Guide wire and connecting structure

Abstract

The present invention provides a guidewire having a flexible tip. The disclosed guidewire (1) includes: a mandrel (9); a coil body (3) covering the front end of the mandrel (9); a front end connector (2) connecting the front end of the coil body (3) and the front end of the mandrel (9); and a base end connector (5) connecting the base end of the coil body (3) and the mandrel (9) and including an adhesive made of resin material.

Description

Technical Field

[0001] This disclosure relates to a medical guidewire and a connection structure. Background Technology

[0002] Patent Document 1 describes a guide wire comprising: a core wire; a metal coil mounted on the outer periphery of the front end of the core wire; a brazing portion mounted between the front end of the metal coil and the front end of the core wire; a brazing portion mounted between the middle portion of the metal coil and the core wire; and a brazing portion mounted between the base end of the metal coil and the core wire.

[0003] Existing technical documents

[0004] Patent documents

[0005] Patent Document 1: Japanese Patent Application Publication No. 2011-143077 Summary of the Invention

[0006] The problem that the invention aims to solve

[0007] In the guide wire described in Patent Document 1, since the brazing part is made of metal material, there is a problem that the rigidity of the guide wire increases, especially in the brazing part.

[0008] The guidewire is inserted along the winding blood vessels inside the patient's body. Therefore, during the procedure, the guidewire can stack inside the patient's body. Due to excessive force applied by the surgeon afterward, the metal coil (hereinafter referred to as the "coil body") may detach from the core wire (hereinafter referred to as the "mandrel"). Therefore, it is desirable to anticipate such a situation and implement safety measures in advance.

[0009] This disclosure was made in view of the above-mentioned problems, and its purpose is to provide a guidewire with a flexible tip.

[0010] Solution for solving the problem

[0011] To address the aforementioned issues, the guide wire of the first embodiment comprises: a mandrel; a coil body covering the front end of the mandrel; a front end connector connecting the front end of the coil body to the front end of the mandrel; and a base end connector connecting the base end of the coil body to the mandrel, and includes an adhesive made of resin material.

[0012] The guidewire designed in the first approach is flexible, thus improving its insertability into the patient's body.

[0013] The second approach, based on the first approach, can also involve the coil body being wound multiple times around the outer periphery of the mandrel, with the base end connection portion forming an outer diameter smaller than the outer diameter of the coil body between adjacent wires.

[0014] The guidewire designed in the second approach is more flexible, thus further improving its insertability into the patient's body.

[0015] The guidewire of the third scheme is based on the guidewire of the first or second scheme, and the base connection portion can be colored.

[0016] According to the guide wire of the third scheme, the length of the base connection portion connected to the coil body can be easily controlled. Therefore, the bonding strength between the mandrel and the coil body can be easily adjusted.

[0017] The fourth approach can be based on the guide wire of any of the first to third approaches, and may also include an intermediate connecting part between the front end connecting part and the base end connecting part to connect the coil body and the core shaft, the intermediate connecting part including an adhesive made of resin material.

[0018] According to the guidewire of the fourth design, the coil body and the mandrel can be connected in the middle between the front end and the base end of the coil body, making the guidewire flexible. Therefore, the insertability of the guidewire into the patient's body can be improved.

[0019] The fifth scheme involves a guide wire that is based on the guide wire of the fourth scheme. Alternatively, the coil body can be wound around the outer periphery of the mandrel multiple times, and the intermediate connecting part can be formed between adjacent wires of the coil body with an outer diameter smaller than the outer diameter of the coil body.

[0020] The guidewire according to the fifth design allows for greater flexibility. Therefore, it further improves the guidewire's insertability into the patient's body.

[0021] The guidewire of the sixth scheme is based on the guidewire of the fourth or fifth scheme, and the intermediate connecting part can be colored.

[0022] According to the guide wire of the sixth scheme, the length of the intermediate connection part connecting to the coil body can be easily controlled. Therefore, the bonding strength between the mandrel and the coil body can be easily adjusted.

[0023] In the seventh scheme, based on the guide wires of any one of the first to sixth schemes, the surface roughness of the coil body can also be greater than the surface roughness of the mandrel.

[0024] According to the guide wire involved in the seventh scheme, even if a large force is applied to the guide wire and the coil body detaches from the spindle, the base connection part detaches while connected to the coil body, which can prevent the base connection part from breaking and scattering.

[0025] The guide wire of the eighth scheme can also be based on the guide wire of any of the first to seventh schemes, and may have an oxide coating formed on the surface of the coil body.

[0026] According to the guide wire involved in the eighth scheme, even if a large force is applied to the guide wire and the coil body is detached from the spindle, the base connection part is detached while connected to the coil body, which can prevent the base connection part from breaking and scattering.

[0027] The guide wire of the ninth scheme can also be based on the guide wire of any of the first to eighth schemes, and can also have multiple grooves formed on the surface of the coil body in a direction that intersects the length direction of the mandrel.

[0028] According to the guide wire involved in the ninth scheme, even if a large force is applied to the guide wire and the coil body detaches from the spindle, the base connection part detaches while connected to the coil body, which can prevent the base connection part from breaking and scattering.

[0029] The guide wire of the tenth scheme can also be based on the guide wire of any of the first to ninth schemes, and can also have multiple grooves formed on the surface of the mandrel in a direction intersecting the length direction of the mandrel.

[0030] According to the guide wire involved in the tenth scheme, even if a large force is applied to the guide wire and the coil body is detached from the spindle, the base connection part is detached from the coil body in a connected state, which can prevent the base connection part from breaking and scattering.

[0031] The eleventh scheme can also be based on the guide wire of any of the first to ninth schemes, and may have multiple grooves formed on the surface of the mandrel along the length of the mandrel.

[0032] According to the guide wire involved in the eleventh scheme, even if a large force is applied to the guide wire and the coil body detaches from the spindle, the base connection part detaches while connected to the spindle, which can prevent the base connection part from breaking and scattering.

[0033] In the twelfth embodiment of the connection structure, an adhesive made of resin material is used to connect the surface of a first component with a first surface roughness to the surface of a second component with a second surface roughness that is larger than the first surface roughness.

[0034] According to the connection structure of the twelfth scheme, even if a large force is applied to the connection structure and the second component detaches from the first component, the adhesive will detach while still connected to the second component, thus preventing the adhesive from breaking and scattering.

[0035] In the connection structure of the thirteenth embodiment, the surface of the first component without an oxide coating is connected to the surface of the second component with an oxide coating by an adhesive made of resin material.

[0036] According to the connection structure of the thirteenth scheme, even if a large force is applied to the connection structure and the second component detaches from the first component, the adhesive will detach while still connected to the second component, thus preventing the adhesive from breaking and scattering. Attached Figure Description

[0037] Figure 1 This is a schematic diagram of the guidewire in the first embodiment.

[0038] Figure 2 This is an enlarged view of the front end of the guidewire in the first embodiment.

[0039] Figure 3 This is a longitudinal sectional view of the front end of the guidewire in the first embodiment.

[0040] Figure 4 This is a longitudinal sectional view of the front end of the guidewire in the second embodiment.

[0041] Figure 5 This is a longitudinal sectional view of the front end of the guidewire in the third embodiment.

[0042] Figure 6 This is a longitudinal sectional view of the front end of the guidewire in the fourth embodiment.

[0043] Figure 7 This is a longitudinal sectional view of the front end of the guidewire in the fifth embodiment.

[0044] Figure 8 This is a longitudinal sectional view of the front end of the guidewire according to the sixth embodiment.

[0045] Figure 9 yes Figure 8 Enlarged view of part A.

[0046] Figure 10 This is an enlarged view of the front end showing the state in which the coil body of the guide wire in the sixth embodiment is detached from the mandrel.

[0047] Figure 11 This is a longitudinal sectional view of the front end of the guidewire according to the seventh embodiment.

[0048] Figure 12 yes Figure 11 Enlarged view of part B.

[0049] Figure 13 This is an enlarged view of the guidewire tip in the eighth embodiment.

[0050] Figure 14 This is a partial enlarged view of the guidewire according to the ninth embodiment.

