A composition containing acetylcurcumin and its preparation method and application

Abstract

This invention relates to the field of skincare technology, disclosing a composition containing acetylated curcumin, its preparation method, and its application. The composition comprises 0.01-0.50 wt% acetylated curcumin, 0.10-0.5 wt% ferulic acid, 0.05-0.40 wt% citric acid compounds, and 5.00-20.00 wt% polyol. Ferulic acid quenches reactive oxygen species and improves the stability of acetylated curcumin; citric acid compounds stabilize the pH of the system, chelate metal ions, block the Fenton reaction, and inhibit the generation of •OH free radicals; the polyol enhances the water solubility of acetylated curcumin and improves the stability of ferulic acid. This invention, through the compounding of ferulic acid, citric acid compounds, and polyol, significantly reduces the problems of discoloration, off-flavor, and pH decrease caused by the decomposition of acetylated curcumin aqueous solutions under high temperature or light conditions. Furthermore, the preparation process is simple, easy to operate, and highly adaptable to various processes.

Description

Technical Field

[0001] This invention relates to the field of skincare technology, specifically to a composition containing acetylcurcumin, its preparation method, and its application. Background Technology

[0002] Acetylzingerone, also known as acetylshogaol or acetylshogaene, CAS: 30881-23-3, is a derivative of gingerol. Gingerol is an antioxidant found in ginger. Studies have found that fresh ginger contains a large amount of gingerol, which is converted into gingerone upon drying or heating. Gingerone and gingerol share the same structural framework as curcumin (the active ingredient in turmeric), and therefore exhibit similar pharmacological activities.

[0003] The chemical structural formula of acetylcurcumin is as follows:

[0004] Acetylcurcumin contains phenolic hydroxyl, methoxy, and carbonyl functional groups. The phenolic hydroxyl group provides hydrogen ions, the methoxy group can physically quench singlet oxygen, and the carbonyl group has a highly efficient ability to scavenge nitrite peroxide. Furthermore, acetylcurcumin can selectively chelate free ferrous ions, inhibiting the Fenton reaction and thus blocking the generation pathway of the most damaging hydroxyl free radicals in the skin.

[0005] In the field of skincare products, acetyl curcumin has shown good application potential and has been reported to have the following outstanding skincare effects: (1) it acts as a multi-target antioxidant; (2) it reduces damage to lipids, proteins and DNA; (3) it inhibits inflammatory responses; (4) it enhances the extracellular matrix and prevents collagen degradation; and (5) it has been clinically proven to improve signs of photoaging.

[0006] Despite its outstanding skincare benefits, the application of acetylcurcumin in skincare products still has some limitations. Due to its structural characteristics, acetylcurcumin is easily oxidized and decomposed. For example, under high temperature or light conditions, the acetyl group hydrolyzes and decomposes to produce vanillin, which causes acetylcurcumin to change its taste. Vanillin will further oxidize to produce vanillic acid, which leads to a decrease in pH. Furthermore, the phenolic hydroxyl groups in acetylcurcumin are oxidized to colored quinones, resulting in discoloration. Summary of the Invention

[0007] This invention provides a composition containing acetylcurcumin, its preparation method, and its application, to solve the problem that acetylcurcumin aqueous solution easily decomposes under high temperature and light conditions, causing discoloration, off-flavor, and pH decrease.

[0008] In a first aspect, the present invention provides a composition containing acetylated curcumin, comprising 0.01wt%-0.50wt% of acetylated curcumin, 0.10wt%-0.50wt% of ferulic acid, 0.05wt%-0.40wt% of citric acid compounds and 5.00wt%-20.00wt% of polyols.

[0009] In one optional embodiment, the mass fraction of the acetylcurcumin is 0.10wt%-0.50wt%; as an example, the mass fraction of the acetylcurcumin is 0.10wt%, 0.20wt%, 0.30wt%, 0.40wt%, 0.50wt%, or within any of the above values.

[0010] In one alternative embodiment, the ferulic acid has a mass fraction of 0.10wt%-0.25wt%. For example, the mass fraction of ferulic acid is 0.10wt%, 0.15wt%, 0.20wt%, 0.25wt%, or within any of the above values.

