Magnetic separation cleaning system and full-automatic chemiluminescence immunity instrument

Abstract

The utility model provides a magnetic separation cleaning system and a full-automatic chemiluminescence immunity instrument, and relates to the technical field of medical instruments, the magnetic separation cleaning system comprises a cleaning liquid barrel, a buffer tank, a diaphragm pump, a waste liquid barrel, a three-way liquid inlet pipeline, a liquid injection needle assembly, a plunger pump and a liquid outlet pipeline, a third passage of the three-way liquid inlet pipeline is connected with the plunger pump, one end of the liquid outlet pipeline is connected with the plunger pump, and the other end of the liquid outlet pipeline is connected with an inlet of the diaphragm pump; the diaphragm pump is arranged between the three-way liquid outlet pipeline and the waste liquid barrel to be matched with the plunger pump to jointly clean the pipeline, so that the pipeline cleaning effect is improved, crystals in the pipeline are reduced, the service life of the plunger pump is prolonged, and the problems that the crystallization effect in the cleaning pipeline of a magnetic separation cleaning system is poor, the pipeline is difficult to completely clean and the cleaning cost is low are solved. The technical problem that the service life of the plunger pump is shortened is solved, and pollution and damage caused by pipeline blockage due to crystallization of magnetic separation cleaning liquid are avoided.

Description

Technical Field

[0001] The utility model relates to the technical field of medical devices, in particular to a magnetic separation and cleaning system and a fully automatic chemiluminescence immunoassay instrument. Background Art

[0002] In the existing technology, the technology of in vitro diagnosis based on the immune principle is constantly developing, and the demand for automation and intelligence of "sample in, result out" is getting higher and higher. Currently, most of the fully automatic chemiluminescence immunoassays and multiplex liquid chip immunoassay analyzers on the market can realize automatic sampling, on-demand incubation, automatic separation of analytes, and automatic analysis of test results.

[0003] In this process, the test object or the test object carrier in the reaction cup needs to be cleaned frequently. Generally, the fully automatic chemiluminescence immunoassay is equipped with a magnetic separation cleaning system, which injects the cleaning liquid into the reaction cup, and sucks out the reaction liquid in the reaction cup and retains the magnetic beads or magnetic sheets in the reaction cup to achieve the cleaning of the test object or the test object carrier in the reaction cup. In order to avoid the problem of pipeline blockage caused by crystallization of the cleaning liquid in the magnetic separation cleaning system due to long-term use, the current magnetic separation cleaning system is generally equipped with a plunger pump, which sequentially draws and injects the cleaning liquid through the liquid passage to achieve the cleaning of the pipeline.

[0004] However, the crystallization effect in the cleaning pipeline of the existing magnetic separation cleaning system is poor, it is difficult to completely clean the pipeline, and the service life of the plunger pump will be shortened. Utility Model Content

[0005] The utility model aims to provide a magnetic separation cleaning system to alleviate the technical problems in the prior art that the crystallization effect in the cleaning pipeline of the magnetic separation cleaning system is poor, the pipeline is difficult to be completely cleaned, and the service life of the plunger pump is shortened.

[0006] The utility model provides a magnetic separation cleaning system, comprising a main system and a liquid injection device;

[0007] The main system includes a cleaning liquid barrel, a buffer tank, a diaphragm pump and a waste liquid barrel, the cleaning liquid barrel is connected to the liquid inlet end of the buffer tank, and the outlet of the diaphragm pump is connected to the waste liquid barrel;

[0008] The injection device includes a three-way liquid inlet pipeline, an injection needle assembly connected to the first passage of the three-way liquid inlet pipeline, a plunger pump and a liquid outlet pipeline. The second passage of the three-way liquid inlet pipeline is connected to the liquid outlet end of the buffer tank, the third passage of the three-way liquid inlet pipeline is connected to the plunger pump, one end of the liquid outlet pipeline is connected to the plunger pump, and the other end of the liquid outlet pipeline is connected to the inlet of the diaphragm pump. The injection needle assembly is used to inject liquid into the reaction cup.

