Low-temperature freeze dryer for biomedical experiments

By introducing a rotary flushing mechanism into the low-temperature freeze-dryer, we can achieve all-round uniform water spraying, which solves the problem of cleaning and precise control of the freeze-dryer in biomedical experiments, and improves the flushing efficiency and the service life of the equipment.

CN222187545UActive Publication Date: 2024-12-17SHANDONG QUANGANG PHARM CO LTD
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Patent Information

Application Number
CN202420596735.4
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-03-26
Publication Date
2024-12-17
Estimated Expiration
2034-03-26

AI Technical Summary

Technical Problem

The existing low-temperature lyophilization machines are difficult to accurately control the lyophilization process and equipment cleaning in biomedical experiments, and the water spraying method of ordinary flushing devices is inefficient and not comprehensive enough, which may damage the equipment.

Method used

A low-temperature lyophilization machine including multiple parallel plate layers and a rotary flushing mechanism is designed. The rotary flushing mechanism consists of a lifting cylinder and a rotary flushing assembly. The rotary flushing assembly can move in the vertical direction to achieve all-round uniform water spraying. , avoid long-term fixed rinsing.

Benefits of technology

It improves the flushing range and efficiency of the freeze-dryer, meets the cleaning requirements of biomedical experiments, avoids equipment damage, and achieves more efficient moisture evaporation control.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model belongs to the technical field of biomedicine, and particularly relates to a low-temperature freeze dryer for biomedicine experiments, which comprises a freeze dryer body, a plurality of plate layers are mounted in the freeze dryer body, a rotary flushing mechanism is mounted at the top of the freeze dryer body, and the rotary flushing mechanism comprises a lifting cylinder and a self-rotating flushing component. Through holes are formed in the centers of the multiple plate layers, the through holes in the centers of the multiple plate layers form a cleaning channel, and the self-rotating flushing assembly can move in the vertical direction of the cleaning channel; compared with the prior art, the rotary flushing mechanism provided by the utility model realizes all-around uniform water spraying in the vertical direction, so that the flushing range and the flushing effect of the interior of the freeze dryer are improved, and the cleaning requirement of a biological medicine experiment is met; through rotary flushing from top to bottom, high flushing efficiency can be guaranteed, a certain part of the equipment cannot be fixedly flushed for a long time, and a certain degree of damage to the flushed surface is avoided.
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Description

Technical Field

[0001] The utility model belongs to the technical field of biomedicine, and in particular relates to a low-temperature freeze dryer used in biomedicine experiments. Background Art

[0002] A freeze dryer is a method of freezing water-containing substances into a solid state and then sublimating the water from the solid state into a gaseous state, thereby removing the water and preserving the substance. The freeze dryer dries at low temperatures and will not deform the protein, but may cause microorganisms to lose their biological activity. It is particularly suitable for biologically active products with poor thermal stability, biochemical products, genetically engineered products, and blood products.

[0003] When low-temperature freeze dryers are used for biomedical experiments, it is necessary to ensure that the equipment is clean and hygienic and meets the strict requirements of biomedical experiments. General freeze dryers use manual cleaning methods to clean the equipment, which is inefficient and cannot be cleaned thoroughly. The flushing nozzles of ordinary flushing devices spray water in a fixed direction at a certain angle. Spraying water in a fixed direction may cause a certain degree of damage to the flushing surface. Secondly, this water spraying method has poor water spraying effect and insufficient cleaning, making it difficult to meet the requirements of biomedical experiments. Utility Model Content

[0004] The utility model aims at the problem that most of the existing low-temperature freeze dryers cannot obtain the water evaporation amount in each time period when conducting biomedical experiments, and it is difficult to more accurately control the freeze-drying process, and provides a low-temperature freeze dryer for biomedical experiments.

