Rapid microfluid mixing device with reciprocating type circulating structure

Abstract

The utility model discloses a rapid microfluid mixing device with a reciprocating type circulating structure, which comprises an LNP mixing box body, and an LNP mixing box cover is arranged at the top end of the LNP mixing box body. The reciprocating mechanism is arranged, the second motor is started to drive the rotating shaft to rotate, and under the action of connection of the connecting rod, the movable rod and the mixing tank at the top end can be further driven to start to move up and down; the stirring shaft and the stirring rods on the two sides of the stirring shaft can be driven to rotate, so that full stirring and up-and-down reciprocating vibration type mixing are achieved at the same time, microfluid in the stirring shaft can be fully mixed, the working efficiency is further improved, and meanwhile the stirring work is more efficient by arranging the two groups of stirring rods in a crossed mode.

Description

Technical Field

[0001] The utility model relates to the technical field of microfluid mixing, in particular to a microfluid rapid mixing device with a reciprocating circulation structure. Background Art

[0002] Microfluidics is a technology that uses microchannels to process or manipulate tiny fluids. The device used is also called a microfluidic chip. It has the characteristics and advantages of light volume, fast reaction speed, low energy consumption, and small amount of samples and reagents. When preparing lipid nanoparticles, a mixing device is needed to mix the ethanol lipid mixture with the acidic aqueous buffer containing oligonucleotides, and then collect them into a separate tube;

[0003] Chinese patent authorization announcement number CN217795843U discloses a microfluid mixing device, including a shell, a side through groove, and a movable protective member. A fixed cylinder and a servo motor are provided at the bottom of the shell. A transmission mechanism is provided between the movable protective member and the fixed cylinder. The transmission mechanism includes a transmission member rotating inside the fixed cylinder, three groups of inclined fixed blocks arranged in a circular array fixed at the bottom of the movable protective member, and a connecting rod provided between the transmission member and the fixed block and used to drive the fixed block. The transmission member cooperates with the driving gear on the output shaft of the servo motor. In the utility model, the driving gear at the output end of the servo motor drives the transmission member to rotate back and forth through the forward and reverse rotation of the servo motor, so that the connecting rod moves back and forth in the arc groove. When the connecting rod moves, it moves in the limit groove opened in the inclined fixed block, so that the fixed block and the movable protective member move back and forth up and down. The above-mentioned existing technical solution has the following shortcomings: this technical solution strengthens the support for movable protective parts, mixing chambers and other structures through three groups of fixed blocks and connecting rods arranged in a circular array, but the structure of this technical solution is relatively simple in terms of stirring and mixing. Therefore, we need to design a microfluidic rapid mixing device with a reciprocating circulation structure to solve the above-mentioned problems. Utility Model Content

[0004] The purpose of the utility model is to provide a microfluid fast mixing device with a reciprocating circulation structure to solve the problem that the stirring structure of the mixing device proposed in the above background technology is relatively simple.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a microfluidic rapid mixing device with a reciprocating circulation structure, comprising an LNP mixing box body, an LNP mixing box cover is installed at the top of the LNP mixing box body, and a feed port is evenly installed at the top of the LNP mixing box cover, a first motor is installed inside the LNP mixing box cover, a mixing tank is installed inside the LNP mixing box body, and a reciprocating mechanism is arranged inside the LNP mixing box body at the bottom of the mixing tank, guide blocks are installed on both sides of the mixing tank, guide grooves are arranged on the inner side of the LNP mixing box body, and the guide grooves are slidably connected to the guide blocks, a sealing ring is installed at the bottom end of the LNP mixing box cover, a sealing groove is arranged at the top of the inside of the LNP mixing box body, and the sealing grooves are snap-fitted and connected to the sealing ring.

[0006] When using a microfluid fast mixing device with a reciprocating circulation structure of the present technical solution, by setting a reciprocating mechanism, it is achieved that the microfluid inside can be fully mixed while being fully stirred and vibrated up and down, thereby improving work efficiency.

[0007] Preferably, the reciprocating mechanism includes a receiving groove, and the receiving groove is arranged inside the LNP mixing box body, a second motor is installed at one end of the receiving groove, and a rotating shaft is installed at one end of the second motor, a turntable is installed on the outside of the rotating shaft, a movable rod is installed inside the receiving groove, and the movable rod is connected to the turntable through a connecting rod, and the movable rod is connected to the mixing tank.

