Motion type sample tube rack

Abstract

The utility model discloses a movable sample tube rack which is used in an automatic exosome enrichment device and comprises a fixed bracket, a movable component, a sliding bracket and a supporting unit, the moving assembly is located in the fixed support. The bottom of the sliding support is inserted into the fixed support and then connected with the movable support. The supporting unit is detachably connected with the sliding bracket; the top of the fixing support is provided with a working position and a conveying position. A limiting plate is arranged at the end, away from the conveying position, of the working position. A support sensor matched with the sliding support is arranged on the side, facing the conveying position, of the limiting plate. The utility model has the beneficial effects that the in-place sensor for determining whether the position of the supporting unit is located at the appointed position of the sliding bracket is arranged on the sliding bracket, so that the supporting unit is prevented from being placed in a wrong position or not placed on the sliding bracket; a limiting plate is arranged at the working position, and a support sensor is arranged on the limiting plate, so that whether the sample pipe frame is located at the working position or not is accurately determined.

Description

Technical Field

[0001] The utility model belongs to the technical field of experimental instruments, and in particular relates to a sample tube rack. Background Art

[0002] Exosomes refer to small membrane vesicles (30-150nm) containing complex RNA and proteins. Nowadays, they specifically refer to discoid vesicles with a diameter of 40-100nm. In 1983, exosomes were first discovered in sheep reticulocytes, and Johnstone named them "exosomes" in 1987. A variety of cells can secrete exosomes under normal and pathological conditions. They are mainly derived from multivesicular bodies formed by the invagination of intracellular lysosomal microparticles, and are released into the extracellular matrix after the multivesicular outer membrane fuses with the cell membrane.

[0003] Exosomes are considered to be specifically secreted membrane vesicles that participate in intercellular communication, and there is growing interest in studying exosomes, both to investigate their functions and to understand how they can be used in the development of minimally invasive diagnostics.

[0004] Neurodegenerative diseases are caused by the loss of neurons and / or their myelin sheaths, which worsen over time and cause functional disorders. Such as Alzheimer's disease (AD), Parkinson's disease (PD), and prion disease. At present, the clear clinical diagnosis of neurodegenerative diseases relies on PET (positron emission tomography), and when pathological changes occur, the disease often develops to an untreatable and irreversible stage. Or the detection of biomarkers through cerebrospinal fluid is highly traumatic and risky, and it is difficult to promote. With the in-depth study of exosomes, it was found that neurogenic exosomes in the blood can be used as samples to detect relevant indicators of neurodegenerative diseases, which can greatly advance the diagnosis of such diseases; and compared with cerebrospinal fluid, this type of sample has stronger compliance for subjects.

[0005] In the process of automated exosome enrichment, a robotic arm is required to drive a test tube clamping device to clamp a test tube with reagents to move the reagents. During this process, the test tube with reagents will be inserted into the inside of the sample tube rack. In order to facilitate the removal of the test tube with reagents, a motion component will be set at the bottom of the sample tube rack to drive the sample tube rack to reciprocate between the working position during automated exosome enrichment and the transfer position for easy removal. If it is not possible to accurately determine whether the sample tube rack is in the working position, the test tube with reagents cannot be inserted into the inside of the sample tube rack, and the automated enrichment of exosomes cannot be completed.

[0006] In view of the above problems, the utility model provides a movable sample tube rack. Utility Model Content

[0007] In order to solve the problem of how to accurately determine whether a sample tube rack is located at a working position, the utility model provides a movable sample tube rack.

[0008] A movable sample tube rack is used in an automated exosome enrichment device, comprising a fixed bracket, a moving component, a sliding bracket and a support unit; the moving component is located inside the fixed bracket; the bottom of the sliding bracket is inserted into the fixed bracket and then connected to the moving bracket; the support unit and the sliding bracket are detachably connected; a working position and a transmission position are provided on the top of the fixed bracket; a limiting plate is provided at one end of the working position away from the transmission position; a bracket sensor adapted to the sliding bracket is provided on the side of the limiting plate facing the transmission position.

[0009] Furthermore, a magnetic attraction structure is provided on the top of the sliding bracket; one end of the magnetic attraction structure is fixed on the sliding bracket, and the other end uses magnetic force to attract the supporting unit.