[0009] Furthermore, the main system includes a first combining valve and a first isolating valve, the first combining valve is arranged between the liquid outlet pipeline and the diaphragm pump, the outlet of the first combining valve is connected to the inlet of the diaphragm pump, the normally closed inlet of the first combining valve is connected to the emptying end of the buffer tank, the normally open inlet of the first combining valve is connected to the liquid outlet pipeline, and the first isolating valve is arranged in the second passage of the three-way liquid inlet pipeline.

[0010] Furthermore, the main system also includes a first diverter valve, which is arranged between the diaphragm pump and the waste liquid barrel, the inlet of the first diverter valve is connected to the outlet of the diaphragm pump, the normally closed outlet of the first diverter valve is connected to the waste liquid barrel, and the normally open outlet of the first diverter valve is connected to the cleaning liquid barrel.

[0011] Furthermore, the main system is also provided with a second diverter valve, which is arranged between the first combining valve and the liquid outlet pipeline, the inlet of the second diverter valve is connected to the liquid outlet pipeline, the normally open outlet of the second diverter valve is connected to the waste liquid barrel, and the normally closed outlet of the second diverter valve is connected to the normally open inlet of the first combining valve.

[0012] Furthermore, the injection device also includes a third diverter valve and a second isolation valve, and several of the third diverter valves are sequentially arranged in series in the second passage of the three-way liquid inlet pipeline, the inlet of any two adjacent third diverter valves is connected to the normally open outlet, the normally closed outlet of the third diverter valve is connected to the first passage of the three-way liquid inlet pipeline, the inlet of the first of the several third diverter valves connected in series is connected to the plunger pump, the normally open outlet of the last of the several third diverter valves connected in series is connected to the first isolation valve, and the second isolation valve is arranged in the liquid outlet pipeline.

[0013] Furthermore, the liquid injection device also includes a pressure sensor, and the pressure sensor is arranged between the third diverter valve and the plunger pump.

[0014] Further, the magnetic separation cleaning system comprises two of the liquid injection devices;

[0015] The main system also includes a second combining valve, the outlet of which is connected to the inlet of a second diverting valve, the normally closed inlet of which is connected to the liquid outlet pipeline of one of the injection devices, and the normally open inlet of which is connected to the liquid outlet pipeline of the other injection device.

[0016] Furthermore, the main system also includes a maintenance fluid tank, a third isolation valve and a fourth isolation valve;

[0017] One end of the third isolation valve is communicated with the maintenance liquid barrel, the other end of the third isolation valve is communicated with the liquid inlet end of the buffer tank, and the fourth isolation valve is arranged between the cleaning liquid barrel and the buffer tank.

[0018] Furthermore, the main system also includes a liquid aspiration pipeline and a liquid aspiration needle assembly connected to one end of the liquid aspiration pipeline, the liquid aspiration needle assembly is used to aspirate liquid from the reaction cup, and the other end of the liquid aspiration pipeline is connected to the waste liquid bucket.

[0019] Another aspect of the utility model provides a fully automatic chemiluminescence immunoassay instrument, comprising the above-mentioned magnetic separation and cleaning system.

[0020] Beneficial effects:

[0021] A magnetic separation cleaning system provided by an embodiment of the utility model comprises a main system and a liquid injection device; the main system comprises a cleaning liquid barrel, a buffer tank, a diaphragm pump and a waste liquid barrel, the cleaning liquid barrel is connected to the liquid inlet end of the buffer tank, and the outlet of the diaphragm pump is connected to the waste liquid barrel; the liquid injection device comprises a three-way liquid inlet pipeline, a liquid injection needle assembly connected to the first passage of the three-way liquid inlet pipeline, a plunger pump and a liquid outlet pipeline, the second passage of the three-way liquid inlet pipeline is connected to the liquid outlet end of the buffer tank, the third passage of the three-way liquid inlet pipeline is connected to the plunger pump, one end of the liquid outlet pipeline is connected to the plunger pump, and the other end of the liquid outlet pipeline is connected to the inlet of the diaphragm pump; by A diaphragm pump is arranged between the three-way liquid outlet pipeline and the waste liquid barrel to work together with the plunger pump to complete the cleaning of the pipeline, thereby improving the effect of pipeline cleaning, reducing crystallization in the pipeline, and thus increasing the service life of the plunger pump. At the same time, a buffer tank is arranged between the cleaning liquid barrel and the injection device, the liquid suction load of the injection device is reduced, and the service life of the plunger pump is also increased, solving the technical problem that the crystallization effect in the cleaning pipeline of the magnetic separation cleaning system is poor, it is difficult to completely clean the pipeline, and the service life of the plunger pump is shortened, thereby avoiding crystallization of the magnetic separation cleaning liquid causing pipeline blockage, resulting in pollution and damage.