[0008] Preferably, balls are evenly arranged inside the LNP mixing box body at the top of the containing tank, and grooves are installed inside the balls.

[0009] Preferably, a stirring main rod is installed at the bottom end of the LNP mixing box cover, and stirring shafts are installed on both sides of the stirring main rod. The stirring shaft and the stirring main rod are connected by a pulley, stirring rods are evenly installed on both sides of the stirring shaft, and scrapers are installed on the outside of the stirring rod.

[0010] Preferably, the stirring rods are distributed on both sides of the stirring shaft in a cross shape.

[0011] Preferably, threaded grooves are provided on both sides of the inside of the LNP mixing box cover, and threaded rods are installed inside the threaded grooves, hand wheels are installed at the tops of the threaded rods, fixed plates are installed at the bottoms of the threaded rods, and fixed grooves are installed at the bottoms of the fixed plates, connecting plates are installed on both sides of the LNP mixing box body, and fixed blocks are provided at the tops of the connecting plates, the fixed blocks are connected to the fixed grooves, and anti-slip teeth are evenly installed at the bottoms of the fixed plates.

[0012] Preferably, the cross-sections of the anti-slip teeth are all triangular, and they are arranged at equal intervals at the bottom end of the fixing plate.

[0013] Compared with the prior art, the beneficial effects of the present invention are: the microfluid fast mixing device with a reciprocating circulation structure not only realizes the function of having a reciprocating structure, but also realizes the function of sufficient stirring;

[0014] (1) By setting a reciprocating mechanism, starting the second motor to drive the rotating shaft to rotate, and under the action of the connecting rod, the movable rod and the mixing tank at the top can be further driven to start moving up and down. At the same time, by starting the first motor and connecting with the pulley, the stirring shaft and the stirring rods on both sides can be driven to rotate, thereby achieving full stirring while reciprocating vibration mixing up and down, so that the microfluid inside can be fully mixed, further improving the work efficiency. At the same time, by distributing the two sets of stirring rods in a cross shape, the stirring work is more efficient;

[0015] (2) By turning the hand wheel and under the action of the threaded connection, the fixed groove can be processed and inserted into the interior of the fixed block in sequence, so that the LNP mixing box cover can be removed from the top of the LNP mixing box body, and the stirring assembly at the bottom can be replaced and repaired, which effectively extends the service life and use value of the stirring assembly. At the same time, by setting a sealing ring and a sealing groove, the liquid inside the mixing tank is prevented from flowing out when it reciprocates up and down. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0017] Figure 1 It is a front view cross-sectional structural schematic diagram of the utility model;

[0018] Figure 2 It is a front view cross-sectional structural diagram of the reciprocating mechanism of the utility model;

[0019] Figure 3 It is a schematic diagram of the side cross-sectional structure of the reciprocating mechanism of the utility model;

[0020] Figure 4 It is a schematic diagram of the three-dimensional structure of the hybrid box cover of the utility model;

[0021] Figure 5 It is a schematic diagram of the three-dimensional structure of the fixing block of the utility model.

[0022] Explanation of the reference numerals in the figure: 1. first motor; 2. feed inlet; 3. LNP mixing box cover; 4. hand wheel; 5. guide groove; 6. mixing tank; 7. scraper; 8. guide block; 9. stirring rod; 10. stirring shaft; 11. movable rod; 12. LNP mixing box body; 13. pulley; 14. connecting plate; 15. reciprocating mechanism; 1501. containing groove; 1502. turntable; 1503. rotating shaft; 1504. connecting rod; 1505. second motor; 1506. groove; 1507. ball; 16. threaded rod; 17. fixing plate; 18. anti-slip teeth; 19. fixing groove; 20. fixing block. DETAILED DESCRIPTION

[0023] In order to make the purpose, technical solution and advantages of the embodiment of the utility model clearer, the technical solution in the embodiment of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiment of the utility model. Obviously, the described embodiment is a part of the embodiment of the utility model, not all the embodiments. Based on the embodiment of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0024] See also Figure 1-Figure 5 The utility model provides an embodiment: a microfluid fast mixing device with a reciprocating circulation structure, comprising an LNP mixing box body 12, and an LNP mixing box cover 3 is installed on the top of the LNP mixing box body 12;