[0011] In one optional embodiment, the citric acid compound has a mass fraction of 0.10 wt% to 0.35 wt%. For example, the mass fraction of the citric acid compound is 0.10 wt%, 0.15 wt%, 0.20 wt%, 0.25 wt%, 0.30 wt%, 0.35 wt%, or within any of the above values; and / or, the citric acid compound includes at least one of citric acid, sodium citrate, and potassium citrate; and / or, the polyol includes at least one of 1,2-pentanediol, 1,3-butanediol, 1,3-propanediol, and dipropylene glycol.

[0012] In one alternative embodiment, the citric acid compound includes at least one of citric acid and sodium citrate.

[0013] In one alternative embodiment, the polyol includes at least one of 1,2-pentanediol and 1,3-butanediol.

[0014] Secondly, the present invention also provides a method for preparing a composition containing acetylglucosamine, comprising the following steps: According to the mass fraction of each component in the above-mentioned composition containing acetylcurcumin, acetylcurcumin, ferulic acid, polyol and citric acid compounds are mixed to obtain the composition containing acetylcurcumin.

[0015] In one alternative embodiment, under heating conditions, acetylcurcumin, ferulic acid, and polyol are first mixed, and then citric acid compounds are added.

[0016] In one alternative implementation, the heating temperature is 40-50°C; as an example, the heating temperature is 40°C, 42°C, 45°C, 48°C, 50°C, or within any range of the above values.

[0017] In one optional embodiment, the mixing process includes a stirring step, wherein the stirring rate is 10-200 rpm; as an example, the stirring rate is 10 rpm, 50 rpm, 80 rpm, 100 rpm, 150 rpm, 200 rpm, or within any range of the above values.

[0018] Thirdly, the application of the acetylcurcumin-containing composition of the present invention or the acetylcurcumin-containing composition prepared by the above-mentioned method for preparing the acetylcurcumin-containing composition in skin care products.

[0019] The technical solution of this invention has the following advantages: 1. This invention provides a composition containing acetylated curcumin, comprising 0.01wt%-0.50wt% acetylated curcumin, 0.10wt%-0.50wt% ferulic acid, 0.05wt%-0.40wt% citric acid compounds, and 5.00wt%-20.00wt% polyol. Reactive oxygen species (ROS) are one of the main causes of molecular structural breakage in acetylated curcumin. This application utilizes the property of ferulic acid to quench ROS, thereby improving the stability of acetylated curcumin at a chemical level; simultaneously, it utilizes the chelating properties of citric acid compounds to chelate metal ions (such as Fe). 2+ / Cu 2+ The ability of citric acid compounds to block the Fenton reaction at its source and inhibit the generation of •OH free radicals, while citric acid compounds can maintain the pH of the system in a weakly acidic environment, reducing the hydrolysis problem of acetylcurcumin caused by pH fluctuations; furthermore, by introducing polyols, this application can improve the poor water solubility of acetylcurcumin, increase its solubility in water and prevent its aggregation and precipitation, and the presence of polyols can change the polar microenvironment of the system, improving the stability of acetylcurcumin. At the same time, polyols can improve the chemical stability of ferulic acid, further improving the stability of acetylcurcumin in the composition.

[0020] 2. This invention provides a method for preparing a composition containing acetylcurcumin. By combining acetylcurcumin with ferulic acid, citric acid compounds, and polyols, the problems of discoloration, off-flavor, and pH decrease caused by decomposition of acetylcurcumin aqueous solution under high temperature or light conditions can be significantly improved. At the same time, the preparation method of this invention can enhance the solubility of acetylcurcumin in aqueous system. The preparation process is simple, easy to operate, and has high process adaptability. Attached Figure Description

[0021] To more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0022] Figure 1 These are photographs of the actual samples from test group C (placed at 50°C in a dark environment for 30 days) in various embodiments of the present invention. Figure 2 These are photographs of the actual test group C of the comparative sample of this invention (placed at 50°C in a dark environment for 30 days). Detailed Implementation

[0023] The following embodiments are provided to better understand the present invention, but the following embodiments do not constitute a limitation on the content and scope of protection of the present invention. Any product that is the same as or similar to the present invention, derived by any person under the guidance of the present invention or by combining the features of the present invention with other prior art, falls within the scope of protection of the present invention.