[0005] In order to achieve the above-mentioned purpose, the technical solution adopted by the utility model is: a low-temperature freeze dryer for biomedical experiments, including a freeze dryer body, a plurality of plate layers installed in the freeze dryer body, the plurality of plate layers are arranged in parallel, a rotary flushing mechanism is installed on the top of the freeze dryer body, the rotary flushing mechanism includes a lifting cylinder and a self-rotating flushing assembly, the lifting cylinder is installed on the top wall of the freeze dryer body, the output end of the lifting cylinder passes through the top wall of the freeze dryer body and is fixedly connected to the self-rotating flushing assembly, the inlet of the self-rotating flushing assembly is connected to a telescopic hose, the telescopic hose passes through the top wall of the freeze dryer body and is connected to a joint, the joint is fixed to the top wall of the freeze dryer body; through holes are opened in the centers of the plurality of plate layers, the through holes in the centers of the plurality of plate layers form a cleaning channel, and the self-rotating flushing assembly can move in the vertical direction along the cleaning channel.

[0006] Preferably, the self-rotating flushing assembly comprises a nozzle body and a rotating part, a bearing is installed in the nozzle body, the rotating part is installed in the bearing, a plurality of spiral blades are installed in the rotating part, and a plurality of water spray outlets are provided on the nozzle body.

[0007] Preferably, the self-rotating flushing assembly includes a connecting part and a rotating water supply part, a bearing is installed in the connecting part, the rotating water supply part is installed in the bearing, the rotating water supply part includes a fixing ring and a nozzle fixing seat, three fan blades are installed on the fixing ring, three dispersed water supply pipes are respectively installed on the nozzle fixing seat, nozzles are installed on the dispersed water supply pipes, and the angle between the center line of the nozzle and the horizontal line is 45°.

[0008] Preferably, a cabinet door is installed on the freeze dryer body, and an observation window is installed on the cabinet door.

[0009] Preferably, a closed valve is installed in the joint.

[0010] Preferably, a control panel is installed on the side wall of the freeze dryer body, and the control panel is communicatively connected to the lifting cylinder.

[0011] Compared with the prior art, the advantages and positive effects of the utility model are:

[0012] Compared with the prior art, the low-temperature freeze dryer for biomedical experiments of the utility model is

[0013] (1) A rotary flushing mechanism is provided. The lifting cylinder in the freeze dryer drives the water spraying port of the self-rotating flushing assembly to realize a full-scale uniform water spray in the vertical direction, thereby improving the flushing range and flushing effect inside the freeze dryer to meet the cleaning requirements of biopharmaceutical experiments;

[0014] (2) Rotating flushing from top to bottom can ensure high flushing efficiency and avoid long-term fixed flushing of a certain part of the equipment, thus avoiding a certain degree of damage to the flushing surface. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] In order to more clearly illustrate the technical solution of the embodiment of the utility model, the following is a brief introduction to the drawings required for describing the embodiment:

[0016] Figure 1 This is a schematic diagram of the structure of a low-temperature freeze dryer used in biomedical experiments.

[0017] Figure 2 This is a schematic diagram of a low-temperature freeze dryer used in biomedical experiments.

[0018] Figure 3 This is a schematic diagram of a self-rotating washing component of Example 1 of a low-temperature freeze dryer for biomedical experiments.

[0019] Figure 4 This is a schematic diagram of the internal structure of the self-rotating washing component of Example 1 of the low-temperature freeze dryer for biomedical experiments.

[0020] Figure 5This is a schematic diagram of the self-rotating washing component of Example 2 of the low-temperature freeze dryer for biomedical experiments.

[0021] Description of reference numerals:

[0022] 1. Freeze dryer body; 2. Plate layer; 3. Rotating flushing mechanism; 4. Lifting cylinder;

[0023] 5. Self-rotating flushing assembly; 501. Nozzle body; 502. Rotating part; 503. Spiral fan blade; 504. Connecting part; 505. Rotating water delivery part; 506. Fixing ring; 507. Nozzle fixing seat; 508. Fan blade; 509. Dispersed water delivery pipe; 510. Nozzle;

[0024] 6. Telescopic hose; 7. Connector; 8. Box door; 9. Observation window; 10. Control panel. DETAILED DESCRIPTION

[0025] In order to more clearly understand the above-mentioned objects, features and advantages of the present invention, the present invention is further described below in conjunction with the accompanying drawings and embodiments.