[0051] Figure 15 This is a partial enlarged view of the guidewire according to the tenth embodiment. Detailed Implementation

[0052] Hereinafter, several embodiments of the present disclosure will be described with reference to the accompanying drawings. The drawings used in the following embodiments are exaggerated for ease of understanding, and their dimensions differ from the actual dimensions. Common parts in the various embodiments are labeled with the same reference numerals, and descriptions of already described parts are sometimes omitted.

[0053] (First Implementation)

[0054] The first embodiment of this disclosure will be described.

[0055] Figure 1 This is a schematic diagram of the guidewire in the first embodiment. Figure 2 This is an enlarged view of the tip of the guidewire in the first embodiment. Figure 3 This is a longitudinal sectional view of the front end of the guidewire in the first embodiment.

[0056] like Figures 1 to 3 As shown, the guide wire 1 of this embodiment includes: a mandrel 9; a coil body 3 covering the front end of the mandrel 9; a front end connecting part 2 connected to the front end of the coil body 3 and the front end of the mandrel 9; a base end connecting part 5 connected to the base end of the coil body 3 and the mandrel 9; and a coating agent 8 covering the outer periphery of the mandrel 9, the coil body 3, the front end connecting part 2 and the base end connecting part 5.

[0057] The mandrel 9 is a long, flexible member with a generally circular cross-section that tapers from the base end toward the front end. The mandrel 9 includes: a base-end cylindrical portion 9c, which is generally cylindrical in shape; a front-end tapered portion 9b, which is continuously formed from the front end of the base-end cylindrical portion 9c toward the front end and gradually tapers toward the front end; and a generally cylindrical front-end cylindrical portion 9a, which is continuously formed from the front end of the front-end tapered portion 9b toward the front end.

[0058] The material of the mandrel 9 is not particularly limited as long as it is a biocompatible material such as stainless steel, Ni-Ti alloys, cobalt alloys, polyethylene, polyethylene terephthalate, polypropylene, polyurethane, polyvinyl chloride, etc. In this embodiment, the material of the mandrel 9 is, for example, stainless steel.

[0059] The coil body 3 is a hollow cylindrical coil body formed by winding one or more metal wires or resin wires. The front end of the coil body 3 is connected to the front end of the core shaft 9 through the front end connecting part 2, and the base end of the coil body 3 is connected to the core shaft 9 through the base end connecting part 5.

[0060] The material of the wire forming the coil body 3 is not particularly limited as long as it is a biocompatible material such as stainless steel, Ni-Ti alloys, cobalt alloys, polyethylene, polyethylene terephthalate, polypropylene, polyurethane, polyvinyl chloride, etc. In this embodiment, the wire material is stainless steel.

[0061] like Figure 3 As shown, a gap 4 is formed between the spindle 9 and the coil body 3.

[0062] The front-end connecting part 2 connects the front end of the coil body 3 to the front end of the core 9. The material of the front-end connecting part 2 is not particularly limited; it can be any biocompatible bonding component such as gold-tin solder or silver-tin solder. In this embodiment, the material of the front-end connecting part 2 is silver-tin solder.

[0063] The base end connection portion 5 connects the base end of the coil body 3 to the core shaft 9. The material of the base end connection portion 5 is not particularly limited; it can be any biocompatible bonding component made of resin materials such as silicone-based adhesives, acrylic adhesives, epoxy adhesives, or cyanoacrylate adhesives. In this embodiment, the material of the base end connection portion 5 is an epoxy adhesive.

[0064] The coating agent 8 covers the outer periphery of the mandrel 9, coil body 3, front end connection 2, and base end connection 5. Materials used for the coating agent 8 include, for example, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycol, polyacrylamide, polyacrylic acid, sodium polyacrylate, poly(2-hydroxyethyl methacrylate), maleic anhydride copolymers, ethylene-vinyl alcohol copolymers, 2-methacryloyloxyethyl phosphorylcholine, copolymers of 2-methacryloyloxyethyl phosphorylcholine, (2-hydroxyethyl methacrylate)-styrene block copolymers, various synthetic peptides, collagen, hyaluronic acid, cellulose polymers, and mixtures thereof. In this embodiment, the material of the coating agent 8 is polyacrylamide.

[0065] In this embodiment, it is described that an adhesive made of resin material is used only for the base end connection portion 5. In the front end connection portion 2, an adhesive made of the same resin material as that used in the base end connection portion 5 may also be used, provided that sufficient bonding strength can be ensured.

[0066] The front end connector 2 can use an adhesive made of the same resin material as the base end connector 5, which is the same not only in this embodiment but also in the embodiments described later.

[0067] The guidewire 1 according to this embodiment includes: a mandrel 9; a coil body 3 covering the front end of the mandrel 9; a front end connecting portion 2 connecting the front end of the coil body 3 and the front end of the mandrel 9; and a base end connecting portion 5 connecting the base end of the coil body 3 and the mandrel 9. The base end connecting portion 5 is made of an adhesive composed of a resin material, thus enabling the guidewire 1 to be flexible. Therefore, the insertability of the guidewire 1 into the patient's body can be improved.

[0068] (Second Implementation)

[0069] The second embodiment will be described.

[0070] The guide wire 10 of the second embodiment differs from the guide wire 1 of the first embodiment in the number of connecting portions that connect the coil body and the spindle. Specifically, the guide wire 1 of the first embodiment has two connecting portions: a front-end connecting portion 2 that connects the front end of the coil body 3 and the front end of the spindle 9, and a base-end connecting portion 5 that connects the base end of the coil body 3 and the spindle 9. In addition to the front-end connecting portion and the base-end connecting portion, the guide wire 10 of this embodiment also has an intermediate connecting portion, which is disposed between the front-end connecting portion and the base-end connecting portion along the length of the guide wire, and connects the coil body and the spindle.

[0071] Figure 4 This is a longitudinal sectional view of the front end of the guidewire in the second embodiment.

[0072] The guide wire 10 of this embodiment includes: a spindle 9; a coil body 3 covering the front end of the spindle 9; a front end connecting portion 2 connected to the front end of the coil body 3 and the front end of the spindle 9; a base end connecting portion 5 connected to the base end of the coil body 3 and the spindle 9; a plurality of intermediate connecting portions 7, namely, a front end side intermediate connecting portion 7a and a base end side intermediate connecting portion 7b, which are arranged in the length direction of the guide wire 10 between the front end connecting portion 2 and the base end connecting portion 5 and connected to the coil body 3 and the spindle 9; and a coating agent 18 covering the outer periphery of the spindle 9, the coil body 3, the front end connecting portion 2, the base end connecting portion 5, the front end side intermediate connecting portion 7a, and the base end side intermediate connecting portion 7b.

[0073] A gap 14 is formed between the spindle 9 and the coil body 3.

[0074] The front-end intermediate connecting portion 7a is disposed between the front-end connecting portion 2 and the base-end connecting portion 5 along the length of the guide wire 10, connecting the coil body 3 and the core shaft 9. The material of the front-end intermediate connecting portion 7a is not particularly limited; it can be any biocompatible bonding component made of resin materials such as silicone-based adhesives, acrylic adhesives, epoxy adhesives, or cyanoacrylate adhesives. In this embodiment, the material of the front-end intermediate connecting portion 7a is an epoxy adhesive.

[0075] The base-end side intermediate connection portion 7b is disposed between the front-end connection portion 2 and the base-end connection portion 5 along the length direction of the guide wire 10, and connects the coil body 3 and the core shaft 9 at a position closer to the base end than the front-end side intermediate connection portion 7a. The material of the base-end side intermediate connection portion 7b is the same as that of the base-end connection portion 5; it is not particularly limited as long as it is a biocompatible bonding component made of resin materials such as silicone-based adhesives, acrylic-based adhesives, epoxy-based adhesives, or cyanoacrylate-based adhesives. In this embodiment, the material of the base-end side intermediate connection portion 7b is an epoxy-based adhesive.

[0076] In this embodiment, such as Figure 4 As shown, the intermediate connecting portion has two intermediate connecting portions: a front-end intermediate connecting portion 7a and a base-end intermediate connecting portion 7b. The number of intermediate connecting portions is not limited to two; it can be one or more.

[0077] The coating agent 18 covers the outer periphery of the mandrel 9, coil body 3, front end connecting part 2, base end connecting part 5, front end side intermediate connecting part 7a, and base end side intermediate connecting part 7b. The material of the coating agent 18 can be the same as the coating agent 8 in the first embodiment, and in this embodiment it is polyacrylamide.