[0022] The utility model also provides a fully automatic chemiluminescence immunoassay instrument, which has all the advantages of the above-mentioned magnetic separation and cleaning system compared with the prior art, and will not be described in detail here. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the specific implementation methods of the utility model or the technical solutions in the prior art, the drawings required for use in the specific implementation methods or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some implementation methods of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0024] Figure 1The overall structure diagram of the magnetic separation cleaning system provided by the embodiment of the utility model;

[0025] Figure 2 A schematic diagram of the structure of the main system in the magnetic separation cleaning system provided in an embodiment of the utility model;

[0026] Figure 3 A schematic structural diagram of a liquid injection device in a magnetic separation and cleaning system provided in an embodiment of the utility model.

[0027] icon:

[0028] 100, main system; 110, cleaning liquid barrel; 120, buffer tank; 130, diaphragm pump; 140, waste liquid barrel; 160, maintenance liquid barrel;

[0029] 101, first converging valve; 102, first isolating valve; 103, first diverting valve; 104, second diverting valve; 105, third isolating valve; 106, fourth isolating valve;

[0030] 200, liquid injection device; 210, three-way liquid inlet pipeline; 220, liquid injection needle assembly; 230, plunger pump; 240, liquid outlet pipeline; 250, pressure sensor;

[0031] 201, third diverter valve; 202, second isolation valve; 203, second converging valve;

[0032] 300. Aspiration pipeline; 310. Aspiration needle assembly. DETAILED DESCRIPTION

[0033] The technical solution of the utility model will be described clearly and completely below in conjunction with the accompanying drawings. Obviously, the described embodiments are part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0034] The present invention is further described in detail below through specific embodiments in conjunction with the accompanying drawings.

[0035] like Figures 1 to 3As shown, a magnetic separation cleaning system provided by an embodiment of the utility model includes a main system 100 and a liquid injection device 200; the main system 100 includes a cleaning liquid barrel 110, a buffer tank 120, a diaphragm pump 130 and a waste liquid barrel 140, the cleaning liquid barrel 110 is connected to the liquid inlet end of the buffer tank 120, and the outlet of the diaphragm pump 130 is connected to the waste liquid barrel 140; the liquid injection device 200 includes a three-way liquid inlet pipeline 210, an injection needle assembly 220 connected to the first passage of the three-way liquid inlet pipeline 210, a plunger pump 230 and a liquid outlet pipeline 240, the second passage of the three-way liquid inlet pipeline 210 is connected to the liquid outlet end of the buffer tank 120, the third passage of the three-way liquid inlet pipeline 210 is connected to the plunger pump 230, one end of the liquid outlet pipeline 240 is connected to the plunger pump 230, and the other end of the liquid outlet pipeline 240 is connected to the inlet of the diaphragm pump 130, and the injection needle assembly 220 is used to inject liquid into the reaction cup.

[0036] That is, a magnetic separation cleaning system provided by an embodiment of the utility model comprises a main system 100 and a liquid injection device 200; the main system 100 comprises a cleaning liquid barrel 110, a buffer tank 120, a diaphragm pump 130 and a waste liquid barrel 140, the cleaning liquid barrel 110 is connected to the liquid inlet end of the buffer tank 120, and the outlet of the diaphragm pump 130 is connected to the waste liquid barrel 140; the liquid injection device 200 comprises a three-way liquid inlet pipeline 210, a liquid injection needle assembly 220 connected to the first passage of the three-way liquid inlet pipeline 210, a plunger pump 230 and a liquid outlet pipeline 240, the second passage of the three-way liquid inlet pipeline 210 is connected to the liquid outlet end of the buffer tank 120, the third passage of the three-way liquid inlet pipeline 210 is connected to the plunger pump 230, one end of the liquid outlet pipeline 240 is connected to the plunger pump 230, and the liquid outlet pipeline 2 The other end of 40 is connected to the inlet of the diaphragm pump 130; by arranging the diaphragm pump 130 between the three-way liquid outlet pipeline 240 and the waste liquid barrel 140 to cooperate with the plunger pump 230 to complete the cleaning of the pipeline, the effect of pipeline cleaning is improved, the crystallization in the pipeline is reduced, and the service life of the plunger pump 230 is increased. At the same time, by arranging the buffer tank 120 between the cleaning liquid barrel 110 and the injection device 200, the liquid suction load of the injection device 200 is reduced, and the service life of the plunger pump 230 is also increased, which solves the technical problems of poor crystallization effect in the cleaning pipeline of the magnetic separation cleaning system, difficulty in completely cleaning the pipeline, and shortening the service life of the plunger pump 230, and avoids the blockage of the pipeline caused by crystallization of the magnetic separation cleaning liquid, resulting in pollution and damage.