[0026] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways than those described herein. Therefore, the present invention is not limited to the specific embodiments of the following disclosure.

[0027] Example 1

[0028] The following is combined with Figure 1 -Attached Figure 4 The utility model is further described as a low-temperature freeze dryer for biomedical experiments, such as Figure 1-Figure 3 As shown, it includes a freeze dryer body 1, and multiple plate layers 2 are installed in the freeze dryer body 1, and the multiple plate layers 2 are arranged in parallel. It is characterized in that a rotary flushing mechanism 3 is installed on the top of the freeze dryer body 1, and the rotary flushing mechanism 3 includes a lifting cylinder 4 and a self-rotating flushing assembly 5. The lifting cylinder 4 is installed on the top wall inside the freeze dryer body 1, and the output end of the lifting cylinder 4 passes through the top wall of the freeze dryer body 1 and is fixedly connected to the self-rotating flushing assembly 5, and the inlet of the self-rotating flushing assembly 5 is connected to a telescopic hose 6, and the telescopic hose 6 passes through the top wall of the freeze dryer body 1 and is connected to a joint 7, and the joint 7 is fixed to the top wall of the freeze dryer body 1; through holes are opened in the centers of the multiple plate layers 2, and the through holes in the centers of the multiple plate layers 2 form a cleaning channel, and the self-rotating flushing assembly 5 can move in the vertical direction along the cleaning channel.

[0029] like Figure 3-Figure 4As shown, the self-rotating flushing assembly 5 includes a nozzle body 501 and a rotating part 502. A bearing is installed in the nozzle body 501, and the rotating part 502 is installed in the bearing. A plurality of spiral blades 503 are installed in the rotating part 502, and a plurality of water spray outlets are provided on the nozzle body 501.

[0030] like Figure 1 As shown, a box door 8 is installed on the freeze dryer body 1, and an observation window 9 is installed on the box door 8.

[0031] A sealed valve is installed in the joint 7, which is not shown in the figure.

[0032] like Figure 1 As shown, a control panel 10 is installed on the side wall of the freeze dryer body 1, and the control panel (10) is communicatively connected to the lifting cylinder (4).

[0033] Example 2

[0034] The difference between this embodiment and embodiment 1 is that Figure 5 As shown, the self-rotating flushing assembly 5 includes a connecting portion 504 and a rotating water delivery portion 505, a bearing is installed in the connecting portion 504, the rotating water delivery portion 505 is installed in the bearing, the rotating water delivery portion 505 includes a fixing ring 506 and a nozzle fixing seat 507, three fan blades 508 are installed on the fixing ring 506, three dispersed water delivery pipes 509 are respectively installed on the nozzle fixing seat 507, and nozzles 510 are installed on the dispersed water delivery pipes 509, and the angle between the center line of the nozzle 510 and the horizontal line is 45°

[0035] The working principle of the low-temperature freeze dryer device for biomedical experiments of the utility model is as follows: when in use, the water inlet pipe is connected to the joint 7, and purified water enters the self-rotating flushing component 5 through the telescopic hose 6, and then the self-rotating flushing component 5 starts to rotate and spray water under the action of water pressure and internal structure, and then the lifting cylinder 4 is started, and the lifting cylinder 4 drives the self-rotating flushing component 5 to move from top to bottom, so that the water spray port of the self-rotating flushing component 5 can realize all-round and uniform water spray in the vertical direction, thereby improving the flushing range and flushing effect of the inside of the freeze dryer to meet the cleaning requirements of biomedical experiments, and the rotating flushing from top to bottom can not only ensure a high flushing efficiency, but also will not perform long-term fixed flushing on a certain part of the equipment, avoiding a certain degree of damage to the flushing surface.