[0024] Unless otherwise specified, all experimental steps or conditions in the examples were performed according to conventional experimental procedures and conditions in the art. Reagents or instruments whose manufacturers are not specified are all commercially available products.

[0025] The acetylcurcumin used in the embodiments and comparative examples of this invention was purchased from Guangdong Xuanjia Medical Products Health Technology Co., Ltd.

[0026] Example 1 This embodiment provides a method for preparing a composition containing acetylated curcumin, the specific steps and parameters of which are as follows: S1, take 0.1g of acetylcurcumin, 0.1g of ferulic acid, 5g of 1,3-butanediol and 3g of 1,2-pentanediol, mix them, heat to 40℃, stir to dissolve, stirring speed 50rpm, stirring time 5 minutes to obtain the pretreated solution; S2, add 0.1g sodium citrate and 91.7g water to the pretreatment solution, stir until completely dissolved, stir at 50rpm for 5 minutes to obtain a composition solution containing acetylcurcumin.

[0027] Example 2 This embodiment provides a method for preparing a composition containing acetylated curcumin, the specific steps and parameters of which are as follows: S1. Take 0.1g of acetylcurcumin, 0.25g of ferulic acid, 5g of 1,3-butanediol, and 3g of 1,2-pentanediol, mix them, heat to 40℃, stir to dissolve, stir at 100rpm for 5 minutes to obtain the pretreated solution. S2, add 0.24g sodium citrate and 91.41g water to the pretreatment solution, stir until completely dissolved, stir at 100rpm for 5 minutes to obtain a composition solution containing acetylcurcumin.

[0028] Example 3 This embodiment provides a method for preparing a composition containing acetylated curcumin, the specific steps and parameters of which are as follows: S1. Take 0.25g of acetylcurcumin, 0.25g of ferulic acid, 5g of 1,3-butanediol, and 3g of 1,2-pentanediol, mix them, heat to 50℃, stir to dissolve, stir at 150rpm for 5 minutes to obtain a pretreated solution. S2, add 0.24g sodium citrate and 91.26g water to the pretreatment solution, stir until completely dissolved, stir at 150rpm for 5 minutes to obtain a composition solution containing acetylcurcumin.

[0029] Example 4 This embodiment provides a method for preparing a composition containing acetylated curcumin, the specific steps and parameters of which are as follows: S1. Take 0.25g of acetylcurcumin, 0.5g of ferulic acid, 10g of 1,3-butanediol, and 10g of 1,2-pentanediol, mix them, heat to 50℃, stir to dissolve, stir at 200rpm for 5 minutes to obtain a pretreated solution. S2, add 0.35g sodium citrate and 78.9g water to the pretreatment solution, stir until completely dissolved, stir at 200rpm for 5 minutes to obtain a composition solution containing acetylcurcumin.

[0030] Example 5 This embodiment provides a method for preparing a composition containing acetylated curcumin, the specific steps and parameters of which are as follows: S1, take 0.01g of acetylcurcumin, 0.1g of ferulic acid, and 5g of 1,3-butanediol, mix them, heat to 40℃, stir to dissolve, stir at 20rpm for 5 minutes to obtain the pretreated solution; S2, add 0.1g sodium citrate and 94.79g water to the pretreatment solution, stir until completely dissolved, stir at 20 rpm for 5 minutes to obtain a composition solution containing acetylcurcumin.

[0031] Example 6 S1. Take 0.5g of acetylcurcumin, 0.25g of ferulic acid, 5g of 1,3-butanediol, and 3g of 1,2-pentanediol, mix them, heat to 40℃, stir to dissolve, stir at 50rpm for 5 minutes to obtain a pretreated solution. S2, add 0.28g sodium citrate and 90.97g water to the pretreatment solution, stir until completely dissolved, stir at 50rpm for 5 minutes to obtain a composition solution containing acetylcurcumin.

