@二氧化钛@银纳米粒子(OCC@TiO2@AgNPs)复合基底,利用半导体‑等离激元协同增强效应,实现了对恩诺沙星(ENR)、磺胺嘧啶(SD)和麦迪霉素(MID)等多种抗生素的广谱、高灵敏检测。同时,通过机器学习算法构建智能化定量分析模型,实现多抗生素的快速识别与精准定量。此外,该平台利用TiO2的光催化自清洁特性,通过紫外光照实现基底的高效再生与循环利用。该智能SERS平台兼具广谱检测、智能分析与可持续利用等优势,为抗生素现场快速检测提供了智能化解决方案。
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