[0078] The guidewire 10 according to this embodiment includes a mandrel 9; a coil body 3 covering the front end of the mandrel 9; a front end connecting portion 2 connecting the front end of the coil body 3 and the front end of the mandrel 9; and a base end connecting portion 5 connecting the base end of the coil body 3 and the mandrel 9. The base end connecting portion 5 is made of an adhesive composed of a resin material, thus enabling the guidewire 10 to be flexible. Therefore, the insertability of the guidewire 10 into the patient's body can be improved.

[0079] According to this embodiment, the guidewire 10 has an intermediate connecting portion 7 between the front connecting portion 2 and the base connecting portion 5, which connects the coil body 3 and the spindle 9. The intermediate connecting portion 7 is made of an adhesive made of resin material, thus making the guidewire 10 flexible. Therefore, the insertability of the guidewire 10 into the patient's body can be improved.

[0080] (Third Implementation)

[0081] The third embodiment will be described.

[0082] The guide wire 20 of the third embodiment differs in shape from the guide wire 1 of the first embodiment in that the base connection portion has a different shape. That is, the outer diameter of the base connection portion 5 in the guide wire 1 of the first embodiment is approximately the same among the wires constituting the coil body 3, while the outer diameter of the base connection portion in the guide wire 20 of this embodiment is smaller than the outer diameter of the coil body among the wires constituting the coil body.

[0083] Figure 5 This is a longitudinal sectional view of the front end of the guidewire in the third embodiment.

[0084] The guide wire 20 of this embodiment includes: a mandrel 9; a coil body 23 covering the front end of the mandrel 9; a front end connecting portion 22 connected to the front end of the coil body 23 and the front end of the mandrel 9; a base end connecting portion 25 connected to the base end of the coil body 23 and the mandrel 9; and a coating agent 28 covering the outer periphery of the mandrel 9, the coil body 23, the front end connecting portion 22 and the base end connecting portion 25.

[0085] A gap 24 is formed between the spindle 9 and the coil body 23.

[0086] The coil body 23 is a hollow cylindrical coil body formed by winding one or more metal wires or resin wires. The coil body 23 is wound multiple times around the outer circumference of the mandrel 9. The front end of the coil body 23 is connected to the front end of the mandrel 9 through the front end connecting part 22, and the base end of the coil body 23 is connected to the mandrel 9 through the base end connecting part 25.

[0087] The material of the wire forming the coil body 23 can be the same as that of the coil body 3 in the first embodiment. In this embodiment, the material of the wire forming the coil body 23 is stainless steel.

[0088] The front-end connection portion 22 joins the front end of the coil body 23 and the front end of the spindle 9. The material of the front-end connection portion 22 can be the same as that of the front-end connection portion 2 in the first embodiment. In this embodiment, the material of the front-end connection portion 22 is silver-tin solder.

[0089] The base end connection portion 25 connects the base end of the coil body 23 to the core 9. The outer diameter R1 of the base end connection portion 25 is smaller than the outer diameter R2 of the coil body 23 among the wires constituting the coil body 23.

[0090] The base connection portion 25 can be made of the same material as the base connection portion 5 in the first embodiment. In this embodiment, the base connection portion 25 is made of an epoxy adhesive.

[0091] In this embodiment, the width of the base connection portion 25 in the longitudinal direction extends over both wires constituting the coil body 23, and a portion with an outer diameter R1 smaller than the outer diameter R2 of the coil body 23 is provided at one point in the base connection portion 25. The width of the base connection portion 25 in the longitudinal direction can also be formed between any number of wires of the coil body 23. A portion with an outer diameter R1 smaller than the outer diameter R2 of the coil body 23 can also be formed at multiple points in the base connection portion 25.

[0092] The coating agent 28 covers the outer periphery of the mandrel 9, coil body 23, front end connection portion 22, and base end connection portion 25. The material of the coating agent 28 can be the same as that of the coating agent 8 in the first embodiment. In this embodiment, the material of the coating agent 28 is polyacrylamide.

[0093] The guidewire 20 according to this embodiment includes a mandrel 9; a coil body 23 covering the front end of the mandrel 9; a front end connecting portion 22 connecting the front end of the coil body 23 and the front end of the mandrel 9; and a base end connecting portion 25 connecting the base end of the coil body 23 and the mandrel 9. The base end connecting portion 25 is made of an adhesive made of resin material, thus enabling the guidewire 20 to be flexible. Therefore, the insertability of the guidewire 20 into the patient's body can be improved.

[0094] According to the guidewire 20 of this embodiment, the coil body 23 is wound multiple times around the outer periphery of the mandrel 9, and the base end connection portion 25 is formed with an outer diameter smaller than the outer diameter of the coil body 23 between the adjacent wires constituting the coil body 23, thus making the guidewire 20 more flexible. Therefore, the insertability of the guidewire 20 into the patient's body can be further improved.

[0095] (Fourth Implementation)

[0096] The fourth embodiment will be described.

[0097] The fourth embodiment of the guide wire 30 differs from the third embodiment of the guide wire 20 in the number of connecting portions that connect the coil body and the mandrel. Specifically, the third embodiment of the guide wire 20 has two connecting portions: a front-end connecting portion 22 that connects the front end of the coil body 23 to the front end of the mandrel 9, and a base-end connecting portion 25 that connects the base end of the coil body 23 to the mandrel 9. In addition to the front-end connecting portion and the base-end connecting portion, the guide wire 30 of this embodiment also has an intermediate connecting portion, which is disposed along the length of the guide wire between the front-end connecting portion and the base-end connecting portion, connecting the coil body and the mandrel.

[0098] Figure 6 This is a longitudinal sectional view of the front end of the guidewire in the fourth embodiment.

[0099] The guide wire 30 of this embodiment includes a mandrel 9; a coil body 23 covering the front end of the mandrel 9; a front end connecting portion 22 connected to the front end of the coil body 23 and the front end of the mandrel 9; a base end connecting portion 35 connected to the base end of the coil body 23 and the mandrel 9; an intermediate connecting portion 37 disposed between the front end connecting portion 22 and the base end connecting portion 35 in the length direction of the guide wire 30 and connected to the coil body 23 and the mandrel 9; and a coating agent 38 covering the outer periphery of the mandrel 9, the coil body 23, the front end connecting portion 22, the base end connecting portion 35 and the intermediate connecting portion 37.

[0100] A gap 34 is formed between the spindle 9 and the coil body 23.

[0101] The base end connection portion 35 connects the base end of the coil body 23 to the core shaft 9. The outer diameter R3 of the base end connection portion 35 is smaller than the outer diameter R2 of the coil body 23 among the wires constituting the coil body 23.

[0102] The base connection portion 35 can be made of the same material as the base connection portion 5 in the first embodiment. In this embodiment, the base connection portion 35 is made of an epoxy adhesive.

[0103] The intermediate connecting portion 37 is disposed between the front connecting portion 22 and the base connecting portion 35 along the length of the guide wire 30, connecting the coil body 23 to the spindle 9. The outer diameter R4 of the intermediate connecting portion 37 is smaller than the outer diameter R2 of the coil body 23 among the wires constituting the coil body 23.

[0104] The intermediate connecting portion 37 can be made of the same material as the front-end side intermediate connecting portion 7a and the base-end side intermediate connecting portion 7b in the second embodiment. In this embodiment, the intermediate connecting portion 37 is made of epoxy adhesive.

[0105] In this embodiment, there is one intermediate connecting part 37. The number of intermediate connecting parts 37 is not limited to one, and there may be two or more.

[0106] In this embodiment, the width of the base connection portion 35 in the longitudinal direction extends over both wires constituting the coil body 23, and a portion with an outer diameter R3 smaller than the outer diameter R2 of the coil body 23 is provided at one point in the base connection portion 35. The width of the base connection portion 35 in the longitudinal direction can also be formed between any number of wires of the coil body 23. A portion with an outer diameter R3 smaller than the outer diameter R2 of the coil body 23 can also be formed at multiple points in the base connection portion 35.