[0032] Comparative Example 1 The preparation method of an aqueous solution of acetylcurcinone provided in this comparative example is as follows: Take 0.1g of acetylcurcumin and mix it with 99.9g of water. Heat the mixture to 40℃, stir to dissolve, stir at 50rpm for 5 minutes to obtain an aqueous solution of acetylcurcumin.

[0033] Comparative Example 2 The preparation method of an aqueous solution of acetylcurcinone provided in this comparative example is as follows: Take 0.25g of acetylcurcumin and mix it with 99.75g of water. Heat the mixture to 40℃, stir to dissolve, stir at 50rpm for 5 minutes to obtain an aqueous solution of acetylcurcumin.

[0034] Comparative Example 3 The preparation method of the composition containing acetylated curcumin provided in this comparative example is as follows: S1, take 0.1g of acetylcurcumin, 5g of 1,3-butanediol and 3g of 1,2-pentanediol, mix them, heat to 40℃, stir to dissolve, stirring speed 50rpm, stirring time 5 minutes to obtain the pretreated solution; S2, add 91.9g of water to the pretreatment solution, stir until completely dissolved, stir at 50rpm for 5 minutes to obtain a composition containing acetylcurcumin.

[0035] Comparative Example 4 The preparation method of the composition containing acetylated curcumin provided in this comparative example is as follows: S1, take 0.5g of acetylcurcumin, 5g of 1,3-butanediol, and 3g of 1,2-pentanediol, mix them, heat to 40℃, stir to dissolve, stir at 50rpm for 5 minutes to obtain a pretreated solution; S2, add 91.5g of water to the pretreatment solution, stir until completely dissolved, stir at 50rpm for 5 minutes to obtain a composition containing acetylcurcumin.

[0036] Comparative Example 5 This comparative example provides a method for preparing a composition containing acetylated curcumin. The difference between this comparative example and Example 6 is that 0.04g of sodium hydroxide is used instead of 0.28g of sodium citrate in Example 6. The pH is adjusted by using 0.04g of sodium hydroxide so that the original pH of the composition containing acetylated curcumin prepared in Comparative Example 5 is basically consistent with the original pH of the composition containing acetylated curcumin prepared in Example 6. The specific preparation method is as follows: S1. Take 0.5g of acetylcurcumin, 0.25g of ferulic acid, 5g of 1,3-butanediol, and 3g of 1,2-pentanediol, mix them, heat to 40℃, stir to dissolve, stir at 50rpm for 5 minutes to obtain a pretreated solution. S2, add 0.04g sodium hydroxide and 91.21g water to the pretreatment solution, stir until completely dissolved, stir at 50rpm for 5 minutes to obtain a composition containing acetylcurcumin.

[0037] Comparative Example 6 This comparative example provides a method for preparing a composition containing acetylated curcumin. The difference between this comparative example and Example 6 is that ferulic acid is not used. The specific preparation method is as follows: S1, take 0.5g of acetylcurcumin, 5g of 1,3-butanediol, and 3g of 1,2-pentanediol, mix them, heat to 40℃, stir to dissolve, stir at 50rpm for 5 minutes to obtain a pretreated solution; S2, add 0.28g sodium citrate and 91.22g water to the pretreatment solution, stir until completely dissolved, stir at 50 rpm for 5 minutes to obtain a composition containing acetylcurcumin.

[0038] Comparative Example 7 This comparative example provides a method for preparing a composition containing acetylated curcumin. The difference between this comparative example and Example 6 is that 0.1g of sodium metabisulfite is used as an antioxidant to replace 0.25g of ferulic acid in Example 6, and 0.06g of citric acid and 0.19g of sodium citrate are used to replace 0.28g of sodium citrate in Example 6. The pH is adjusted by using 0.06g of citric acid and 0.19g of sodium citrate so that the initial pH of the composition containing acetylated curcumin prepared in Comparative Example 7 is essentially the same as the initial pH of the composition containing acetylated curcumin prepared in Example 6. The specific preparation method is as follows: S1, take 0.5g of acetylcurcumin, 5g of 1,3-butanediol, and 3g of 1,2-pentanediol, mix them, heat to 40℃, stir to dissolve, stir at 50rpm for 5 minutes to obtain a pretreated solution; S2, add 0.1g sodium metabisulfite, 0.06g citric acid, 0.19g sodium citrate, and 91.15g water to the pretreatment solution, stir until completely dissolved, at a stirring speed of 50 rpm for 5 minutes, to obtain a composition containing acetylcurcumin.