[0010] Furthermore, an in-position sensor is provided inside the magnetic attraction structure; and a positioning hole adapted to the in-position sensor is provided on the support unit.

[0011] Furthermore, a limiting frame is provided on the top of the sliding bracket; the limiting frames are evenly arrayed on the top of the sliding bracket; and the gap between adjacent limiting frames is greater than the thickness of the supporting unit.

[0012] Furthermore, the motion assembly includes a driving motor and a transmission assembly; the transmission assembly is located inside the fixed bracket; and the main shaft of the driving motor is connected to the transmission assembly after being inserted into the fixed bracket.

[0013] Furthermore, the transmission assembly includes a driven wheel, a driven shaft, a transmission medium and a driving wheel; the interior of the driving wheel is connected to the main shaft of the driving motor, and the exterior is connected to the outer wall of the driven wheel through the transmission medium; the driven shaft is located at the center of the driven wheel; the bottom of the sliding bracket is inserted into the interior of the fixed bracket and connected to the transmission medium.

[0014] Furthermore, the driven shaft is rotatably connected to the fixed bracket.

[0015] Furthermore, the fixed bracket includes a pillar, a fixed platform and a protective platform; one end of the fixed platform is fixedly connected to the pillar, and the other end is fixedly connected to the anti-slip platform; the pillars are regularly arrayed on the fixed platform; and the transmission assembly is located between the fixed platform and the protective platform.

[0016] Furthermore, the driving motor is arranged on a side of the fixed platform away from the protection platform; and the sliding bracket is located on a side of the fixed platform away from the support column.

[0017] Furthermore, a mounting frame is provided on a side of the fixed platform away from the protective platform; one end of the mounting frame is connected to the protective platform, and the other end is connected to the driving motor.

[0018] The beneficial effects of the utility model include: an on-site sensor is arranged on the sliding bracket to determine whether the support unit is located at the specified position of the sliding bracket, so as to prevent the support unit from being misplaced or not being placed on the sliding bracket; a limit plate is arranged at the working position, and a bracket sensor is arranged on the limit plate, so as to accurately determine whether the sample tube rack is located at the working position. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a structural schematic diagram of a sample tube rack for implementing the utility model;

[0020] Figure 2 A side view of a sample tube rack for implementing the utility model;

[0021] Figure 3 for Figure 2 AA section view;

[0022] Figure 4 A top view of a sample tube rack for implementing the utility model;

[0023] Figure 5 for Figure 4 BB section view;

[0024] Figure 6 It is a structural schematic diagram of a sliding bracket for implementing the utility model;

[0025] Figure 7 It is a schematic diagram of the structure in a support unit for implementing the utility model;

[0026] In the figure, 1. fixed bracket; 2. driving motor; 3. transmission assembly; 4. sliding bracket; 5. supporting unit; 6. limiting plate; 11. pillar; 12. fixed platform; 13. protection platform; 14. mounting bracket; 31. driven wheel; 32. driven shaft; 33. transmission medium; 34. driving wheel; 41. in-position sensor; 42. magnetic structure; 43. limiting bracket; 51. holding end; 52. mounting hole; 53. positioning hole; 61. bracket sensor. DETAILED DESCRIPTION

[0027] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. The utility model can also be implemented or applied through other different specific implementation methods. In the absence of conflict, the following embodiments and features in the embodiments can be combined with each other. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the utility model.

[0028] In the description of the present invention, it should be understood that the terms "center", "thickness", "up", "down", "front", "back", "top", "bottom", "inside", "outside", etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.

[0029] In addition, in the description of the present invention, “plurality” means two or more than two, unless otherwise clearly and specifically defined.

[0030] like Figure 1-7 A movable sample tube rack shown is used in an automated exosome enrichment device, which includes a fixed bracket 1, a moving component, a sliding bracket 4 and a support unit 5; the moving component is located inside the fixed bracket 1; the bottom of the sliding bracket 4 is inserted into the interior of the fixed bracket 1 and then connected to the movable bracket; the support unit 5 and the sliding bracket 4 are detachably connected; a working position and a transmission position are provided on the top of the fixed bracket 1; a limiting plate 6 is provided at the end of the working position away from the transmission position; a bracket sensor 61 adapted to the sliding bracket 4 is provided on the side of the limiting plate 6 facing the transmission position, so as to accurately determine whether the sample tube rack is in the working position.

