A pH-responsive hydrogel composite dressing as well as a preparation method and application thereof

By loading engineered exosomes and platelet-rich plasma onto a pH-responsive hydrogel composite dressing, the problem of existing dressings being unable to simultaneously neutralize α-toxins of MRSA infection and reshape the immune microenvironment of the wound was solved, achieving rapid wound healing and immune regulation.

CN122537582APending Publication Date: 2026-08-11SHENYANG PHARMA UNIV
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Patent Information

Application Number
CN202610974433.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-07-01
Publication Date
2026-08-11

AI Technical Summary

Technical Problem

Existing diabetic wound dressings cannot simultaneously achieve targeted neutralization of alpha-toxins in MRSA infection and remodeling of the wound immune microenvironment, resulting in poor treatment outcomes.

Method used

A pH-responsive hydrogel composite dressing is used to form a dynamic covalent cross-linked network through a Schiff base reaction. This network is loaded with engineered exosomes and platelet-rich plasma, and combined with the hydrogel matrix formed by the Schiff base reaction, engineered exosomes with high expression of ADAM10 protein on their surface are loaded to achieve toxin capture and immune metabolism regulation.

Benefits of technology

It effectively neutralizes α-toxins from MRSA infection, promotes angiogenesis, reduces lactic acid buildup, reverses immunosuppression, and promotes macrophage polarization towards a pro-repair phenotype, thereby achieving rapid wound healing and remodeling of the immune microenvironment.

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Abstract

This invention relates to a pH-responsive hydrogel composite dressing, its preparation method, and its application, belonging to the field of biomedical materials and drug delivery technology. The pH-responsive hydrogel composite dressing comprises a hydrogel matrix and engineered exosomes and platelet-rich plasma uniformly loaded within the hydrogel matrix. The hydrogel matrix comprises a three-dimensional dynamic cross-linked network formed by a Schiff base reaction between an amino-containing polysaccharide derivative and an oxidized aldehyde-containing polysaccharide derivative. The engineered exosomes are derived from donor cells subjected to pathogen-associated molecular pattern stress treatment. The dressing provided by this invention possesses both toxin capture and immunometabolic regulation functions, achieving synergistic therapeutic effects against MRSA-infected diabetic wounds.
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