[0039] Comparative Example 8 This comparative example provides a method for preparing a composition containing acetylated curcumin. The difference between this comparative example and Example 1 is that sodium citrate is not used. The specific preparation method is as follows: S1, take 0.1g of acetylcurcumin, 0.1g of ferulic acid, 5g of 1,3-butanediol and 3g of 1,2-pentanediol, mix them, heat to 40℃, stir to dissolve, stirring speed 50rpm, stirring time 5 minutes to obtain the pretreated solution; S2, add 91.8g of water to the pretreatment solution, stir until completely dissolved, stir at 50rpm for 5 minutes to obtain a composition containing acetylcurcumin.

[0040] Test case The appearance, odor, pH value, and acetylcurcumin content of the composition samples prepared in each embodiment and comparative example were tested under different conditions. The test methods are as follows: 1. Color and odor test: Visually inspect the color and state of the sample under room temperature and in non-direct sunlight conditions, and smell its odor.

[0041] 2. pH test: Insert the electrode of the calibrated pH meter into the sample to be tested, ensuring that the electrode is in full contact with the solution. After the pH meter reading stabilizes, read the pH value.

[0042] 3. Test method for acetylcurcumin content: Detected by high performance liquid chromatography according to General Chapter 0512 of Part IV of the Chinese Pharmacopoeia (2020 Edition).

[0043] The test grouping is as follows: (1) Prepare compositions containing acetylcurcumin according to each example and comparative example. Immediately after preparation, record the color, odor and pH value of the compositions containing acetylcurcumin, and record them as the original group; (2) After placing each composition sample containing acetylcurcumin in the original group at 5°C in a dark environment for 30 days, observe the color, odor and pH value of the sample and record it as test group A; (3) After placing each composition sample containing acetylcurcumin in the original group at 25°C in a dark environment for 30 days, observe the color, odor and pH value of the sample and record it as test group B; (4) After placing each composition sample containing acetylcurcumin in the original group at 50°C in a dark environment for 30 days, observe the color, odor, and pH value of the sample, and test the content of acetylcurcumin. This is recorded as test group C. (5) After placing each composition sample containing acetylcurcumin in the original group under the illumination of D65 standard light source (according to GB / T 20147.2-2026 "Colorimetry Part 2: CIE Standard Illuminators") at 25℃ for 30 days, observe the color, odor, and pH value of the sample, and test the content of acetylcurcumin. This is recorded as test group D. (6) Compare the original group, test group A, test group B, test group C, and test group D to analyze the stability of the compositions containing acetylcurcumin prepared in each example and comparative example.

[0044] The test data of appearance, odor and pH value of the original group, test group A, test group B, test group C and test group D containing acetylcurcumin are shown in Table 1. The test data of acetylcurcumin content of the test group C and test group D containing acetylcurcumin are shown in Table 2. The acetylcurcumin retention rate = acetylcurcumin content measured after the test / initial amount of acetylcurcumin added × 100%.

[0045] Table 1

[0046] Table 2

[0047] Table 1 shows that the compositions containing acetylcurcumin prepared in Examples 1-6 are colorless and odorless solutions with a pH value maintained at approximately 5.1-5.2. The pH value remained stable after 30 days under different environmental conditions. The color of the compositions containing acetylcurcumin prepared in Examples 1-6 remained unchanged after 30 days at low temperature (5℃) and 25℃, remaining colorless. Slight color change may only occur after 30 days at high temperature (50℃) or under light. The color after 30 days at high temperature (50℃) is shown below. Figure 1As shown, the odor of the acetylcurcumin-containing compositions prepared in Examples 1-6 remained unchanged after 30 days at low temperature (5°C), but slightly changed in odor after 30 days at 25°C, high temperature (50°C), and under light. This indicates that the technical solution provided by the present invention can effectively inhibit severe changes in color, odor, and pH value of the acetylcurcumin-containing compositions under high temperature (50°C) and light conditions. Table 2 shows that the acetylcurcumin content of the acetylcurcumin-containing compositions prepared in Examples 1-6 did not change significantly after 30 days under high temperature (50°C) or light conditions, and the percentage of acetylcurcumin content was above 94%. This indicates that the oxidative decomposition of the acetylcurcumin-containing compositions prepared in Examples 1-6 was effectively inhibited under high temperature and light conditions, and therefore its color, odor, and pH value changes were small under high temperature (50°C) and light conditions.