[0037] Specifically, in the present embodiment, the buffer tank 120 has five external interfaces a, b, c, d, and e, of which interfaces a and b are liquid inlet ends, interface c is an emptying end, and interfaces d and e are liquid outlet ends. The cleaning liquid barrel 110 is connected to interface b through a pipeline. The second passage of the three-way liquid inlet pipeline 210 is connected to interface d or interface e, so that the cleaning liquid can enter the buffer tank 120 and then enter the three-way liquid inlet pipeline 210, and the load of the three-way liquid inlet pipeline 210 is reduced through the buffer tank 120. The first passage of the three-way liquid inlet pipeline 210 is connected to the injection needle assembly 220, and the injection needle assembly 220 is provided with an injection pipeline and an injection needle at the end of the pipeline, and the injection needle can extend into the reaction cup to be cleaned and inject the cleaning liquid therein. The third passage of the three-way inlet pipeline 210 is connected to one end of the plunger pump 230, and the other end of the plunger pump 230 is connected to the outlet pipeline 240, and the outlet pipeline 240 is connected to the inlet of the diaphragm pump 130. The cleaning of the pipeline is generally used when the equipment is used for the first time or the cleaning liquid is reapplied after maintenance. The purpose is to remove the air in the pipeline and clean the corresponding pipeline, so as to avoid the bubbles in the liquid circuit affecting the injection amount during the subsequent injection, and to avoid the maintenance liquid and other impurities in the liquid circuit affecting the magnetic separation effect during the subsequent injection, and to avoid crystallization and other impurities blocking the pipeline. At this time, the cleaning liquid can enter the buffer tank 120 from the cleaning barrel 110, fill the buffer tank 120, enter the three-way inlet pipeline 210, and then flow through the plunger pump 230, the outlet pipeline 240 and the diaphragm pump 130 in sequence and enter the waste liquid barrel 140 to complete the cleaning of the pipeline. During the cleaning process, the plunger pump 230 reciprocates at full stroke to ensure that the plunger surface is cleaned. At the same time, the diaphragm pump 130 and the plunger pump 230 operate simultaneously and work together to improve the cleaning effect of the pipeline and reduce the workload of the plunger pump 230.

[0038] Furthermore, if Figure 1 and Figure 2 As shown, the main system 100 includes a first combining valve 101 and a first isolating valve 102. The first combining valve 101 is arranged between the liquid outlet pipeline 240 and the diaphragm pump 130. The outlet of the first combining valve 101 is connected to the inlet of the diaphragm pump 130. The normally closed inlet of the first combining valve 101 is connected to the emptying end of the buffer tank 120. The normally open inlet of the first combining valve 101 is connected to the liquid outlet pipeline 240. The first isolating valve 102 is arranged in the second passage of the three-way liquid inlet pipeline 210.