[0107] In this embodiment, the width of the intermediate connecting portion 37 in the longitudinal direction extends across the three wires constituting the coil body 23, and the portion with an outer diameter R4 smaller than the outer diameter R2 of the coil body 23 is provided at two locations in the intermediate connecting portion 37. The width of the intermediate connecting portion 37 in the longitudinal direction can also be formed between any number of wires of the coil body 23. The portion with an outer diameter R4 smaller than the outer diameter R2 of the coil body 23 can be at one location or at more than three locations in the intermediate connecting portion 37.

[0108] The coating agent 38 covers the outer periphery of the mandrel 9, coil body 23, front end connection portion 22, base end connection portion 35, and intermediate connection portion 37. The material of the coating agent 38 can be the same as that of the coating agent 8 in the first embodiment. In this embodiment, the material of the coating agent 38 is polyacrylamide.

[0109] The guidewire 30 according to this embodiment includes a mandrel 9; a coil body 23 covering the front end of the mandrel 9; a front end connecting portion 22 connecting the front end of the coil body 23 to the front end of the mandrel 9; and a base end connecting portion 35 connecting the base end of the coil body 23 to the mandrel 9. The base end connecting portion 35 is made of an adhesive made of resin material, thus enabling the guidewire 30 to be flexible. Therefore, the insertability of the guidewire 30 into the patient's body can be improved.

[0110] According to this embodiment, the guidewire 30 has an intermediate connecting portion 37 between the front connecting portion 22 and the base connecting portion 35, which connects the coil body 23 and the spindle 9. The intermediate connecting portion 37 is made of an adhesive made of resin material, thus making the guidewire 30 flexible. Therefore, the insertability of the guidewire 30 into the patient's body can be improved.

[0111] According to the guidewire 30 of this embodiment, the coil body 23 is wound multiple times around the outer periphery of the mandrel 9, and the base end connection portion 35 is formed with an outer diameter smaller than the outer diameter of the coil body 23 between the adjacent wires constituting the coil body 23, thus making the guidewire 30 more flexible. Therefore, the insertability of the guidewire 30 into the patient's body can be further improved.

[0112] Furthermore, according to the guide wire 30 of this embodiment, the coil body 23 is wound multiple times around the outer periphery of the mandrel 9, and at least one intermediate connecting portion 37 is formed between adjacent wires constituting the coil body 23 at a position lower than the outer diameter of the coil body 23. Therefore, the guide wire 30 can be made more flexible, thereby further improving the insertability of the guide wire 30 into the patient's body.

[0113] (Fifth implementation method)

[0114] The fifth embodiment will be described.

[0115] Compared to the guidewire 30 of the fourth embodiment, the guidewire 40 of the fifth embodiment has a different color for its base connection portion and intermediate connection portion. That is, the base connection portion 35 and intermediate connection portion 37 of the guidewire 30 of the fourth embodiment are colorless and transparent, while the base connection portion and intermediate connection portion of the guidewire 40 of this embodiment are colored.

[0116] In this embodiment, "colored" refers to magenta, cyan, yellow, and black, as well as colors formed by combining these colors.

[0117] By coloring the base connection portion, the length of the base connection portion connected to the coil body can be easily controlled, and the bonding strength between the mandrel and the coil body can be easily adjusted. By coloring the intermediate connection portion, the length of the intermediate connection portion connected to the coil body can be easily controlled, and the bonding strength between the mandrel and the coil body can be easily adjusted.

[0118] This is based on the following theory: Since the winding pitch of the coil body relative to the mandrel is known in advance during the manufacturing of the guide wire, the amount of coil wire housed in the base connection and intermediate connection can be adjusted by adjusting the length of the guide wire in the length direction of the base connection and intermediate connection, thereby adjusting the bonding strength between the mandrel and the coil body. Therefore, as long as the length of the intermediate connection connected to the coil body can be easily controlled, the bonding strength between the mandrel and the coil body can be easily controlled.

[0119] Figure 7 This is a longitudinal sectional view of the front end of the guidewire according to the fifth embodiment. Figure 7 In the image, a net-like shading pattern is used to represent the colored parts.

[0120] The guide wire 40 of this embodiment includes: a spindle 9; a coil body 23 covering the front end of the spindle 9; a front end connecting portion 22 connected to the front end of the coil body 23 and the front end of the spindle 9; a base end connecting portion 45 connected to the base end of the coil body 23 and the spindle 9; an intermediate connecting portion 47 disposed between the front end connecting portion 22 and the base end connecting portion 45 in the length direction of the guide wire 40 and connected to the coil body 23 and the spindle 9; and a coating agent 48 covering the outer periphery of the spindle 9, the coil body 23, the front end connecting portion 22, the base end connecting portion 45 and the intermediate connecting portion 47.

[0121] A gap 44 is formed between the spindle 9 and the coil body 23.

[0122] The base end connection portion 45 connects the base end of the coil body 23 to the core shaft 9. The outer diameter of the base end connection portion 45 is smaller than the outer diameter of the coil body 23 among the wires constituting the coil body 23.

[0123] The material of the base connection portion 45 can be a pigmented material, similar to that of the base connection portion 5 in the first embodiment. In this embodiment, the material of the base connection portion 45 is a biocompatible ink containing hydroxypropyl cellulose (HPC) and gelatin as the main components in an epoxy adhesive. Alternatively, the material of the base connection portion 45 may contain a component that emits light when irradiated with ultraviolet light. In this case, the base connection portion 45 may be colorless or colored under visible light. Such a component may be, for example, an epoxy resin, an acrylic resin, or a resin that has an absorption peak at the wavelength of ultraviolet light.

[0124] An intermediate connecting portion 47 is disposed between the front connecting portion 22 and the base connecting portion 45 along the length of the guide wire 40, connecting the coil body 23 to the spindle 9. The outer diameter of the intermediate connecting portion 47 is smaller than the outer diameter of the coil body 23 among the wires constituting the coil body 23.

[0125] The material of the intermediate connecting portion 47 can be a pigmented material, similar to the materials of the front-side intermediate connecting portion 7a and the base-side intermediate connecting portion 7b in the second embodiment. In this embodiment, the intermediate connecting portion 47, like the material of the base-side connecting portion 45, is a biocompatible ink containing hydroxypropyl cellulose (HPC) and gelatin as the main components in an epoxy adhesive. Alternatively, the material of the intermediate connecting portion 47 may contain a component that emits light when irradiated with ultraviolet light. In this case, the intermediate connecting portion 47 can be colorless or colored under visible light. Such a component could be, for example, epoxy resin, acrylic resin, or other resins that have an absorption peak at the wavelength of ultraviolet light.

[0126] In this embodiment, there is one intermediate connecting part 47. The number of intermediate connecting parts 47 is not limited to one, and there may be two or more.

[0127] In this embodiment, the width of the base connection portion 45 in the longitudinal direction extends over both wires constituting the coil body 23, and the portion with an outer diameter smaller than the outer diameter of the coil body 23 is located at one point in the base connection portion 45. The width of the base connection portion 45 in the longitudinal direction can also be formed between any number of wires of the coil body 23. The portion with an outer diameter smaller than the outer diameter of the coil body 23 can also be formed at multiple points in the base connection portion 45.

[0128] The intermediate connecting portion 47 is formed such that its width in the longitudinal direction extends across the three wires constituting the coil body 23, and there are two locations in the intermediate connecting portion 47 where the outer diameter is smaller than the outer diameter of the coil body 23. The width of the intermediate connecting portion 47 in the longitudinal direction can also be formed between any number of wires of the coil body 23. The locations in the intermediate connecting portion 47 where the outer diameter is smaller than the outer diameter of the coil body 23 can be one location or more than three locations.

[0129] The coating agent 48 covers the outer periphery of the mandrel 9, coil body 23, front end connection portion 22, base end connection portion 45, and intermediate connection portion 47. The material of the coating agent 48 can be the same as that of the coating agent 8 in the first embodiment. In this embodiment, the material of the coating agent 48 is polyacrylamide.

[0130] The guidewire 40 according to this embodiment includes a mandrel 9; a coil body 23 covering the front end of the mandrel 9; a front end connecting portion 22 connecting the front end of the coil body 23 to the front end of the mandrel 9; and a base end connecting portion 45 connecting the base end of the coil body 23 to the mandrel 9. The base end connecting portion 45 is made of an adhesive made of resin material, thus enabling the guidewire 40 to be flexible. Therefore, the insertability of the guidewire 40 into the patient's body can be improved.