[0048] Table 2 shows that Comparative Examples 1 and 2 are aqueous solutions of acetylcurcumin with mass percentages of 0.01% and 0.25%, respectively. Initially, both Comparative Examples 1 and 2 are colorless, odorless solutions with a pH of approximately 6.5. After 30 days at low temperature (5℃) and 25℃, the color remained unchanged, remaining colorless, but a slight change in taste and a significant decrease in pH occurred. Under high temperature (50℃) or light conditions, severe discoloration and odor changes occurred, and the pH decreased significantly. The color after 30 days at high temperature (50℃) is shown below. Figure 2 The corresponding partial images of Comparative Examples 1 and 2 are shown in Table 2. Table 2 shows that the content of acetylcurcumin in Comparative Examples 1 and 2 changed significantly after being placed in a high-temperature (50℃) environment for 30 days, with the percentage of acetylcurcumin content both below 90%. Under light conditions, the decrease in acetylcurcumin content was even more pronounced after 30 days, with the percentages reaching 73% and 81%, respectively. Comparative Examples 1 and 2 demonstrate that aqueous solutions of acetylcurcumin at different concentrations are easily oxidized and hydrolyzed under high-temperature or light conditions.

[0049] Comparative Examples 3 and 4 did not contain ferulic acid or citric acid compounds; only polyols were added. Table 1 shows that both Comparative Examples 3 and 4 exhibited significant discoloration and off-flavors after being placed in a high-temperature (50℃) environment or under light for 30 days, and their pH values ​​dropped sharply. The color changes after 30 days in the high-temperature (50℃) environment are shown in Table 1. Figure 2 The corresponding partial images of Comparative Examples 3 and 4 are shown in Table 2. Table 2 shows that the content of acetylcurcumin in Comparative Examples 3 and 4 decreased significantly after being placed in a high temperature (50℃) environment or under light for 30 days. This indicates that polyols cannot inhibit the oxidative decomposition of acetylcurcumin. Polyols are mainly used to increase the solubility of acetylcurcumin in water.

[0050] The difference between Comparative Example 5 and Example 6 is that Comparative Example 5 uses 0.04g of sodium hydroxide instead of 0.28g of sodium citrate in Example 6. Table 1 shows that, compared to Example 6, Comparative Example 5 showed no significant change in pH under different test conditions, but it severely changed color and taste under high temperature (50°C). The color after 30 days at high temperature (50°C) is shown in Table 1. Figure 2 The partial images corresponding to Comparative Example 5 are shown in Table 2. Table 2 shows that, compared with Example 6, Comparative Example 5 showed significant oxidative decomposition of acetylcurcumin after being placed under high temperature (50°C) or light conditions for 30 days. The percentage content of acetylcurcumin was 81.8% and 89.4%, respectively, indicating that the use of sodium citrate is more conducive to inhibiting the oxidative decomposition of acetylcurcumin.

[0051] The difference between Comparative Example 6 and Example 6 is that Comparative Example 6 did not contain ferulic acid. Table 1 shows that, compared to Example 6, Comparative Example 6 exhibited a decrease in pH under different test conditions, and showed significant discoloration and odor changes under high temperature (50°C) or light conditions. The color after 30 days at high temperature (50°C) is shown in Table 1. Figure 2 The partial images corresponding to Comparative Example 6 are shown in Table 2. Table 2 shows that, compared with Example 6, Comparative Example 6 showed significant oxidative decomposition of acetylacetonine after being placed under high temperature (50°C) or light conditions for 30 days, indicating that ferulic acid can stabilize acetylacetonine and inhibit its oxidative decomposition.