[0025] A stirring main rod is installed at the bottom end of the LNP mixing box cover 3, and stirring shafts 10 are installed on both sides of the stirring main rod. The stirring shaft 10 is connected to the stirring main rod through a pulley 13. Stirring rods 9 are evenly installed on both sides of the stirring shaft 10, and scrapers 7 are installed on the outer sides of the stirring rods 9. The stirring rods 9 are distributed on both sides of the stirring shaft 10 in a cross shape;

[0026] Specifically, Figure 1 and Figure 4 As shown, when in use, by installing the stirring rods 9 in a cross-shaped distribution, the solution can be mixed more efficiently;

[0027] Both sides of the LNP mixing box cover 3 are provided with threaded grooves, and threaded rods 16 are installed inside the threaded grooves, hand wheels 4 are installed at the tops of the threaded rods 16, and fixing plates 17 are installed at the bottoms of the threaded rods 16, and fixing grooves 19 are installed at the bottoms of the fixing plates 17. Connecting plates 14 are installed on both sides of the LNP mixing box body 12, and fixing blocks 20 are provided at the tops of the connecting plates 14, and the fixing blocks 20 are connected to the fixing grooves 19. Anti-skid teeth 18 are evenly installed at the bottoms of the fixing plates 17, and the cross-sections of the anti-skid teeth 18 are all arranged in a triangular shape, and are evenly spaced and distributed at the bottoms of the fixing plates 17;

[0028] Specifically, Figure 1 and Figure 5 As shown, when in use, the fixing groove 19 can be processed and pulled out from the inside of the fixing block 20 through the hand wheel 4 and the threaded connection, so as to facilitate the replacement and maintenance of the stirring assembly;

[0029] The top of the LNP mixing box cover 3 is evenly provided with a feed port 2, the inside of the LNP mixing box cover 3 is provided with a first motor 1, the inside of the LNP mixing box body 12 is provided with a mixing tank 6, and the inside of the LNP mixing box body 12 at the bottom of the mixing tank 6 is provided with a reciprocating mechanism 15;

[0030] The reciprocating mechanism 15 includes a receiving groove 1501, and the receiving groove 1501 is arranged inside the LNP mixing box body 12, a second motor 1505 is installed at one end of the receiving groove 1501, and a rotating shaft 1503 is installed at one end of the second motor 1505, a rotating disk 1502 is installed outside the rotating shaft 1503, a movable rod 11 is installed inside the receiving groove 1501, and the movable rod 11 is connected to the rotating disk 1502 through a connecting rod 1504, and the movable rod 11 is connected to the mixing tank 6, and balls 1507 are evenly arranged inside the LNP mixing box body 12 at the top of the receiving groove 1501, and grooves 1506 are installed inside the balls 1507;

[0031] Specifically, Figure 1 , Figure 2 and Figure 3 As shown, when in use, by setting the reciprocating mechanism 15, sufficient stirring and reciprocating vibration mixing are achieved, so that the microfluid inside can be fully mixed, thereby improving the working efficiency. At the same time, the ball 1507 can make the reciprocating mechanism 15 run more flexibly;

[0032] Guide blocks 8 are installed on both sides of the mixing tank 6, guide grooves 5 are provided on the inner side of the LNP mixing box body 12, and the guide grooves 5 are slidably connected to the guide blocks 8, a sealing ring (21) is installed at the bottom end of the LNP mixing box cover (3), and a sealing groove (22) is provided at the top end of the LNP mixing box body (12), and the sealing grooves (22) are snap-fitted and connected to the sealing ring (21).

[0033] Working principle: When the utility model is used, the ethanol lipid mixture and the acidic water containing oligonucleotides flow from the feed port 2 into the interior of the LNP mixing box body 12, and then the first motor 1 is started and connected with the pulley 13, the stirring shaft 10 and the stirring rods 9 on both sides can be driven to rotate, and at the same time, the second motor 1505 is started to drive the rotating shaft 1503 to rotate, and under the action of the connection rod 1504, the movable rod 11 and the mixing tank 6 at the top can be further driven to move up and down, thereby achieving full stirring while reciprocating vibration mixing, so that the solution is mixed more evenly;

[0034] When the stirring assembly needs to be replaced or repaired, the hand wheel 4 is turned and under the action of the threaded connection, the fixing groove 19 can be processed and pulled out from the inside of the fixing block 20, thereby completing the disassembly of the LNP mixing box cover 3.