[0131] According to this embodiment, the guidewire 40 has an intermediate connecting portion 47 between the front connecting portion 22 and the base connecting portion 45, which connects the coil body 23 and the spindle 9. The intermediate connecting portion 47 is made of an adhesive made of resin material, thus making the guidewire 40 flexible. Therefore, the insertability of the guidewire 40 into the patient's body can be improved.

[0132] According to the guidewire 40 of this embodiment, the coil body 23 is wound multiple times around the outer periphery of the mandrel 9, and the base end connection portion 45 is formed with an outer diameter smaller than the outer diameter of the coil body 23 between the adjacent wires constituting the coil body 23, thus making the guidewire 40 more flexible. Therefore, the insertability of the guidewire 40 into the patient's body can be further improved.

[0133] According to the guidewire 40 of this embodiment, the coil body 23 is wound multiple times around the outer periphery of the mandrel 9, and the intermediate connecting portion 47 is formed between the adjacent wires constituting the coil body 23 with an outer diameter smaller than the outer diameter of the coil body 23, thus making the guidewire 40 more flexible. Therefore, the insertability of the guidewire 40 into the patient's body can be further improved.

[0134] In this embodiment, since the base connection portion 45 of the guide wire 40 is colored, the length X2 of the guide wire 40 connected to the base connection portion 45 of the coil body 23 in the longitudinal direction can be easily controlled. Therefore, the bonding strength between the mandrel 9 and the coil body 23 can be easily adjusted.

[0135] In this embodiment, since the intermediate connecting portion 47 of the guide wire 40 is colored, the length X1 of the guide wire 40 connected to the coil body 23 in the longitudinal direction can be easily controlled. Therefore, the bonding strength between the mandrel 9 and the coil body 23 can be easily adjusted.

[0136] (Sixth Implementation Method)

[0137] The sixth embodiment will be described.

[0138] The sixth embodiment of the guide wire 50 differs from the fourth embodiment of the guide wire 30 in that the connection method between the coil body and the base end connection portion, as well as the connection method between the coil body and the intermediate connection portion, are different. That is, the guide wire 50 of this embodiment differs from the guide wire 30 of the fourth embodiment in that the surface roughness of the coil body is greater than the surface roughness of the core shaft.

[0139] Figure 8 This is a longitudinal sectional view of the front end of the guidewire according to the sixth embodiment. Figure 9 yes Figure 8 Enlarged view of part A, Figure 10 This is an enlarged view of the front end showing the state in which the coil body of the guide wire in the sixth embodiment is detached from the mandrel.

[0140] like Figure 8 and Figure 9 As shown, the guide wire 50 of this embodiment includes: a mandrel 9; a coil body 53 covering the front end of the mandrel 9; a front end connecting portion 52 connected to the front end of the coil body 53 and the front end of the mandrel 9; a base end connecting portion 55 connected to the base end of the coil body 53 and the mandrel 9; an intermediate connecting portion 57 disposed between the front end connecting portion 52 and the base end connecting portion 55 in the length direction of the guide wire 50 and connected to the coil body 53 and the mandrel 9; and a coating agent 58 covering the outer periphery of the mandrel 9, the coil body 53, the front end connecting portion 52, the base end connecting portion 55 and the intermediate connecting portion 57.

[0141] A gap 54 is formed between the spindle 9 and the coil body 53.

[0142] The coil body 53 is a hollow cylindrical coil body formed by winding one or more metal wires or resin wires. The coil body 53 is wound multiple times around the outer circumference of the mandrel 9. The front end of the coil body 53 is connected to the front end of the mandrel 9 through the front end connecting part 52, and the base end of the coil body 53 is connected to the mandrel 9 through the base end connecting part 55.

[0143] The surface roughness of the wire constituting the coil body 53 is greater than the surface roughness of the core 9. Undulated portions 53a are formed on the surface of the wire constituting the coil body 53 by processing methods such as sandblasting.

[0144] The material of the wire forming the coil body 53 can be the same as that of the coil body 3 in the first embodiment. In this embodiment, the material of the wire of the coil body 53 is stainless steel.

[0145] The front-end connection portion 52 connects the front end of the coil body 53 to the front end of the spindle 9. The material of the front-end connection portion 52 can be the same as that of the front-end connection portion 2 in the first embodiment. In this embodiment, the material of the front-end connection portion 52 is silver-tin solder.

[0146] The base connection portion 55 connects the base end of the coil body 53 to the core shaft 9. For example... Figure 8 as well as Figure 9 As shown, the outer diameter of the base connection portion 55 is smaller than the outer diameter of the coil body 53 among the wires constituting the coil body 53.

[0147] The base connection portion 55 can be made of the same material as the base connection portion 5 in the first embodiment. In this embodiment, the base connection portion 55 is made of an epoxy adhesive.

[0148] The intermediate connecting portion 57 is disposed between the front connecting portion 52 and the base connecting portion 55 along the length of the guide wire 50, connecting the coil body 53 to the spindle 9. Figure 8 as well as Figure 9As shown, the outer diameter of the intermediate connecting part 47 is smaller than the outer diameter of the coil body 23 between the wires constituting the coil body 23.

[0149] The intermediate connecting portion 47 can be made of the same material as the front-end side intermediate connecting portion 7a and the base-end side intermediate connecting portion 7b in the second embodiment. In this embodiment, the intermediate connecting portion 47 is made of epoxy adhesive.

[0150] In this embodiment, such as Figure 8 As shown, there is also one intermediate connecting part 57. The number of intermediate connecting parts 57 is not limited to one, and there may be two or more.

[0151] In this embodiment, such as Figure 8 As shown, the width of the base connection portion 55 in the longitudinal direction extends across the two wires constituting the coil body 53, and the portion with an outer diameter smaller than the outer diameter of the coil body 53 is located at one point in the base connection portion 55. The width of the base connection portion 55 in the longitudinal direction can also be formed between any number of wires of the coil body 53. The portion with an outer diameter smaller than the outer diameter of the coil body 53 can also be formed at multiple points in the base connection portion 55.

[0152] The intermediate connecting portion 57 is formed such that its width in the longitudinal direction extends across the three wires constituting the coil body 53, and there are two portions in the intermediate connecting portion 57 whose outer diameter is smaller than that of the coil body 53. The width of the intermediate connecting portion 57 in the longitudinal direction can also be formed between several wires of the coil body 53. The portions in the intermediate connecting portion 57 with outer diameters smaller than that of the coil body 53 can be located at one or more locations.

[0153] The coating agent 58 covers the outer periphery of the mandrel 9, coil body 53, front end connection portion 52, base end connection portion 55, and intermediate connection portion 57. The material of the coating agent 58 can be the same as that of the coating agent 8 in the first embodiment. In this embodiment, the material of the coating agent 58 is polyacrylamide.

[0154] In the guidewire 50 described above, in the event that the coil body 53 detaches from the mandrel 9 during surgery, the surface roughness of the wire constituting the coil body 53 is set to be greater than the surface roughness of the mandrel 9. Therefore, as... Figure 10 As shown, the intermediate connecting part 57 or the base connecting part 55 is integrated with the coil body 53 and detached from the spindle 9, which can prevent at least one of the intermediate connecting part 57 and the base connecting part 55 from being damaged and flowing into the lumen of the patient's blood vessels, etc.

[0155] As with the guide wire 50 in this embodiment, the surface roughness of the coil body 53 is made greater than the surface roughness of the spindle 9, and the coil body 53 and the spindle 9 are connected by an adhesive made of resin material. This can be applied to a connection structure in which the surface of a first component having a predetermined first surface roughness and the surface of a second component having a second surface roughness greater than the first surface roughness are connected by an adhesive made of resin material.

[0156] In this case, even if a large force is applied to the connecting structure and the second component detaches from the first component, it is possible to prevent the adhesive from detaching while connected to the second component, thus preventing the adhesive from breaking and scattering.

[0157] The guidewire 50 according to this embodiment includes a mandrel 9; a coil body 53 covering the front end of the mandrel 9; a front end connecting portion 52 connecting the front end of the coil body 53 to the front end of the mandrel 9; and a base end connecting portion 55 connecting the base end of the coil body 53 to the mandrel 9. The base end connecting portion 55 is made of an adhesive composed of a resin material, thus enabling the guidewire 50 to be flexible. Therefore, the insertability of the guidewire 50 into the patient's body can be improved.