[0031] In one embodiment of the present application, a buckle is provided on the top of the sliding bracket 4 to match the support unit 5. When the support unit 5 is inserted into the interior of the sliding bracket 4, the buckle limits the position of the support unit 5 to prevent the support unit 5 from being offset from the sliding bracket 4 during the movement of the sliding assembly. If the support unit 5 is offset from the sliding bracket 4, the robot arm will still not be able to align with the test tube after the sliding bracket 4 reaches the working position.

[0032] In some embodiments of the present application, a magnetic attraction structure 42 is provided on the top of the sliding bracket 4; one end of the magnetic attraction structure 42 is fixed to the sliding bracket 4, and the other end uses magnetic force to attract the support unit 5. The magnetic attraction structure 42 uses magnetic force to restrict the support unit 5 to a fixed position to prevent the support unit 5 from being displaced.

[0033] In some exemplary embodiments of the present application, a position sensor 41 is provided inside the magnetic attraction structure 42; and a positioning hole 53 adapted to the position sensor 41 is provided on the support unit 5. The purpose of the position sensor 41 is to identify whether the support unit 5 is in a specified position on the sliding bracket 4, so as to prevent the support unit 5 from being misplaced or not being placed on the sliding bracket 4.

[0034] like Figure 6 As shown, a limiting frame 43 is also provided on the top of the sliding bracket 4; the limiting frames 43 are evenly arrayed on the top of the sliding bracket 4. Figure 2-4 It can be seen that the gap between adjacent limiting frames 43 is greater than the thickness of the supporting unit 5 .

[0035] In some embodiments of the present application, four limiting frames 43 are provided on the top of the sliding bracket 4 to place three supporting units 5 .

[0036] like Figure 7 As shown, a gripping end 51 is provided on one side of the support unit 5 away from the positioning hole 53, so as to facilitate the removal of the sliding bracket 4 from the support unit 5. A plurality of mounting holes 52 for placing test tubes are provided on the top of the support unit 5.

[0037] Preferably, eight mounting holes 52 are provided.

[0038] like Figure 1-5 As shown, the motion assembly includes a driving motor 2 and a transmission assembly 3; the transmission assembly 3 is located inside the fixed bracket 1; the main shaft of the driving motor 2 is inserted into the fixed bracket 1 and connected to the transmission assembly 3. The driving motor 2 drives the sliding bracket 4 to move on the top of the fixed bracket 1 through the transmission assembly 3, so that the sliding bracket 4 reciprocates between the working position during the automated exosome enrichment and the transmission position for easy access. During the automated exosome enrichment process, the sliding bracket 4 is located at the working position. After the exosome enrichment is completed, the motion assembly transfers the sliding bracket 4 to the transmission position for easy access to the test tube.

[0039] In the specific example of the present application, the transmission assembly 3 includes a driven wheel 31, a driven shaft 32, a transmission medium 33 and a driving wheel 34; the interior of the driving wheel 34 is connected to the main shaft of the driving motor 2, and the exterior is connected to the outer wall of the driven wheel 31 through the transmission medium 33; the driven shaft 32 is located at the center of the driven wheel 31; the bottom of the sliding bracket 4 is inserted into the interior of the fixed bracket 1 and connected to the transmission medium 33.

[0040] Specifically, the driving wheel 34 and the driven wheel 31 are sprockets, and the transmission medium 33 is a chain.

[0041] Alternatively, the driving wheel 34 and the driven wheel 31 are pulleys, and the transmission medium 33 is a belt.

[0042] Although this embodiment only provides a solution in which the measuring bracket includes chain drive and belt rotation, those skilled in the art can use this embodiment as other solutions that can drive the sliding bracket 4 to perform linear reciprocating motion on the top of the fixed bracket 1 without departing from the spirit and scope of the present invention.

[0043] Preferably, the driven shaft 32 is rotatably connected to the fixed bracket 1 to limit the position of the driven wheel 31 .