[0036] When the flushing is completed, the joint 7 is connected to the compressed air to blow out the moisture in the pipeline to ensure that there is no residual water in the pipeline, so that the pipeline will not be frozen and cracked due to the water in the pipeline when the freeze dryer is cooled down again; at the same time, the rotating flushing mechanism 3 is connected to the clean compressed air to blow out the moisture inside the freeze dryer after the cleaning stops, so as to ensure that the inside of the equipment is dry when it is cooled down next time, which is convenient for the next use.

[0037] As the technical solution of the utility model, the hardware setting provided is only for the convenience of realizing specific braking control on the basis of hardware facilities. How to realize braking control and braking control method specifically are not the technical problems to be solved and the objects to be protected by the utility model. At the same time, the communication methods between the devices all adopt the existing communication methods, which are not the invention points of the present application.

[0038] The above description is only a preferred embodiment of the present invention and does not constitute any other form of limitation to the present invention. Any technician familiar with the profession may use the technical contents disclosed above to change or modify them into equivalent embodiments with equivalent changes for application in other fields. However, any simple modification or equivalent change made to the above embodiments based on the technical essence of the present invention without departing from the technical solution of the present invention still falls within the protection scope of the technical solution of the present invention.

Claims

1. A low-temperature freeze dryer for biomedical experiments, comprising a freeze dryer body (1), wherein a plurality of plate layers (2) are installed in the freeze dryer body (1), wherein the plurality of plate layers (2) are arranged in parallel, and wherein: A rotary flushing mechanism (3) is installed on the top of the freeze dryer body (1), and the rotary flushing mechanism (3) comprises a lifting cylinder (4) and a self-rotating flushing assembly (5). The lifting cylinder (4) is installed on the top wall of the freeze dryer body (1), and the output end of the lifting cylinder (4) passes through the top wall of the freeze dryer body (1) and is fixedly connected to the self-rotating flushing assembly (5). The inlet of the self-rotating flushing assembly (5) is connected to a telescopic hose (6), and the telescopic hose (6) passes through the top wall of the freeze dryer body (1) and is connected to a joint (7), and the joint (7) is fixedly arranged on the top wall of the freeze dryer body (1); Through holes are provided at the centres of the plurality of plate layers (2), the through holes at the centres of the plurality of plate layers (2) forming a cleaning channel, and the self-rotating flushing component (5) is capable of moving in a vertical direction along the cleaning channel.

2. The low-temperature freeze dryer for biomedical experiments according to claim 1, characterized in that: The self-rotating flushing assembly (5) comprises a nozzle main body (501) and a rotating part (502), wherein a bearing is installed in the nozzle main body (501), the rotating part (502) is installed in the bearing, a plurality of spiral blades (503) are installed in the rotating part (502), and a plurality of water spraying ports are provided on the nozzle main body (501).

3. The low-temperature freeze dryer for biomedical experiments according to claim 1, characterized in that: The self-rotating flushing assembly (5) comprises a connecting portion (504) and a rotating water supply portion (505), wherein a bearing is installed in the connecting portion (504), and the rotating water supply portion (505) is installed in the bearing. The rotating water supply portion (505) comprises a fixing ring (506) and a nozzle fixing seat (507), wherein three fan blades (508) are installed on the fixing ring (506), and three dispersed water supply pipes (509) are respectively installed on the nozzle fixing seat (507), and nozzles (510) are installed on the dispersed water supply pipes (509), and the angle between the center line of the nozzle (510) and the horizontal line is 45°.

4. The low-temperature freeze dryer for biomedical experiments according to claim 2, characterized in that: The freeze dryer body (1) is provided with a cabinet door (8), and the cabinet door (8) is provided with an observation window (9).

5. The low-temperature freeze dryer for biomedical experiments according to claim 1, characterized in that: A sealed valve is installed in the joint (7).

6. The low-temperature freeze dryer for biomedical experiments according to claim 1, characterized in that: A control panel (10) is installed on the side wall of the freeze dryer body (1), and the control panel (10) is communicatively connected to the lifting cylinder (4).