[0158] According to this embodiment, the guidewire 50 has an intermediate connecting portion 57 between the front connecting portion 52 and the base connecting portion 55, which connects the coil body 53 and the spindle 9. The intermediate connecting portion 57 is made of an adhesive made of resin material, thus making the guidewire 50 flexible. Therefore, the insertability of the guidewire 50 into the patient's body can be improved.

[0159] According to the guidewire 50 of this embodiment, the coil body 53 is wound multiple times around the outer periphery of the mandrel 9, and the base end connection portion 55 is formed between the adjacent wires constituting the coil body 23 with an outer diameter smaller than the outer diameter of the coil body 53, thus making the guidewire 50 more flexible. Therefore, the insertability of the guidewire 50 into the patient's body can be further improved.

[0160] According to the guidewire 50 of this embodiment, the coil body 53 is wound multiple times around the outer periphery of the mandrel 9, and the intermediate connecting portion 57 is formed between the adjacent wires constituting the coil body 53 with an outer diameter smaller than the outer diameter of the coil body 53, thus making the guidewire 50 more flexible. Therefore, the insertability of the guidewire 50 into the patient's body can be further improved.

[0161] According to the guide wire 50 of this embodiment, since the surface roughness of the coil body 53 is greater than that of the core shaft 9, even if a large force is applied to the guide wire 50 and the coil body 53 is detached from the core shaft 9, the base end connection portion 55 and the intermediate connection portion 57 will detach while still connected to the coil body 53, thus preventing at least one of the base end connection portion 55 and the intermediate connection portion 57 from breaking and scattering.

[0162] (Seventh Implementation)

[0163] The seventh embodiment will be described.

[0164] The seventh embodiment of the guide wire 60 differs from the sixth embodiment in the connection methods between the coil body and the base connection portion, and between the coil body and the intermediate connection portion. Specifically, the sixth embodiment's guide wire 50 is configured such that the surface roughness of the coil body is greater than the surface roughness of the mandrel, allowing the base connection portion 55 and the intermediate connection portion 57 to disengage from the coil body 53 while connected. In this embodiment, the guide wire 60 has an oxide coating on the surface of the coil body, but no oxide coating on the surface of the mandrel, thereby allowing the base connection portion and the intermediate connection portion to disengage from the coil body while connected.

[0165] Figure 11 This is a longitudinal sectional view of the front end of the guidewire according to the seventh embodiment. Figure 12 yes Figure 11 Enlarged view of part B.

[0166] The guide wire 60 of this embodiment includes: a spindle 9; a coil body 63 covering the front end of the spindle 9; a front end connecting portion 62 connected to the front end of the coil body 63 and the front end of the spindle 9; a base end connecting portion 65 connected to the base end of the coil body 63 and the spindle 9; an intermediate connecting portion 67 disposed between the front end connecting portion 62 and the base end connecting portion 65 in the length direction of the guide wire 60 and connected to the coil body 63 and the spindle 9; and a coating agent 68 covering the outer periphery of the spindle 9, the coil body 63, the front end connecting portion 62, the base end connecting portion 65 and the intermediate connecting portion 67.

[0167] A gap 64 is formed between the spindle 9 and the coil body 63.

[0168] The coil body 63 is a hollow cylindrical coil body formed by winding one or more metal wires or resin wires. The coil body 63 is wound multiple times around the outer circumference of the mandrel 9. The front end of the coil body 63 is connected to the front end of the mandrel 9 through the front end connecting part 62, and the base end of the coil body 63 is connected to the mandrel 9 through the base end connecting part 65.

[0169] The material of the wire forming the coil body 63 can be the same as that of the coil body 3 in the first embodiment. In this embodiment, the material of the wire forming the coil body 63 is stainless steel. An oxide coating 63a is formed on the surface of the wire constituting the coil body 63, which mainly combines oxygen through oxidation with chromium in the stainless steel.

[0170] The front-end connection portion 62 connects the front end of the coil body 63 to the front end of the spindle 9. The material of the front-end connection portion 62 can be the same as that of the front-end connection portion 2 in the first embodiment. In this embodiment, the material of the front-end connection portion 62 is silver-tin solder.

[0171] The base end connection portion 65 connects the base end of the coil body 63 to the core shaft 9. The outer diameter of the base end connection portion 65 is smaller than the outer diameter of the coil body 63 among the wires constituting the coil body 63.

[0172] The base connection portion 65 can be made of the same material as the base connection portion 5 in the first embodiment. In this embodiment, the base connection portion 65 is made of an epoxy adhesive.

[0173] An intermediate connecting portion 67 is disposed between the front connecting portion 62 and the base connecting portion 65 along the length of the guide wire 60, connecting the coil body 63 to the spindle 9. The outer diameter of the intermediate connecting portion 67 is smaller than the outer diameter of the coil body 63 among the wires constituting the coil body 63.

[0174] The intermediate connecting portion 67 can be made of the same material as the front-end side intermediate connecting portion 7a and the base-end side intermediate connecting portion 7b in the second embodiment. In this embodiment, the intermediate connecting portion 67 is made of epoxy adhesive.

[0175] In this embodiment, there is one intermediate connecting part 67. The number of intermediate connecting parts 67 is not limited to one, and there may be two or more.

[0176] In this embodiment, the width of the base connection portion 65 in the longitudinal direction extends over both wires constituting the coil body 63, and the portion with an outer diameter smaller than the outer diameter of the coil body 63 is located at one point in the base connection portion 65. The width of the base connection portion 65 in the longitudinal direction can also be formed between any number of wires of the coil body 63. The portion with an outer diameter smaller than the outer diameter of the coil body 63 can also be formed at multiple points in the base connection portion 65.

[0177] The intermediate connecting portion 67 is formed such that its width in the longitudinal direction extends across the three wires constituting the coil body 63, and there are two locations in the intermediate connecting portion 67 where the outer diameter is smaller than the outer diameter of the coil body 63. The width of the intermediate connecting portion 67 in the longitudinal direction can also be formed between any number of wires of the coil body 63. The portions with outer diameters smaller than the outer diameter of the coil body 63 can be formed in one location or in three or more locations in the intermediate connecting portion 67.

[0178] The coating agent 68 covers the outer periphery of the mandrel 9, coil body 63, front end connection portion 62, base end connection portion 65, and intermediate connection portion 67. The material of the coating agent 68 can be the same as that of the coating agent 8 in the first embodiment. In this embodiment, the material of the coating agent 68 is polyacrylamide.

[0179] In the guidewire 60 described above, when the coil body 63 detaches from the spindle 9 during surgery, the wire that forms the coil body 63 with an oxide coating 63a on its surface, the intermediate connecting portion 67 and the base connecting portion 65 are integrated with the coil body 63 and detach from the spindle 9. This prevents either the intermediate connecting portion 67 or the base connecting portion 65 from being damaged and flowing into the lumen of the patient's blood vessels, etc.

[0180] As with the guide wire 60 of this embodiment, the fact that the surface of the spindle 9 without an oxide coating and the surface of the coil body 63 with an oxide coating are connected by an adhesive made of resin material can be applied to a connection structure in which the surface of the first component without an oxide coating and the surface of the second component with an oxide coating are connected by an adhesive made of resin material.

[0181] In this case, even if a large force is applied to the connecting structure and the second component detaches from the first component, the adhesive will detach while still connected to the second component, thus preventing the adhesive from breaking and scattering.

[0182] The guidewire 60 according to this embodiment includes a mandrel 9; a coil body 63 covering the front end of the mandrel 9; a front end connecting portion 62 connecting the front end of the coil body 63 to the front end of the mandrel 9; and a base end connecting portion 65 connecting the base end of the coil body 63 to the mandrel 9. The base end connecting portion 65 is made of an adhesive made of resin material, thus enabling the guidewire 60 to be flexible. Therefore, the insertability of the guidewire 60 into the patient's body can be improved.

[0183] According to this embodiment, the guidewire 60 has an intermediate connecting portion 67 between the front connecting portion 62 and the base connecting portion 65, which connects the coil body 63 and the spindle 9. The intermediate connecting portion 67 is made of an adhesive made of resin material, thus making the guidewire 60 flexible. Therefore, the insertability of the guidewire 60 into the patient's body can be improved.