[0052] The difference between Comparative Example 7 and Example 6 is that, while maintaining a similar initial pH value as in Example 6, sodium metabisulfite was used instead of ferulic acid as the antioxidant. Table 1 shows that the pH value of Comparative Example 7 decreased significantly, and it exhibited noticeable flavor changes at high temperature (50°C). The color changes after 30 days at high temperature (50°C) are shown in Table 1. Figure 2 The partial images corresponding to Comparative Example 7 are shown in Table 2. Table 2 shows that the content of acetylcurcumin in Comparative Example 7 changed significantly under high temperature (50℃) and light conditions, with the percentages of acetylcurcumin content being 83.4% and 79.4%, respectively. This indicates that ferulic acid, as an antioxidant, is more effective in inhibiting the oxidative decomposition of acetylcurcumin, and can exert an effect that general antioxidants cannot achieve in inhibiting the oxidative decomposition of acetylcurcumin.

[0053] The difference between Comparative Example 8 and Example 1 is that sodium citrate was not added in Comparative Example 8. Table 1 shows that Comparative Example 8 has a lower pH value and exhibits severe flavor changes at high temperature (50°C). The color changes after 30 days at high temperature (50°C) are shown in Table 1. Figure 2The partial image corresponding to Comparative Example 8 is shown in Table 2. Table 2 shows that the content of acetylacetamone in Comparative Example 8 changed significantly under high temperature (50℃) and light conditions. This indicates that sodium citrate not only stabilizes the pH of the acetylacetamone-containing composition but also effectively inhibits the oxidative decomposition of acetylacetamone, thus improving its stability.

[0054] Obviously, the above embodiments are merely illustrative examples for clear explanation and are not intended to limit the implementation. Those skilled in the art will recognize that other variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. However, obvious variations or modifications derived therefrom are still within the scope of protection of this invention.

Claims

1. A composition containing acetylated curcumin, characterized in that, It includes 0.01wt%-0.50wt% of acetylglucanone, 0.10wt%-0.50wt% of ferulic acid, 0.05wt%-0.40wt% of citric acid compounds, and 5.00wt%-20.00wt% of polyols.

2. The composition containing acetylated curcumin according to claim 1, characterized in that, The mass fraction of the acetylcurcumin is 0.10wt%-0.50wt%.

3. The composition containing acetylated curcumin according to claim 1, characterized in that, The mass fraction of ferulic acid is 0.10wt%-0.25wt%.

4. The composition containing acetylated curcumin according to claim 1, characterized in that, The mass fraction of the citric acid compound is 0.10 wt%-0.35 wt%. And / or, the citric acid compounds include at least one of citric acid, sodium citrate, and potassium citrate; And / or, the polyol includes at least one of 1,2-pentanediol, 1,3-butanediol, 1,3-propanediol, and dipropylene glycol.

5. The composition containing acetylated curcumin according to claim 4, characterized in that, The citric acid compounds include at least one of citric acid and sodium citrate.

6. The composition containing acetylated curcumin according to claim 4, characterized in that, The polyol includes at least one of 1,2-pentanediol and 1,3-butanediol.

7. A method for preparing a composition containing acetylated curcumin as described in any one of claims 1-6, characterized in that, Includes the following steps: According to the mass fraction of each component in the composition containing acetylcurcumin as described in any one of claims 1-6, acetylcurcumin, ferulic acid, polyol and citric acid compound are mixed to obtain the composition containing acetylcurcumin.

8. The method for preparing the composition containing acetylated curcumin according to claim 7, characterized in that, Under heating conditions, acetylcurcumin, ferulic acid, and polyols are first mixed, and then citric acid compounds are added.

9. The method for preparing the composition containing acetylated curcumin according to claim 8, characterized in that, The heating temperature is 40-50℃.

10. The use of a composition containing acetylated curcumin as described in any one of claims 1-6 or a composition containing acetylated curcumin prepared by the method of preparing a composition containing acetylated curcumin as described in any one of claims 7-9 in a skin care product.

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