[0039] Specifically, the emptying end of the buffer tank 120 is its c interface, which is connected to the normally closed inlet of the first converging valve 101 through a pipeline, so that the air or liquid in the buffer tank 120 can enter the first converging valve 101 from the c interface. The first converging valve 101 is configured as an electromagnetic three-way valve, which is provided with an outlet and two inlets, the two inlets are respectively a normally open inlet and a normally closed inlet. When the power is on, the normally open inlet is closed and the normally closed inlet is opened, and when the power is not on, the normally closed inlet is closed and the normally open inlet is opened. Therefore, when the first converging valve 101 is powered on, the inlet of the diaphragm pump 130 is connected to the c interface of the buffer tank 120, and when the first converging valve 101 is not powered on, the inlet of the diaphragm pump 130 is connected to the liquid outlet pipeline 240. The first isolation valve 102 is an electromagnetic valve, which is arranged on the second passage of the three-way liquid inlet pipeline 210. When it is not powered, the valve is closed, the second passage of the three-way liquid inlet pipeline 210 is in an open circuit state, and the cleaning liquid in the buffer tank 120 cannot enter the liquid injection device 200. When it is powered, the valve is opened, the second passage of the three-way liquid inlet pipeline 210 is in a pass state, and the cleaning liquid in the buffer tank 120 can enter the liquid injection device 200. Before the liquid injection cleaning, the buffer tank 120 needs to be emptied and cleaned. At this time, the first isolation valve 102 is closed without power, and the first confluence valve 101 is powered, so that the c interface of the buffer tank 120 is connected to the diaphragm pump 130, and the liquid outlet pipeline 240 is disconnected from the diaphragm pump 130. At this time, the operation of the diaphragm pump 130 will continuously pump the cleaning liquid into the buffer tank 120, and the remaining air or maintenance liquid or cleaning liquid in the buffer tank 120 will be pumped into the diaphragm pump 130, and discharged into the waste liquid barrel 140, so as to avoid bubbles in the liquid path affecting the injection volume during subsequent injection, and to avoid the maintenance liquid and other impurities in the liquid path affecting the magnetic separation effect during subsequent injection; and finally the buffer tank 120 is filled with cleaning liquid, and the plunger pump 230 directly extracts the cleaning liquid in the buffer tank 120 during subsequent injection, thereby reducing the workload of the plunger pump 230.

[0040] Preferably, the main system 100 also includes a first diverter valve 103, which is arranged between the diaphragm pump 130 and the waste liquid barrel 140, the inlet of the first diverter valve 103 is connected to the outlet of the diaphragm pump 130, the normally closed outlet of the first diverter valve 103 is connected to the waste liquid barrel 140, and the normally open outlet of the first diverter valve 103 is connected to the cleaning liquid barrel 110.

[0041] Specifically, the first diverter valve 103 is configured as a three-way solenoid valve, which is provided with an inlet and two outlets, the two outlets being a normally open outlet and a normally closed outlet, respectively. When the power is on, the normally open outlet is closed and the normally closed outlet is opened, and when the power is off, the normally closed outlet is closed and the normally open outlet is opened. The inlet of the first diverter valve 103 is connected to the outlet of the diaphragm pump 130 through a pipeline, the normally closed outlet of the first diverter valve 103 is connected to the waste liquid barrel 140 through a pipeline, and the normally open outlet of the first diverter valve 103 is connected to the cleaning liquid barrel 110 through a pipeline. When the first diverter valve 103 is powered on, the outlet of the diaphragm pump 130 is connected to the waste liquid barrel 140, and when the first diverter valve 103 is not powered, the outlet of the diaphragm pump 130 is connected to the cleaning liquid barrel 110. When the emptying and cleaning process of the buffer tank 120 has been running for a certain period of time, or the emptying times have reached a predetermined number, the first diverter valve 103 can be de-energized, and the cleaning liquid drawn from the buffer tank 120 can be reintroduced into the cleaning liquid barrel 110, waiting for further cleaning operations, thereby reducing the waste of cleaning liquid and reducing the cost of use.

[0042] Furthermore, the main system 100 is also provided with a second diverter valve 104, which is arranged between the first combining valve 101 and the liquid outlet pipeline 240, the inlet of the second diverter valve 104 is connected to the liquid outlet pipeline 240, the normally open outlet of the second diverter valve 104 is connected to the waste liquid barrel 140, and the normally closed outlet of the second diverter valve 104 is connected to the normally open inlet of the first combining valve 101.