[0184] According to the guidewire 60 of this embodiment, the coil body 63 is wound multiple times around the outer periphery of the mandrel 9, and the base connection portion 65 is formed between the adjacent wires constituting the coil body 63 at a position lower than the outer diameter of the coil body 63, thus enabling the guidewire 60 to be further flexible. Therefore, the insertability of the guidewire 60 into the patient's body can be further improved.

[0185] According to the guidewire 60 of this embodiment, the coil body 63 is wound multiple times around the outer periphery of the mandrel 9, and the intermediate connecting portion 67 is formed between the adjacent wires constituting the coil body 63 with an outer diameter smaller than the outer diameter of the coil body 63, thus making the guidewire 60 more flexible. Therefore, the insertability of the guidewire 60 into the patient's body can be further improved.

[0186] According to the present embodiment, since an oxide coating 63a is formed on the surface of the coil body 63, even if a large force is applied to the guide wire 60 and the coil body 63 is detached from the spindle 9, the base end connection 65 and the intermediate connection 67 are also detached from the coil body 63 in a connected state, which can prevent at least one of the base end connection 65 and the intermediate connection 67 from being broken and scattered.

[0187] (Eighth Implementation)

[0188] The eighth embodiment of this disclosure will be described.

[0189] Compared to the guide wire 1 of the first embodiment, the guide wire 70 of the eighth embodiment has an intermediate connecting portion, and the connection methods between the coil body and the base connecting portion, as well as the connection method between the coil body and the intermediate connecting portion, are different. That is, the guide wire 70 of the eighth embodiment is configured such that by forming a plurality of grooves on the surface of the coil body in a direction intersecting the length direction of the core shaft, the base connecting portion and the intermediate connecting portion are disengaged when connected to the coil body.

[0190] Figure 13 This is an enlarged view of the guidewire tip in the eighth embodiment.

[0191] The guide wire 70 of this embodiment includes: a spindle 9; a coil body 73 covering the front end of the spindle 9; a front end connecting portion 72 connected to the front end of the coil body 73 and the front end of the spindle 9; a base end connecting portion 75 connected to the base end of the coil body 73 and the spindle 9; an intermediate connecting portion 77 disposed between the front end connecting portion 72 and the base end connecting portion 75 in the length direction of the guide wire 70 and connected to the coil body 73 and the spindle 9; and a coating agent 78 covering the outer periphery of the spindle 9, the coil body 73, the front end connecting portion 72, the base end connecting portion 75 and the intermediate connecting portion 77.

[0192] Inside the coil body 73, a gap 74 is formed between the core 9 and the coil body 73.

[0193] The coil body 73 is a hollow cylindrical coil body formed by winding one or more metal wires or resin wires. The coil body 73 is wound multiple times around the outer circumference of the mandrel 9. The front end of the coil body 73 is connected to the front end of the mandrel 9 through the front end connecting part 72, and the base end of the coil body 73 is connected to the mandrel 9 through the base end connecting part 75.

[0194] The material of the wire forming the coil body 73 can be the same as that of the coil body 3 in the first embodiment. In this embodiment, the material of the wire forming the coil body 73 is stainless steel. Multiple grooves 73a are formed on the surface of the wire constituting the coil body 73 in a direction substantially perpendicular to the length direction of the mandrel 9. Figure 13In the middle, multiple grooves 73a are represented by vertical stripes of shading.

[0195] In this embodiment, a plurality of grooves 73a are formed on the surface of the wire constituting the coil body 73 in a direction substantially perpendicular to the length direction of the mandrel 9. These plurality of grooves are not limited to being formed in a direction substantially perpendicular to the length direction of the mandrel, as long as they are formed on the surface of the wire constituting the coil body in a direction intersecting the length direction of the mandrel.

[0196] The front-end connection portion 72 connects the front end of the coil body 73 to the front end of the spindle 9. The material of the front-end connection portion 72 can be the same as that of the front-end connection portion 2 in the first embodiment. In this embodiment, the material of the front-end connection portion 72 is silver-tin solder.

[0197] The base connection portion 75 connects the base end of the coil body 73 to the mandrel 9. The base connection portion 75 can be made of the same material as the base connection portion 5 in the first embodiment. In this embodiment, the base connection portion 75 is made of epoxy adhesive.

[0198] An intermediate connecting portion 77 is disposed between the front connecting portion 72 and the base connecting portion 75 along the length of the guide wire 70, connecting the coil body 73 to the spindle 9. The intermediate connecting portion 77 can be made of the same material as the front-side intermediate connecting portion 7a and the base-side intermediate connecting portion 7b in the second embodiment. In this embodiment, the intermediate connecting portion 77 is made of epoxy adhesive.

[0199] In this embodiment, such as Figure 13 As shown, there is also one intermediate connecting part 77. The number of intermediate connecting parts 77 is not limited to one, and there may be two or more.

[0200] The width of the base connection portion 75 in the longitudinal direction can also be formed between several wires of the coil body 73. The width of the intermediate connection portion 77 in the longitudinal direction can also be formed between any number of wires of the coil body 73.

[0201] The coating agent 78 covers the outer periphery of the mandrel 9, coil body 73, front end connection portion 72, base end connection portion 75, and intermediate connection portion 77. The material of the coating agent 78 can be the same as that of the coating agent 8 in the first embodiment. In this embodiment, the material of the coating agent 78 is polyacrylamide.

[0202] In the guidewire 70 described above, when the coil body 73 detaches from the spindle 9 during surgery, the coil body 73, which is made of wire with multiple grooves 73a formed in a direction approximately perpendicular to the length direction of the spindle 9, the intermediate connecting portion 77 and the base connecting portion 75 are integrated with the coil body 73 and detach from the spindle 9. This prevents at least one of the intermediate connecting portion 77 and the base connecting portion 75 from being damaged and flowing into the lumen of the patient's blood vessels, etc.

[0203] The guidewire 70 according to this embodiment includes: a mandrel 9; a coil body 73 covering the front end of the mandrel 9; a front end connecting portion 72 connecting the front end of the coil body 73 to the front end of the mandrel 9; and a base end connecting portion 75 connecting the base end of the coil body 73 to the mandrel 9. The base end connecting portion 75 is made of an adhesive made of resin material, thus enabling the guidewire 70 to be flexible. Therefore, the insertability of the guidewire 70 into the patient's body can be improved.

[0204] According to this embodiment, the guidewire 70 has an intermediate connecting portion 77 between the front connecting portion 72 and the base connecting portion 75, which connects the coil body 73 and the spindle 9. The intermediate connecting portion 77 is made of an adhesive made of resin material, thus making the guidewire 70 flexible. Therefore, the insertability of the guidewire 70 into the patient's body can be improved.

[0205] According to the guide wire 70 of this embodiment, since a plurality of grooves 73a are formed on the surface of the coil body 73 in a direction intersecting the length direction of the spindle 9, even if a large force is applied to the guide wire 70 and the coil body 73 is detached from the spindle 9, the base end connection 75 and the intermediate connection 77 are also detached from the coil body 73 in a connected state, which can prevent at least one of the base end connection 75 and the intermediate connection 77 from being broken and scattered.

[0206] (Ninth Implementation)

[0207] The ninth embodiment of this disclosure will be described.

[0208] The guide wire 70 of the ninth embodiment differs from the guide wire 30 of the fourth embodiment in that the mandrel structure is different. Specifically, the mandrel 81 of the ninth embodiment is configured such that a plurality of grooves 82 are formed in a direction intersecting the length direction of the mandrel 81, and the base end connection portion and the intermediate connection portion are detached when connected to the coil body.

[0209] Figure 14 This is a partial enlarged view of the guidewire according to the ninth embodiment. Figure 14 This is an enlarged view of the portion of the guidewire in the ninth embodiment that corresponds to the intermediate connecting portion 37 of the guidewire 30 in the fourth embodiment. Figure 14 This indicates the cross-section of the intermediate connecting part 37 and the side of the spindle 81.

[0210] The mandrel 81 has a plurality of grooves 82 in a direction intersecting the length direction of the mandrel 81. The grooves 82 may be provided on the entire mandrel 81, or only in the area connected to either the intermediate connecting portion 37 or the base connecting portion 35.