[0035] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installation", "connection" and "connection" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0036] The device embodiments described above are merely illustrative, wherein the units described as separate components may or may not be physically separated, and the components shown as units may or may not be physical units, i.e., they may be located in one place, or they may be distributed on multiple network units. Some or all of the modules may be selected according to actual needs to achieve the purpose of the scheme of this embodiment. Those of ordinary skill in the art may understand and implement it without creative effort.

[0037] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the utility model, rather than to limit it. Although the utility model has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various embodiments of the utility model.

Claims

1. A microfluid fast mixing device with a reciprocating circulation structure, comprising an LNP mixing box body (12), characterized in that: The top of the LNP mixing box body (12) is provided with an LNP mixing box cover (3), and the top of the LNP mixing box cover (3) is evenly provided with a feed port (2), the inside of the LNP mixing box cover (3) is provided with a first motor (1), the inside of the LNP mixing box body (12) is provided with a mixing tank (6), and the inside of the LNP mixing box body (12) at the bottom of the mixing tank (6) is provided with a reciprocating mechanism (15), both sides of the mixing tank (6) are provided with guide blocks (8), the inner side of the LNP mixing box body (12) is provided with guide grooves (5), and the guide grooves (5) are slidably connected to the guide blocks (8), the bottom end of the LNP mixing box cover (3) is provided with a sealing ring (21), the top of the inside of the LNP mixing box body (12) is provided with a sealing groove (22), and the sealing grooves (22) are snap-fitted and connected to the sealing ring (21).

2. A microfluidic rapid mixing device with a reciprocating circulation structure according to claim 1, characterized in that: The reciprocating mechanism (15) comprises a receiving groove (1501), and the receiving groove (1501) is arranged inside the LNP mixing box body (12); a second motor (1505) is installed at one end inside the receiving groove (1501), and a rotating shaft (1503) is installed at one end of the second motor (1505); a rotating disk (1502) is installed on the outer side of the rotating shaft (1503); a movable rod (11) is installed inside the receiving groove (1501), and the movable rod (11) is connected to the rotating disk (1502) through a connecting rod (1504); and the movable rod (11) is connected to the mixing tank (6).

3. A microfluidic rapid mixing device with a reciprocating circulation structure according to claim 2, characterized in that: Balls (1507) are evenly arranged inside the LNP mixing box body (12) at the top of the containing groove (1501), and grooves (1506) are installed inside the balls (1507).

4. A microfluidic rapid mixing device with a reciprocating circulation structure according to claim 1, characterized in that: A stirring main rod is installed at the bottom end of the LNP mixing box cover (3), and stirring shafts (10) are installed on both sides of the stirring main rod. The stirring shaft (10) is connected to the stirring main rod through a pulley (13). Stirring rods (9) are evenly installed on both sides of the stirring shaft (10), and scrapers (7) are installed on the outer sides of the stirring rods (9).

5. A microfluidic rapid mixing device with a reciprocating circulation structure according to claim 4, characterized in that: The stirring rods (9) are distributed on both sides of the stirring shaft (10) in a cross shape.

6. A microfluidic rapid mixing device with a reciprocating circulation structure according to claim 1, characterized in that: The LNP mixing box cover (3) is provided with threaded grooves on both sides, and threaded rods (16) are installed inside the threaded grooves, and hand wheels (4) are installed at the top ends of the threaded rods (16), and fixed plates (17) are installed at the bottom ends of the threaded rods (16), and fixed grooves (19) are installed at the bottom ends of the fixed plates (17). The LNP mixing box body (12) is provided with connecting plates (14) on both sides, and fixed blocks (20) are provided at the top ends of the connecting plates (14), and the fixed blocks (20) are connected to the fixed grooves (19), and anti-slip teeth (18) are evenly installed at the bottom ends of the fixed plates (17).

7. A microfluidic rapid mixing device with a reciprocating circulation structure according to claim 6, characterized in that: The cross-sections of the anti-slip teeth (18) are all arranged in a triangular shape, and are arranged at equal intervals at the bottom end of the fixing plate (17).

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