[0043] Specifically, the second diverter valve 104 is configured as a three-way solenoid valve with the same structure as the first diverter valve 103, and the normally open outlet of the second diverter valve 104 is connected to the waste liquid barrel 140. The normally closed outlet of the second diverter valve 104 is connected to the normally open inlet of the first converging valve 101 through a pipeline. When the second diverter valve 104 is powered on, the liquid outlet pipeline 240 is connected to the normally open inlet of the first converging valve 101, and when the second diverter valve 104 is not powered on, the liquid outlet pipe is directly connected to the waste liquid barrel 140. Therefore, when the pipeline is cleaned, the second diverter valve 104 is always in a powered state. Before the pipeline is cleaned, the liquid injection device 200 needs to be initialized. When the equipment is initialized, the second diverter valve 104 is not energized, the first isolation valve 102 is energized and opened, the cleaning liquid enters the injection assembly from the buffer tank 120, and the plunger pump 230 is operated, so that the cleaning liquid flows into the plunger pump 230 through the three-way liquid inlet pipeline 210 and enters the liquid outlet pipeline 240, and then flows through the second diverter valve 104 and is discharged into the waste liquid barrel 140. After the cleaning liquid is completely filled into the liquid injection device 200 and the plunger pump 230 reaches the predetermined initial position, the plunger pump 230 stops running, the equipment initialization is completed, the second diverter valve 104 is energized, and the liquid outlet pipeline 240 is connected to the diaphragm pump 130, that is, the initialization of the liquid injection is completed.

[0044] Furthermore, if Figure 1 and Figure 3 As shown, the injection device 200 also includes a third diverter valve 201 and a second isolation valve 202. Several third diverter valves 201 are arranged in series in the second passage of the three-way liquid inlet pipeline 210 in sequence. The inlet of any two adjacent third diverter valves 201 is connected to the normally open outlet, and the normally closed outlet of the third diverter valve 201 is connected to the first passage of the three-way liquid inlet pipeline 210. The inlet of the first third diverter valve 201 among the several third diverter valves 201 connected in series is connected to the plunger pump 230, and the normally open outlet of the last third diverter valve 201 among the several third diverter valves 201 connected in series is connected to the first isolation valve 102, and the second isolation valve 202 is arranged in the liquid outlet pipeline 240.

[0045] Specifically, in this embodiment, the injection device 200 is provided with four injection needle assemblies 220, and correspondingly, four third diverter valves 201 are also provided. The third diverter valve 201 is configured as an electromagnetic three-way valve with the same structure as the first diverter valve 103 and the second diverter valve 104. The four third diverter valves 201 are arranged in series in sequence, and the normally closed outlet of each third diverter valve 201 is respectively connected to an injection needle assembly 220 through a pipeline. The inlet of the first third diverter valve 201 in the four third diverter valves 201 in series is connected to the plunger pump 230, and the normally open outlet of the last third diverter valve 201 in the four third diverter valves 201 in series is connected to the first isolation valve 102. The second isolation valve 202 is arranged on the liquid outlet pipeline 240, and the second isolation valve 202 is specifically configured as a solenoid valve. When it is powered on, the liquid outlet pipeline 240 is in a passage state. When it is not powered on, the liquid outlet pipeline 240 is in a disconnected state. After the injection device 200 is initialized, the injection needle assembly 220 can be injected in sequence. At this time, the first isolation valve 102 is powered off, and the three-way liquid inlet passage is not connected to the buffer tank 120. The second isolation valve 202 is powered off, and the liquid outlet pipeline 240 is disconnected. The first third diverter valve 201 is powered on, so that the plunger pump 230 is connected to the first group of liquid aspiration needle assemblies 310, and the plunger pump 230 is operated to inject the cleaning liquid into the first group of liquid aspiration needle assemblies 310 to complete the injection. Subsequently, the first third diverter valve 201 is powered off, and the second third diverter valve 201 is powered on, so that the plunger pump 230 is connected to the second injection needle assembly 220, and the plunger pump 230 is operated to inject the cleaning liquid into the second injection needle assembly 220 to complete the injection. Then all the injection needle assemblies 220 in the injection device 200 are injected in sequence. In other embodiments of the present application, other numbers of injection needle assemblies 220 may be provided and arranged in sequence on the three-way liquid inlet pipeline 210. The injection sequence and whether to inject liquid may also be adjusted according to actual conditions.

[0046] Preferably, the liquid injection device 200 further includes a pressure sensor 250 , and the pressure sensor 250 is disposed between the third diverter valve 201 and the plunger pump 230 .

[0047] Specifically, the detection end of the pressure sensor 250 is set in the passage between the third diverter valve 201 and the plunger pump 230. The pressure sensor 250 can detect the pressure value in the injection device 200 in real time, thereby providing effective data for the staff to judge the operation status of the injection device 200.