[0211] According to the guide wire 80 of this embodiment, since a plurality of grooves 82 are formed on the surface of the spindle 81 in a direction intersecting the length direction of the spindle 81, even if a large force is applied to the guide wire 80 and the coil body 23 is detached from the spindle 81, the base end connection 35 and the intermediate connection 37 are also detached from the coil body 23 in a state of being connected, which can prevent at least one of the base end connection 35 and the intermediate connection 37 from being broken and scattered.

[0212] (Tenth Implementation)

[0213] The tenth embodiment of this disclosure will be described.

[0214] The guide wire 90 of the tenth embodiment differs from the guide wire 30 of the fourth embodiment in that the spindle structure is different. Specifically, the spindle 91 of the tenth embodiment has a plurality of grooves 92 formed along the length direction of the spindle 91, and the coil body 23 detaches from the spindle 91 when the base connection portion and the intermediate connection portion are connected to the spindle 91.

[0215] Figure 15 This is a partial enlarged view of the guidewire according to the tenth embodiment. Figure 15 This is an enlarged view of the portion of the guidewire in the tenth embodiment that corresponds to the intermediate connecting portion 37 of the guidewire 30 in the fourth embodiment. Figure 15 This indicates the cross-section of the intermediate connecting part 37 and the side of the spindle 91.

[0216] The mandrel 91 has a plurality of grooves 92 along the length of the mandrel 91. The grooves 92 may be provided on the entire mandrel 91, or only in the area connected to either the intermediate connecting portion 37 or the base connecting portion 35.

[0217] According to the guide wire 90 of this embodiment, a plurality of grooves 92 are formed on the surface of the spindle 91 in a direction intersecting the length direction of the spindle 91. Therefore, even if a large force is applied to the guide wire 90 and the coil body 23 is detached from the spindle 91, the base end connection 35 and the intermediate connection 37 remain connected to the spindle 91, which can prevent at least one of the base end connection 35 and the intermediate connection 37 from being broken and scattered.

[0218] The guide wires of several embodiments of this disclosure have been described above. This disclosure is not limited to the embodiments described above, and various modifications can be made to implement it without departing from its spirit.

[0219] For example, as with the guidewire 40 of the fifth embodiment, any one of the base connection portion and the intermediate connection portion can be set as a colored dot. This can also be applied to the front end connection portion 2 and the base end connection portion 5 of the guidewire 1 of the first embodiment, the front end connection portion 2, the front end side intermediate connection portion 7a, the base end side intermediate connection portion 7b and the base end connection portion 5 of the guidewire 10 of the second embodiment, the front end connection portion 22 and the base end connection portion 25 of the guidewire 20 of the third embodiment, the front end connection portion 22 of the guidewire 40 of the fifth embodiment, the front end connection portion 52, the intermediate connection portion 57 and the base end connection portion 55 of the guidewire 50 of the sixth embodiment, the front end connection portion 62, the intermediate connection portion 67 and the base end connection portion 65 of the guidewire 60 of the seventh embodiment, and the front end connection portion 72, the intermediate connection portion 77 and the base end connection portion 75 of the guidewire 70 of the eighth embodiment.

[0220] In this case, the lengths of the front end connection, the middle connection, and the base connection can be easily determined, and the bonding strength between each spindle and the coil body can be easily adjusted.

[0221] The principle that the outer diameter of the intermediate connecting portion and the base connecting portion is smaller than the outer diameter of the coil body among the wires constituting the coil body can also be applied to the front connecting portion 72, intermediate connecting portion 77 and base connecting portion 75 of the guide wire 70 in the eighth embodiment.

[0222] In this case, the guidewire 70 can be made more flexible. Therefore, the insertability of the guidewire 70 into the patient's body can be further improved.

[0223] The fact that the surface roughness of the coil body is greater than that of the core shaft, as in the sixth embodiment of the guide wire 50, the fact that an oxide coating is formed on the surface of the coil body but not on the core shaft, as in the seventh embodiment of the guide wire 60, and the fact that multiple grooves are formed on the surface of the coil body in a direction intersecting the length direction of the core shaft, as in the eighth embodiment of the guide wire 70, can also be applied to the guide wire 1 of the first embodiment, the guide wire 10 of the second embodiment, and the guide wire 20 of the third embodiment.

[0224] In this case, even if a large force is applied to the guide wire and the coil body is detached from the spindle, the base connection and the intermediate connection are detached from the coil body while still connected to it, which can prevent at least one of the base connection and the intermediate connection from breaking and scattering.

[0225] The fact that multiple grooves 82 are formed on the surface of the mandrel 81 in a direction intersecting the length direction of the mandrel 81, as in the guide wire 80 of the ninth embodiment, can also be applied to the mandrels of the guide wires of the first to third embodiments and the fifth to eighth embodiments.

[0226] In this case, even if a large force is applied to the guide wire and the coil body is detached from the spindle, the base connection and the intermediate connection are detached from the coil body while still connected to it, which can prevent at least one of the base connection and the intermediate connection from breaking and scattering.

[0227] The fact that a plurality of grooves 92 are formed on the surface of the mandrel 91 along the length direction of the mandrel 91, as in the guide wire 90 of the tenth embodiment, can also be applied to the mandrels of the guide wires of the first to third embodiments and the fifth embodiment.

[0228] In this case, even if a large force is applied to the guide wire and the coil body detaches from the spindle, the base connection 35 and the intermediate connection 37 remain connected to the spindle 91, which can prevent at least one of the base connection 35 and the intermediate connection 37 from breaking and scattering.

Claims

1. A guidewire (1, 10, 20, 30, 40, 50, 60, 70, 80, 90), characterized in that, have: Mandrels (9, 81, 91); Coil bodies (3, 23, 53, 63) cover the front end of the mandrel; The front end connecting part (2, 22, 52, 62, 72) connects the front end of the coil body and the front end of the spindle; as well as The base connection portion (5, 25, 35, 45, 55, 65, 75) connects the base end of the coil body and the core shaft, and includes an adhesive made of resin material.

2. The guidewire (20, 30, 40, 50, 60, 80, 90) according to claim 1, characterized in that, The coil bodies (23, 53, 63) are wound multiple times around the outer circumference of the mandrel. The base connection portion (25, 35, 45, 55, 65) is formed between adjacent wires of the coil body with an outer diameter smaller than the outer diameter of the coil body.

3. The guidewire (40) according to claim 1 or 2, characterized in that, The base end connection (45) is colored.

4. The guidewire (30, 40, 50, 60) according to any one of claims 1 to 3, characterized in that, An intermediate connecting portion (7, 7a, 7b, 37, 47, 57, 67) is provided between the front end connecting portion and the base end connecting portion to connect the coil body and the mandrel. The intermediate connecting part includes an adhesive made of resin material.

5. The guidewire (30, 40, 50, 60) according to claim 4, characterized in that, The coil body (23) is wound multiple times around the outer periphery of the mandrel. The intermediate connecting portions (37, 47, 57, 67) are formed between adjacent wires of the coil body with an outer diameter smaller than the outer diameter of the coil body.

6. The guidewire (40) according to claim 4 or 5, characterized in that, The intermediate connecting part (47) is colored.

7. The guidewire (50) according to any one of claims 1 to 6, characterized in that, The surface roughness of the coil body (53) is greater than the surface roughness of the mandrel (9).

8. The guidewire (60) according to any one of claims 1 to 7, characterized in that, An oxide coating (63a) is formed on the surface of the coil body (63).

9. The guidewire (70) according to any one of claims 1 to 8, characterized in that, On the surface of the coil body (73), a plurality of grooves (73a) are formed in a direction intersecting the length direction of the spindle (9).

10. The guidewire (80) according to any one of claims 1 to 9, characterized in that, On the surface of the mandrel (81), a plurality of grooves (82) are formed in a direction intersecting the length direction of the mandrel (81).

11. The guidewire (90) according to any one of claims 1 to 9, characterized in that, On the surface of the mandrel (91), a plurality of grooves (92) are formed along the length direction of the mandrel (91).

12. A connection structure, characterized in that, The surfaces of a first component (53) with a first surface roughness and a second component (9) with a second surface roughness greater than the first surface roughness are connected by an adhesive made of resin material.

13. A connection structure, characterized in that, The surface of the first component (9) without an oxide coating and the surface of the second component (63) with an oxide coating (63a) are connected by an adhesive made of resin material.

Images