[0044] like Figure 1-5 As shown, the fixed support 1 includes a pillar 11, a fixed platform 12 and a protective platform 13; one end of the fixed platform 12 is fixedly connected to the pillar 11, and the other end is fixedly connected to the anti-slip platform; the pillars 11 are regularly arrayed on the fixed platform 12; the transmission assembly 3 is located between the fixed platform 12 and the protective platform 13. The pillars 11 prop up the fixed platform 12 and the protective platform 13, so that the sliding support 4 and the supporting unit 5 reach a specified height.

[0045] Specifically, the driving motor 2 is arranged on a side of the fixed platform 12 away from the protection platform 13 ; the sliding bracket 4 is located on a side of the fixed platform 12 away from the support 11 , so as to ensure that the driving motor 2 does not interfere with the movement of the sliding bracket 4 .

[0046] In some examples of the present application, a mounting frame 14 is provided on one side of the fixed platform 12 away from the protection platform 13; one end of the mounting frame 14 is connected to the protection platform 13, and the other end is connected to the drive motor 2. The purpose of the mounting frame 14 is to limit the position of the drive motor 2.

[0047] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "illustrative embodiments", "examples", "specific examples", "some examples", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the utility model. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0048] The embodiments described in this application are only part of the embodiments of the utility model, not all of the embodiments. Those skilled in the art can easily understand other advantages and effects of the utility model from the contents disclosed in this specification. The utility model can also be implemented or applied through other different specific implementation methods. In the absence of conflict, the following embodiments and features in the embodiments can be combined with each other. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

Claims

1. A movable sample tube rack, used in an automated exosome enrichment device, comprising a fixed bracket, a moving component, a sliding bracket and a supporting unit; the moving component is located inside the fixed bracket; the bottom of the sliding bracket is inserted into the fixed bracket and connected to the moving bracket; the supporting unit is detachably connected to the sliding bracket; characterized in that, A working position and a transmission position are provided on the top of the fixed bracket; a limit plate is provided at one end of the working position away from the transmission position; and a bracket sensor adapted to the sliding bracket is provided on the side of the limit plate facing the transmission position.

2. The movable sample tube rack according to claim 1, characterized in that: A magnetic attraction structure is provided on the top of the sliding bracket; one end of the magnetic attraction structure is fixed on the sliding bracket, and the other end uses magnetic force to attract the supporting unit.

3. The movable sample tube rack according to claim 2, characterized in that: An in-position sensor is arranged inside the magnetic attraction structure; and a positioning hole adapted to the in-position sensor is arranged on the support unit.

4. The movable sample tube rack according to claim 2, characterized in that: A limiting frame is also provided on the top of the sliding bracket; the limiting frames are evenly arrayed on the top of the sliding bracket; and the gap between adjacent limiting frames is greater than the thickness of the supporting unit.

5. A movable sample tube rack according to any one of claims 1 to 4, characterized in that: The motion assembly includes a driving motor and a transmission assembly; the transmission assembly is located inside the fixed bracket; the main shaft of the driving motor is connected to the transmission assembly after being inserted into the fixed bracket.

6. The movable sample tube rack according to claim 5, characterized in that: The transmission assembly includes a driven wheel, a driven shaft, a transmission medium and a driving wheel; the interior of the driving wheel is connected to the main shaft of the driving motor, and the exterior is connected to the outer wall of the driven wheel through the transmission medium; the driven shaft is located at the center of the driven wheel; the bottom of the sliding bracket is inserted into the interior of the fixed bracket and connected to the transmission medium.

7. The movable sample tube rack according to claim 6, characterized in that: The driven shaft is rotatably connected to the fixed bracket.

8. The movable sample tube rack according to claim 5, characterized in that: The fixed bracket includes a pillar, a fixed platform and a protective platform; one end of the fixed platform is fixedly connected to the pillar, and the other end is fixedly connected to the anti-skid platform; the pillars are regularly arrayed on the fixed platform; the transmission assembly is located between the fixed platform and the protective platform.

9. The movable sample tube rack according to claim 8, characterized in that: The driving motor is arranged on a side of the fixed platform away from the protection platform; the sliding bracket is located on a side of the fixed platform away from the support column.

10. The movable sample tube rack according to claim 8, characterized in that: A mounting frame is provided on one side of the fixed platform away from the protective platform; one end of the mounting frame is connected to the protective platform, and the other end is connected to the driving motor.

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