[0048] Furthermore, the magnetic separation cleaning system includes two liquid injection devices 200; the main system 100 also includes a second merging valve 203, the outlet of the second merging valve 203 is connected to the inlet of the second diverter valve 104, the normally closed inlet of the second merging valve 203 is connected to the liquid outlet pipeline 240 of one of the liquid injection devices 200, and the normally open inlet of the second merging valve 203 is connected to the liquid outlet pipeline 240 of the other liquid injection device 200.

[0049] Specifically, the second converging valve 203 is configured as an electromagnetic three-way valve with the same structure as the first converging valve 101, and the liquid outlet pipelines 240 of the two injection devices 200 are respectively connected to the normally closed inlet and the normally open inlet of the second converging valve 203. The second passages of the three-way liquid inlet pipelines 210 of the two injection devices 200 are respectively connected to the two liquid outlet ends of the d interface and the e interface on the buffer tank 120. Therefore, the operation of the two injection devices 200 can be controlled separately by controlling the second converging valve 203, and the two injection devices 200 do not interfere with each other during the initialization, pipeline cleaning and other operating processes. Setting two groups of injection devices 200 can be different types and numbers of injection needle assemblies 220 to achieve different injection functions and improve the diversification of injection types of the injection devices 200.

[0050] Furthermore, the main system 100 also includes a maintenance fluid barrel 160, a third isolation valve 105 and a fourth isolation valve 106; one end of the third isolation valve 105 is connected to the maintenance fluid barrel 160, and the other end of the third isolation valve 105 is connected to the liquid inlet end of the buffer tank 120, and the fourth isolation valve 106 is arranged between the cleaning fluid barrel 110 and the buffer tank 120.

[0051] Specifically, the maintenance liquid barrel 160 is set as an open plastic barrel or metal barrel. The maintenance liquid barrel 160 is connected to the a interface of the buffer tank 120 through a passage. The third isolation valve 105 and the fourth isolation valve 106 are respectively set with electromagnetic valves of the same structure as the first isolation valve 102 and the second isolation valve 202, which are connected after power is turned on and disconnected after power is turned off. In order to avoid the mixing of cleaning liquid and maintenance liquid, the third isolation valve 105 and the fourth isolation valve 106 are opened crosswise. When cleaning liquid needs to be injected into the equipment, the third isolation valve 105 is normally closed and the fourth isolation valve 106 is normally open. When the equipment needs maintenance, the third isolation valve 105 is powered on and opened, and the fourth isolation valve 106 is powered off and disconnected. At this time, the emptying process is started, and the buffer tank 120 can be completely filled with maintenance liquid, foreign matter or cleaning liquid can be cleaned, and the diaphragm pump 130 can be maintained. When the cleaning process of the liquid injection device 200 is restarted, the maintenance liquid can be completely entered into the cleaning device, and the liquid injection device can be maintained.

[0052] Furthermore, the main system 100 also includes a liquid pipetting pipeline 300 and a liquid pipetting needle assembly 310 connected to one end of the liquid pipetting pipeline 300 . The liquid pipetting needle assembly 310 is used to pipette liquid from the reaction cup. The other end of the liquid pipetting pipeline 300 is connected to the waste liquid bucket 140 .

[0053] Specifically, the aspiration needle assembly 310 is arranged in a one-to-one correspondence with the injection needle assembly 220, and a peristaltic pump is arranged on the aspiration pipeline 300, which can suck out the cleaning liquid or maintenance liquid in the reaction cup and introduce it into the waste liquid barrel 140 after the aspiration needle assembly 310 enters the reaction cup, thereby completing the cleaning of the reaction cup.

[0054] Another aspect of the present invention provides a fully automatic chemiluminescence immunoassay instrument, which includes all the features of the above-mentioned magnetic separation and cleaning system and naturally has all the advantages of the above-mentioned magnetic separation and cleaning system, which will not be described in detail here.

[0055] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the utility model, rather than to limit it. Although the utility model has been described in detail with reference to the aforementioned embodiments, ordinary technicians in the field should understand that they can still modify the technical solutions recorded in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the utility model.

Claims

1. A magnetic separation cleaning system, characterized in that: It includes a main system and a liquid injection device; The main system includes a cleaning liquid barrel, a buffer tank, a diaphragm pump and a waste liquid barrel, the cleaning liquid barrel is connected to the liquid inlet end of the buffer tank, and the outlet of the diaphragm pump is connected to the waste liquid barrel; The injection device includes a three-way liquid inlet pipeline, an injection needle assembly connected to the first passage of the three-way liquid inlet pipeline, a plunger pump and a liquid outlet pipeline. The second passage of the three-way liquid inlet pipeline is connected to the liquid outlet end of the buffer tank, the third passage of the three-way liquid inlet pipeline is connected to the plunger pump, one end of the liquid outlet pipeline is connected to the plunger pump, and the other end of the liquid outlet pipeline is connected to the inlet of the diaphragm pump. The injection needle assembly is used to inject liquid into the reaction cup.

2. The magnetic separation cleaning system according to claim 1, characterized in that: The main system includes a first combining valve and a first isolating valve. The first combining valve is arranged between the liquid outlet pipeline and the diaphragm pump. The outlet of the first combining valve is connected to the inlet of the diaphragm pump. The normally closed inlet of the first combining valve is connected to the emptying end of the buffer tank. The normally open inlet of the first combining valve is connected to the liquid outlet pipeline. The first isolating valve is arranged in the second passage of the three-way liquid inlet pipeline.

3. The magnetic separation cleaning system according to claim 2, characterized in that: The main system also includes a first diverter valve, which is arranged between the diaphragm pump and the waste liquid barrel, the inlet of the first diverter valve is connected to the outlet of the diaphragm pump, the normally closed outlet of the first diverter valve is connected to the waste liquid barrel, and the normally open outlet of the first diverter valve is connected to the cleaning liquid barrel.

4. The magnetic separation cleaning system according to claim 2, characterized in that: The main system is also provided with a second diverter valve, which is arranged between the first combining valve and the liquid outlet pipeline, the inlet of the second diverter valve is connected to the liquid outlet pipeline, the normally open outlet of the second diverter valve is connected to the waste liquid barrel, and the normally closed outlet of the second diverter valve is connected to the normally open inlet of the first combining valve.

5. The magnetic separation cleaning system according to claim 2, characterized in that: The injection device also includes a third diverter valve and a second isolation valve. Several of the third diverter valves are sequentially arranged in series in the second passage of the three-way liquid inlet pipeline. The inlet of any two adjacent third diverter valves is connected to the normally open outlet, and the normally closed outlet of the third diverter valve is connected to the first passage of the three-way liquid inlet pipeline. The inlet of the first of the several third diverter valves in series is connected to the plunger pump, and the normally open outlet of the last of the several third diverter valves in series is connected to the first isolation valve. The second isolation valve is arranged in the liquid outlet pipeline.

6. The magnetic separation cleaning system according to claim 5, characterized in that: The liquid injection device further comprises a pressure sensor, and the pressure sensor is arranged between the third diverter valve and the plunger pump.

7. The magnetic separation cleaning system according to any one of claims 1 to 6, characterized in that: The magnetic separation cleaning system comprises two liquid injection devices; The main system also includes a second combining valve, the outlet of which is connected to the inlet of a second diverting valve, the normally closed inlet of which is connected to the liquid outlet pipeline of one of the injection devices, and the normally open inlet of which is connected to the liquid outlet pipeline of the other injection device.

8. The magnetic separation cleaning system according to any one of claims 1 to 6, characterized in that: The main system also includes a maintenance fluid tank, a third isolation valve and a fourth isolation valve; One end of the third isolation valve is communicated with the maintenance liquid barrel, the other end of the third isolation valve is communicated with the liquid inlet end of the buffer tank, and the fourth isolation valve is arranged between the cleaning liquid barrel and the buffer tank.

9. The magnetic separation cleaning system according to any one of claims 1 to 6, characterized in that: The main system also includes a liquid aspiration pipeline and a liquid aspiration needle assembly connected to one end of the liquid aspiration pipeline, the liquid aspiration needle assembly is used to aspirate liquid from the reaction cup, and the other end of the liquid aspiration pipeline is connected to the waste liquid bucket.

10. A fully automatic chemiluminescence immunoassay, characterized in that: It comprises the magnetic separation and cleaning system as described in any one of claims 1 to 9.

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